Cited by 159Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietNutrition, Genetics, and Disease

Urinary metabolites as biomarkers of polyphenol intake in humans—a systematic review

Open access
Pérez-Jiménez, Jara, Hubert, Jane, Hooper, Lee, Cassidy, Aedin, Manach, Claudine, Williamson, Gary, Scalbert, Augustin·2010·The American Journal of Clinical Nutrition

Abstract

Background To identify associations between polyphenol intake and health and disease outcomes in cohort studies, it is important to identify biomarkers of intake for the various compounds commonly consumed as part of the diet.Objective The objective of this systematic review was to assess the usefulness of polyphenol metabolites excreted in urine as biomarkers of polyphenol intake in humans.Design The method included a structured search strategy for polyphenol intervention studies on Ovid MEDLINE, EMBASE (Ovid), and Cochrane databases; formal inclusion and exclusion criteria; data extraction into an Access database; validity assessment; and meta-analysis.Results One hundred sixty-two controlled intervention studies with polyphenols were included, and mean recovery yield and correlations with the dose ingested were determined for 40 polyphenols. Polyphenols such as daidzein, genistein, glycitein, enterolactone, and hydroxytyrosol showed both a high recovery yield (12-37%) and a high correlation with the dose (Pearson's correlation coefficients: 0.67-0.87), which showed good sensitivity and robustness as biomarkers of intake throughout the different studies. Weaker recovery for anthocyanins (0.06-0.2%) and weaker correlations with dose [Pearson's correlation coefficients: 0.21-0.52 for hesperidin, naringenin, (-)-epicatechin, (-)-epigallocatechin, quercetin, and 3 microbial metabolites of isoflavones (dihydrodaidzein, equol, and O-desmethylangolensin)] suggest that they are currently less suitable as biomarkers of intake.Conclusions These data confirm the value of certain urinary polyphenols as biomarkers of intake. A validation in populations is now needed to evaluate their specificity, sensitivity, and responsiveness to dose under free-living conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3945/ajcn.2010.29924

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Weaker correlations with intakes of foods or their constituents were observed for microbial metabolites compared with untransformed food compounds and host-transformed metabolites.

    “Consequently, weaker correlations with intakes of foods or of their constituents were observed for microbial metabolites when compared with untransformed food compounds and host-transformed metabolites (41).”

    From The food metabolome: a window over dietary exposure (2014) · cites this paper as [41]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Pérez-Jiménez, J., Hubert, J., Hooper, L., Cassidy, A., Manach, C., Williamson, G., & Scalbert, A.
Affiliations
  • Université Clermont Auvergne (FR)
  • University of East Anglia (GB)
  • University of Leeds (GB)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2010-10
Volume
92
Issue
4
Pages
801-809
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2023955936
Cited by
159
References
45
Citations by year
2026: 5 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 16 · 2016: 14 · 2015: 15 · 2014: 18 · 2013: 14 · 2012: 14
FWCI
1.00
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (Queen's University Belfast) (submittedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
dietary polyphenols, isoflavones, daidzein, genistein, glycitein, enterolactone, hydroxytyrosol, anthocyanins, hesperidin, naringenin, epicatechin, epigallocatechin, quercetin, microbial metabolites, equol, O-desmethylangolensin, dihydrodaidzein, recovery yield, dose-response relationship
MeSH terms
Anthocyanins, Eating, Flavonoids, Humans, Phenols, Review Literature as Topic, Stilbenes, Biomarkers, Flavanones, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review