The growing family of interferon regulatory factors

TGF-β SIGNAL TRANSDUCTION

Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080

Function and Activation of NF-kappaB in the Immune System

Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745

Functional Role of Type I and Type II Interferons in Antiviral Defense

Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., & Aguet, M. (1994) · Science · doi:10.1126/science.8009221 · Cited by 2,453

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656

Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)

Russo, J. J., Bohenzky, R. A., Chien, M.-C., Chen, J., Yan, M., Maddalena, D., Parry, J. P., Peruzzi, D., Edelman, I. S., Chang, Y., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14862 · Cited by 1,457

STATs: Signal Transducers and Activators of Transcription

Ihle, J. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81277-5 · Cited by 1,381

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., & Taniguchi, T. (1988) · Cell · doi:10.1016/s0092-8674(88)91307-4 · Cited by 971

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., & Taniguchi, T. (1989) · Cell · doi:10.1016/0092-8674(89)90107-4 · Cited by 957

Diesel exhaust enhances virus- and poly(I:C)-induced Toll-like receptor 3 expression and signaling in respiratory epithelial cells

Ciencewicki, J., Brighton, L. E., Wu, W.-D., Madden, M. C., & Jaspers, I. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00318.2005 · Cited by 54

Transcriptional Activation of Interferon-Stimulated Genes but Not of Cytokine Genes after Primary Infection of Rhesus Macaques with Dengue Virus Type 1

Sariol, C. A., Muñoz‐Jordán, J. L., Abel, K., Rosado, L. C., Pantoja, P., Giavedoni, L. D., Rodríguez, I. V., White, L., Martínez, M. I., Arana, T., et al. (2007) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00052-07 · Cited by 51

Review: IRF Regulation of HIV-1 Long Terminal Repeat Activity

Battistini, A., Marsili, G., Sgarbanti, M., Ensoli, B., & Hiscott, J. B. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452638 · Cited by 48

Composition and transcription of all interferon regulatory factors (IRFs), IRF1‒11 in a perciform fish, the mandarin fish, Siniperca chuatsi

Laghari, Z. A., Li, L., Chen, S. N., Huo, H. J., Huang, B., Zhou, Y., & Nie, P. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.11.015 · Cited by 49

Differential Expression of Interferon (IFN) Regulatory Factors and IFN-Stimulated Genes at Early Times after West Nile Virus Infection of Mouse Embryo Fibroblasts

Scherbik, S. V., Stockman, B. M., & Brinton, M. A. (2007) · Journal of Virology · doi:10.1128/jvi.01359-07 · Cited by 48

Induction of antiviral state in fish cells by Japanese flounder, Paralichthys olivaceus, interferon regulatory factor-1

Caipang, C. M. A., Hırono, I., & Aoki, T. (2005) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2004.12.008 · Cited by 48

Interferon regulatory factor 3 (IRF-3) in Japanese flounder, Paralichthys olivaceus: Sequencing, limited tissue distribution, inducible expression and induction of fish type I interferon promoter

Hu, G., Yin, X., Lou, H., Xia, J., Dong, X., Zhang, J., & Liu, Q. (2010) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2010.09.003 · Cited by 48

Review: Nuclear/Cytoplasmic Localization of IRFs in Response to Viral Infection or Interferon Stimulation

Reich, N. C. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452719 · Cited by 48

IFN Consensus Sequence Binding Protein (Icsbp) Is Critical for Eosinophil Development

Milanovic, M., Terszowski, G., Struck, D., Liesenfeld, O., & Carstanjen, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.5045 · Cited by 49

Molecular cloning and expression analysis of interferon regulatory factor-1 (IRF-1) of turbot and sea bream

Ordás, M. C., Abollo, E., Costa, M. M., Figueras, A. J., & Novoa, B. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2005.06.034 · Cited by 47

Morphine Suppresses IFN Signaling Pathway and Enhances AIDS Virus Infection

Wang, Y., Wang, X., Li, Y., Li, J., Li, S., Fulambarkar, N., & Ho, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031167 · Cited by 46

