Expression of Na + /glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners
Open accessAbstract
In an intensive livestock production, a shorter suckling period allows more piglets to be born. However, this practice leads to a number of disorders including nutrient malabsorption, resulting in diarrhoea, malnutrition and dehydration. A number of strategies have been proposed to overcome weaning problems. Artificial sweeteners, routinely included in piglets' diet, were thought to enhance feed palatability. However, it is shown in rodent models that when included in the diet, they enhance the expression of Na + /glucose co-transporter (SGLT1) and the capacity of the gut to absorb glucose. Here, we show that supplementation of piglets' feed with a combination of artificial sweeteners saccharin and neohesperidin dihydrochalcone enhances the expression of SGLT1 and intestinal glucose transport function. Artificial sweeteners are known to act on the intestinal sweet taste receptor T1R2/T1R3 and its partner G-protein, gustducin, to activate pathways leading to SGLT1 up-regulation. Here, we demonstrate that T1R2, T1R3 and gustducin are expressed together in the enteroendocrine cells of piglet intestine. Furthermore, gut hormones secreted by the endocrine cells in response to dietary carbohydrates, glucagon-like peptides (GLP)-1, GLP-2 and glucose-dependent insulinotrophic peptide (GIP), are co-expressed with type 1 G-protein-coupled receptors (T1R) and gustducin, indicating that L- and K-enteroendocrine cells express these taste elements. In a fewer endocrine cells, T1R are also co-expressed with serotonin. Lactisole, an inhibitor of human T1R3, had no inhibitory effect on sweetener-induced SGLT1 up-regulation in piglet intestine. A better understanding of the mechanism(s) involved in sweetener up-regulation of SGLT1 will allow the identification of nutritional targets with implications for the prevention of weaning-related malabsorption.
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In animals, a wide range of sweet stimuli, including LCS, upregulate SGLT-1 expression and function.
“In animals, a wide range of sweet stimuli are capable of upregulating SGLT-1 expression and function, including LCS (45-48), indicating that SGLT-1 activity is modulated by an upstream and broadly tuned sweet taste sensor.”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [47]
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Nelson, G., Chandrashekar, J. V., Hoon, M. A., Feng, L., Zhao, G., Ryba, N. J. P., & Zuker, C. S. (2002) · Nature · doi:10.1038/nature726 · Cited by 1,523 · see citing works
Human receptors for sweet and umami taste
Li, X., Staszewski, L. M., Xu, H., Durick, K., Zoller, M. J., & Adler, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072090199 · Cited by 1,380 · see citing works
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 1× · see citing works
“Furthermore, in response to natural sugars and artificial sweeteners, enteroendocrine cells secrete GLP-1 and GIP through the activation of sweet taste receptor, indicating the involvement of these gut hormones in SGLT1 up-regulation((8,36)).”
BackgroundMargolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882 · see citing works
Self-citationElliott, R. M., Morgan, L. M., Tredger, J. A., Deacon, S., Wright, J., & Marks, V. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1380159 · Cited by 695 · see citing works
Gustducin is a taste-cell-specific G protein closely related to the transducins
McLaughlin, S. K., McKinnon, P. J., & Margolskee, R. F. (1992) · Nature · doi:10.1038/357563a0 · Cited by 679 · see citing works
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., & Margolskee, R. F. (2003) · Science · doi:10.1126/science.1087155 · Cited by 632 · see citing works
Endocrine cells in human intestine: an immunocytochemical study
Sjölund, K., Sandén, G., Håkanson, R., & Sundler, F. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80080-8 · Cited by 520 · see citing works
Wu, S.-Z., Rozengurt, N., Yang, M. Y., Young, S. H., Sinnett‐Smith, J. W., & Rozengurt, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042617699 · Cited by 493 · see citing works
A candidate taste receptor gene near a sweet taste locus
Montmayeur, J., Liberles, S. D., Matsunami, H., & Buck, L. B. (2001) · Nature Neuroscience · doi:10.1038/87440 · Cited by 472 · see citing works
The Senses: A Comprehensive Reference
(2020) · Elsevier eBooks · doi:10.1016/c2015-1-04516-1 · Cited by 406 · see citing works
Dyer, J., Salmon, K. S. H., Zibrik, L., & Shirazi‐Beechey, S. P. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330302 · Cited by 383 · see citing works
Self-citationEnteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing
Sternini, C., Anselmi, L., & Rozengurt, E. (2008) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3282f43a73 · Cited by 377 · see citing works
The Senses: A Comprehensive Reference
(2008) · Elsevier eBooks · doi:10.1016/c2009-1-03845-3 · Cited by 373 · see citing works
The New Biology of Gastrointestinal Hormones
Rehfeld, J. F. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.4.1087 · Cited by 327 · see citing works
Lactisole Interacts with the Transmembrane Domains of Human T1R3 to Inhibit Sweet Taste
Jiang, P., Cui, M., Zhao, B., Liu, Z., Snyder, L., Benard, L. M. J., Osman, R., Margolskee, R. F., & Max, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414287200 · Cited by 316 · see citing works
Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo
Cheeseman, C. I. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.6.r1965 · Cited by 267 · see citing works
Glucose sensing in the intestinal epithelium
Dyer, J., Vayro, S., King, T. P., & Shirazi‐Beechey, S. P. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03721.x · Cited by 117 · see citing works
Self-citationWeaning piglets as a model for studying pathophysiology of diarrhea
Nabuurs, M. J. A. (1998) · Veterinary Quarterly · doi:10.1080/01652176.1998.9694967 · Cited by 109 · see citing works
Moran, A. W., Al-Rammahi, M. A., Arora, D. K., Batchelor, D. J., Coulter, E. A., Ionescu, C., Bravo, D., & Shirazi‐Beechey, S. P. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000954 · Cited by 109 · see citing works
Self-citationMolecular characterisation of carbohydrate digestion and absorption in equine small intestine
Dyer, J., MEREDIZ, E. F., Salmon, K. S. H., PROUDMAN, C. J., Edwards, G. B., & Shirazi‐Beechey, S. P. (2002) · Equine Veterinary Journal · doi:10.2746/042516402776249209 · Cited by 108 · see citing works
Self-citationStearns, A. T., Balakrishnan, A., Rhoads, D. B., & Tavakkolizadeh, A. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181d96e1f · Cited by 106 · see citing works
Winnig, M., Bufe, B., & Meyerhof, W. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-22 · Cited by 102 · see citing works
Preparation and properties of brush-border membrane vesicles from human small intestine
Shirazi‐Beechey, S. P., Davies, A. G., Tebbutt, K., Dyer, J., Ellis, A., Taylor, C. J., Fairclough, P. D., & BEECHEY, R. B. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90288-c · Cited by 99 · see citing works
Self-citationNutrient regulation of human intestinal sugar transporter (SGLT1) expression.
Dyer, J., Hosie, K. B., & Shirazi‐Beechey, S. P. (1997) · Gut · doi:10.1136/gut.41.1.56 · Cited by 93 · see citing works
Self-citationControl of development of gastrointestinal system in neonates.
