Preventive Effects of Cladosiphon Fucoidan Against Helicobacter pylori Infection in Mongolian gerbils
Abstract
BACKGROUND: Recently, the acquisition by Helicobacter pylori of resistance to antibiotics has become a serious problem. Therefore, nonantibiotic substances are required to diminish H. pylori-induced gastric lesions. In the present study, the effects of Cladosiphon fucoidan were examined in terms of H. pylori attachment to porcine gastric mucin in vitro and Helicobacter pylori-induced gastritis in vivo. METHODS: The inhibitory effect of Cladosiphon fucoidan and other polysaccharides on H. pylori attachment to porcine gastric mucin was assayed in vitro with mucin-coated microtiter plates. The effect of Cladosiphon fucoidan on H. pylori-induced gastritis was examined in vivo using Mongolian gerbils. H. pylori-inoculated gerbils were given fucoidan in drinking water. Six weeks after H. pylori-inoculation, gerbils were sacrificed for macroscopic and microscopic examination of gastric lesions and counting of viable H. pylori in the gastric mucosa. RESULTS: Cladosiphon fucoidan inhibited the H. pylori attachment to porcine gastric mucin at pH 2.0 and 4.0. Two other sulfated polysaccharides, Fucus fucoidan and dextran sulfate sodium, also inhibited the attachment but only at pH 2.0. Inhibitory effects of these three sulfated polysaccharides were not observed at pH 7.2 and nonsulfated polysaccharides, such as mannan and dextran, exerted no influence at any pH. In the in vivo experiment, the H. pylori-induced gastritis and the prevalence of H. pylori infected animals were markedly reduced by fucoidan in a dose-dependent manner, at doses of 0.05 and 0.5% in the drinking water. CONCLUSION: Cladosiphon fucoidan may deserve particular attention as a safe agent that can prevent H. pylori infection and reduce the risk of associated gastric cancer.
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Cladosiphon fucoidan prevented attachment of Helicobacter pylori to gastric mucin and reduced risk of associated gastric cancer.
“It was reported that Cladosiphon fucoidan prevented the attachment of Helicobacter pylori to the mucin of the gastric tract and, therefore, reduced the risk of associated gastric cancer [34].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [34]
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- Authors
- Shibata, H., Iimuro, M., Uchiya, N., Kawamori, T., Nagaoka, M., Ueyama, S., Hashimoto, S., Yokokura, T., Sugimura, T., & Wakabayashi, K.
- Affiliations
- Yakult Central Institute (JP)
- National Cancer Center Research Institute (JP)
- Corresponding author
- Shibata, Hideyuki
- Venue
- Helicobacter
- Publisher
- Wiley
- Published
- 2003-02
- Volume
- 8
- Issue
- 1
- Pages
- 59-65
- ISSN
- 1083-4389 (ISSN-L)
- 1523-5378
- OpenAlex
- W2110590245
- Cited by
- 157
- References
- 23
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 25 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 12 · 2013: 9 · 2012: 7
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Helicobacter (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Helicobacter pylori, fucoidan, sulfated polysaccharides, gastritis, gastric cancer prevention, antibiotic resistance, Mongolian gerbil, dextran sulfate, mannan, dextran
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacterial Adhesion, Gastric Mucosa, Gastritis, Gerbillinae, Mucins, Polysaccharides, Seaweed, Swine, Helicobacter pylori, Helicobacter Infections
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