Icsbp1 /IRF-8 Is Required for Innate and Adaptive Immune Responses against Intracellular Pathogens

Turcotte, K., Gauthier, S., Malo, D., Tam, M., Stevenson, M. M., & Gros, P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2467 · Cited by 43

Identification of CXCL11 as a STAT3-Dependent Gene Induced by IFN

Yang, C. H., Wei, L., Pfeffer, S. R., Du, Z., Murti, A., Valentine, W. J., Zheng, Y., & Pfeffer, L. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.2.986 · Cited by 46

Impaired myelopoiesis in mice devoid of interferon regulatory factor 1

Testa, U., Stellacci, E., Pelosi, E., Sestili, P., Venditti, M., Orsatti, R., Fragale, A., Petrucci, E., Pasquini, L., Belardelli, F., et al. (2004) · Leukemia · doi:10.1038/sj.leu.2403472 · Cited by 48

The Involvement of Mammalian and Plant FK506-Binding Proteins (FKBPs) in Development

Breiman, A., & Camus, I. (2002) · Transgenic Research · doi:10.1023/a:1016331814412 · Cited by 47

The interferons and cell death: guardians of the cell or accomplices of apoptosis?

Barber, G. N. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0313 · Cited by 46

Transcriptional Regulation of Mouse μ Opioid Receptor Gene by PU.1

Hwang, C. K., Kim, C. S., Choi, H. S., McKercher, S. R., & Loh, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400755200 · Cited by 46

Interaction between Interferon Consensus Sequence-binding Protein and COP9/Signalosome Subunit CSN2 (Trip15)

Cohen, H., Azriel, A., Cohen, T., Meraro, D., Hashmueli, S., Bech-Otschir, D., Kraft, R., Dubiel, W., & Levi, B.-Z. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004900200 · Cited by 45

Methamphetamine enhances Hepatitis C virus replication in human hepatocytes

Ye, L., Peng, J. S., Wang, X., Wang, Y. J., Luo, G. G., & Ho, W. (2008) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2007.00940.x · Cited by 45

The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond

Suprunenko, T., & Hofer, M. J. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.03.002 · Cited by 44

The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases

Zhang, X., Jiang, D., & Li, H. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12881 · Cited by 44

Mechanisms of Autoinhibition of IRF-7 and a Probable Model for Inactivation of IRF-7 by Kaposi's Sarcoma-associated Herpesvirus Protein ORF45

Sathish, N., Zhu, F. X., Golub, E. E., Liang, Q., & Yuan, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.150920 · Cited by 46

Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies

Pirini, F., Noazin, S., Jahuira-Arias, M. H., Rodríguez‐Torres, S., Friess, L., Michailidi, C., Cok, J., Combe, J., Vargas, G., Prado, W., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16258 · Cited by 44

PACT, a Double-Stranded RNA Binding Protein Acts as a Positive Regulator for Type I Interferon Gene Induced by Newcastle Disease Virus

Iwamura, T., Yoneyama, M., Koizumi, N., Okabe, Y., Namiki, H., Samuel, C. E., & Fujita, T. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4606 · Cited by 44

Ubiquitin-dependent Degradation of Interferon Regulatory Factor-8 Mediated by Cbl Down-regulates Interleukin-12 Expression

Xiong, H., Li, H., Kong, H. J., Chen, Y., Zhao, J., Xiong, S., Huang, B., Gu, H., Mayer, L., Ozato, K., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414296200 · Cited by 44

Mutation analysis of the Pip interaction domain reveals critical residues for protein–protein interactions

Ortiz, M. A., Light, J. P., Maki, R. A., & Assa‐Munt, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2740 · Cited by 44

MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma

Kempf, W., Kutzner, H., Cozzio, A., Sander, C. A., Pfaltz, M. C., Müller, B., & Pfaltz, M. C. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08566.x · Cited by 43

The first exon of the human sc gene contains an androgen responsive unit and an interferon regulatory factor element

Haelens, A., Verrijdt, G., Schoenmakers, E., Alen, P., Peeters, B., Rombauts, W., & Claessens, F. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00079-9 · Cited by 43

