Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders: Results from the WHO World Mental Health (WMH) surveys
Open accessAbstract
Background The treatment gap between the number of people with mental disorders and the number treated represents a major public health challenge. We examine this gap by socio-economic status (SES; indicated by family income and respondent education) and service sector in a cross-national analysis of community epidemiological survey data. Methods Data come from 16 753 respondents with 12-month DSM-IV disorders from community surveys in 25 countries in the WHO World Mental Health Survey Initiative. DSM-IV anxiety, mood, or substance disorders and treatment of these disorders were assessed with the WHO Composite International Diagnostic Interview (CIDI). Results Only 13.7% of 12-month DSM-IV/CIDI cases in lower-middle-income countries, 22.0% in upper-middle-income countries, and 36.8% in high-income countries received treatment. Highest-SES respondents were somewhat more likely to receive treatment, but this was true mostly for specialty mental health treatment, where the association was positive with education (highest treatment among respondents with the highest education and a weak association of education with treatment among other respondents) but non-monotonic with income (somewhat lower treatment rates among middle-income respondents and equivalent among those with high and low incomes). Conclusions The modest, but nonetheless stronger, an association of education than income with treatment raises questions about a financial barriers interpretation of the inverse association of SES with treatment, although future within-country analyses that consider contextual factors might document other important specifications. While beyond the scope of this report, such an expanded analysis could have important implications for designing interventions aimed at increasing mental disorder treatment among socio-economically disadvantaged people. © 2017 Cambridge University Press.
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Claims the paper makes
12 of 25 cited sources checked · 2 supported · 0 flagged · accuracy not yet measured
- Premisecitation
Disorder characteristics are known to predict treatment.
“these disorder characteristics are known to predict treatment (Andrade et al. 2014)”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Andrade et al. 2014 source
The Results (page not supplied) show that disorder severity is associated with perceived need for treatment and with reported barriers to seeking it. The paper does not establish that disorder characteristics predict whether someone actually receives treatment; its regression models examine barriers rather than treatment receipt. (LLM, conf=0.83)
Experimental — accuracy not yet measured
- Premisecitation
Socio-economic status is known to have an inverse relationship with these disorder characteristics.
“SES is known to be inversely related to these disorder characteristics (Scott et al. 2014)”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Scott et al. 2014 source
- Premisecitation
Some evidence indicates cross-national differences in how SES relates to mental disorder treatment.
“there is some evidence of cross-national differences in the association of SES with mental disorder treatment (Kessler et al. 1997; Van Doorslaer & Masseria, 2004; Devaux & De Looper, 2012).”
Quote in the paperSubstantial claim2 of 3 sources checked- cites Kessler et al. 1997 source
The paper’s introductory discussion (section labeled Abstract; page unavailable) contrasts access in Ontario and the United States and says people with limited financial resources face greater barriers in the United States. This supports a possible cross-national socioeconomic difference, but the reported analyses compare treatment by level of need, not the association between SES and treatment across countries. (LLM, conf=0.78)
Experimental — accuracy not yet measured - cites Van Doorslaer & Masseria, 2004 source
- cites Devaux & De Looper, 2012 source
Section 4.1 (Doctor visits, paragraph 42) reports that the income gradient in doctor visits differs across countries. But the paper analyzes general health-service use, not mental disorder treatment specifically; its cross-national findings do not establish that narrower claim. (LLM, conf=0.85)
Experimental — accuracy not yet measured
- Findingown data
Bipolar spectrum disorder had significant ORs predicting treatment in the SMH sector (OR=1.2-1.3).
“And two disorders, social phobia and bipolar spectrum disorder, had significant ORs predicting treatment in the SMH sector (OR=1.2-1.3).”
Quote in the paperNot a substantial claim - Findingown data
Alcohol use disorder was the only disorder associated with multiple significantly decreased ORs, involving any treatment and treatment in GM and human services sectors (OR=0.6-0.7).
“Alcohol use disorder was the only disorder associated with multiple significantly decreased ORs, which involved any treatment and treatment in the GM and human services sectors (OR=0.6-0.7)”
Quote in the paperNot a substantial claim
- Findingown data
A weighted 14.9% of Part II respondents across surveys met criteria for at least one 12-month DSM-IV/CIDI disorder.
“A weighted 14.9% of Part II respondents across surveys met criteria for at least one 12-month DSM-IV/CIDI disorder.”
Quote in the paperNot a substantial claim - Findingown data
The GM sector had the highest treatment rate (17.8%).
“The GM sector had the highest treatment rate (17.8%).”
Quote in the paperNot a substantial claim - Findingown data
The SMH sector had the second highest treatment rate (13.5%).
“The SMH sector had the second highest treatment rate (13.5%).”
Quote in the paperNot a substantial claim - Findingown data
29.0% of respondents with 12-month disorders received 12-month treatment.
“29.0% of respondents with 12-month disorders received 12-month treatment.”
Quote in the paperSubstantial claim - Findingown data
Disorder number was significantly associated with each type of treatment due to significantly decreased ORs for 4+ disorders (OR=0.6-0.7).
“Disorder number was significantly associated with each type of treatment (χ22=9.4-11.7, p =.003-.009) due to significantly decreased ORs for 4+ disorders (OR=0.6-0.7).”
Quote in the paperNot a substantial claim- The authors state this as an assumption: The 3-way and higher-order interactions among disorders predicting treatment were subject to a constant multiplier that could be 1.0 or different from 1.0.
- Findingown data
Income had a significant inverse association with HS treatment, due to elevated ORs for respondents in each of the two lowest income categories (OR=1.5-1.7) relative to the highest income category.
“In addition, income had a significant inverse association with HS treatment (χ23=9.4, p=.024) due to elevated ORs for respondents in each of the two lowest income categories (OR=1.5-1.7) relative to the highest income category.”
Quote in the paperSubstantial claim- The authors state this as an assumption: The mechanisms by which income and education affect treatment are different.
- Findingown data
Social phobia had significant ORs predicting treatment in the SMH sector (OR=1.2-1.3).
“And two disorders, social phobia and bipolar spectrum disorder, had significant ORs predicting treatment in the SMH sector (OR=1.2-1.3).”
Quote in the paperNot a substantial claim - Findingown data
Agoraphobia had significantly elevated ORs predicting any treatment and treatment in SMH and GM sectors (OR=1.6-1.9).
“Two disorders had significantly elevated ORs predicting any treatment and treatment in the SMH and GM sectors: panic disorders (OR=2.4-3.4) and agoraphobia (OR=1.6-1.9).”
Quote in the paperNot a substantial claim - Findingown data
Major depressive episodes had significantly elevated ORs in 4 equations (OR=1.5-2.4), except human services treatment.
“Major depressive episodes had significantly elevated ORs in 4 equations (OR=1.5-2.4), the exception being human services treatment.”
Quote in the paperNot a substantial claim - Findingown data
Within each service sector, treatment rates decreased with country income level.
“Although there was a consistent trend for treatment rates to decrease with country income level within each sector ((F2,5366=132.7, p<.001 for SMH; F2,5366=231.4, p<.001 for GM; F2,5366=6.0, p=.003 for HS; F2,5366=33.2, p<.001 for CAM) as well as overall (F2,5366=221.1, p<.001)”
Quote in the paperSubstantial claim - Findingown data
Panic disorder had significantly elevated ORs predicting any treatment and treatment in SMH and GM sectors (OR=2.4-3.4).
“Two disorders had significantly elevated ORs predicting any treatment and treatment in the SMH and GM sectors: panic disorders (OR=2.4-3.4) and agoraphobia (OR=1.6-1.9).”
Quote in the paperNot a substantial claim - Findingown data
Drug use disorder had significantly elevated ORs predicting any treatment and treatment in SMH and CAM sectors (OR=1.6-1.8).
“Drug use disorder had significantly elevated ORs predicting any treatment and treatment in the SMH and CAM sectors (OR=1.6-1.8).”
Quote in the paperNot a substantial claim - Findingown data
Generalized anxiety disorder and PTSD had significantly elevated ORs in all 5 equations (OR=1.4-2.0).
“Generalized anxiety disorder and PTSD had significantly elevated ORs in all 5 equations (OR=1.4-2.0).”
Quote in the paperNot a substantial claim - Findingown data
Treatment rates were much lower in the human services sector (3.7%) and CAM sector (3.7%).
“The treatment rates were much lower in the human services sector (3.7%) and CAM sector (3.7%).”
Quote in the paperNot a substantial claim - Findingown data
Controlling income, respondent education was significantly and positively associated with treatment overall and in three service sectors, except GM.
“Controlling income, respondent education was significantly and positively associated with treatment overall (χ23=17.0, p<.001) and in three service sectors (χ23=8.9-32.2, p=.030-<.001), the exception being the GM sector.”
Quote in the paperSubstantial claim- The authors state this as an assumption: The mechanisms by which income and education affect treatment are different.
- Findingown data
Family income was not significant overall in predicting any treatment in a model controlling for education.
“Family income, in comparison, while not significant overall in predicting any treatment in a model that controlled for education (χ23=4.3, p=.233)”
Quote in the paperNot a substantial claim- The authors state this as an assumption: The mechanisms by which income and education affect treatment are different.
- Findingown data
Comorbidity was associated with increased odds of treatment.
“The significant disorder-specific ORs were overwhelmingly greater than 1.0, indicating that comorbidity was associated with increased odds of treatment.”
Quote in the paperNot a substantial claim- The authors state this as an assumption: The 3-way and higher-order interactions among disorders predicting treatment were subject to a constant multiplier that could be 1.0 or different from 1.0.
- Findingown data
The education associations were due to reduced ORs of 0.4-0.8 for respondents in each of the three lower education categories relative to high-education respondents.
“These significant associations were due to reduced ORs of 0.4-0.8 for respondents in each of the three lower education categories relative to high-education respondents(Table 3).”
Quote in the paperSubstantial claim - Findingown data
Lowest income was for the most part not associated with lowest odds of GM treatment.
“Perhaps the clearest observation about this specification is that it showed that lowest income was for the most part not associated with lowest odds of GM treatment.”
Quote in the paperSubstantial claim - Findingown data
The non-significant association of income with any treatment in the total sample masked a significantly positive association among severe cases in lower-middle income countries (ORs 0.2-0.4 among lower income subgroups).
“Subgroup analysis showed that the non-significant association of income with any treatment in the total sample masked a significantly positive association among severe cases in lower-middle income countries (significant ORs of 0.2-0.4 among respondents in lower income subgroups; χ23=20.1, p<.001)”
Quote in the paperSubstantial claim - Findingown data
The non-significant association of education with GM treatment in the total sample did not vary significantly by disorder severity or country income.
“The non-significant association of education with GM treatment found in the total sample was found not to vary significantly by disorder severity or country income.”
Quote in the paperNot a substantial claim - Findingown data
The lowest odds of SMH treatment were among respondents with intermediate income levels across all levels of disorder severity and country income groups.
“We found neither pattern, as the lowest odds of SMH treatment were among respondents having intermediate income levels across all levels of disorder severity and country income groups.”
Quote in the paperSubstantial claim - Premisecitation
Only a minority of people with mental disorders receive treatment.
“only a minority of people with these disorders receives treatment (Wang et al. 2007).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Wang et al. 2007 source
- Study design and conductreasoning
Because the treatment question was not disorder-specific, the study could not determine which disorders respondents sought treatment for.
“Importantly, this question was not disorder-specific, which means that we have no way of knowing which disorders respondents sought treatment for.”
Quote in the paperNot a substantial claim - Interpretationown data
The finding that education was more strongly associated with treatment than income raises doubts about a financial-barriers explanation for the SES-treatment relationship.
“The modest, but nonetheless stronger, association of education than income with treatment raises questions about a financial barriers interpretation of the inverse association of SES with treatment”
Quote in the paperSubstantial claim - Premisecitation
Illness severity affects the probability of receiving treatment.
“probability of receiving treatment is influenced by illness severity (Wang et al. 2007).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Wang et al. 2007 source
- Interpretationreasoning
The elevated odds of treatment due to comorbidity increase at a decreasing rate as comorbidity becomes more complex.
“These decreased ORs indicate that the elevated odds of treatment due to comorbidity (i.e., the generally positive sign pattern of disorder-specific ORs) increase at a decreasing rate as comorbidity becomes more complex.”
Quote in the paperNot a substantial claim- The authors state this as an assumption: The 3-way and higher-order interactions among disorders predicting treatment were subject to a constant multiplier that could be 1.0 or different from 1.0.
- Study design and conductnone given
The study lacked statistical power to carry out parallel analyses of interactions predicting HS and CAM treatment.
“We lacked the statistical power to carry out parallel analyses of interactions predicting HS and CAM treatment.”
Quote in the paperNot a substantial claim - Premisecitation
Specialist mental health treatment resources are less available than general medical and nonmedical resources.
“specialist mental health (SMH) treatment resources are scarcer than general medical and nonmedical resources”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Thornicroft & Tansella, 2013 source
- Premisecitation
Access to specialist mental health treatment is often limited by gatekeepers to the most severe and complex cases.
“access to SMH treatment is often restricted through gatekeepers to the most severe-complex cases (Thornicroft & Tansella, 2013).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Thornicroft & Tansella, 2013 source
- Interpretationreasoning
Respondents with any other disorder profiles were significantly less likely to obtain treatment in GM and human services sectors in the presence than absence of comorbid alcohol use disorder.
“indicating that respondents with any other disorder profiles were significantly less likely to obtain treatment in these sectors in the presence than absence of comorbid alcohol use disorder.”
Quote in the paperNot a substantial claim - Interpretationown data
The two SES indicators, respondent education and family income, were much less consistently associated with 12-month treatment than the authors had anticipated.
“However, the two SES indicators considered here, respondent education and family income, were much less consistently associated with 12-month treatment than we had anticipated.”
Quote in the paperSubstantial claim - Study design and conductreasoning
The only contextual variable considered was a simple 3-category measure of country income level.
“Fourth, the only contextual variable considered was a simple 3-category measure of country income level.”
Quote in the paperSubstantial claim - Interpretationreasoning
The education-SMH associations are presumably not due to financial barriers because they were obtained after controlling income.
“These associations are presumably not due to financial barriers given that they were obtained after controlling income.”
Quote in the paperSubstantial claim - Study design and conductnone given
Some severe disorders, such as schizophrenia, were not assessed.
“some severe disorders, such as schizophrenia, were not assessed”
Quote in the paperNot a substantial claim
- Classified as probably not a substantial claim. 21
- May combine two claims. 39
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationPrior WMH analyses have found models with dummy variables for three and four or more disorders and constant multiplier constraints to be useful.
“Models of this form have been shpwn to be useful in a number of prior WMH analyses (e.g., Stein et al. 2016; McGrath et al. 2016).”
Quote in the paperNot a substantial claim2 of 2 sources checked- cites Stein et al. 2016 source
In Results > Predictors of PTSD (page unavailable), Stein et al. use a model in which each additional prior anxiety disorder from zero to three has the same incremental odds ratio. This supports the constant-multiplier aspect, but our copy does not show dummy variables for three and four or more disorders; it says three was the maximum count with enough respondents for a stable estimate. (LLM, conf=0.84)
Experimental — accuracy not yet measured - cites McGrath et al. 2016 source
The Method > Statistical Analysis section describes WMH models with dummy predictors for exactly three and more than three prior disorders, and says these predictors characterize non-additive associations. Our copy does not describe constant multiplier constraints, so it supports the cited example only in part. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationCross-national variation in treatment rates is strongly affected by healthcare spending.
“cross-national differences in treatment rates are strongly influenced by healthcare spending (Lewer et al. 2015)”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Lewer et al. 2015 source
The Conclusions say healthcare spending explains some variation in antidepressant use across Europe and is strongly associated with regularity of use; the Results likewise link higher spending to higher odds of regular use. The claim broadens this to treatment rates generally and describes spending as a strong influence, whereas the paper establishes an association, particularly for regular antidepressant use. (LLM, conf=0.85)
Experimental — accuracy not yet measured
May combine two claims.
PremisecitationThe treatment gap is larger for people with low SES and for those in low-income countries, even after adjustment for disorder severity.
“This gap is even greater for people with low socio-economic status (SES) and those living in low-income countries (Steele et al. 2007; Ormel et al. 2008) even adjusting for disorder severity (Mojtabai, 2010; Andrade et al. 2014).”
Quote in the paperSubstantial claim2 of 3 sources checked- cites Steele et al. 2007 source
- cites Ormel et al. 2008 source
The ‘Self-reported disorder prevalence and treatment’ section (page unavailable) reports a larger mental-versus-physical treatment gap in low- and middle-income countries than in high-income countries, including among severely disabling disorders. Our copy does not establish a larger gap for people with low SES. The citing sentence attributes the severity-adjustment clause to other citations, not specifically to Ormel et al.; this paper reports comparisons by severity rather than an adjusted SES finding. (LLM, conf=0.86)
Experimental — accuracy not yet measured - cites Mojtabai, 2010
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationResearch on mental disorder treatment quality finds that low-SES patients are significantly more likely than other patients to receive lower-quality treatment.
“The small amount of research that exists on mental disorder treatment quality finds that low-SES patients are significantly more likely than other patients to receive lower-quality treatment (Amaddeo & Jones, 2007; Young & Rabiner, 2015).”
Quote in the paperNot a substantial claim2 of 2 sources checked- cites Amaddeo & Jones, 2007 source
The Introduction and ‘How SES Affects Mental Health Service Use’ discuss psychiatric morbidity, service use, and possible barriers to access for people with lower SES. A search for treatment quality and quality of care found no passage reporting that low-SES patients receive significantly lower-quality treatment. The indexed passages provide no page numbers. (LLM, conf=0.76)
Experimental — accuracy not yet measured - cites Young & Rabiner, 2015 source
The Previous Research section links lower SES to reduced initiation or continuation of child mental health treatment, not to the quality of treatment received. The Results section reports no significant effect of household income on the barriers studied. Searches for SES and treatment quality found no passage establishing the claimed significant difference in treatment quality. (LLM, conf=0.76)
Experimental — accuracy not yet measured
May combine two claims.
Study design and conductcitationTreatment measures were limited to self-reports, which have been found to over-estimate treatment compared to administrative records.
“Third, the treatment measures were limited to self-reports, which have been found to over-estimate treatment compared to administrative records (Rhodes & Fung, 2004).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Rhodes & Fung, 2004 source
The Abstract reports that highly distressed people reported more mental-health service use than appeared in their administrative records. But the claim presents overestimation as a general property of self-reported treatment measures; the paper limits the finding to particular groups and notes in the Introduction that people may also under-report use. The paper does not establish that the citing study’s own treatment measures were overestimates. (LLM, conf=0.88)
Experimental — accuracy not yet measured
May combine two claims.
Findingown dataFamily income was significantly and positively associated with SMH treatment, due to an OR of 0.8 for respondents in each of the three lower income categories relative to the highest income category.
“was significantly and positively associated with SMH treatment (χ23=8.0, p=.045) due to an OR of 0.8 for respondents in each of the three lower income categories relative to the highest income category.”
Quote in the paperNot a substantial claim- The authors state this as an assumption: The mechanisms by which income and education affect treatment are different.
May combine two claims.
Findingown dataDisorder type significantly predicted overall treatment and treatment in each service sector.
“Disorder type was significant in predicting treatment in the base multivariate model predicting overall treatment (χ212=506.1, p<.001) as well as treatment in each service sector (χ212=36.4-315.1, p<.001).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataTreatment rate was highest in high-income countries (36.8%), lower in upper-middle-income countries (22.0%), and lowest in lower-middle-income countries (13.7%).
“The treatment rate was highest in high-income countries (36.8%), lower in upper-middle-income countries (22.0%), and lowest in lower-middle-income countries (13.7%; F2,5366=221.1, p<.001).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataDisorder severity had a significant monotonic relationship with each treatment outcome, with severe disorders having highest relative-odds (OR=2.0-2.9), moderate (OR=1.3-1.5), compared to mild.
“Disorder severity, finally, had a significant monotonic relationship with Each treatment outcome (χ22=21.3-186.0, p<.001), with severe disorders having highest relative-odds (OR=2.0-2.9) followed by moderate disorders (OR=1.3-1.5) compared to mild disorders.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataRespondents with the highest SES had a somewhat greater likelihood of receiving any treatment, but this pattern was mainly confined to specialty mental health treatment.
“Highest-SES respondents were somewhat more likely to receive treatment, but this was true mostly for specialty mental health treatment”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataEducation had a modest but stronger association with treatment than income did.
“The modest, but nonetheless stronger, association of education than income with treatment raises questions about a financial barriers interpretation of the inverse association of SES with treatment”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe 3-way interactions were significant for both education and income predicting any treatment and for income predicting GM treatment.
“The 3-way interactions were significant for both education and income predicting any treatment (χ212=22.9-29.8, p=.029-.003) and for income predicting GM treatment (χ212=26.8, p=.008).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAcross sectors, treatment was most common in GM, followed by SMH, and much lower in human services and CAM.
“treatment was consistently most common in the GM sector followed by the SMH sector and much lower in the human services and CAM sectors.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe 4-category measures of respondent education and income were significantly correlated (polychoric correlation = 0.295, p < .001).
“The 4-category measures of respondent education and income were significantly correlated with each other (polychoric correlation = 0.295, p = <.001; see Appendix Table 2 for within-survey distributions and associations).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataWithin specialty mental health treatment, education was positively associated with treatment, with the highest treatment rate among the most educated and only a weak education-treatment association among other respondents.
“where the association was positive with education (highest treatment among respondents with highest education and a weak association of education with treatment among other respondents)”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataWithin specialty mental health treatment, income showed a non-monotonic association with treatment: middle-income respondents had somewhat lower treatment rates, while high- and low-income respondents had equivalent rates.
“but non-monotonic with income (somewhat lower treatment rates among middle-income respondents and equivalent among those with high and low incomes).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe sum of sector-specific treatment rates (38.7 per 100) exceeded the 29.0% with any treatment because some patients were treated in multiple sectors.
“The sum of sector-specific treatment rates (38.7/100 respondents) exceeded the 29.0% of individuals with any treatment due to some patients being treated in multiple sectors.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe highest treatment rate across surveys was in Murcia, Spain (49.6%) and the lowest in Shenzhen, PRC (6.7%).
“The highest treatment rate across surveys was in Murcia, Spain (49.6%) and the lowest in Shenzhen in the People’s Republic of China (PRC; 6.7%).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAmong 12-month DSM-IV/CIDI cases, the treated proportion was 13.7% in lower-middle-income countries, 22.0% in upper-middle-income countries, and 36.8% in high-income countries.
“Only 13.7% of 12-month DSM-IV/CIDI cases in lower-middle-income countries, 22.0% in upper-middle-income countries, and 36.8% in high-income countries received treatment.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataEducation was most consistently associated with SMH treatment, while associations of education with treatment in other service sectors were relatively weak (ORs 0.6-0.8).
“Education, in comparison, was most consistently associated with SMH treatment, as the associations of education with treatment in other service sectors were relatively weak (significant ORs in the range 0.6-0.8).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe 2-way interactions of income with severity and with country income level were significant in a model excluding 3-way interactions in predicting SMH treatment.
“The 2-way interactions of income with severity and with country income level were significant in a model that excluded the 3-way interactions in predicting SMH treatment (χ26=12.9-13.6, p=.045-.035).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe non-significant association of income with any treatment in the total sample masked a significantly negative association among mild cases in upper-middle-income countries (OR=1.8 for low-income respondents).
“and a significantly negative association among mild cases in upper-middle-income countries (a significant OR=1.8 for low-income respondents; χ23=14.9, p=.002).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe association of education with SMH treatment was stable across all levels of disorder severity and country income groups, with the significant association due to comparatively high odds of treatment among people at the highest education level (ORs 0.6-0.7 for lower education levels, equivalent to 1.4-1.7 higher odds at highest versus lower levels).
“The association of education with SMH treatment was stable across all levels of disorder severity and country income groups, with the significant association due to a comparatively high odds of treatment among people at the highest education level (ORs of 0.6-0.7 for lower education levels equivalent to 1.4-1.7 higher odds at highest versus lower levels).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataSubgroup analysis found no significant association of income with overall treatment in the total sample and only inconsistent opposite-sign associations in subsamples.
“Subgroup analysis found no significant association of income with overall treatment in the total sample and only inconsistent opposite-sign associations in subsamples.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe significant association of income with SMH treatment in the total sample was consistent across country income groups due to especially low odds of treatment in intermediate income groups within each severity subsample (OR=0.3-0.5) rather than in the lowest income group (OR=0.7-0.9).
“The significant association of income with SMH treatment in the total sample was consistent across country income groups due to especially low odds of treatment in intermediate income groups within each severity subsample (OR=0.3-0.5) rather than in the lowest income group (OR=0.7-0.9).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe non-significant association of income with GM treatment in the total sample masked a significantly positive association among moderately severe cases in lower-middle income countries and mild cases in both lower-middle and high income countries (ORs 0.2-0.7).
“The non-significant association of income with GM treatment in the total sample, finally, was found to mask a significantly positive association among moderately severe cases in lower-middle income countries and mild cases in both lower-middle and high income countries (significant ORs of 0.2-0.7; χ23=8.8-18.3, p=.032-<.001)”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe significant association of education with any treatment in the total sample was limited to severe and moderate cases in high-income countries, with significant ORs among lower education respondents in the range 0.5-0.8.
“Subgroup analysis showed that the significant association of education with any treatment in the total sample was limited to severe and moderate cases in high-income countries (χ23=9.9-17.2, p=.019-.001). Significant ORs among respondents with lower levels of education were in the range 0.5-0.8.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe non-significant association of income with GM treatment in the total sample masked significantly negative associations among mild cases in upper-middle-income countries and severe cases in high income countries (ORs 1.5-2.0).
“and significantly negative associations among mild cases in upper-middle-income countries and severe cases in high income countries (significant ORs of 1.5-2.0; χ23=15.1-44.3,, p=.002-<.001).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAlthough income was not significantly associated with GM treatment in the total sample, a significant 3-way interaction was found due to a series of opposite-sign subgroup associations with no apparent patterning.
“Although the association of income with GM treatment was non-significant in the total sample, a significant 3-way interaction was found due to a series of opposite-sign subgroup associations that had no apparent patterning.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe significant association of education with SMH treatment in the total sample varied by disorder severity and country income, with significant ORs among lower education respondents in the range 0.6-0.7.
“The significant association of education with SMH treatment in the total sample varied by disorder severity and country income, with significant ORs among respondents of lower education were in the range 0.6-0.7.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe income discrepancy in sector was small: highest income category had only about 25% higher odds of SMH treatment than lower income categories, and there were no differences in odds of receiving SMH treatment across the lower three income categories.
“This discrepancy was small, though, as cases in the highest income category (roughly one-fourth of the population) had only about 25% higher odds of specialty mental health treatment than those in lower income categories and, as noted in the prior paragraph, there were no differences in odds of receiving specialty treatment across the lower three income categories.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenThe sampling design used multi-stage clustered area probability households.
“The samples were based on a multi-stage clustered area probability household design.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationThe CIDI translation, back-translation, adaptation, and harmonization protocol required bilingual clinicians with cultural competence to review, modify, and approve symptom-describing phrases.
“The CIDI interview translation, back-translation, adaptation, and harmonization protocol required culturally competent bilingual clinicians to review, modify, and approve key phrases describing symptoms (Harkness et al. 2008).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Harkness et al. 2008
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Classified as probably not a substantial claim. May combine two claims.
Study design and conductcitationMental disorders were assessed using the WHO Composite International Diagnostic Interview (CIDI) Version 3.0, a fully structured interview that yields lifetime and 12-month prevalence estimates for common DSM-IV disorders.
“Mental disorders were assessed with the WHO Composite International Diagnostic Interview (CIDI) Version 3.0 (Kessler & Ustun, 2004), a fully-structured interview generating lifetime and 12-month prevalence estimates of common DSM-IV disorders.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Kessler & Ustun, 2004 source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationBlinded clinical reappraisal interviews using the Structured Clinical Interview for DSM-IV in several WMH surveys showed generally good agreement with CIDI diagnoses.
“Blinded clinical reappraisal interviews with the Structured Clinical Interview for DSM-IV (First et al. 2002) in a number of WMH surveys found generally good concordance with diagnoses based on the CIDI (Haro et al. 2006).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Haro et al. 2006 source
Classified as probably not a substantial claim. May combine two claims.
Study design and conductnone givenWeights corrected for under-sampling of Part I respondents without disorders, within-household selection probabilities, and residual sample-population differences on Census demographic-geographic variables.
“Weights adjusted for under-sampling Part I respondents without disorders, differences in within-household probabilities of selection (due to the selection of only one respondent per household no matter the number of eligible residents), and residual discrepancies between sample and population distributions on Census demographic-geographic variables.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductcitationSurvey response rates ranged from 45.9% to 97.2%, with a sample-size-weighted average of 70.1% under the AAPOR RR1w definition.
“Response rates were 45.9-97.2% across surveys with a weighted (by sample size) average of 70.1% using the American Association for Public Opinion research RR1w definition (AAPOR, 2016).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites AAPOR, 2016
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataIn 25 countries, the surveys used samples intended to represent adult household residents.
“The surveys were administered to representative samples of adult household residents in 25 countries.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe sample contained no countries classified as low-income.
“There were no low-income countries in the sample.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataNineteen surveys were nationally representative; three represented all urbanized areas; the remaining surveys represented selected regions or metropolitan areas.
“Samples were nationally representative in 19 surveys, representative of all urbanized areas in 3 others (Colombia, Mexico, Peru), and representative of selected regions (Nigeria) or Metropolitan areas (Sao Paulo in Brazil, Medellin in Colombia, a series of cities in Japan, Beijing/Shanghai and Shenzhen in the Peoples Republic of China) in the others.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe models adjusted for respondent age, sex, and marital status.
“Our models controlled for respondent age, sex, and marital status.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationConfidence intervals for prevalence estimates and odds ratios were computed with Taylor series linearization in SUDAAN to account for weighting and geographic clustering.
“Confidence intervals for prevalence estimates and ORs were estimated using the Taylor series linearization method (Wolter, 1985) implemented in the SUDAAN software system (Research Triangle Institute, 2002) to adjust for weighting and geographic clustering of data.”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Wolter, 1985
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Research Triangle Institute, 2002
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Classified as probably not a substantial claim.
Study design and conductreasoningThe model controlled adequately for disorder characteristics so that estimates of SES effects on treatment would be accurate.
“making it important to control adequately for these characteristics to obtain accurate estimates of effects of SES on treatment.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductreasoningBecause of the large number of tests, over-fitting was possible, so results should be considered exploratory.
“Even with these global tests, though, over-fitting was possible due to the large number of tests, making it important to consider results only exploratory.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductreasoningPart II data were weighted to correct for under-sampling of Part I non-cases, so weighted Part II prevalence estimates matched Part I estimates.
“Part II data were weighted to adjust for the under-sampling of Part I non-cases, making weighted Part II prevalence estimates identical to Part I estimates.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataEven though people of different financial means were equally likely to receive some type of treatment, a significant discrepancy existed in the sector in which treatment was received.
“However, the significant positive association with specialty mental health treatment and the significant inverse association with human services treatment in the total sample showed that even though people of different financial means were equally likely to receive some type of treatment, a significant discrepancy existed in the sector in which treatment was received.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenSurvey response might have been related to social status, presence and severity of mental disorders or treatment in ways that were uncorrected by post-stratification adjustments.
“Although we attempted to control for differential response through post-stratification adjustments, survey response might have been related to social status, presence and severity of mental disorders or treatment in ways that were uncorrected.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningBecause the number of countries was small (n=25) and no information was available about within-country geographic characteristics in most surveys, there were too few geographic units to carry out quantitative analyses of other contextual factors.
“However, as the number of countries was small (n = 25) and no information was available about within-country geographic characteristics in most surveys, we had too few geographic units of analysis to carry out quantitative analyses of other contextual factors.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataIn the total sample, low SES had an especially low rate of treatment only for SMH treatment, and income was inversely related to HS treatment, so income was related more to sector of treatment than to whether treatment was received.
“We also broadly confirmed previous evidence that people with low SES have an especially low rate of treatment, although in the total sample this was true only for SMH treatment and income was inversely related to HS treatment, resulting in income being related more to sector of treatment than to whether or not treatment was received.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductcitationValidity of disorder measures, although good in WMH surveys where assessed, was not assessed in all surveys and might have varied with SES.
“validity, although good in the WMH surveys were it was assessed (Haro et al. 2006), was not assessed in all surveys and might have varied with SES.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Haro et al. 2006 source
May combine two claims.
Interpretationown dataThe significant associations of SES with treatment were most consistent in predicting SMH treatment, but they were less strong than anticipated.
“The significant associations of SES with treatment were most consistent in predicting SMH treatment, but they were less strong than anticipated.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenDuration was not measured for the disorders that were assessed.
“duration was not measured for the disorders that were assessed”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductnone givenThe sample of countries was non-representative and the response rate varied widely across countries.
“First, the sample was limited in that the sample of countries was non-representative and the response rate varied widely across countries.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductreasoningSelf-reports only assessed number of visits rather than treatment quality.
“In addition, these self-reports only assessed number of visits rather than treatment quality.”
Quote in the paperNot a substantial claim
The authors state this as an assumption.
For respondents with two disorders, the added predictive effect of each individual disorder is multiplicative.
“The incremental predictive effects of individual disorders among people with 2 disorders were then assumed to be multiplicative; that is, if the OR associated with Disorder X was 1.5, we would expect respondents with exactly 1 other disorder would have a 1.5 increased odds of obtaining treatment in the presence versus absence of Disorder X.”
The authors state this as an assumption.
The odds ratio for a given disorder is the same across all combinations of that disorder with exactly one other disorder.
“This specification imposed parsimony on the data by constraining the OR of Disorder X to be the same across all 11 combinations of Disorder X with exactly l other disorder”
The authors state this as an assumption.
The 3-way and higher-order interactions among disorders predicting treatment were subject to a constant multiplier that could be 1.0 or different from 1.0.
“The dummy variables for 3 and 4+ disorders imposed additional constraints by assuming that the 3-way and higher-order interactions among disorders predicting treatment were subject to a constant multiplier that could be 1.0 (i.e., the interactions were strictly multiplicative) or different from 1.0.”
The authors state this as an assumption.
The mechanisms by which income and education affect treatment are different.
“We considered it appropriate to include both, though, as the mechanisms involved in the two are presumably different.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Barriers to help-seeking are more highly represented among low socioeconomic groups, perpetuating a cycle of disadvantage.
“These barriers are more highly represented among low socioeconomic groups (7) further perpetuating a cycle of disadvantage.”
From The impact of digital interventions on help-seeking behaviour for mental health problems: a systematic literature review (2022) · cites this paper as [7]
The Conclusions (page unavailable) report especially low treatment rates among people with low socioeconomic status, particularly for specialty mental health care. But lower treatment rates do not establish that help-seeking barriers are more prevalent in this group; the authors say direct investigation of reported barriers is needed. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn lower-middle-income countries only 13.7% of adults who met criteria for mental disorders received treatment, compared to 22.0% in upper-middle-income countries and 36.8% in high-income countries.
“In lower-middle-income countries only 13.7% of adults who met criteria for mental disorders received treatment, compared to 22.0% in upper-middle-income countries, and 36.8% in high-income countries (13).”
From Use of mental health services by children with mental disorders in two major cities in Brazil (2019) · cites this paper as [13]
There is a huge gap between the number of individuals who need mental health care and those who receive treatment, despite the availability of effective treatments for mental illness.
“Despite the availability of effective treatments for mental illness, there is a huge gap between the number of individuals who need mental health care, and those who receive treatment.”
86.3% of people with anxiety, mood or substance disorders in low or middle-income countries (LMICs) received no treatment in the past 12 months.
“The recent World Health Organization (WHO) World Mental Health Survey initiative reported that 86.3% of people with anxiety, mood or substance disorders in low or middle-income countries (LMICs) received no treatment in the past 12 months [1].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Education's specialty-treatment association is described as both varying and stable
MinorThe results say the education-specialty-treatment association varied by disorder severity and country income, while the discussion says it was stable across those same groups.
“The significant association of education with SMH treatment in the total sample varied by disorder severity and country income, with significant ORs among respondents of lower education were in the range 0.6-0.7.”
“The association of education with SMH treatment was stable across all levels of disorder severity and country income groups, with the significant association due to a comparatively high odds of treatment among people at the highest education level”
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“Mental disorders were assessed with the WHO Composite International Diagnostic Interview (CIDI) Version 3.0 (Kessler & Ustun, 2004), a fully-structured interview generating lifetime and 12-month prevalence estimates of common DSM-IV disorders.”
InfluentialSelf-citationPrevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative
Merikangas, K. R., Jin, R., He, J.-P., Kessler, R. C., Lee, S., Sampson, N. A., Viana, M. C., Andrade, L. H., Hu, C., Karam, E. G., et al. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.12 · Cited by 2,627 · cited 1× · see citing works
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BackgroundSelf-citationEstimating the true global burden of mental illness
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“Although mental disorders are a leading cause of disability (World Health Organization, 2012; Whiteford et al. 2015; Vigo et al. 2016), only a minority of people with these disorders receives treatment (Wang et al.”
BackgroundSelf-citationWang, P. S., Aguilar-Gaxiola, S., Alonso, J., Angermeyer, M. C., Borges, G., Bromet, E. J., Bruffaerts, R., de Girolamo, G., de Graaf, R., Gureje, O., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61414-7 · Cited by 1,655 · see citing works
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Andrade, L. H., Alonso, J., Mneimneh, Z., Wells, J. E., Al-Hamzawi, A., Borges, G., Bromet, E., Bruffaerts, R., de Girolamo, G., de Graaf, R., et al. (2014) · Psychological Medicine · doi:10.1017/s0033291713001943 · Cited by 1,289 · see citing works
Self-citationWhiteford, H. A., Ferrari, A. J., Degenhardt, L., Feigin, V., & Vos, T. (2015) · PLOS ONE · doi:10.1371/journal.pone.0116820 · Cited by 1,175 · cited 2× · see citing works
“Although mental disorders are a leading cause of disability (World Health Organization, 2012; Whiteford et al. 2015; Vigo et al. 2016), only a minority of people with these disorders receives treatment (Wang et al.”
BackgroundHaro, J. M., Arbabzadeh-Bouchez, S., Brugha, T. S., De Girolamo, G., Guyer, M. E., Jin, R., Lepine, J. P., Mazzi, F., Reneses, B., Vilagut, G., et al. (2006) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.196 · Cited by 1,082 · cited 10× · see citing works
“…limited in that some severe disorders, such as schizophrenia, were not assessed, duration was not measured for the disorders that were assessed, and validity, although good in the WMH surveys where it was assessed (Haro et al. 2006), was not assessed in all surveys and might have varied with SES.”
BackgroundMethodResultInfluentialSelf-citationAssessing Psychiatric Impairment in Primary Care with the Sheehan Disability Scale
Leon, A. C., Olfson, M., Portera, L., Farber, L., & Sheehan, D. V. (1997) · The International Journal of Psychiatry in Medicine · doi:10.2190/t8em-c8yh-373n-1uwd · Cited by 987 · cited 3× · see citing works
“Respondents not classified severe were classified moderate if at least one of their 12-month disorders included substance dependence without a physiological dependence syndrome or at least one disorder with moderate interference in any SDS domain.”
BackgroundMethodIntroduction to Variance Estimation
Hidiroglou, M. A., & Wolter, K. M. (1986) · Technometrics · doi:10.2307/1269086 · Cited by 820 · see citing works
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Self-citationIncome-Related Inequality in the Use of Medical Care in 21 OECD Countries
(2004) · OECD Health Working Papers · doi:10.1787/687501760705 · Cited by 630 · see citing works
Disability and treatment of specific mental and physical disorders across the world
Ormel, J., Petukhova, M., Chatterji, S., Aguilar-Gaxiola, S., Alonso, J., Angermeyer, M. C., Bromet, E. J., Burger, H., Demyttenaere, K., de Girolamo, G., et al. (2008) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.039107 · Cited by 389 · cited 2× · see citing works
“This gap is even greater for people with low socio-economic status (SES) and those living in low-income countries (Steele et al. 2007; Ormel et al. 2008) even adjusting for disorder severity (Mojtabai, 2010; Andrade et al. 2014).”
BackgroundResultSelf-citationIncome-Related Inequalities in Health Service Utilisation in 19 OECD Countries, 2008-2009
(2012) · OECD Health Working Papers · doi:10.1787/5k95xd6stnxt-en · Cited by 304 · see citing works
The Bidirectional Associations Between Psychotic Experiences and DSM-IV Mental Disorders
McGrath, J. J., Saha, S., Al-Hamzawi, A., Andrade, L., Benjet, C., Bromet, E. J., Browne, M. O., Caldas de Almeida, J. M., Chiu, W. T., Demyttenaere, K., et al. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15101293 · Cited by 235 · cited 1× · see citing works
“Models of this form have been shown to be useful in a number of prior WMH analyses (e.g. McGrath et al. 2016; Stein et al. 2016).”
MethodSelf-citationMental illness stigma and willingness to seek mental health care in the European Union
Mojtabai, R. (2009) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-009-0109-2 · Cited by 219 · cited 2× · see citing works
“2008) even adjusting for disorder severity (Mojtabai, 2010; Andrade et al. 198 2014).”
Levinson, D., Lakoma, M. D., Petukhova, M., Schoenbaum, M., Zaslavsky, A. M., Angermeyer, M., Borges, G., Bruffaerts, R., de Girolamo, G., de Graaf, R., et al. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.073635 · Cited by 211 · cited 1× · see citing works
“Family income was also divided into four categories using the within-country approach adopted in international studies of welfare economics (Levinson et al. 2010), which defines high income as greater than three times the within-country median per capita family income (i.e. income divided by number…”
MethodSelf-citationDifferences in the Use of Psychiatric Outpatient Services between the United States and Ontario
Kessler, R. C., Frank, R. G., Edlund, M., Katz, S. J., Lin, E., & Leaf, P. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702203360806 · Cited by 185 · cited 1× · see citing works
“Nor do we know how stable such a pattern is across countries, although there is some evidence of cross-national differences in the association of SES with mental disorder treatment (Kessler et al. 1997; Van Doorslaer & Masseria, 2004; Devaux & De Looper, 2012).”
BackgroundSelf-citation(2008) · Cited by 162 · see citing works
Self-citationThe balanced care model for global mental health
Thornicroft, G., & Tansella, M. (2013) · Psychological Medicine · doi:10.1017/s0033291712001420 · Cited by 162 · cited 1× · see citing works
“We also know that specialist mental health (SMH) treatment resources are scarcer than general medical (GM) and nonmedical resources and that access to SMH treatment is often restricted through gatekeepers to the most severe-complex cases (Thornicroft & Tansella, 2013).”
BackgroundSelf-citationSocioeconomic Status and Self-Reported Barriers to Mental Health Service Use
Steele, L., Dewa, C., & Lee, K. (2007) · The Canadian Journal of Psychiatry · doi:10.1177/070674370705200312 · Cited by 152 · cited 4× · see citing works
“Why did we find weaker and less consistent associations of income and education with treatment than previous studies (Rossi et al. 2005; Tello et al. 2005; Steele et al. 2007)?”
BackgroundResultInfluentialLewer, D., O'Reilly, C., Mojtabai, R., & Evans-Lacko, S. (2015) · British Journal of Psychiatry · doi:10.1192/bjp.bp.114.156786 · Cited by 150 · cited 2× · see citing works
“We know that cross-national differences in treatment rates are strongly influenced by healthcare spending (Lewer et al. 2015) and that probability of receiving treatment is influenced by illness severity (Wang et al. 2007).”
BackgroundSelf-citationScott, K. M., Al-Hamzawi, A. O., Andrade, L. H., Borges, G., Caldas-de-Almeida, J. M., Fiestas, F., Gureje, O., Hu, C., Karam, E. G., Kawakami, N., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1337 · Cited by 146 · cited 2× · see citing works
“…are known to predict treatment (Andrade et al. 2014) and because SES is known to be inversely related to these disorder characteristics (Scott et al. 2014), making it important to control adequately for these characteristics to obtain accurate estimates of effects of SES on treatment.”
BackgroundSelf-citationThe WHO World Mental Health (WMH) Surveys
Aguilar‐Gaxiola, S., Alonso, J., Chatterji, S., Lee, S., