Cited by 1,948RNA Research and SplicingRNA regulation and diseaseRNA and protein synthesis mechanisms

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AU-rich elements: characterization and importance in mRNA degradation

Chen, Chyi-Ying A., Shyu, Ann-Bin·1995·Trends in Biochemical Sciences

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Abstract

Adenylate/uridylate-rich elements (AREs) are found in the 3' untranslated region (UTR) of many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription factors and cytokines. They represent the most common determinant of RNA stability in mammalian cells. Moreover, ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines and transcription inhibitors. These observations suggest that AREs play a critical role in the regulation of gene expression during cell growth and differentiation, and in the immune response.

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Authors: Chen, C.-Y. A., & Shyu, A.-B.
Affiliations: The University of Texas Health Science Center at Houston (US)
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 1995-11
Volume: 20
Issue: 11
Pages: 465-470
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/s0968-0004(00)89102-1
OpenAlex: W2029706883
Cited by: 1,948
References: 38
Citations by year: 2026: 13 · 2025: 29 · 2024: 28 · 2023: 33 · 2022: 36 · 2021: 36 · 2020: 49 · 2019: 32 · 2018: 52 · 2017: 33 · 2016: 33 · 2015: 52 · 2014: 61 · 2013: 68 · 2012: 63
FWCI: 4.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM046454, GM-46454)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: AU-rich elements, mRNA degradation, 3' untranslated region, RNA stability, proto-oncogenes, transcription factors, cytokines, phorbol ester, calcium ionophore, gene expression regulation, cell growth and differentiation, immune response
MeSH terms: Adenine, Animals, Base Composition, Gene Expression Regulation, RNA, Messenger, Transcription, Genetic, Protein Biosynthesis, Uracil, Signal Transduction, RNA-Binding Proteins, Conserved Sequence

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AU-rich elements: characterization and importance in mRNA degradation

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