Impact of foods enriched with n-3 long-chain polyunsaturated fatty acids on erythrocyte n-3 levels and cardiovascular risk factors
Open accessAbstract
Consumption of fish or fish oils rich in the n-3 long chain PUFA EPA and DHA may improve multiple risk factors for CVD. The objective of this study was to determine whether regular consumption of foods enriched with n-3 long-chain PUFA can improve n-3 long-chain PUFA status (erythrocytes) and cardiovascular health. Overweight volunteers with high levels of triacylglycerols (TG; >1.6 mmol/l) were enrolled in a 6-month dietary intervention trial conducted in Adelaide (n 47) and Perth (n 39), and randomised to consume control foods or n-3-enriched foods to achieve an EPA + DHA intake of 1 g/d. Test foods were substituted for equivalent foods in their regular diet. Erythrocyte fatty acids, plasma TG and other CVD risk factors were monitored at 0, 3 and 6 months. There were no significant differences between groups for blood pressure, arterial compliance, glucose, insulin, lipids, C-reactive protein (CRP) or urinary 11-dehydro-thromboxane B2 (TXB2) over 6 months, even though regular consumption of n-3-enriched foods increased EPA + DHA intake from 0.2 to 1.0 g/d. However, the n-3 long-chain PUFA content of erythrocytes increased by 35 and 53 % at 3 and 6 months, respectively, in subjects consuming the n-3-enriched foods. These increases were positively associated with measures of arterial compliance and negatively associated with serum CRP and urinary 11-dehydro-TXB2 excretion. Sustainable increases in dietary intakes and erythrocyte levels of n-3 long-chain PUFA can be achieved through regular consumption of suitably enriched processed foods. Such increases may be associated with reduced CV risk.
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Self-citation
- Authors
- Murphy, K. J., Meyer, B. J., Mori, T. A., Burke, V., Mansour, J., Patch, C. S., Tapsell, L. C., Noakes, M., Clifton, P. A., Barden, A., Puddey, I. B., Beilin, L. J., & Howe, P. R. C.
- Affiliations
- University of South Australia (AU)
- University of Wollongong (AU)
- The University of Western Australia (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Corresponding author
- Howe, Peter R. C.
- ORCID
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-03-09
- Volume
- 97
- Issue
- 4
- Pages
- 749-757
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2017487070
- Cited by
- 110
- References
- 46
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- UWA Profiles and Research Repository (University of Western Australia) (submittedVersion)
- UniSA Research Outputs Repository (University of South Australia) (submittedVersion)
- Funders
- Commonwealth Scientific and Industrial Research Organisation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- n-3 long-chain polyunsaturated fatty acids, EPA, docosahexaenoic acid, cardiovascular risk factors, triglycerides, arterial compliance, C-reactive protein, urinary 11-dehydrothromboxane B2, blood pressure, overweight, dietary intervention, processed foods
- MeSH terms
- Adult, Aged, Blood Pressure, Body Constitution, Cardiovascular Diseases, Diet, Docosahexaenoic Acids, Double-Blind Method, Eating, Erythrocytes, Female, Food Analysis, Food, Fortified, Humans, Male, Middle Aged, Risk Factors, Vascular Resistance, Fatty Acids, Omega-3
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