Effect of dietary laminarin and fucoidan on selected microbiota, intestinal morphology and immune status of the newly weaned pig
Open accessAbstract
A 2 × 2 factorial experiment was conducted to investigate the interactions between laminarin (LAM; 0 and 300 parts per million (ppm)) and fucoidan (FUC; 0 and 240 ppm) levels on intestinal morphology, selected microbiota and inflammatory cytokine gene expression in the weaned pig. There was an interaction between LAM and FUC supplementation on the Enterobacteriaceae population (P< 0·05) and the abundance of attaching and effacing Escherichia coli (AEEC) strains (P< 0·05) in the colon. Pigs offered the FUC diet had a reduced Enterobacteriaceae population compared with pigs offered the basal diet. However, the effect of FUC on the Enterobacteriaceae population was not observed when combined with LAM. Pigs offered the LAM diet had reduced abundance of AEEC strains compared with pigs offered the basal diet. However, there was no effect of LAM on the abundance of AEEC strains when combined with FUC. There was an interaction between LAM and FUC supplementation on villous height (P< 0·01) and the villous height:crypt depth ratio (P< 0·01) in the duodenum. Pigs offered the LAM or FUC diet had an increased villous height and villous height:crypt depth ratio compared with pigs offered the basal diet. However, there was no effect of the LAM and FUC combination diet on intestinal morphology. Pigs offered the LAM-supplemented diets had a lower IL-6 (P< 0·05), IL-17A (P< 0·01) and IL-1β (P< 0·01) mRNA expression in the colon compared with pigs offered the diets without LAM. In conclusion, supplementation with either LAM or FUC alone modified intestinal morphology and selected intestinal microbiota, but these effects were lost when offered in combination.
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Fucoidan supplementation in pigs reduced Enterobacteriaceae counts and improved faecal consistency by inhibiting attachment of certain bacteria in the porcine gastrointestinal tract.
“The animals receiving fucoidan showed a reduction in Enterobacteriaceae counts and improved faecal consistency due to the ability of fucoidan to inhibit the attachment of certain bacterial species in the porcine gastrointestinal tract”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Walsh et al., 2013
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Cites
Van Soest, P. J., Robertson, J. B., & Lewis, B. A. (1991) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(91)78551-2 · Cited by 28,658 · see citing works
Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., & Speleman, F. (2002) · Genome Biology · doi:10.1186/gb-2002-3-7-research0034 · Cited by 20,038 · see citing works
Diarrheagenic Escherichia coli
Nataro, J. P., & Kaper, J. B. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.1.142 · Cited by 5,109 · see citing works
Hellemans, J., Mortier, G., De Paepe, A., Speleman, F., & Vandesompele, J. (2007) · Genome Biology · doi:10.1186/gb-2007-8-2-r19 · Cited by 4,023 · see citing works
Chomczyński, P., & Sacchi, N. (2006) · Nature Protocols · doi:10.1038/nprot.2006.83 · Cited by 2,084 · see citing works
Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · see citing works
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works
Factors influencing the structure and function of the small intestine in the weaned pig: a review
Pluske, J. R., Hampson, D. J., & Williams, I. H. (1997) · Livestock Production Science · doi:10.1016/s0301-6226(97)00057-2 · Cited by 1,099 · see citing works
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048 · see citing works
Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026 · see citing works
Montagné, L., Pluske, J. R., & Hampson, D. J. (2003) · Animal Feed Science and Technology · doi:10.1016/s0377-8401(03)00163-9 · Cited by 999 · see citing works
Fairbrother, J. M., Nadeau, É., & Gyles, C. L. (2005) · Animal Health Research Reviews · doi:10.1079/ahr2005105 · Cited by 895 · see citing works
Culture-Independent Analysis of Gut Bacteria: the Pig Gastrointestinal Tract Microbiota Revisited
Leser, T. D., Amenuvor, J. Z., Jensen, T. K., Lindecrona, R. H., Boyé, M., & Møller, K. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.2.673-690.2002 · Cited by 868 · see citing works
Tables of composition and nutritional value of feed materials
(2004) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-668-7 · Cited by 798 · see citing works
