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The endocytic receptor protein LRP also mediates neuronal calcium signaling via N -methyl- d -aspartate receptors
Abstract
The low density lipoprotein receptor-related protein (LRP) is an endocytic receptor that is a member of the low density lipoprotein receptor family. We report that the LRP ligand, activated α 2 -macroglobulin (α 2 M*), induces robust calcium influx in cultured primary neurons, but not in nonneuronal LRP-containing cells in the same culture. The calcium influx is mediated through N -methyl- d -aspartate receptor channels, which explains the neuron specificity of the response. Microapplication of α 2 M* leads to a localized response at the site of application that dissipates rapidly, suggesting that the calcium signal is temporally and spatially discrete. Calcium influx to α 2 M* is blocked by the physiological LRP inhibitor, receptor-associated protein. Bivalent antibodies to the extracellular domain of LRP, but not Fab fragments of the same antibody, cause calcium influx, indicating that the response is specific to LRP and may require dimerization of the receptor. Thus, LRP is an endocytic receptor with a novel signaling role.
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The cleavage of LRP observed could modulate signaling roles of LRP in neurons.
“However, both LRP (48,49) and other members of the LDL receptor-related family (50) have been implicated as having signaling roles in neurons, and it seems likely that the cleavage of LRP we observe could modulate such signaling.”
From The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate (2005) · cites this paper as [48]
LRP and other LDL receptor-related family members have signaling roles in neurons.
“However, both LRP (48,49) and other members of the LDL receptor-related family (50) have been implicated as having signaling roles in neurons, and it seems likely that the cleavage of LRP we observe could modulate such signaling.”
From The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate (2005) · cites this paper as [48]
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Cites
Reelin Is a Ligand for Lipoprotein Receptors
D'Arcangelo, G., Homayouni, R., Keshvara, L., Rice, D. S., Sheldon, M., & Curran, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80860-0 · Cited by 808
Willnow, T. E., Rohlmann, A., Horton, J., Otani, H., Braun, J. R., Hammer, R. E., & Herz, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00623.x · Cited by 276
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Research works printed but not linked: 36
- 10.1016/0896-6273(93)90070-8 · DOI · Paper page
- 10.1002/j.1460-2075.1988.tb03306.x · DOI
- 10.1016/S0021-9258(18)38172-9 · DOI
- 10.1016/S0021-9258(19)50384-2 · DOI
- 10.1074/jbc.274.2.717 · DOI
- 10.1016/0378-1119(94)90565-7 · DOI
- 10.1016/1047-8477(91)90086-C · DOI
- 10.1016/1047-8477(92)90036-A · DOI
- 10.1074/jbc.273.48.32213 · DOI
- 10.1016/S0021-9258(19)83641-4 · DOI
- 10.1046/j.1471-4159.1998.71051993.x · DOI
- 10.1074/jbc.272.1.647 · DOI
- 10.1046/j.1471-4159.1999.0731393.x · DOI · Paper page
- 10.1016/S0021-9258(17)45368-3 · DOI
- 10.1016/S0021-9258(18)43962-2 · DOI
- 10.1016/S0021-9258(17)32340-2 · DOI · Paper page
- 10.1016/S0021-9258(17)32305-0 · DOI
- 10.1006/abbi.1996.0359 · DOI
- 10.1006/bbrc.1994.1576 · DOI
- 10.1111/j.1750-3639.1998.tb00190.x · DOI
- 10.1523/JNEUROSCI.19-16-07100.1999 · DOI · Paper page
- 10.1016/S0166-2236(98)01277-6 · DOI
- 10.1002/(SICI)1097-4547(19960201)43:3<282::AID-JNR3>3.0.CO;2-F · DOI
- 10.1523/JNEUROSCI.20-02-00542.2000 · DOI
- 10.1073/pnas.92.21.9480 · DOI · Paper page
- 10.1016/0006-8993(96)00741-X · DOI
- 10.1016/0006-8993(91)90820-L · DOI
- 10.1016/S0014-5793(98)00475-X · DOI
- 10.1016/S0092-8674(00)80782-5 · DOI · Paper page
- 10.1097/00005072-199604000-00012 · DOI · Paper page
- 10.1016/S0306-4522(98)00489-8 · DOI · Paper page
- 10.1016/0092-8674(95)90320-8 · DOI · Paper page
- 10.1523/JNEUROSCI.18-01-00195.1998 · DOI · Paper page
- 10.1046/j.1471-4159.1997.69051904.x · DOI · Paper page
- 10.1001/archneur.57.5.646 · DOI
- 10.1074/jbc.273.50.33556 · DOI · Paper page
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Dumanis, S. B., Cha, H.-J., Song, J. M., Trotter, J. H., Spitzer, M., Lee, J.-Y., Weeber, E. J., Turner, R. S., Pak, D. T. S., Rebeck, G. W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017203 · Cited by 45
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“Primary cortical neurons were isolated from E15 CD1 mouse embryos as described (Bacskai et al., 2000).”
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Metadata
- Authors
- Bacskai, B. J., Xia, M. Q., Strickland, D. K., Rebeck, G. W., & Hyman, B. T.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-10-03
- Volume
- 97
- Issue
- 21
- Pages
- 11551-11556
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 163
- References
- 2
- Language
- en
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