Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters
Abstract
Background: Patients with major depressive disorder (MDD) show deficits in processing of facial emotions that persist beyond recovery and cessation of treatment. Abnormalities in neural areas supporting attentional control and emotion processing in remitted depressed (rMDD) patients suggests that there may be enduring, trait-like abnormalities in key neural circuits at the interface of cognition and emotion, but this issue has not been studied systematically. Method: Nineteen euthymic, medication-free rMDD patients (mean age 33.6 years; mean duration of illness 34 months) and 20 age- and gender-matched healthy controls (HC; mean age 35.8 years) performed the Emotional Face N-Back (EFNBACK) task, a working memory task with emotional distracter stimuli. We used blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to measure neural activity in the dorsolateral (DLPFC) and ventrolateral prefrontal cortex (VLPFC), orbitofrontal cortex (OFC), ventral striatum and amygdala, using a region of interest (ROI) approach in SPM2. Results: rMDD patients exhibited significantly greater activity relative to HC in the left DLPFC [Brodmann area (BA) 9/46] in response to negative emotional distracters during high working memory load. By contrast, rMDD patients exhibited significantly lower activity in the right DLPFC and left VLPFC compared to HC in response to positive emotional distracters during high working memory load. These effects occurred during accurate task performance. Conclusions: Remitted depressed patients may continue to exhibit attentional biases toward negative emotional information, reflected by greater recruitment of prefrontal regions implicated in attentional control in the context of negative emotional information.
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Studying remitted depression mitigates potential confounding effects of current mood state, illness severity, non-specific effects of chronic illness and stress, and psychotropic medication usage.
“It also has the advantage of mitigating the potential confounding effects of current mood state, illness severity, non-specific effects of chronic illness and stress, and effects of psychotropic medication usage [237,238].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [237]
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- Authors
- Kerestes, R., Ladouceur, C. D., Meda, S., Nathan, P. J., Blumberg, H. P., Maloney, K., Ruf, B., Saricicek, A., Pearlson, G. D., Bhagwagar, Z., & Phillips, M. L.
- Affiliations
- Yale University (US)
- University of Pittsburgh (US)
- University of Cambridge (GB)
- Corresponding author
- Kerestes, R.
- ORCID
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-07-07
- Volume
- 42
- Issue
- 1
- Pages
- 29-40
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2031594408
- Cited by
- 128
- References
- 69
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 12 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 15 · 2014: 10 · 2013: 9 · 2012: 7
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institutes of Health (5k23mh077914-02, 5r01mh076971-05)
- National Institute of Mental Health (R01-MH076971, K23-MH077914, K01MH083001, R01MH074797, 5 R37 MH43775-14, R37MH043775, R01MH077945)
- National Center for Research Resources (UL1RR024139)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- remitted depression, major depressive disorder, attentional control, attentional bias, working memory, emotional distracters, prefrontal cortex, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, orbitofrontal cortex, amygdala, ventral striatum, emotional face processing
- MeSH terms
- Adult, Analysis of Variance, Attention, Basal Ganglia, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Emotions, Facial Expression, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Memory, Short-Term, Oxygen, Photic Stimulation, Reaction Time, Regression Analysis, Case-Control Studies, Prefrontal Cortex
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