Berteau, O. (2003) · Glycobiology · doi:10.1093/glycob/cwg058 · Cited by 769 · see citing works
Absolute and relative QPCR quantification of plasmid copy number in Escherichia coli
Lee, C., Kim, J., Shin, S. G., & Hwang, S. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.11.014 · Cited by 641 · see citing works
Short-Chain Fatty Acids in the Human Colon: Relation to Gastrointestinal Health and Disease
Mortensen, P. B., & Clausen, M. R. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609094568 · Cited by 513 · see citing works
Immune recognition of fungal β-glucans
Brown, G. D., & Gordon, S. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00505.x · Cited by 421 · see citing works
Rice, P. J., Adams, E. L., Ozment-Skelton, T. R., Gonzalez, A. J., Goldman, M. P., Lockhart, B. E., Barker, L. A., Breuel, K. F., DePonti, W. K., Kalbfleisch, J. H., et al. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085415 · Cited by 333 · see citing works
Role of yeast cell wall polysaccharides in pig nutrition and health protection
Kogan, G., & Kocher, A. (2007) · Livestock Science · doi:10.1016/j.livsci.2007.01.134 · Cited by 308 · see citing works
Small Intestine Epithelial Barrier Function Is Compromised in Pigs with Low Feed Intake at Weaning
Spreeuwenberg, M. A. M., Verdonk, J. M. A. J., Gaskins, H. R., & Verstegen, M. W. A. (2001) · Journal of Nutrition · doi:10.1093/jn/131.5.1520 · Cited by 300 · see citing works
Pluske, J. R., Thompson, M. J., Atwood, C. S., Bird, P. H., Williams, I. H., & Hartmann, P. E. (1996) · British Journal of Nutrition · doi:10.1079/bjn19960046 · Cited by 286 · see citing works
Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs1
Manzanilla, E. G., Pérez, J. F., Martı́n, M., Kamel, C., Baucells, F., & Gasa, J. (2004) · Journal of Animal Science · doi:10.2527/2004.82113210x · Cited by 276 · see citing works
Macfarlane, G. T., Gibson, G. R., Beatty, E. R., & Cummings, J. H. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05764.x · Cited by 255 · see citing works
New insights into the epidemiology of enteropathogenic Escherichia coli infection
Ochoa, T. J., Barletta, F., Contreras, C. A., & Mercado, E. H. (2008) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2008.03.017 · Cited by 222 · see citing works
Analysis of the structural heterogeneity of laminarin by electrospray-ionisation-mass spectrometry
Read, S. M., Currie, G., & Bacic, A. (1996) · Carbohydrate Research · doi:10.1016/0008-6215(95)00350-9 · Cited by 209 · see citing works
Cytokine regulation of epithelial permeability and ion transport
McKay, D. M., & Baird, A. W. (1999) · Gut · doi:10.1136/gut.44.2.283 · Cited by 201 · see citing works
Li, J., Li, D. F., Xing, J. J., Cheng, Z., & Lai, C. (2006) · Journal of Animal Science · doi:10.2527/jas.2004-541 · Cited by 174 · see citing works
Shibata, H., Iimuro, M., Uchiya, N., Kawamori, T., Nagaoka, M., Ueyama, S., Hashimoto, S., Yokokura, T., Sugimura, T., & Wakabayashi, K. (2003) · Helicobacter · doi:10.1046/j.1523-5378.2003.00124.x · Cited by 157 · see citing works
Lynch, M. B., Sweeney, T., Callan, J. J., O’Sullivan, J. T., & O’Doherty, J. V. (2009) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3834 · Cited by 148 · see citing works
Self-citationReilly, P., O’Doherty, J. V., Pierce, K. M., Callan, J. J., O’Sullivan, J. T., & Sweeney, T. (2008) · animal · doi:10.1017/s1751731108002711 · Cited by 142 · see citing works
Self-citationMetzler-Zebeli, B. U., Hooda, S., Pieper, R., Zijlstra, R. T., Kessel, A. G. V., Mosenthin, R., & Gänzle, M. G. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00257-10 · Cited by 139 · see citing works
O’Doherty, J. V., Dillon, S., Figat, S., Callan, J. J., & Sweeney, T. (2010) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2010.03.004 · Cited by 131 · see citing works
Self-citationKrause, G., Zimmermann, S., & Beutin, L. (2005) · Veterinary Microbiology · doi:10.1016/j.vetmic.2004.11.012 · Cited by 130 · see citing works
Polysaccharides of Algae: 55. Polysaccharide Composition of Several Brown Algae from Kamchatka
Usov, A. I., Smirnova, G. P., & Клочкова, Н. Г. (2001) · Russian Journal of Bioorganic Chemistry · doi:10.1023/a:1012992820204 · Cited by 124 · see citing works
Innate immune signaling in defense against intestinal microbes
Kinnebrew, M. A., & Pamer, E. G. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01081.x · Cited by 123 · see citing works
Michel, C., Lahaye, M., Bonnet, C., Mabeau, S., & Barry, J. L. (1996) · British Journal Of Nutrition · doi:10.1079/bjn19960129 · Cited by 118 · see citing works
