Using probiotics and prebiotics to improve gut health

Tuohy, Kieran M; Probert, Hollie M; Smejkal, Chris W; Gibson, Glann R

doi:10.1016/s1359-6446(03)02746-6

Cited by 420Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Using probiotics and prebiotics to improve gut health

Tuohy, Kieran M, Probert, Hollie M, Smejkal, Chris W, Gibson, Glann R·2003·Drug Discovery Today

DOI 10.1016/s1359-6446(03)02746-6

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Abstract

Recent molecular-based investigations have confirmed the species diversity and metabolic complexity of the human gut microbiota. It is also increasingly clear that the human gut microbiota plays a crucial role in host health, both as a source of infection and environmental insult and, conversely, in protection against disease and maintenance of gut function. Although little is known about the health impact of the dominant groups of gut bacteria it is generally accepted that bifidobacteria and lactobacilli are important components of what might be termed the beneficial gut microbiota. The microbiota management tools of probiotics, prebiotics and synbiotics have been developed and, indeed, commercialized over the past few decades with the expressed purpose of increasing numbers of bifidobacteria and/or lactobacilli within the gastrointestinal tract.

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The use of probiotic bacteria, particularly Lactobacillus and Bifidobacterium species, has been shown to modify GI microbiota.
“Finally, the use of probiotic bacteria, particularly including the gram-positive genera Lactobacillus and Bifidobacterium species, has been shown to modify GI microbiota [144] and may provide an adjunct nutritional strategy in cases pertaining to acute GI disruption (e.g., GI dysbiosis, exercise-associated GI permeability).”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [144]

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Authors: Tuohy, K. M., Probert, H. M., Smejkal, C. W., & Gibson, G. R.
Affiliations: University of Reading (GB)
Corresponding author: Tuohy, Kieran M
ORCID: Tuohy, Kieran M
Venue: Drug Discovery Today
Publisher: Elsevier BV
Published: 2003-08
Volume: 8
Issue: 15
Pages: 692-700
ISSN: 1359-6446 (ISSN-L)
DOI: 10.1016/s1359-6446(03)02746-6
OpenAlex: W1966102539
Cited by: 420
References: 77
Citations by year: 2026: 7 · 2025: 14 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 24 · 2017: 14 · 2016: 20 · 2015: 32 · 2014: 22 · 2013: 25 · 2012: 33
FWCI: 3.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Drug Discovery Today (publishedVersion)
PubMed (publishedVersion)
CentAUR (University of Reading) (acceptedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: probiotics, prebiotics, synbiotics, gut microbiota, gut health, Bifidobacterium, lactobacilli, host-microbe interactions
MeSH terms: Animals, Digestive System, Digestive System Physiological Phenomena, Gastrointestinal Diseases, Humans, Probiotics

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