The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Inflammatory mediators in the pathogenesis of periodontitis
Open accessAbstract
Periodontitis is a chronic inflammatory condition of the periodontium involving interactions between bacterial products, numerous cell populations and inflammatory mediators. It is generally accepted that periodontitis is initiated by complex and diverse microbial biofilms which form on the teeth, i.e. dental plaque. Substances released from this biofilm such as lipopolysaccharides, antigens and other virulence factors, gain access to the gingival tissue and initiate an inflammatory and immune response, leading to the activation of host defence cells. As a result of cellular activation, inflammatory mediators, including cytokines, chemokines, arachidonic acid metabolites and proteolytic enzymes collectively contribute to tissue destruction and bone resorption. This review summarises recent studies on the pathogenesis of periodontitis, with the main focus on inflammatory mediators and their role in periodontal disease.
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Citations
Cites
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
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Experimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481 · cited 1×
“In the 1960s and 1970s, research on humans and animals showed that bacteria play a critical role in initiating gingivitis and periodontitis (Refs 23, 24, 25).”
BackgroundResolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Periodontitis: a polymicrobial disruption of host homeostasis
Darveau, R. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2337 · Cited by 1,688
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Mechanistic insight into osteoclast differentiation in osteoimmunology
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Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo
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Control of cytokine mRNA expression by RNA-binding proteins and microRNAs
Palanisamy, V., Jakymiw, A., Van Tubergen, E. A., D’Silva, N. J., & Kirkwood, K. L. (2012) · Journal of Dental Research · doi:10.1177/0022034512437372 · Cited by 117
Cited by
The association of periodontal diseases with metabolic syndrome and obesity
Jepsen, S., Suvan, J., & Deschner, J. (2020) · Periodontology 2000 · doi:10.1111/prd.12326 · Cited by 298
The oral microbiome and adverse pregnancy outcomes
Cobb, C., Kelly, P., Williams, K., Babbar, S., Angolkar, M., & Derman, R. (2017) · International Journal of Women's Health · doi:10.2147/ijwh.s142730 · Cited by 164
Cytokines during periodontal wound healing: potential application for new therapeutic approach
Morand, D., Davideau, J., Clauss, F., Jessel, N., Tenenbaum, H., & Huck, O. (2017) · Oral Diseases · doi:10.1111/odi.12469 · Cited by 80
Zeigler, C. C., Wondimu, B., Marcus, C., & Modéer, T. (2015) · BMC Oral Health · doi:10.1186/s12903-015-0026-6 · Cited by 41
Outside the limits of bacterial viability: Postbiotics in the management of periodontitis
Moraes, R. M., Schlagenhauf, U., & Anbinder, A. L. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115072 · Cited by 29
Metadata
- Authors
- Yucel-Lindberg, T., & Båge, T.
- Venue
- Expert Reviews in Molecular Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013
- Volume
- 15
- Pages
- e7-e7
- ISSN
- 1462-3994 (ISSN-L)
- OpenAlex
- W2110043964
- Cited by
- 472
- References
- 12
- FWCI
- 28.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