Zabielski, R., Godlewski, M., & Guilloteau, P. (2008) · PubMed · Cited by 90 · see citing works
Dyer, J., Al-Rammahi, M., Waterfall, L., Salmon, K. S. H., Geor, R. J., Bouré, L., Edwards, G. B., Proudman, C. J., & Shirazi-Beechey, S. P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0620-4 · Cited by 88 · see citing works
Self-citationIntestinal glucose sensing and regulation of intestinal glucose absorption
Dyer, J., Daly, K., Salmon, K. S. H., Arora, D. K., Kokrashvili, Z., Margolskee, R. F., & Shirazi‐Beechey, S. P. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351191 · Cited by 85 · see citing works
Self-citationGustatory responses of pigs to various natural and artificial compounds known to be sweet in man
Gläser, D., Wanner, M., Tinti, J.-M., & NOFRE, C. (2000) · Food Chemistry · doi:10.1016/s0308-8146(99)00212-5 · Cited by 77 · see citing works
Sterk, A. R., Schlegel, P., Mul, A. J., Ubbink-Blanksma, M., & Bruininx, E. M. A. M. (2008) · Journal of Animal Science · doi:10.2527/jas.2007-0591 · Cited by 68 · see citing works
Cypha™ [Propionic acid, 2-(4-methoxyphenol) salt] inhibits sweet taste in humans, but not in rats
Sclafani, A. J., & Pérez, C. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00316-2 · Cited by 41 · see citing works
Glucose-dependent insulinotropic polypeptide (GIP) stimulates transepithelial glucose transport
Singh, S. K., Bartoo, A. C., Krishnan, S., Boylan, M. O., Schwartz, J. H., & Wolfe, M. M. (2008) · Obesity · doi:10.1038/oby.2008.393 · Cited by 40 · see citing works
Nabuurs, M. J. A., Hoogendoorn, A., & Bemmel, A. V. Z.-V. (1996) · Research in Veterinary Science · doi:10.1016/s0034-5288(96)90114-9 · Cited by 39 · see citing works
Ponter, A. A. A., Salter, D. N., Morgan, L., & Flatt, P. R. (1991) · British Journal Of Nutrition · doi:10.1079/bjn19910024 · Cited by 27 · see citing works
Kinnamon, S. C., & Margolskee, R. F. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00412-6 · Cited by 7 · see citing works
[Nutrition of young piglets in relation to weaning problems].
Everts, H., van Beers-Schreurs, H. M. G., & Vellenga, L. (1999) · PubMed · Cited by 6 · see citing works
Flagged first, then by citations
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Research works printed but not linked: 2
- RR Hoy, GM Shepherd, AI Basbaum, A Kaneko and G Westheimer, editors]. Amsterdam: Elsevier.
- RR Hoy, GM Shepherd, AI Basbaum, A Kaneko and G Westheimer, editors]. Amsterdam: Elsevier.
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Roura, E., Koopmans, S. J., Lallès, J. P., Huërou‐Luron, I. L., de Jager, N., Schuurman, T., & Val‐Laillet, D. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000020 · Cited by 301 · see citing works
Metabolic effects of non-nutritive sweeteners
Pepino, M. Y. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.06.024 · Cited by 285 · see citing works
Sucralose affects glycemic and hormonal responses to an oral glucose load
Pepino, M. Y., Tiemann, C. D., Patterson, B. W., Wice, B. M., & Klein, S. (2013) · Diabetes Care · doi:10.2337/dc12-2221 · Cited by 253 · see citing works
Jeukendrup, A. E. (2017) · Sports Medicine · doi:10.1007/s40279-017-0690-6 · Cited by 208 · see citing works
Role of gut nutrient sensing in stimulating appetite and conditioning food preferences
Sclafani, A. J., & Ackroff, K. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2012 · Cited by 199 · see citing works
Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion
Daly, K., Al-Rammahi, M. A., Moran, A. W., Marcello, M., Ninomiya, Y., & Shirazi‐Beechey, S. P. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00074.2012 · Cited by 195 · see citing works
Self-citationTaste receptors in innate immunity
