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Cited by 462

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Colonic metabolites of berry polyphenols: the missing link to biological activity?

Open access
Williamson, Gary, Clifford, Michael N.·2010·British Journal of Nutrition
DOI 10.1017/s0007114510003946
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Abstract

The absorption of dietary phenols, polyphenols and tannins (PPT) is an essential step for biological activity and effects on health. Although a proportion of these dietary bioactive compounds are absorbed intact, depending on their chemical structure and the nature of any attached moiety (e.g. sugar, organic acid), substantial amounts of lower molecular weight catabolites are absorbed after biotransformation by the colon microflora. The main products in the colon are (a) benzoic acids (C 6–C 1), especially benzoic acid and protocatechuic acid; (b) phenylacetic acids (C 6–C 2), especially phenylacetic acid per se; (c) phenylpropionic acids (C 6–C 3), where the latter are almost entirely in the dihydro form, notably dihydrocaffeic acid, dihydroferulic acid, phenylpropionic acid and 3-(3′-hydroxyphenyl)-propionic acid. As a result of this biotransformation, some of these compounds can each reach m m concentrations in faecal water. Many of these catabolites are efficiently absorbed in the colon, appear in the blood and are ultimately excreted in the urine. In the case of certain polyphenols, such as anthocyanins, these catabolites are major products in vivo; protocatechuic acid is reported to represent a substantial amount of the ingested dose of cyanidin-3-O-glucoside. The major catabolites of berries, and especially blackcurrants, are predicted based on compositional data for polyphenols from berries and other sources. Since microbial catabolites may be present at many sites of the body in higher concentration than the parent compound, it is proposed that at least a part of the biological activities ascribed to berry polyphenols and other PPT are due to their colonic catabolites.

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Metadata

Authors
Williamson, G., & Clifford, M. N.
Venue
British Journal of Nutrition
Publisher
Cambridge University Press (CUP)
Published
2010-10
Volume
104
Issue
S3
Pages
S48-S66
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1017/s0007114510003946
OpenAlex
W2119200558
Cited by
462
References
4
FWCI
16.97
Type
journal article
Language
en
Open access
green

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