Cited by 284Cytokine Signaling Pathways and Interactionsinterferon and immune responsesImmune Response and Inflammation

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Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity

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Varinou, Louisa, Ramsauer, Katrin, Karaghiosoff, Marina, Kolbe, Thomas, Pfeffer, Klaus, Müller, Mathias, Decker, Thomas·2003·Immunity

DOI 10.1016/s1074-7613(03)00322-4

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Abstract

Stat1 is phosphorylated on serine 727 within its transactivating domain (TAD) in response to interferons or other immunological signals. We generated gene-targeted mutant mice expressing a serine727-alanine mutant of Stat1. These animals showed increased mortality upon infection with Listeria monocytogenes and impaired clearance of the bacteria from spleen and liver. The Stat1S727A mice were more resistant to the LPS-induced septic shock syndrome, suggesting that Stat1 serine phosphorylation promotes inflammatory responses. Expression of IFN-gamma-induced genes was strongly reduced in macrophages expressing Stat1(S727A). While mutation of Stat1 at S727 did not reduce its binding to chromatin, association with the coactivator CBP and histone acetylation at the interferon-responsive GBP promoter was strongly reduced, suggesting defective recruitment of histone acetylases as the mechanism underlying IFN-gamma hyporesponsiveness. Our data demonstrate that the increase in transcription factor activity caused by Stat serine phosphorylation contributes to macrophage activation and to IFN-gamma-dependent immune responses in vivo.

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Authors: Varinou, L., Ramsauer, K., Karaghiosoff, M., Kolbe, T., Pfeffer, K., Müller, M., & Decker, T.
Affiliations: University of Vienna (AT)
Heinrich Heine University Düsseldorf (DE)
Corresponding author: Decker, Thomas
ORCID: Ramsauer, Katrin
Kolbe, Thomas
Pfeffer, Klaus
Müller, Mathias
Decker, Thomas
Venue: Immunity
Publisher: Elsevier BV
Published: 2003-12
Volume: 19
Issue: 6
Pages: 793-802
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/s1074-7613(03)00322-4
OpenAlex: W2087814657
Cited by: 284
References: 41
Citations by year: 2026: 5 · 2025: 10 · 2024: 26 · 2023: 15 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 6 · 2018: 12 · 2017: 10 · 2016: 8 · 2015: 7 · 2014: 16 · 2013: 20 · 2012: 10
FWCI: 6.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3516 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: STAT1, serine 727 phosphorylation, transactivation domain, interferon-gamma, innate immunity, Listeria monocytogenes infection, septic shock, macrophage activation, CBP, histone acetylation, transcriptional coactivator
MeSH terms: Animals, DNA-Binding Proteins, Immunity, Innate, Interferon-gamma, Lipopolysaccharides, Mice, Transgenic, Phosphorylation, Phosphotransferases, Serine, Shock, Septic, Trans-Activators, Amino Acid Substitution, STAT1 Transcription Factor, Mice

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Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity

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