Diet, insulin secretion and insulin sensitivity–the dose-responses to exercise training (DR’s EXTRA) study (ISRCTN45977199)

Heikkilä, Harri M.; Krachler, Benno; Rauramaa, Rainer; Schwab, Ursula S.

doi:10.1017/s0007114514002426

Cited by 12Food composition and propertiesDiabetes, Cardiovascular Risks, and LipoproteinsNutritional Studies and Diet

Diet, insulin secretion and insulin sensitivity–the dose-responses to exercise training (DR’s EXTRA) study (ISRCTN45977199)

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Heikkilä, Harri M., Krachler, Benno, Rauramaa, Rainer, Schwab, Ursula S.·2014·British Journal of Nutrition

DOI 10.1017/s0007114514002426

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Abstract

Intakes of saturated fat (SF) and dietary fibre, body mass and physical activity are all associated with the incidence of type 2 diabetes mellitus. Their relative importance for the maintenance of normal glucose metabolism is not fully known. In a population-based sample of 1114 individuals, aged 58–78 years, dietary intakes were assessed by 4 d food records and cardiorespiratory fitness as maximal oxygen uptake. Insulin secretion, insulin sensitivity, the early-phase disposition index (DI30) and the total disposition index (DI120) were assessed based on an oral glucose tolerance test. Linear associations were modelled using linear regression. Combined effects were studied by introducing SF and fibre intakes, as well as cardiorespiratory fitness and waist circumference (WC) as dichotomised variables in general linear models. Intakes of dietary fibre and whole-grain bread were positively associated with insulin sensitivity, independent of physical fitness and WC. In women, dietary fibre intake was also positively associated with DI30. The negative association of high WC with DI30 was attenuated by a combination of low SF intake and high cardiorespiratory fitness. In conclusion, dietary fibre and a combination of low SF intake and high cardiorespiratory fitness may contribute to the maintenance of normal glucose metabolism, independent of WC.

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Authors: Heikkilä, H. M., Krachler, B., Rauramaa, R., & Schwab, U. S.
Affiliations: Umeå University (SE)
Kuopio University Hospital (FI)
University of Eastern Finland (FI)
Corresponding author: Heikkilä, Harri M.
ORCID: Krachler, Benno
Schwab, Ursula S.
Venue: British Journal of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2014-09-18
Volume: 112
Issue: 9
Pages: 1530-1541
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114514002426
OpenAlex: W2160181064
Semantic Scholar: d3c2cf40202adfe351265adb0ce7df4ebe5e39bb
Cited by: 12
References: 45
Citations by year: 2025: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1
FWCI: 1.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
DiVA at Umeå University (Umeå University) (submittedVersion, other-oa)
Funders: Foundation for Cardiovascular Research
European Commission (LSHMCT-2004-005272)
Kela
Academy of Finland (104943, 123885)
Juho Vainion Säätiö
Kuopion Yliopistollinen Sairaala
Sydäntutkimussäätiö
Diabetesliitto
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: type 2 diabetes, insulin secretion, insulin sensitivity, dietary fiber, saturated fat intake, whole grain bread, cardiorespiratory fitness, waist circumference, disposition index, glucose metabolism, older adults, exercise training
MeSH terms: Insulin Secretion, Aged, Blood Glucose, Bread, Edible Grain, Diet, Dietary Fats, Dietary Fiber, Exercise Test, Fasting, Female, Finland, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Oxygen Consumption, Physical Fitness, Exercise, Diet Records, Body Mass Index, Waist Circumference

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Diet, insulin secretion and insulin sensitivity–the dose-responses to exercise training (DR’s EXTRA) study (ISRCTN45977199)

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