Lee, R. J., & Cohen, N. A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1736-7 · Cited by 159 · see citing works
Glucose sensing and signalling; regulation of intestinal glucose transport
Shirazi-Beechey, S. P., Moran, A. W., Batchelor, D. J., Daly, K., & Al-Rammahi, M. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111000103 · Cited by 139 · see citing works
Self-citationIntestinal Fructose and Glucose Metabolism in Health and Disease
Merino, B., Fernández-Díaz, C. M., Cózar‐Castellano, I., & Perdomo, G. (2019) · Nutrients · doi:10.3390/nu12010094 · Cited by 136 · see citing works
Frankenfeld, C. L., Sikaroodi, M., Lamb, E., Shoemaker, S., & Gillevet, P. M. (2015) · Annals of Epidemiology · doi:10.1016/j.annepidem.2015.06.083 · Cited by 123 · see citing works
The avian taste system: Potential implications in poultry nutrition
Roura, E., Baldwin, M. W., & Klasing, K. C. (2012) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2012.11.001 · Cited by 123 · see citing works
Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic Syndrome
Liauchonak, I., Qorri, B., Dawoud, F., Riat, Y., & Szewczuk, M. R. (2019) · Nutrients · doi:10.3390/nu11030644 · Cited by 119 · see citing works
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Foster, S. R., Roura, E., & Thomas, W. G. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.004 · Cited by 112 · see citing works
Moran, A. W., Al-Rammahi, M. A., Arora, D. K., Batchelor, D. J., Coulter, E. A., Ionescu, C., Bravo, D., & Shirazi‐Beechey, S. P. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000954 · Cited by 109 · see citing works
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Sclafani, A. J., Glass, D. S., Margolskee, R. F., & Glendinning, J. I. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00495.2010 · Cited by 92 · see citing works
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Shirazi‐Beechey, S. P., Daly, K., Al-Rammahi, M. A., Moran, A. W., & Bravo, D. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002286 · Cited by 85 · see citing works
Self-citationThe Effects of Critical Illness on Intestinal Glucose Sensing, Transporters, and Absorption*
Deane, A. M., Rayner, C. K., Keeshan, A., Cvijanovic, N., Marino, Z., Nguyen, N. Q., Chia, B., Summers, M. J., Sim, J. A., van Beek, T., et al. (2014) · Critical Care Medicine · doi:10.1097/ccm.0b013e318298a8af · Cited by 84 · see citing works
Neto, H. A. P., Ausina, P., Gomez, L. S., Leandro, J. G. B., Zancan, P., & Sola‐Penna, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01478 · Cited by 77 · see citing works
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Zhou, H. W., Yu, B., Gao, J. L., Htoo, J. K. K., & Chen, D. (2017) · Animal Science Journal · doi:10.1111/asj.12937 · Cited by 74 · see citing works
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Clouard, C., Meunier‐Salaün, M. C., & Val‐Laillet, D. (2011) · animal · doi:10.1017/s1751731111001315 · Cited by 73 · see citing works
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Batchelor, D. J., Al-Rammahi, M. A., Moran, A. W., Brand, J. G., Li, X., Haskins, M. E., German, A. J., & Shirazi‐Beechey, S. P. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00262.2010 · Cited by 60 · see citing works
Self-citationvan der Wielen, N., van Avesaat, M. H. P., de Wit, N. J. W., Vogels, J., Troost, F. J., Masclee, A., Koopmans, S. J., van der Meulen, J., Boekschoten, M. V., Müller, M. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107531 · Cited by 59 · see citing works
Zhang, G., Hasek, L. Y., Lee, B.-H., & Hamaker, B. R. (2015) · Food & Function · doi:10.1039/c4fo00803k · Cited by 55 · see citing works
