Cited by 213Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromosomal and Genetic Variations

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Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila

Schotta, Gunnar, Ebert, Anja, Dorn, Rainer, Reuter, Gunter·2003·Seminars in Cell & Developmental Biology

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Abstract

In position-effect variegation (PEV) genes become silenced by heterochromatisation. Genetic dissection of this process has been performed by means of dominant suppressor [Su(var)] and enhancer [E(var)] mutations. Selective genetic screens allowed mass isolation of more than 380 PEV modifier mutations identifying about 150 genes. Genetic fine structure studies revealed unique dosage dependent effects. Most of the haplo-dependent Su(var) and E(var) genes do not display triplo-dependent effects. Several Su(var) loci with triplo-dependent opposite enhancer effects have been identified and shown to encode heterochromatin-associated proteins. From these the evolutionary conserved histone H3 lysine 9 methyltransferase SU(VAR)3-9 plays a central role in heterochromatic gene silencing. Molecular function of most PEV modifier genes is still unknown also including genes identified with mutations displaying lethal interaction to heterochromatin. Their analysis should contribute to further understanding of processes connected with regulation of higher order chromatin structure and epigenetic programming.

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Authors: Schotta, G., Ebert, A., Dorn, R., & Reuter, G.
Affiliations: Martin Luther University Halle-Wittenberg (DE)
ORCID: Schotta, Gunnar
Ebert, Anja
Venue: Seminars in Cell & Developmental Biology
Publisher: Elsevier BV
Published: 2003-02
Volume: 14
Issue: 1
Pages: 67-75
ISSN: 1084-9521 (ISSN-L)
DOI: 10.1016/s1084-9521(02)00138-6
OpenAlex: W2053291659
Cited by: 213
References: 62
Citations by year: 2026: 2 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 5 · 2019: 6 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 14 · 2013: 14 · 2012: 5
FWCI: 1.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: position effect variegation, heterochromatin, gene silencing, dose-dependent effects, Su(var)3-9, histone H3 lysine 9 methylation, chromatin regulation, epigenetic regulation, Drosophila
MeSH terms: Animals, Chromatin, Drosophila, Heterochromatin, Methyltransferases, Mutation, Phenotype, Gene Silencing

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Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila

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