Sweeney, T., Collins, C. B., Reilly, P., Pierce, K. M., Ryan, M., & O'Doherty, J. V. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511006751 · Cited by 116 · see citing works
Self-citationMcdonnell, P. J., Figat, S., & O’Doherty, J. V. (2009) · animal · doi:10.1017/s1751731109991376 · Cited by 115 · see citing works
Self-citationAttaching and Effacing Escherichia coli Infections in Calves, Pigs, Lambs, and Dogs
Janke, B. H., Francis, D. H., Collins, J. E., et al. (1989) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/104063878900100104 · Cited by 111 · see citing works
Gahan, D. A., Lynch, M. B., Callan, J. J., O’Sullivan, J. T., & O’Doherty, J. V. (2008) · animal · doi:10.1017/s1751731108003017 · Cited by 87 · see citing works
Self-citationPierce, K. M., Sweeney, T., Brophy, P. O., et al. (2006) · Animal Science · doi:10.1079/asc200634 · Cited by 87 · see citing works
Self-citationLeonard, S. G., Sweeney, T., Bahar, B., & O’Doherty, J. V. (2011) · Journal of Animal Science · doi:10.2527/jas.2010-3243 · Cited by 82 · see citing works
Self-citationLeverton, L. Q., & Kaper, J. B. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.1034-1043.2005 · Cited by 80 · see citing works
Melin, L., Mattsson, S., Katouli, M., et al. (2004) · Journal of Veterinary Medicine Series B · doi:10.1111/j.1439-0450.2003.00723.x · Cited by 68 · see citing works
Leonard, S. G., Sweeney, T., Bahar, B., Lynch, B., & O’Doherty, J. V. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003739 · Cited by 63 · see citing works
Self-citationHogaboam, C. M., Steinhauser, M. L., Schock, H., et al. (1998) · Infection and Immunity · doi:10.1128/iai.66.2.650-655.1998 · Cited by 43 · see citing works
O’Shea, C. J., Sweeney, T., Bahar, B., Ryan, M. T., Thornton, K. H., & O’Doherty, J. V. (2012) · Journal of Animal Science · doi:10.2527/jas.2011-4461 · Cited by 36 · see citing works
Self-citationAn, H., Fairbrother, J. M., Désautels, C., et al. (2000) · Microbial Pathogenesis · doi:10.1006/mpat.1999.0346 · Cited by 30 · see citing works
O’Shea, C. J., Sweeney, T., Lynch, M. B., Callan, J. J., & O’Doherty, J. V. (2011) · Journal of Animal Science · doi:10.2527/jas.2010-2922 · Cited by 24 · see citing works
Self-citationRyan, M. T., Collins, C. B., O’Doherty, J. V., & Sweeney, T. (2010) · Livestock Science · doi:10.1016/j.livsci.2010.06.020 · Cited by 18 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- NRC (1998) Nutrient Requirements of Swine, 10th ed. Washington, DC: National Academy Press.
Cited by
Sorted by citations
Garcia-Vaquero, M., Rajauria, G., O'Doherty, J. V., & Sweeney, T. (2017) · Food Research International · doi:10.1016/j.foodres.2016.11.016 · Cited by 364 · see citing works
Self-citationModulation of Gut Microbiota–Brain Axis by Probiotics, Prebiotics, and Diet
Liu, X., Cao, S., & Zhang, X. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02404 · Cited by 304 · see citing works
Cian, R., Drago, S., De Medina, F., & Martínez-Augustin, O. (2015) · Marine Drugs · doi:10.3390/md13085358 · Cited by 238 · see citing works
Algae as Food in Europe: An Overview of Species Diversity and Their Application
Mendes, M., Navalho, S., Ferreira, A., Paulino, C., Figueiredo, D., Silva, D., Gao, F., Gama, F., Bombo, G., Jacinto, R., et al. (2022) · Foods · doi:10.3390/foods11131871 · Cited by 234 · see citing works
- Authors
- Walsh, A. M., Sweeney, T., O'Shea, C. J., Doyle, D. N., & O'Doherty, J. V.
- Affiliations
- University College Dublin (IE)
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-03-26
- Volume
- 110
- Issue
- 9
- Pages
- 1630-1638
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2132758189
- Cited by
- 121
- References
- 51
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 2 · 2014: 3 · 2013: 3
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Enterprise Ireland
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- laminarin, fucoidan, dietary supplementation, weaned piglets, gut microbiota, Enterobacteriaceae, attaching and effacing Escherichia coli, intestinal morphology, villus height, crypt depth, inflammatory cytokines, interleukin-6, IL-17A, IL-1β, colonic gene expression, dietary interactions
- MeSH terms
- Phaeophyceae, Animals, Colon, Drug Therapy, Combination, Duodenum, Enterobacteriaceae, Escherichia coli, Glucans, Intestinal Mucosa, Intestines, Polysaccharides, RNA, Messenger, Swine, Weaning, Interleukin-6, Dietary Supplements, Interleukin-1beta, Microbiota
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