Zhang, S., Yang, Q., Ren, M., Qiao, S., He, P., Li, D., & Zeng, X. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002439 · Cited by 54 · see citing works
Cheled-Shoval, S. L., Druyan, S., & Uni, Z. (2015) · Poultry Science · doi:10.3382/ps/pev152 · Cited by 54 · see citing works
The influence of odour, taste and nutrients on feeding behaviour and food preferences in horses
van den Berg, M., Giagos, V., Lee, C., Brown, W. Y., Cawdell-Smith, A. J., & Hinch, G. N. (2016) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2016.08.015 · Cited by 54 · see citing works
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Jeukendrup, A. E., & McLaughlin, J. (2011) · Nestlé Nutrition Institute Workshop Series · doi:10.1159/000329268 · Cited by 46 · see citing works
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da Silva, E. C., de Jager, N., Burgos-Paz, W. O., Reverter, A., Miguel Pérez-enciso, A., & Roura, E. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1057 · Cited by 42 · see citing works
Gut mechanisms linking intestinal sweet sensing to glycemic control
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Chan, C. B., Hashemi, Z., & Subhan, F. B. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0705 · Cited by 39 · see citing works
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Cheled-Shoval, S. L., Reicher, N., Niv, M. Y., & Uni, Z. (2017) · Poultry Science · doi:10.3382/ps/pex003 · Cited by 38 · see citing works
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Self-citationMace, O. J., & Marshall, F. H. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5906 · Cited by 36 · see citing works
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Self-citationShirazi‐Beechey, S. P., Moran, A. W., Bravo, D., & Al-Rammahi, M. A. (2011) · Journal of Animal Science · doi:10.2527/jas.2010-3695 · Cited by 32 · see citing works
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Roura, E., & Foster, S. R. (2017) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-030117-014740 · Cited by 25 · see citing works
Non-nutritive Sweeteners and Glycaemic Control
Kim, Y., Keogh, J. B., & Clifton, P. M. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0814-6 · Cited by 26 · see citing works
Uerlings, J., Sureda, E. A., Schroyen, M., Kroeske, K., Tanghe, S., Vos, M. D., Bruggeman, G., Wavreille, J., Bindelle, J., Purcaro, G., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.650211 · Cited by 24 · see citing works
Kim, Y., Keogh, J. B., & Clifton, P. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17239049 · Cited by 24 · see citing works
Expression and regulation of α‐transducin in the pig gastrointestinal tract
Mazzoni, M., GIORGIO, R. D., Latorre, R., Vallorani, C., Bosi, P., Trevisi, P., Barbara, G., Stanghellini, V., Corinaldesi, R., Forni, M., et al. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12026 · Cited by 23 · see citing works
Gut chemosensing: implications for disease pathogenesis
Berg, C. J., & Kaunitz, J. D. (2016) · F1000Research · doi:10.12688/f1000research.9208.1 · Cited by 22 · see citing works
Sensation of dietary nutrients by gut taste receptors and its mechanisms
Xie, F., Shen, J., Liu, T., Zhou, M., Johnston, L. J., Zhao, J., Zhang, H., & Ma, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.2021388 · Cited by 22 · see citing works
Physiological and metabolic control of diet selection
Roura, E., & Navarro, M. (2018) · Animal Production Science · doi:10.1071/an16775 · Cited by 23 · see citing works
Chegeni, M., Amiri, M., Nichols, B. L., Nairn, H. Y., & Hamaker, B. R. (2018) · The FASEB Journal · doi:10.1096/fj.201701029r · Cited by 22 · see citing works
Liou, A. P. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5910 · Cited by 20 · see citing works
