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The global burden of anxiety disorders in 2010
Abstract
Background: Despite their high prevalence, the global burden of anxiety disorders has never been calculated comprehensively. The new Global Burden of Disease (GBD) study has estimated burden due to morbidity and mortality caused by any anxiety disorder. Method: Prevalence was estimated using Bayesian meta-regression informed by data identified in a systematic review. Years of life lived with disability (YLDs) were calculated by multiplying prevalent cases by an average disability weight based on severity proportions (mild, moderate and severe). Disability-adjusted life years (DALYs) were then calculated and age standardized using global standard population figures. Estimates were also made for additional suicide mortality attributable to anxiety disorders. Findings are presented for YLDs, DALYs and attributable burden due to suicide for 21 world regions in 1990 and 2010. Results: Anxiety disorders were the sixth leading cause of disability, in terms of YLDs, in both high-income (HI) and low- and middle-income (LMI) countries. Globally, anxiety disorders accounted for 390 DALYs per 100 000 persons [95% uncertainty interval (UI) 191–371 DALYs per 100 000] in 2010, with no discernible change observed over time. Females accounted for about 65% of the DALYs caused by anxiety disorders, with the highest burden in both males and females experienced by those aged between 15 and 34 years. Although there was regional variation in prevalence, the overlap between uncertainty estimates means that substantive differences in burden between populations could not be identified. Conclusions: Anxiety disorders are chronic, disabling conditions that are distributed across the globe. Future estimates of burden could be further improved by obtaining more representative data on severity state proportions.
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“In particular, depression and anxiety are leading causes of reduced quality of life among children and adolescents [4–8].”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [8]
In the citing paper
“Experiences of depressive and anxiety symptoms in childhood and adolescence are associated with an elevated risk of poor mental health in adulthood [8–12]”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [8]
In the citing paper
“Direct and indirect costs of depression and anxiety make these disorders main contributors to the global burden of disease [42, 43]”
From Mobile Apps for the Management of Comorbid Overweight/Obesity and Depression/Anxiety: A Systematic Review (2020) · cites this paper as [42]
In the citing paper
“Anxiety disorders are common, burdensome and costly to individuals and wider society.”
From Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety (2018) · cites this paper as [4]
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Ponzini, G. T., Snider, M. D. H., Evey, K. J., & Steinman, S. A. (2021) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000001315 · Cited by 14
“The lack of available information about PPA and CBTas an effective treatment is concerning given the chronicity and severity of these disorders (Baxter et al., 2014; Ross and McLean, 2006).”
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“They are substantially associated with high treatment costs, disability, and chronicity (Cuijpers et al., 2012; Baxter et al., 2014).”
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Childhood inhibition predicts adolescent social anxiety: Findings from a longitudinal twin study
Goldsmith, H. H., Hilton, E. C., Phan, J., Sarkisian, K. L., Carroll, I. C., Lemery‐Chalfant, K., & Planalp, E. M. (2022) · Development and Psychopathology · doi:10.1017/s0954579422000864 · Cited by 16
“The burden is disproportionately borne by 15–34 year-olds (Baxter et al., 2014), where 8.6% of adolescents and 13% of adults meet diagnostic criteria for Social Anxiety Disorder (SA; Kessler et al., 2012).”
BackgroundInfluentialLokkerbol, J., van Voorthuijsen, J. M., Geomini, A., Tiemens, B. G., van Straten, A., Smit, F., Risseeuw, A., van Balkom, A. J. L. M., & Hiligsmann, M. (2018) · Journal of Medical Economics · doi:10.1080/13696998.2018.1555403 · Cited by 14
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What do Anxiety Scales Really Measure? An Item Content Analysis of Self-Report Measures of AnxietyPreprint
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Kondapura, M. B., Manjunatha, N., Nagaraj, A. K. M., Praharaj, S. K., Kumar, C. N., Math, S. B., & Rao, G. N. (2022) · Indian Journal of Psychological Medicine · doi:10.1177/02537176221108867 · Cited by 14
Szeska, C., Klepzig, K., Hamm, A. O., & Weymar, M. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03352-0 · Cited by 13
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“Anxiety disorders are diagnosed more in females than in males (Baxter et al., 2014; Kessler et al., 2009; Tolin and Foa, 2006).”
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Hormonal contraceptive use moderates the association between worry and error-related brain activity
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Metadata
- Authors
- Baxter, A. J., Vos, T., Scott, K. M., Ferrari, A. J., & Whiteford, H. A.
- Affiliations
- The University of Queensland (AU)
- University of Washington (US)
- University of Otago (NZ)
- Corresponding author
- Baxter, A. J.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-01-22
- Volume
- 44
- Issue
- 11
- Pages
- 2363-2374
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2007965977
- Cited by
- 768
- References
- 31
- Citations by year
- 2026: 30 · 2025: 56 · 2024: 82 · 2023: 112 · 2022: 103 · 2021: 84 · 2020: 106 · 2019: 62 · 2018: 53 · 2017: 39 · 2016: 23 · 2015: 9 · 2014: 8
- FWCI
- 38.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bill and Melinda Gates Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- anxiety disorders, global burden of disease, disability-adjusted life years, years lived with disability, suicide mortality, prevalence, sex differences, age distribution, regional variation, low- and middle-income countries
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anxiety Disorders, Female, Humans, Male, Middle Aged, Global Health, Cost of Illness, Young Adult
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