Upregulation of Flt3 Expression within the Bone Marrow Lin−Sca1+c-kit+ Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting

Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908

IFNα activates dormant haematopoietic stem cells in vivo

Essers, M. A. G., Offner, S., Blanco-Bose, W. E., Waibler, Z., Kalinke, U., Duchosal, M. A., & Trumpp, A. (2009) · Nature · doi:10.1038/nature07815 · Cited by 1,368

Origin, fate and dynamics of macrophages at central nervous system interfaces

Goldmann, T., Wieghofer, P., Jordão, M. J. C., Prutek, F., Hagemeyer, N., Frenzel, K., Amann, L., Staszewski, O., Kierdorf, K., Krueger, M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3423 · Cited by 1,209

Cell intrinsic alterations underlie hematopoietic stem cell aging

Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152

Hematopoiesis: a human perspective

Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Kowalczyk, M. S., Tirosh, I., Heckl, D., Rao, T. N., Dixit, A., Haas, B. J., Schneider, R. K., Wagers, A. J., Ebert, B. L., & Regev, A. (2015) · Genome Research · doi:10.1101/gr.192237.115 · Cited by 778

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Orford, K. W., & Scadden, D. T. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2269 · Cited by 851

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy

Pronk, C. J. H., Rossi, D. J., Månsson, R., Attema, J. L., Norddahl, G. L., Chan, C. K. F., Sigvardsson, M., Weissman, I. L., & Bryder, D. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.07.005 · Cited by 671

Transcription factors in myeloid development: balancing differentiation with transformation

Rosenbauer, F., & Tenen, D. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2024 · Cited by 606

Long-Term Propagation of Distinct Hematopoietic Differentiation Programs In Vivo

Dykstra, B., Kent, D., Bowie, M., McCaffrey, L., Hamilton, M., Lyons, K., Lee, S.-J., Brinkman, R., & Eaves, C. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.05.015 · Cited by 609

Thymopoiesis independent of common lymphoid progenitors.

Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A. (2003) · Nature Immunology · doi:10.1038/ni878 · Cited by 544

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

Hock, H., Hamblen, M. J., Rooke, H. M., Schindler, J. W., Saleque, S., Fujiwara, Y., & Orkin, S. H. (2004) · Nature · doi:10.1038/nature02994 · Cited by 541

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

Wilson, N. K., Kent, D. G., Buettner, F., Shehata, M., Macaulay, I. C., Calero-Nieto, F. J., Sánchez Castillo, M., Oedekoven, C. A., Diamanti, E., Schulte, R., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.04.004 · Cited by 466

The earliest thymic progenitors for T cells possess myeloid lineage potential

Bell, J. J., & Bhandoola, A. (2008) · Nature · doi:10.1038/nature06840 · Cited by 460

Myeloid Lineage Commitment from the Hematopoietic Stem Cell

Iwasaki, H., & Akashi, K. (2007) · Immunity · doi:10.1016/j.immuni.2007.06.004 · Cited by 394

The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3

D'Amico, A., & Wu, L. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030107 · Cited by 386

STAT3 is required for Flt3L-dependent dendritic cell differentiation

Laouar, Y., Welte, T., Fu, X.-Y., & Flavell, R. A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00332-7 · Cited by 334

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

Maillard, I., Koch, U., Dumortier, A., Shestova, O., Xu, L., Sai, H., Pross, S. E., Aster, J. C., Bhandoola, A., Radtke, F., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.02.011 · Cited by 317

Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages

Arinobu, Y., Mizuno, S.-I., Chong, Y., Shigematsu, H., Iino, T., Iwasaki, H., Graf, T., Mayfield, R., Chan, S., Kastner, P., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.07.004 · Cited by 309

The Transcription Factor EGR1 Controls Both the Proliferation and Localization of Hematopoietic Stem Cells

Min, I. M., Pietramaggiori, G., Kim, F. S., Passegué, E., Stevenson, K. E., & Wagers, A. J. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.01.015 · Cited by 305

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Mizuki, M., Schwäble, J., Steur, C., Choudhary, C., Agrawal, S., Sargin, B., Steffen, B., Matsumura, I., Kanakura, Y., Böhmer, F. D., et al. (2003) · Blood · doi:10.1182/blood-2002-06-1677 · Cited by 298

p57Kip2 and p27Kip1 Cooperate to Maintain Hematopoietic Stem Cell Quiescence through Interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I., & Suda, T. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.003 · Cited by 289

Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential

Benveniste, P., Frelin, C., Janmohamed, S., Barbara, M., Herrington, R., Hyam, D., & Iscove, N. N. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.11.014 · Cited by 216

Signal integration and crosstalk during thymocyte migration and emigration

Love, P. E., & Bhandoola, A. (2011) · Nature Reviews Immunology · doi:10.1038/nri2989 · Cited by 213

In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis

Göthert, J. R., Gustin, S. E., Hall, M. A., Green, A. R., Göttgens, B., Izon, D. J., & Begley, C. G. (2005) · Blood · doi:10.1182/blood-2004-08-3037 · Cited by 203

Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development

Onai, N., Obata-Onai, A., Tussiwand, R., Lanzavecchia, A., & Manz, M. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051645 · Cited by 156

Stem cells and aging in the hematopoietic system

Warren, L. A., & Rossi, D. J. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.010 · Cited by 128

Regulation of Lymphoid versus Myeloid Fate 'choice' by the Transcription Factor Mef2c

Stehling-Sun, S., Dade, J., Nutt, S. L., DeKoter, R. P., & Camargo, F. D. (2009) · Nature Immunology · doi:10.1038/ni.1694 · Cited by 125

The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis

Schoedel, K. B., Morcos, M. N. F., Zerjatke, T., Roeder, I., Grinenko, T., Voehringer, D., Göthert, J. R., Waskow, C., Roers, A., & Gerbaulet, A. (2016) · Blood · doi:10.1182/blood-2016-03-706010 · Cited by 120

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis

Staron, M., Yang, Y., Liu, B., Li, J., Shen, Y., Zúñiga-Pflücker, J. C., Aguila, H. L., Goldschneider, I., & Li, Z. (2010) · Blood · doi:10.1182/blood-2009-07-233031 · Cited by 120

Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

Porse, B. T., Bryder, D., Theilgaard-Mönch, K., Hasemann, M. S., Anderson, K., Damgaard, I., Jacobsen, S. E. W., & Nerlov, C. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050067 · Cited by 117

Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies

Warr, M. R., Pietras, E. M., & Passegué, E. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.145 · Cited by 112

Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance

Perry, S. S., Zhao, Y., Nie, L., Cochrane, S. W., Huang, Z., & Sun, X.-H. (2007) · Blood · doi:10.1182/blood-2007-01-069914 · Cited by 100

MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells

Sheikh, B. N., Yang, Y., Schreuder, J., Nilsson, S. K., Bilardi, R., Carotta, S., McRae, H. M., Metcalf, D., Voss, A. K., & Thomas, T. (2016) · Blood · doi:10.1182/blood-2015-10-676072 · Cited by 98

Surprising new roles for PU.1 in the adaptive immune response

Carotta, S., Wu, L., & Nutt, S. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00955.x · Cited by 93

T/B lineage choice occurs prior to intrathymic Notch signaling

Harman, B. C., Jenkinson, W. E., Parnell, S. M., Rossi, S. W., Jenkinson, E. J., & Anderson, G. (2005) · Blood · doi:10.1182/blood-2004-12-4881 · Cited by 80

Multiple prethymic defects underlie age-related loss of T progenitor competence

Zediak, V. P., Maillard, I., & Bhandoola, A. (2007) · Blood · doi:10.1182/blood-2007-01-071605 · Cited by 79

FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm

Chu, S. H., Heiser, D., Li, L., Kaplan, I., Collector, M., Huso, D., Sharkis, S. J., Civin, C., & Small, D. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.027 · Cited by 79

Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis?

Dakic, A., Wu, L., & Nutt, S. L. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.006 · Cited by 72

Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions

Jeong, M., Piao, Z.-H., Kim, M. S., Lee, S. H., Yun, S., Sun, H.-N., Yoon, S. R., Chung, J. W., Kim, T.-D., Jeon, J. H., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804221 · Cited by 58

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

Konturek-Ciesla, A., Dhapola, P., Zhang, Q., Säwén, P., Wan, H., Karlsson, G., & Bryder, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112304 · Cited by 48

Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation

Shima, H., Takubo, K., Tago, N., Iwasaki, H., Arai, F., Takahashi, T., & Suda, T. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.08.004 · Cited by 35

PTEN in Regulating Hematopoiesis and Leukemogenesis

Wu, Y., Zhu, H., & Wu, H. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036244 · Cited by 22