Do SCFA have a role in appetite regulation?
Open accessAbstract
The recently discovered SCFA-activated G-coupled protein receptors FFA receptor 2 and FFA receptor 3 are co-localised in l -cells with the anorexigenic ‘ileal brake’ gut hormone peptide YY, and also in adipocytes, with activation stimulating leptin release. Thus, SCFA such as acetate and propionate show promise as a candidate to increase satiety-enhancing properties of food. We therefore postulate SCFA may have a role in appetite regulation and energy homeostasis. SCFA can be delivered either directly within food, or indirectly via the colon by the provision of fermentable non-digestible carbohydrates. A review of studies investigating the effects of oral SCFA ingestion on appetite suggests that while oral SCFA ingestion is associated with enhanced satiety, this may be explained by product palatability rather than a physiological effect of SCFA. Colon-derived SCFA generated during microfloral fermentation have also been suggested to explain satiety-enhancing properties of non-digestible carbohydrates. However, findings are mixed from investigations into the effects of the prebiotic inulin-type fructans on appetite. Overall, data presented in this review do not support a role for SCFA in appetite regulation.
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Supplementation with prebiotic inulin-type fructans (1 to 12 weeks) can influence appetite sensations, such as fullness and hunger, as well as satiety gut peptides (mainly GLP-1 and PYY).
“In line with this hypothesis, supplementation with prebiotic inulin-type fructans (1 to 12 weeks) can influence appetite sensations, such as fullness and hunger, as well as satiety gut peptides (mainly GLP-1 and PYY) [84].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [84]
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- Authors
- Darzi, J., Frost, G. S., & Robertson, M. D.
- Affiliations
- University of Surrey (GB)
- Imperial College London (GB)
- Corresponding author
- Darzi, Julia
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-01-25
- Volume
- 70
- Issue
- 1
- Pages
- 119-128
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2094138113
- Cited by
- 94
- References
- 75
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 14 · 2013: 9 · 2012: 9
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of The Nutrition Society (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- short-chain fatty acids, appetite regulation, satiety, L cells, ileal brake, peptide YY, leptin, energy homeostasis, non-digestible carbohydrates, prebiotics, inulin-type fructans, gut microbiota fermentation, acetate, propionate, palatability
- MeSH terms
- Appetite Regulation, Colon, Dietary Fats, Dietary Fiber, Fatty Acids, Volatile, Gastrointestinal Hormones, Humans, Satiation, Taste, Prebiotics
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