The WD repeat: a common architecture for diverse functions

Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

Soda, M., Choi, Y. L., Enomoto, M., Takada, S., Yamashita, Y., Ishikawa, S., Fujiwara, S.-I., Watanabe, H., Kurashina, K., Hatanaka, H., et al. (2007) · Nature · doi:10.1038/nature05945 · Cited by 5,439

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry

Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575

The SCF ubiquitin ligase: insights into a molecular machine

Cardozo, T., & Pagano, M. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1471 · Cited by 1,114

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., & Yoshimori, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00381 · Cited by 791

Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

Keskin, O., Gursoy, A., Ma, B., & Nussinov, R. (2008) · Chemical Reviews · doi:10.1021/cr040409x · Cited by 697

Hemopexin: structure, function, and regulation

Tolosano, E., & Altruda, F. (2002) · DNA and Cell Biology · doi:10.1089/104454902753759717 · Cited by 426

Iron-Sulfur Protein Biogenesis in Eukaryotes: Components and Mechanisms

Lill, R., & Mühlenhoff, U. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104538 · Cited by 365

WIPI-1α (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy

Proikas-Cezanne, T., Waddell, S., Gaugel, A., Frickey, T., Lupas, A., & Nordheim, A. (2004) · Oncogene · doi:10.1038/sj.onc.1208331 · Cited by 332

SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.

Hughes, A. L., Todd, B. L., & Espenshade, P. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.012 · Cited by 320

Mutant WD-repeat protein in triple-A syndrome

Tullio-Pelet, A., Salomon, R., Hadj-Rabia, S., Mugnier, C., de Laet, M.-H., Chaouachi, B., Bakiri, F., Brottier, P., Cattolico, L., Penet, C., et al. (2000) · Nature Genetics · doi:10.1038/81642 · Cited by 312

Stress and mTORture signaling

Reiling, J. H., & Sabatini, D. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209889 · Cited by 311

Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene

Handschug, K. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.3.283 · Cited by 257

Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans

Chang, Y. C., Bien, C. M., Lee, H., Espenshade, P. J., & Kwon‐Chung, K. J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05676.x · Cited by 212

Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome

Murray, J. T., Panaretou, C., Stenmark, H., Miaczynska, M., & Backer, J. M. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30605.x · Cited by 185

Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin

Wright, D. P., Rosendale, D. I., & Roberton, A. M. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09265.x · Cited by 185

Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820

Du, X., Volkov, O. A., Czerwinski, R. M., Tan, H., Huerta, C., Morton, E. R., Rizzi, J. P., Wehn, P. M., Xu, R., Nijhawan, D., et al. (2019) · Structure · doi:10.1016/j.str.2019.10.005 · Cited by 181

Antiviral Protein Ski8 Is a Direct Partner of Spo11 in Meiotic DNA Break Formation, Independent of Its Cytoplasmic Role in RNA Metabolism

Arora, C., Kee, K., Maleki, S., & Keeney, S. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00063-2 · Cited by 173

A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life

Haas, C. E., Rodionov, D. A., Kropat, J., Malasarn, D., Merchant, S. S., & de Crécy-Lagard, V. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-470 · Cited by 159

Chlamydomonas IFT172 Is Encoded by FLA11, Interacts with CrEB1, and Regulates IFT at the Flagellar Tip

Pedersen, L. B., Miller, M. S., Geimer, S., Leitch, J. M., Rosenbaum, J. L., & Cole, D. G. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.037 · Cited by 164

Phototransduction: crystal clear

Ridge, K. D., Abdulaev, N. G., Sousa, M., & Palczewski, K. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00172-5 · Cited by 163

Mutation analysis ofPEX7 in 60 probands with rhizomelic chondrodysplasia punctata and functional correlations of genotype with phenotype

Braverman, N., Chen, L., Lin, P., Obie, C., Steel, G., Douglas, P., Chakraborty, P. K., Clarke, J. T. R., Boneh, A., Moser, A., et al. (2002) · Human Mutation · doi:10.1002/humu.10124 · Cited by 134

Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition

Tessé, S., Storlazzi, A., Kleckner, N., Gargano, S., & Zickler, D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2034282100 · Cited by 132

Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p

Barth, H., Meiling-Wesse, K., Epple, U. D., & Thumm, M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03016-2 · Cited by 123

Mutational spectrum in the PEX7 gene and functional analysis of mutant alleles in 78 patients with rhizomelic chondrodysplasia punctata type 1

Motley, A. M., Brites, P., Gerez, L., Hogenhout, E., Haasjes, J., Benne, R., Tabak, H. F., Wanders, R. J. A., & Waterham, H. R. (2002) · The American Journal of Human Genetics · doi:10.1086/338998 · Cited by 107

Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM3 Ubiquitin Ligase in Rat Hippocampal Neurons

Hung, A. Y., Sung, C. C., Brito, I. L., & Sheng, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009842 · Cited by 106

Exploiting Adaptive Laboratory Evolution of Streptomyces clavuligerus for Antibiotic Discovery and Overproduction

Charusanti, P., Fong, N. L., Nagarajan, H., Pereira, A. R., Li, H. J., Abate, E. A., Su, Y., Gerwick, W. H., & Palsson, B. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033727 · Cited by 93

Deficiency of ferritin heavy-chain nuclear import in Triple A syndrome implies nuclear oxidative damage as the primary disease mechanism

Storr, H. L., Kind, B., Parfitt, D. A., Chapple, J. P., Lorenz, M., Koehler, K., Huebner, A., & Clark, A. J. L. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0056 · Cited by 84

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction

Macdonald, J. D., Chacón Simon, S., Han, C., Wang, F., Shaw, J. G., Howes, J. E., Sai, J., Yuh, J. P., Camper, D., Alicie, B. M., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01411 · Cited by 66

Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective

Chen, X., Xu, J., Wang, X., Long, G., You, Q., & Guo, X. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00037 · Cited by 63

Functional interactions among members of the meiotic initiation complex in fission yeast

Steiner, S., Kohli, J., & Ludin, K. (2010) · Current Genetics · doi:10.1007/s00294-010-0296-0 · Cited by 34

snow white, a Zebrafish Model of Hermansky-Pudlak Syndrome Type 5

Daly, C. M. S., Willer, J., Gregg, R., & Gross, J. M. (2013) · Genetics · doi:10.1534/genetics.113.154898 · Cited by 33

The interactome of CCT complex—a computational analysis

Narayanan, A., Pullepu, D., & Kabir, M. A. (2016) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2016.09.002 · Cited by 29

The WD40-protein CFAP52/WDR16 is a centrosome/basal body protein and localizes to the manchette and the flagellum in male germ cells

Tapia Contreras, C., & Hoyer-Fender, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-71120-9 · Cited by 27

WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling

Yan, S., & Willis, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.144 · Cited by 16

T and Z , partial seed coat patterning genes in common bean, provide insight into the structure and protein interactions of a plant MBW complex

McClean, P. E., Roy, J., Colbert, C. L., Osborne, C., Lee, R., Miklas, P. N., & Osorno, J. M. (2024) · G3: Genes, Genomes, Genetics · doi:10.1093/g3journal/jkae184 · Cited by 13

WDR2 regulates the orphan kinesin KIN-G to promote hook complex and Golgi biogenesis in Trypanosoma brucei

(2025) · doi:10.1128/mbio.00371-25 · Cited by 3