Cvijanovic, N., Feinle‐Bisset, C., Young, R. L., & Little, T. J. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu026 · Cited by 20 · see citing works
Lipid-Lowering Pharmaceutical Clofibrate Inhibits Human Sweet Taste
Kochem, M., & Breslin, P. A. S. (2016) · Chemical Senses · doi:10.1093/chemse/bjw104 · Cited by 19 · see citing works
Daly, K., Moran, A. W., Al-Rammahi, M. A., Weatherburn, D., & Shirazi‐Beechey, S. P. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.032 · Cited by 17 · see citing works
Self-citationOtero-Rodiño, C., Librán-Pérez, M., Velasco, C., Álvarez‐Otero, R., López‐Patiño, M. A., Míguez, J. M., & Soengas, J. L. (2015) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2015.09.008 · Cited by 17 · see citing works
Latorre, R., Mazzoni, M., GIORGIO, R. D., Vallorani, C., Bonaldo, A., Gatta, P. P., Corinaldesi, R., Ruggeri, E., Bernardini, C., Chiocchetti, R., et al. (2013) · Fish Physiology and Biochemistry · doi:10.1007/s10695-013-9808-4 · Cited by 17 · see citing works
(FEEDAP), E. P. O. A. A. P. O. S. U. I. A. F., Rychen, G., Aquilina, G., Azimonti, G., Bampidis, V., Bastos, M. D. L., Bories, G. F., Cocconcelli, P. S., Flachowsky, G., Gropp, J., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5208 · Cited by 17 · see citing works
Malbert, C., Horowitz, M., & Young, R. L. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04430-4 · Cited by 17 · see citing works
Taste Receptor Gene Expression Outside the Gustatory System
Behrens, M., Prandi, S., & Meyerhof, W. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_79 · Cited by 16 · see citing works
Effects of pre-exercise sucralose ingestion on carbohydrate oxidation during exercise
Stellingwerff, T., Godin, J.-P., Beaumont, M., Tavenard, A., Grathwohl, D., van Bladeren, P. J., Kapp, A.-F., Coutre, J. L., & Damak, S. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.6.584 · Cited by 15 · see citing works
GIORGIO, R. D., Mazzoni, M., Vallorani, C., Latorre, R., Bombardi, C., Bacci, M. L., Forni, M., Falconi, M., Sternini, C., & Clavenzani, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148954 · Cited by 15 · see citing works
Kroscher, K. A., Fausnacht, D. W., McMillan, R. P., El‐Kadi, S. W., Wall, E. H., Bravo, D. M., & Rhoads, R. P. (2022) · Journal of Animal Science · doi:10.1093/jas/skac195 · Cited by 14 · see citing works
Self-citationMoran, A. W., Al-Rammahi, M. A., Daly, K., Grand, E., Ionescu, C., Bravo, D. M., Wall, E. H., & Shirazi‐Beechey, S. P. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b04995 · Cited by 14 · see citing works
Self-citationLiu, W., wang, H., Mu, Q., & Gong, T. (2024) · Theriogenology · doi:10.1016/j.theriogenology.2024.10.019 · Cited by 13 · see citing works
Solà‐Oriol, D., Roura, E., & Torrallardona, D. (2013) · Journal of Animal Science · doi:10.2527/jas.2013-6791 · Cited by 13 · see citing works
Nutrient Sensing for the Future of Land-Farmed Animal and Aquaculture Nutrition
Gao, Z., Liu, C., Mai, K., & He, G. (2022) · Engineering · doi:10.1016/j.eng.2022.05.019 · Cited by 12 · see citing works
Otero-Rodiño, C., Velasco, C., Álvarez‐Otero, R., López‐Patiño, M. A., Míguez, J. M., & Soengas, J. L. (2016) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2016.04.010 · Cited by 12 · see citing works
Guzmán-Pino, S. A., Solà‐Oriol, D., Figueroa, J., Dwyer, D. M., & Pérez, J. F. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.009 · Cited by 12 · see citing works
Beyond sweetness: The high-intensity sweeteners and farm animals
Chen, J., Lei, Y., Zhang, Y., He, S., Liu, L., & Dong, X. (2020) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2020.114571 · Cited by 11 · see citing works
Gastrointestinal taste receptors: could tastants become drugs?