The molecular mechanism of chronic myelogenous leukemia and its therapeutic implications: studies in a murine model

Ren, R. (2002) · Oncogene · doi:10.1038/sj.onc.1206090 · Cited by 43

Dcp2 Decapping Protein Modulates mRNA Stability of the Critical Interferon Regulatory Factor (IRF) IRF-7

Li, Y., Dai, J., Song, M.-G., Fitzgerald-Bocarsly, P. A., & Kiledjian, M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06328-11 · Cited by 42

Interferon Regulatory Factor 1 Mediates the Interferon-γ Induction of the Human Immunoproteasome Subunit Multicatalytic Endopeptidase Complex-like 1

Foss, G. S., & Prydz, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.35196 · Cited by 42

Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications

Puri, P., & Sartorelli, V. (2000) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200011)185:2 · Cited by 299

IFNγ regulates retinal pigment epithelial fluid transport

Li, R., Maminishkis, A., Banzon, T. M., Wan, Q., Jalickee, S., Chen, S., & Miller, S. S. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00255.2009 · Cited by 43

Cloning and expression analysis of interferon regulatory factor (IRF) 3 and 7 in large yellow croaker, Larimichthys crocea

Yao, C.-L., Huang, X., Fan, Z.-J., Kong, P., & Wang, Z. (2012) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2012.02.015 · Cited by 41

Metastatic Melanoma Cells Evade Immune Detection by Silencing STAT1

Osborn, J. L., & Greer, S. F. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16024343 · Cited by 43

Interferon Regulatory Factor 4 (IRF-4) Targets IRF-5 to Regulate Epstein-Barr Virus Transformation

Xu, D., Meyer, F., Ehlers, E., Blasnitz, L., & Zhang, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.210542 · Cited by 39

Genomic, cDNA and embryonic expression analysis of zebrafish IRF6, the gene mutated in the human oral clefting disorders Van der Woude and popliteal pterygium syndromes

Ben, J., Jabs, E. W., & Chong, S. S. (2005) · Gene Expression Patterns · doi:10.1016/j.modgep.2005.03.002 · Cited by 40

A conserved interferon regulation factor 1 (IRF-1) from Pacific oyster Crassostrea gigas functioned as an activator of IFN pathway

Lu, M., Yang, C., Li, M., Yi, Q., Lu, G., Wu, Y., Qu, C., Wang, L., & Song, L. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.02.024 · Cited by 40

Antiviral and Immunoregulatory Effects of Indoleamine-2,3-Dioxygenase in Hepatitis C Virus Infection

Lepiller, Q., Soulier, E., Li, Q., Lambotin, M., Barths, J., Fuchs, D., Stoll‐Keller, F., Liang, T. J., & Barth, H. (2015) · Journal of Innate Immunity · doi:10.1159/000375161 · Cited by 42

Stat2-Dependent Regulation of MHC Class II Expression

Zhao, W., Cha, E. N., Lee, C., Park, C. Y., & Schindler, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.463 · Cited by 40

Down-regulation of interferon regulatory factor 4 gene expression in leukemic cells due to hypermethylation of CpG motifs in the promoter region

Ortmann, C. A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1001 · Cited by 40

Interferon Consensus Sequence Binding Protein Confers Resistance against Yersinia enterocolitica

Hein, J., Kempf, V. A. J., Diebold, J., Bücheler, N., Preger, S., Horak, I., Sing, A., Kramer, U., & Autenrieth, I. B. (2000) · Infection and Immunity · doi:10.1128/iai.68.3.1408-1417.2000 · Cited by 39

Multiple signal transducers and activators of transcription are induced by EBV LMP-1

Zhang, L., Hong, K., Zhang, J., & Pagano, J. S. (2004) · Virology · doi:10.1016/j.virol.2004.03.007 · Cited by 40

Epigenetic silencing of the interferon regulatory factor ICSBP/IRF8 in human multiple myeloma

Tshuikina, M., Jernberg‐Wiklund, H., Nilsson, K., & Oberg, F. G. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.08.001 · Cited by 39

Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Replication and Transcription Activator Regulates Viral and Cellular Genes via Interferon-Stimulated Response Elements

Zhang, J., Wang, J.-Z., Wood, C., Xu, D.-S., & Zhang, L.-W. (2005) · Journal of Virology · doi:10.1128/jvi.79.9.5640-5652.2005 · Cited by 45

Mechanism of Interferon Action: Functional Characterization of Positive and Negative Regulatory Domains That Modulate Transcriptional Activation of the Human RNA-Dependent Protein KinasePkrPromoter

Kuhen, K., & Samuel, C. E. (1999) · Virology · doi:10.1006/viro.1998.9536 · Cited by 41

Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury

Klune, J. R., Dhupar, R., Kimura, S., Ueki, S., Cardinal, J. S., Nakao, A., Nace, G., Evankovich, J. W., Murase, N., Tsung, A., et al. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00050.2012 · Cited by 38

Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis

Zhang, Q., Zhang, L., Li, L., Wang, Z., Ying, J., Fan, Y., Xu, B., Wang, L., Liu, Q., Chen, G., et al. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.07.040 · Cited by 38

Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3

Iwashima, T., Kudome, Y., Kishimoto, Y., Saita, E., Tanaka, M., Taguchi, C., Hirakawa, S., Mitani, N., Kondo, K. N., & Iida, K. (2019) · Food & Nutrition Research · doi:10.29219/fnr.v63.3361 · Cited by 38

Dysregulation of IFN-γ Signaling Pathways in the Absence of TGF-β1

McCartney-Francis, N. L., & Wahl, S. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5941 · Cited by 38

Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population

Matsunami, N., Hensel, C. H., Baird, L. M., Stevens, J., Otterud, B., Leppert, M., Varvil, T., Hadley, D., Glessner, J., Pellegrino, R., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-5 · Cited by 38

Correlation between Pretreatment Levels of Interferon Response Genes and Clinical Responses to an Immune Response Modifier (Imiquimod) in Genital Warts

Arany, I., Tyring, S. K., Brysk, M. M., Stanley, M., Tomai, M. A., Miller, R. L., Smith, M. H., McDERMOTT, D. J., & Slade, H. B. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.7.1869-1873.2000 · Cited by 38

Molecular cloning and expression of IRF1 in large yellow croaker, Pseudosciaena crocea

Yao, C.-L., Kong, P., Huang, X., & Wang, Z. (2010) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2009.12.026 · Cited by 37

The Cell Cycle Control Element of Histone H4 Gene Transcription Is Maximally Responsive to Interferon Regulatory Factor Pairs IRF-1/IRF-3 and IRF-1/IRF-7

Xie, R., van Wijnen, A. J., van der Meijden, C. M. J., Luong, M. X., Stein, J. L., & Stein, G. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010391200 · Cited by 37

Interferon regulatory factor-2 drives megakaryocytic differentiation

Stellacci, E., Testa, U., Petrucci, E., Benedetti, E., Orsatti, R., Feccia, T., Stafsnes, M., Coccia, E. M., Marziali, G., & Battistini, A. (2004) · Biochemical Journal · doi:10.1042/bj20031166 · Cited by 37

Macrophage-restricted and Interferon γ-inducible Expression of the Allograft Inflammatory Factor-1 Gene Requires Pu.1

Sibinga, N. E. S., Feinberg, M. W., Yang, H., Werner, F., & Jain, M. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200935200 · Cited by 37

Molecular Cloning and Genomic Structure of a Gene Encoding Interferon Regulatory Factor in the Pufferfish (Fugu rubripes)

Richardson, M. P., Tay, B. H., Goh, B. Y., Venkatesh, B., & Brenner, S. (2001) · Marine Biotechnology · doi:10.1007/s101260000066 · Cited by 36

Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 genePreprint

Karpova, A. Y., Howley, P. M., & Ronco, L. V. (2000) · Genes & Development · doi:10.1101/gad.813800 · Cited by 36

Expression profile of carp IFN correlate with the up-regulation of interferon regulatory factor-1 (IRF-1) in vivo and in vitro: the pivotal molecules in antiviral defense

