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Diverse roles for the LDL receptor family

Strickland, Dudley K., Gonias, Steven L., Argraves, W.Scott·2002·Trends in Endocrinology & Metabolism
DOI 10.1016/s1043-2760(01)00526-4
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Abstract

The low-density lipoprotein (LDL) receptor family consists of several related scavenger receptors that not only function as important cargo transporters, but also inform the cell of changes in its environment by mediating signaling responses. The LDL receptor was the first family member to be characterized and its function seems to be restricted to lipoprotein metabolism. By contrast, lipoprotein metabolism does not appear to be the exclusive function of the other characterized LDL receptor family members. It is now apparent that cargo transport by members of the LDL receptor family is closely associated with regulation of cellular physiology and cellular signaling events. Here, we focus on the diverse biological activities of certain members of this family.

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  • LRP1 is a plasma membrane receptor mediating endocytosis, phagocytosis, chemotaxis and signaling for extracellular ligands including ApoE, lipoproteins, α2-macroglobulin, proteases, extracellular matrix proteins, growth factors, complement factors, heat shock proteins and dozens of other natural ligands.

    “Low density lipoprotein (LDL) receptor related protein 1 (LRP1) is a plasma membrane receptor mediating endocytosis, phagocytosis, chemotaxis and signaling for extracellular ligands, including apolipoprotein E (ApoE), lipoproteins, α2-macroglobulin, proteases, extracellular matrix proteins, growth factors, complement factors, heat shock proteins and dozens of other natural ligands (1–5).”

    From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [3]

  • LRP1 and related LDL family receptors regulate a wide range of cellular processes, including endocytosis, phagocytosis, chemotaxis and signaling in response to dozens of ligands.

    “Outside the brain, LRP1 and related LDL family receptors regulate a wide range of cellular processes, including endocytosis, phagocytosis, chemotaxis and signaling in response to dozens of ligands (1–4).”

    From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [3]

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Research works printed but not linked: 55

