Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder

Jacobs, R. H.; Barba, A.; Gowins, J. R.; Klumpp, H.; Jenkins, L. M.; Mickey, B. J.; Ajilore, O.; Peciña, M.; Sikora, M.; Ryan, K. A.; Hsu, D. T.; Welsh, R. C.; Zubieta, J.-K.; Phan, K. L.; Langenecker, S. A.

doi:10.1017/s0033291715002615

Cited by 108Functional Brain Connectivity StudiesTreatment of Major DepressionMental Health Research Topics

Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder

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Jacobs, R. H., Barba, A., Gowins, J. R., Klumpp, H., Jenkins, L. M., Mickey, B. J., Ajilore, O., Peciña, M. +7 more·2016·Psychological Medicine

DOI 10.1017/s0033291715002615PMC PMC4810773

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Abstract

Background: Recent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features of illness. Heterogeneity of findings to date may stem from the relative lack of data parsing clinical features of MDD such as phase of illness and the burden of multiple episodes. Method: Resting-state functional magnetic resonance imaging data were collected from 17 active MDD and 34 remitted MDD patients, and 26 healthy controls (HCs) across two sites. Participants were medication-free and further subdivided into those with single v.multiple episodes to examine disease burden. Seed-based connectivity using the posterior cingulate cortex (PCC) seed to probe the default mode network as well as the amygdala and subgenual anterior cingulate cortex (sgACC) seeds to probe the salience network (SN) were conducted. Results: Young adults with remitted MDD demonstrated hyperconnectivity of the left PCC to the left inferior frontal gyrus and of the left sgACC to the right ventromedial prefrontal cortex (PFC) and left hippocampus compared with HCs. Episode-independent effects were observed between the left PCC and the right dorsolateral PFC, as well as between the left amygdala and right insula and caudate, whereas the burden of multiple episodes was associated with hypoconnectivity of the left PCC to multiple cognitive control regions as well as hypoconnectivity of the amygdala to large portions of the SN. Conclusions: This is the first study of a homogeneous sample of unmedicated young adults with a history of adolescent-onset MDD illustrating brain-based episodic features of illness.

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The evidence in favour of abnormal resting-state functional connectivity of the subgenual anterior cingulate cortex is heterogeneous and relies on partially overlapping samples.
“Second, the evidence in favour of abnormal RSFC of the sgACC, on which we based our hypotheses and analyses, is admittedly heterogeneous and also does rely on partially overlapping samples15,19–21.”
From The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse (2020) · cites this paper as [20]
The Discussion (Episode-dependent and episode-independent differences in resting-state connectivity; page unavailable) says sgACC connectivity differs between active and remitted depression and suggests that more nuanced participant criteria could produce more homogeneous results. The Introduction describes extending earlier work, but our copy does not establish that the cited studies used partially overlapping samples. (LLM, conf=0.78)
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Mood Disorders
(2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018 · Cited by 3 · see citing works
Machine Learning for Major Depressive Disorder: An Overview
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Neuroimaging Studies of Effects of Psychotherapy in Depression
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Electrophysiological Biomarkers for Mood Disorders
Ramakrishnan, N., Murphy, N., Selvaraj, S., & Cho, R. Y. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.015 · Cited by 2 · see citing works
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Cortical thickness associated with past year mood episode in major depressive and bipolar disorders
Mackenzie, K. A., Heywood, A. A., Bae, J., Schreiner, M. W., Stange, J. P., Chen, L., Thomas, E. H. X., Cerins, A., Wang, L., Langenecker, S. A., et al. (2026) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2026.112158 · Cited by 1 · see citing works
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Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder
Schreiner, M. W., Thomas, L. R., Le, H. D. H., Pazdera, M., Feldman, D. A., Farstead, B. W., Bessette, K. L., Welsh, R. C., Crowell, S. E., Kaufman, E. A., et al. (2025) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2025.100479 · Cited by 1 · see citing works
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Brain Imaging and the Mechanisms of Antidepressant Action
Godlewska, B. R., Selvaraj, S., & Cowen, P. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.020 · Cited by 1 · see citing works
Effects of Lithium on Brain Structure in Bipolar Disorder
Kaur, J., Kafantaris, V., & Szeszko, P. R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.018 · Cited by 1 · see citing works
Functional Connectome in Bipolar Disorder
Cha, J., & Anand, A. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.008 · Cited by 1 · see citing works
Imaging Genetic and Epigenetic Markers in Mood Disorders
Poletti, S., Mazza, E. A., Vai, B., & Benedetti, F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.012
Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders
Kumar, P., Jiang, Y., & Whitton, A. E. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.006
Resting-State Functional Connectivity in Unipolar Depression
Chen, Z., & Gong, Q. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.007
Brain Imaging Methods in Mood Disorders
Selvaraj, S., Brambilla, P., & Soares, J. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.002
Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders
Kious, B. M., & Renshaw, P. F. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.009
Neuroimaging Brain Inflammation in Mood Disorders
Meyer, J. H. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.011
Functional Near-Infrared Spectroscopy Studies in Mood Disorders
Matsuo, K., & Matsubara, T. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.014
Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus
Arnone, D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.003
Neuroimaging Biomarkers in Pediatric Mood Disorders
West, M. P., Tang, W. J., & Singh, M. K. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.005
fMRI Neurofeedback as Treatment for Depression
Skottnik, L., & Linden, D. E. J. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.013
Neuroanatomical Findings in Bipolar Disorder
Tronchin, G., & McDonald, C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.004
Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders
Scotti-Muzzi, E., Otaduy, M. C. G., Soeiro‐de‐Souza, M. G., & Machado‐Vieira, R. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.010
Molecular Imaging of Dopamine and Antipsychotics in Bipolar Disorder
Jauhar, S. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.019
Magnetoencephalography Studies in Mood Disorders
Nugent, A. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.016
Investigation of brain networks for personalized rTMS in healthy subjects and patients with major depressive disorder: A translational study
Singh, A. (2021) · doi:10.53846/goediss-8452
Index
Selvaraj, S., Brambilla, P., & Soares, J. C. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.022

Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis
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Anomalous functional connectivity of amygdala subregional networks in major depressive disorder
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Aberrant resting-state functional connectivity in limbic and cognitive control networks relates to depressive rumination and mindfulness: A pilot study among adolescents with a history of depression
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Abnormal resting-state functional connectivity in subregions of amygdala in adults and adolescents with major depressive disorder
Guan, L., Liu, R., Wang, C., Fan, Q., Zhou, J., Wang, Y., Feng, Y., Liu, J., Zhou, Y., Wang, G., et al. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05977-9 · Cited by 10 · see citing works
Anomalous functional connectivity of amygdala subregional networks in adolescents with major depressive disorder
Tang, M., Zhou, Z., Cao, L., Gao, Y., Zhang, L., Li, H., Wang, Y., Gong, Q., & Huang, X. (2023) · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · doi:10.58530/2022/3076

Authors: Jacobs, R. H., Barba, A., Gowins, J. R., Klumpp, H., Jenkins, L. M., Mickey, B. J., Ajilore, O., Peciña, M., Sikora, M., Ryan, K. A., Hsu, D. T., Welsh, R. C., Zubieta, J.-K., Phan, K. L., & Langenecker, S. A.
Affiliations: University of Illinois Chicago (US)
University of Michigan (US)
Corresponding author: Langenecker, S. A.
ORCID: Jacobs, R. H.
Klumpp, H.
Jenkins, L. M.
Mickey, B. J.
Ajilore, O.
Peciña, M.
Sikora, M.
Ryan, K. A.
Welsh, R. C.
Phan, K. L.
Langenecker, S. A.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2016-01-20
Volume: 46
Issue: 5
Pages: 1055-1067
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291715002615
PMC: PMC4810773
OpenAlex: W2262083186
Cited by: 108
References: 44
Citations by year: 2026: 5 · 2025: 9 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 35 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 5
FWCI: 6.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000050, 5r01ns052514-04, KL2TR000434)
National Institute of Mental Health (R01MH091811, K01MH085035, R01MH101497, K23MH092648, R01MH086858, K23MH093679, R01MH101487)
National Institute of Neurological Disorders and Stroke (1R01NS052514, R01-NS052514)
National Center for Advancing Translational Sciences (UL1TR00050)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords: recurrent major depressive disorder, adolescent-onset depression, salience network, amygdala, default mode network, posterior cingulate cortex, subgenual anterior cingulate cortex, resting-state functional connectivity, remitted depression, cognitive control, young adults
MeSH terms: Adolescent, Adult, Amygdala, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Frontal Lobe, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Recurrence, Case-Control Studies, Young Adult, Executive Function

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Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder

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