Behrens, M., & Somoza, V. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000531 · Cited by 10 · see citing works
Calf intestinal health: Assessment and dietary interventions for its improvement
Marquez, J. C. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 9 · see citing works
Effects of Nonnutritive Sweeteners on Body Composition Changes during Pubertal Growth
Chien, Y.-H., Lin, C., Hsu, S., Chen, Y., Wu, H., Huang, S.-W., & Chen, Y. (2023) · Nutrients · doi:10.3390/nu15102319 · Cited by 8 · see citing works
Forage taste agents modifying yak grazing decrease soil microbial diversity in alpine meadow
You, Y., Ren, J., Wu, J., Ma, Z., Gu, Y., Wang, Y., Wang, Z., Bowatte, S., Zhou, Q., & Hou, F. (2021) · Applied Soil Ecology · doi:10.1016/j.apsoil.2021.104160 · Cited by 8 · see citing works
Figueroa, J., Valenzuela, C., V, & Guzmán-Pino, S. A. (2022) · Veterinary Sciences · doi:10.3390/vetsci9050233 · Cited by 7 · see citing works
Yang, L., Ma, X., Yang, C., Jiang, S., Yang, W., & Jiang, S. (2022) · Agriculture · doi:10.3390/agriculture12070912 · Cited by 7 · see citing works
Shirazi‐Beechey, S. P., Moran, A. W., Batchelor, D. J., Daly, K., & Al-Rammahi, M. A. (2011) · Cited by 6 · see citing works
Self-citationFurness, J. B., & Cottrell, J. J. (2017) · Animal Production Science · doi:10.1071/an17276 · Cited by 5 · see citing works
Evaluating the Effects of Non-Nutritive Sweeteners on Pigs: A Systematic Review
Jansen, M., & Kim, K. (2024) · Animals · doi:10.3390/ani14203032 · Cited by 4 · see citing works
Rose, B. D., Pezos, N., Choo, J. M., Wu, T., Rogers, G. B., Ivey, K. L., Rayner, C. K., & Young, R. L. (2024) · Nutrients · doi:10.3390/nu16213628 · Cited by 2 · see citing works
Ma, C., Wang, F., Li, R., Huang, K., Zhao, Q., Qin, Y., Zhang, J., & Si, W. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.11.025 · Cited by 2 · see citing works
Zhou, S., Hang, Y., Wang, J., & Fang, R. (2018) · Animal nutrition · doi:10.1016/j.aninu.2018.06.003 · Cited by 2 · see citing works
Chapter 8 Dietary fibre, gut sensing and modulation of feed intake in pigs and chickens
Roura, E. (2019) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-893-3_8 · Cited by 2 · see citing works
Hańczakowska, E., Niwińska, B., GRELA, E. R., Węglarzy, K., & Okoń, K. (2016) · Annals of Animal Science · doi:10.1515/aoas-2016-0039 · Cited by 1 · see citing works
Smith, L., Moran, A. W., Al-Rammahi, M. A., Daly, K., & Shirazi‐Beechey, S. P. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1325135 · Cited by 1 · see citing works
Self-citationCiullo, D., & Dotson, C. (2015) · Chemosensory Perception · doi:10.1007/s12078-015-9190-y · Cited by 1 · see citing works
Efficacy of butyrate-producing therapies for use in pediatric intestinal failure
Barnes, J. L. (2013) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 1 · see citing works
Szűcs, Z., Ábel, T., & Lengyel, G. (2016) · Orvosi Hetilap · doi:10.1556/oh.2016.30466 · Cited by 1 · see citing works
- Authors
- Moran, A. W., Al-Rammahi, M. A., Arora, D. K., Batchelor, D. J., Coulter, E. A., Daly, K., Ionescu, C., Bravo, D., & Shirazi-Beechey, S. P.
- Affiliations
- University of Liverpool (GB)
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-03-26
- Volume
- 104
- Issue
- 5
- Pages
- 637-646
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2135356931
- Cited by
- 114
- References
- 37
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 11
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- SGLT1, artificial sweeteners, weaning piglets, intestinal glucose transport, saccharin, neohesperidin dihydrochalcone, gustducin, enteroendocrine cells, glucagon-like peptide-1, glucagon-like peptide-2, serotonin, lactisole, gastrointestinal hormones
- MeSH terms
- Animals, Benzene Derivatives, Biological Transport, Dietary Carbohydrates, Glucagon-Like Peptides, Female, Gastric Inhibitory Polypeptide, Hesperidin, Intestine, Small, Male, Saccharin, Serotonin, Sweetening Agents, Swine, Weaning, Transducin, Up-Regulation, Dietary Supplements, Enteroendocrine Cells, Receptors, G-Protein-Coupled, Chalcones, Sodium-Glucose Transporter 1
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