The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Association between circadian rhythms and neurodegenerative diseases
Open accessAbstract
Dysfunction in 24-h circadian rhythms is a common occurrence in aging adults, however, circadian rhythm disruptions (CRD) are more severe in people with age-related neurodegenerative diseases, including Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease (PD). Manifestations of CRD differ according to type and severity of neurodegenerative disease, and importantly, could occur before onset of typical clinical symptoms of neurodegeneration. Evidence from preliminary studies suggest that—in addition to being a symptom of neurodegeneration—CRD might also be a potential risk factor for developing ADRD and PD, although large, longitudinal studies are needed to confirm this. The mechanistic link between circadian rhythms and neurodegeneration is not fully understood, although proposed underlying pathways include alterations in protein homeostasis, and immune and inflammatory function. While preliminary clinical studies are promising, more studies of CRD and its mechanisms are needed, and treatment trials are required to determine whether circadian interventions may prevent or delay the onset of neurodegenerative diseases.
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Metadata
- Authors
- Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K.
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 18
- Issue
- 3
- Pages
- 307-318
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2911993021
- Cited by
- 654
- References
- 114
- FWCI
- 29.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. (2019). Association between circadian rhythms and neurodegenerative diseases. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(18)30461-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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