Shan, S., Qi, C., Zhu, Y., Li, H., An, L., & Yang, G. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.03.019 · Cited by 35

Chicken interferon regulatory factor 1 (IRF1) involved in antiviral innate immunity via regulating IFN-β production

Liu, Y., Cheng, Y., Shan, W., Ma, J., Wang, H., Sun, J., & Yan, Y. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.07.003 · Cited by 35

A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon

Saikh, K. U., Morazzani, E. M., Piper, A. E., Bakken, R. R., & Glass, P. J. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104854 · Cited by 35

Modulation of the early immune response against viruses by a teleostean interferon regulatory factor-1 (IRF-1)

Caipang, C. M. A., Hırono, I., & Aoki, T. (2008) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2008.11.022 · Cited by 35

Interferon Regulatory Factor 4 Contributes to Transformation of v-Rel-Expressing Fibroblasts

Hrdličková, R., Nehyba, J., & Bose, H. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6369-6386.2001 · Cited by 35

Interferon regulatory factor 7: a key cellular mediator of LMP-1 in EBV latency and transformation

Zhang, L., & Pagano, J. S. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2001.0411 · Cited by 35

Nodal Diffuse Large B-cell Lymphomas in Children and Adolescents: Immunohistochemical Expression Patterns and c-MYC Translocation in Relation to Clinical Outcome

Gualco, G., Weiss, L. M., Harrington, W. J., & Bacchi, C. E. (2009) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3181bb9a18 · Cited by 34

Dengue Virus Infection Activates Cellular Chaperone Hsp70 in THP-1 Cells: Downregulation of Hsp70 by siRNA Revealed Decreased Viral Replication

Padwad, Y. S., Mishra, K. P., Jain, M., Chanda, S., & Ganju, L. (2010) · Viral Immunology · doi:10.1089/vim.2010.0052 · Cited by 34

Cloning and Functional Analysis of the Human IRF-3 Promoter

Lowther, W. J., Moore, P. A., Carter, K. C., & Pitha, P. M. (1999) · DNA and Cell Biology · doi:10.1089/104454999314962 · Cited by 34

p48 (ISGF-3γ) Is Involved in Interferon-α-induced Suppression of Hepatitis B Virus Enhancer-1 Activity

Nakao, K., Nakata, K., Yamashita, M., Tamada, Y., Hamasaki, K., Ishikawa, H., Kato, Y., Eguchi, K., & Ishii, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28075 · Cited by 33

IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells

Cui, L., Deng, Y., Rong, Y., Lou, W., Mao, Z., Feng, Y., Xie, D., & Jin, D. (2011) · Tumor Biology · doi:10.1007/s13277-011-0273-3 · Cited by 32

The tumor suppressor interferon regulatory factor 8 inhibits β-catenin signaling in breast cancers, but is frequently silenced by promoter methylation

Luo, X., Xiong, X., Shao, Q., Xiang, T., Li, L., Yin, X., Li, X., Tao, Q., & Ren, G. (2017) · Oncotarget · doi:10.18632/oncotarget.16511 · Cited by 32

Genetic pathways and histogenetic models of AIDS-related lymphomas

Carbone, A., Gloghini, A., Capello, D., & Gaïdano, G. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00119-8 · Cited by 32

Retinoic acid resistance in NB4 APL cells is associated with lack of interferon α synthesis Stat1 and p48 induction

Pelicano, L., Brumpt, C., Pitha, P. M., & Chelbi‐Alix, M. K. (1999) · Oncogene · doi:10.1038/sj.onc.1202802 · Cited by 32

The IRF-2 DNA binding domain facilitates the activation of the class II transactivator (CIITA) type IV promoter by IRF-1

Xi, H., & Blanck, G. (2003) · Molecular Immunology · doi:10.1016/s0161-5890(02)00214-6 · Cited by 31

Functional characterization of the interferon regulatory element in the enhancer 1 region of the hepatitis B virus genome.

Alcantara, F. F., Tang, H., & McLachlan, A. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.9.2068 · Cited by 32

Interferon Alfa Down–Regulates Cd81 in Patients With Chronic Hepatitis C

Kronenberger, B., Rüster, B., Elez, R., Weber, S., Piiper, A., Lee, J., Roth, K. W., & Zeuzem, S. (2001) · Hepatology · doi:10.1053/jhep.2001.24668 · Cited by 31

Frequent expression of multiple myeloma 1/interferon regulatory factor 4 in Burkitt lymphoma

Gualco, G., Queiroga, E., Weiss, L. M., Klumb, C. E., Harrington, W. J., & Bacchi, C. E. (2009) · Human Pathology · doi:10.1016/j.humpath.2008.07.021 · Cited by 31

Structural and expression studies of interferon regulatory factor 8 in Japanese flounder, Paralichthys olivaceus

Hu, G., Chen, X., Gong, Q., Liu, Q., Zhang, S., & Dong, X. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.06.016 · Cited by 30

Morphine Inhibits Intrahepatic Interferon‐α Expression and Enhances Complete Hepatitis C Virus Replication

Li, Y., Ye, L., Peng, J., Wang, C., Luo, G. G., Zhang, T., Wan, Q., & Ho, W. (2007) · The Journal of Infectious Diseases · doi:10.1086/520093 · Cited by 30

IFN-type-I-mediated signaling is regulated by modulation of STAT2 nuclear export

Frahm, T., Häuser, H., & Köster, M. (2006) · Journal of Cell Science · doi:10.1242/jcs.02822 · Cited by 30

IRF3 function and immunological gaps in sepsis

Basak, B., & Akashi‐Takamura, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1336813 · Cited by 30

Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells

Albanesi, J., Noguera, N. I., Banella, C., Colangelo, T., Marinis, E. D., Leone, S., Palumbo, O., Voso, M. T., Ascenzi, P., Nervi, C., et al. (2020) · Cells · doi:10.3390/cells9112423 · Cited by 32

Interleukin-15 induces IL-12 receptor β1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling

Musikacharoen, T., Oguma, A., Yoshikai, Y., Chiba, N., Masuda, A., & Matsuguchi, T. (2004) · Blood · doi:10.1182/blood-2004-03-0842 · Cited by 29

Interferon Consensus Sequence-binding Protein Is Constitutively Expressed and Differentially Regulated in the Ocular Lens

Li, W., Nagineni, C. N., Ge, H., Efiok, B. J. S., Chepelinsky, A. B., & Egwuagu, C. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9686 · Cited by 28

Alcohol impairs interferon signaling and enhances full cycle hepatitis C virus JFH-1 infection of human hepatocytes

Ye, L., Wang, S., Wang, X., Zhou, Y., Li, J., Persidsky, Y., & Ho, W. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.05.008 · Cited by 28

HCV NS5A and IRF9 compete for CypA binding

Bobardt, M. D., Hopkins, S., Baugh, J., Chatterji, U., Hernandez, F. B., Hiscott, J. B., Sluder, A. E., Lin, K. W., & Gallay, P. A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.007 · Cited by 28

Identification and characterization of interferon regulatory factor-1 from orange-spotted grouper (Epinephelus coioides)

Shi, Y., Zhu, X., Yin, J.-K., Zhang, Q.-Y., & Gui, J. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9544-0 · Cited by 28

Protein-DNA Array-based Identification of Transcription Factor Activities Regulated by Interaction with the Glucocorticoid Receptor

Jiang, X., Norman, M., Roth, L. A., & Li, X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403948200 · Cited by 28

Hypoxia regulates inflammatory gene expression in endothelial cells

Flamant, L., Toffoli, S., Raes, M. J., & Michiels, C. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.11.020 · Cited by 27

Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding

Ioannes, P. D., Escalante, C. R., & Aggarwal, A. K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr325 · Cited by 27

A predictive transcriptomic signature of oropharyngeal cancer according to HPV16 status exclusively

Mirghani, H., Ugolin, N., Ory, C., Lefèvre, M., Baulande, S., Hofman, P. M., Guily, J. L. S., Chevillard, S., & Lacave, R. (2014) · Oral Oncology · doi:10.1016/j.oraloncology.2014.07.019 · Cited by 27

Ubiquitination network in the type I IFN‐induced antiviral signaling pathway

Zhao, Q., Zhang, R., Qiao, C., Miao, Y., Yuan, Y., & Zheng, H. (2023) · European Journal of Immunology · doi:10.1002/eji.202350384 · Cited by 28

Modulation of Intracellular Restriction Factors Contributes to Methamphetamine- Mediated Enhancement of Acquired Immune Deficiency Syndrome Virus Infection of Macrophages

Wang, X., Wang, Y., Li, Y., Li, J., Zhou, Y., Sakarcan, S., & Ho, W. (2012) · Current HIV Research · doi:10.2174/157016212802138797 · Cited by 27

κ-Opioid Regulation of Thymocyte IL-7 Receptor and C-C Chemokine Receptor 2 Expression

Zhang, L., & Rogers, T. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.5088 · Cited by 27

Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation

Coccia, E. M., Stellacci, E., Valtieri, M., Masella, B., Feccia, T., Marziali, G., Hiscott, J. B., Testa, U., Peschle, C., & Battistini, A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600285 · Cited by 27

The influence of T cell receptor and cytokine genes on sarcoidosis susceptibility in African Americans

Rybicki, B. A., MALIARIK, M. J., Malvitz, E., Sheffer, R., Major, M. L., Popovich, J., & Iannuzzi, M. C. (1999) · Human Immunology · doi:10.1016/s0198-8859(99)00050-6 · Cited by 28

Molecular characterization and expression analysis of interferon regulatory factor 5 (IRF-5) in turbot, Scophthalmus maximus

Xia, J., Hu, G., Dong, X., Liu, Q.-M., & Zhang, S. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2011.10.021 · Cited by 26

IRF-1 acts as a positive regulator in the transcription of grass carp (Ctenopharyngodon idella) IFN gene

Lai, Q., Lin, G., Ma, M., Huang, S., Li, W., Li, D., Gu, M., Mao, H., & Hu, C. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.03.358 · Cited by 26

Molecular cloning and expression analysis of a fish specific interferon regulatory factor, IRF11, in orange spotted grouper, Epinephelus coioides

Huang, W. S., Zhu, M., Chen, S., Wang, Z., Liang, Y., Huang, B., & Nie, P. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.12.007 · Cited by 26

Expression of Interferon-γ in the Lens Exacerbates Anterior Uveitis and Induces Retinal Degenerative Changes in Transgenic Lewis Rats

Egwuagu, C. E., Mahdi, R. M., Chan, C., Sztein, J., Li, W., Smith, J. A., & Chepelinsky, A. B. (1999) · Clinical Immunology · doi:10.1006/clim.1999.4701 · Cited by 26

Arthritis suppression by NADPH activation operates through an interferon-β pathway

Olofsson, P., Nerstedt, A., Hultqvist, M. H., Nilsson, E. C., Andersson, S., Bergelin, A., & Holmdahl, R. (2007) · BMC Biology · doi:10.1186/1741-7007-5-19 · Cited by 26

Interferon regulatory factors: the next generation

Mamane, Y., Heylbroeck, C., Génin, P., Algarté-Génin, M., Servant, M. J., Page, C. L., DeLuca, C., Kwon, H., Lin, R., & Hiscott, J. B. (1999) · Gene · doi:10.1016/s0378-1119(99)00262-0 · Cited by 576

The role of interferon regulatory factors in the interferon system and cell growth control

Harada, H., Taniguchi, T., & Tanaka, N. (1998) · Biochimie · doi:10.1016/s0300-9084(99)80017-0 · Cited by 132

The interferon regulatory factors and oncogenesis

Tanaka, N., & Taniguchi, T. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0310 · Cited by 85

The Interferon Regulatory Factor Family in Host Defense: Mechanism of Action

Ozato, K., Tailor, P. B., & Kubota, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700003200 · Cited by 191

Interferon Regulatory Factor Family

Han-chun, C. (2002) · Life Science Research