  1. Goldstein, 1974, Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia, J. Biol. Chem., 249, 5153, 10.1016/S0021-9258(19)42341-7 · DOI · Paper page
  2. Yamamoto, 1984, The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA, Cell, 39, 27, 10.1016/0092-8674(84)90188-0 · DOI · Paper page
  3. Brown, 1979, Receptor-mediated endocytosis: insights from the lipoprotein receptor system, Proc. Natl. Acad. Sci. U.S.A., 76, 3330, 10.1073/pnas.76.7.3330 · DOI · Paper page
  4. Russell, 1989, Different combinations of cysteine-rich repeats mediate binding of LDL receptor to different proteins, J. Biol. Chem., 264, 21682, 10.1016/S0021-9258(20)88240-4 · DOI · Paper page
  5. Herz, 1992, LDL receptor-related protein internalizes and degrades uPA–PAI-1 complexes and is essential for embryo implantation, Cell, 71, 411, 10.1016/0092-8674(92)90511-A · DOI · Paper page
  6. Swarnakar, 2001, The apolipoprotein E-dependent low density lipoprotein cholesteryl ester selective uptake pathway in murine adrenocortical cells involves chondroitin sulfate proteoglycans and an alpha 2-macroglobulin receptor, J. Biol. Chem., 276, 21121, 10.1074/jbc.M101691200 · DOI
  7. Xu, 2001, Low density lipoprotein receptor-related protein is required for macrophage-mediated oxidation of low density lipoprotein by 12/15-lipoxygenase, J. Biol. Chem., 276, 36454, 10.1074/jbc.M105093200 · DOI
  8. Wolf, 1992, Characterization and immunohistochemical localization of α2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain, Am. J. Pathol., 141, 37
  9. Poirier, 1993, Cholesterol synthesis and lipoprotein reuptake during synaptic remodeling in hippocampus in adult rats, Neuroscience, 55, 81, 10.1016/0306-4522(93)90456-P · DOI
  10. Nathan, 1994, Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro, Science, 264, 850, 10.1126/science.8171342 · DOI · Paper page
  11. Nathan, 1995, The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization, J. Biol. Chem., 270, 19791, 10.1074/jbc.270.34.19791 · DOI · Paper page
  12. Kounnas, 1992, The α2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A, J. Biol. Chem., 267, 12420, 10.1016/S0021-9258(18)42291-0 · DOI
  13. Hofer, 1994, Members of the low density lipoprotein receptor family mediate cell entry of a minor-group common cold virus, Proc. Natl. Acad. Sci. U.S.A., 91, 1839, 10.1073/pnas.91.5.1839 · DOI
  14. Liu, 2000, Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands, Nat. Med., 6, 1380, 10.1038/82199 · DOI
  15. Quinn, 1999, Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP), Exp. Cell Res., 251, 433, 10.1006/excr.1999.4590 · DOI · Paper page
  16. Hussaini, 1996, Transcriptional regulation of LDL receptor-related protein by IFN-gamma and the antagonistic activity of TGF-β1 in the RAW 264.7 macrophage-like cell line, J. Leukocyte Biol., 59, 733, 10.1002/jlb.59.5.733 · DOI
  17. Barmina, 1999, Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization, J. Biol. Chem., 274, 30087, 10.1074/jbc.274.42.30087 · DOI
  18. Yang, 2000, Extracellular MMP2 levels are regulated by the LRP scavenger receptor and thrombospondin 2, J. Biol. Chem., 276, 8403, 10.1074/jbc.M008925200 · DOI
  19. Hahn-Dantona, 2001, The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism, J. Biol. Chem., 276, 15498, 10.1074/jbc.M100121200 · DOI
  20. Warshawsky, 1996, The low density lipoprotein receptor-related protein can function independently from heparan sulfate proteoglycans in tissue factor pathway inhibitor endocytosis, J. Biol. Chem., 271, 25873, 10.1074/jbc.271.42.25873 · DOI
  21. Hembrough, 2001, Tissue factor pathway inhibitor inhibits endothelial cell proliferation via association with the very low density lipoprotein receptor, J. Biol. Chem., 276, 12241, 10.1074/jbc.M010395200 · DOI
  22. Hamik, 1999, Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein, J. Biol. Chem., 274, 4962, 10.1074/jbc.274.8.4962 · DOI
  23. Kounnas, 1995, LDL receptor-related protein, a multifunctional apoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation, Cell, 82, 331, 10.1016/0092-8674(95)90320-8 · DOI · Paper page
  24. Ulery, 2000, Modulation of β-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease, J. Biol. Chem., 275, 7410, 10.1074/jbc.275.10.7410 · DOI · Paper page
  25. Stefansson, 1998, Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein, J. Biol. Chem., 273, 6358, 10.1074/jbc.273.11.6358 · DOI
  26. Nykjaer, 1997, Recycling of the urokinase receptor upon internalization of the uPA: serpin complexes, EMBOJ., 16, 2610, 10.1093/emboj/16.10.2610 · DOI
  27. Weaver, 1997, Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin, J. Biol. Chem., 272, 14372, 10.1074/jbc.272.22.14372 · DOI
  28. Webb, 1999, The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro, J. Biol. Chem., 274, 7412, 10.1074/jbc.274.11.7412 · DOI
  29. Willnow, 1996, Defective forebrain development in mice lacking gp330/megalin, Proc. Natl. Acad. Sci. U.S.A., 93, 8460, 10.1073/pnas.93.16.8460 · DOI
  30. Leheste, 1999, Megalin knockout mice as an animal model of low molecular weight proteinuria, Am. J. Pathol., 155, 1361, 10.1016/S0002-9440(10)65238-8 · DOI
  31. Marino, 2000, Megalin-mediated transcytosis of thyroglobulin by thyroid cells is a calmodulin-dependent process, Thyroid, 10, 461, 10.1089/thy.2000.10.461 · DOI
  32. Nielsen, 2001, Transcellular transport of vitamin B(12) in LLC-PK1 renal proximal tubule cells, J. Am. Soc. Nephrol., 12, 1099, 10.1681/ASN.V1261099 · DOI
  33. Marino, 2001, Transcytosis of retinol-binding protein across renal proximal tubule cells after megalin (gp330)-mediated endocytosis, J. Am. Soc. Nephrol., 12, 637, 10.1681/ASN.V124637 · DOI
  34. Kounnas, 1993, Glycoprotein 330, a member of the LDL receptor family, binds lipoprotein lipase in vitro, J. Biol. Chem., 268, 14176, 10.1016/S0021-9258(19)85224-9 · DOI
  35. Orlando, 1993, Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex, Proc. Natl. Acad. Sci. U.S.A., 90, 4082, 10.1073/pnas.90.9.4082 · DOI
  36. Sakai, 1994, Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene, J. Biol. Chem., 269, 2173, 10.1016/S0021-9258(17)42151-X · DOI
  37. Wyne, 1996, Expression of the VLDL receptor in endothelial cells, Arterioscler. Thromb. Vasc. Biol., 16, 407, 10.1161/01.ATV.16.3.407 · DOI
  38. Multhaupt, 1996, Expression of very low density lipoprotein receptor in the vascular wall: analysis of human tissues by in situ hybridization and immunohistochemistry, Am. J. Pathol., 148, 1985
  39. Frykman, 1995, Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor, Proc. Natl. Acad. Sci. U.S.A., 92, 8453, 10.1073/pnas.92.18.8453 · DOI · Paper page
  40. Kobayashi, 1996, Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor, J. Biol. Chem., 271, 6852, 10.1074/jbc.271.12.6852 · DOI
  41. Argraves, 1997, The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor, J. Clin. Invest., 100, 2170, 10.1172/JCI119753 · DOI · Paper page
  42. Tacken, 2000, LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice, J. Lipid Res., 41, 2055, 10.1016/S0022-2275(20)32367-1 · DOI
  43. Trommsdorff, 1998, Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein, J. Biol. Chem., 273, 33556, 10.1074/jbc.273.50.33556 · DOI · Paper page
  44. Gotthardt, 2000, Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction, J. Biol. Chem., 275, 25616, 10.1074/jbc.M000955200 · DOI · Paper page
  45. Apodaca, 2001, Endocytic traffic in polarized epithelial cells: role of the actin and microtubule cytoskeleton, Traffic, 2, 149, 10.1034/j.1600-0854.2001.020301.x · DOI
  46. Verhey, 2001, Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules, J. Cell Biol., 152, 959, 10.1083/jcb.152.5.959 · DOI · Paper page
  47. Muramatsu, 2000, LDL receptor-related protein as a component of the midkine receptor, Biochem. Biophys. Res. Commun., 270, 936, 10.1006/bbrc.2000.2549 · DOI
  48. Huang, 1996, Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways, Proc. Natl. Acad. Sci. U.S.A., 93, 8699, 10.1073/pnas.93.16.8699 · DOI
  49. Zhuo, 2000, Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation, J. Neurosci., 20, 542, 10.1523/JNEUROSCI.20-02-00542.2000 · DOI · Paper page
  50. Bacskai, 2000, The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-d-aspartate receptors, Proc. Natl. Acad. Sci. U.S.A., 97, 11551, 10.1073/pnas.200238297 · DOI · Paper page
  51. Barnes, 2001, Tyrosine phosphorylated LDL receptor-related protein 1 (LRP1) associates with the adaptor protein Shc in Src-transformed cells, J. Biol. Chem., 22, 19119, 10.1074/jbc.M011437200 · DOI
  52. Trommsdorff, 1999, Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2, Cell, 97, 689, 10.1016/S0092-8674(00)80782-5 · DOI · Paper page
  53. Howell, 1999, The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids, Mol. Cell Biol., 19, 5179, 10.1128/MCB.19.7.5179 · DOI · Paper page
  54. Webb, 2001, Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth, J. Cell Biol., 152, 741, 10.1083/jcb.152.4.741 · DOI
  55. Haugh, 1999, Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts, J. Biol. Chem., 274, 34350, 10.1074/jbc.274.48.34350 · DOI

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Metadata

Authors
Strickland, D. K., Gonias, S. L., & Argraves, W. S.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2002-03
Volume
13
Issue
2
Pages
66-74
ISSN
1043-2760
DOI
10.1016/s1043-2760(01)00526-4
Cited by
284
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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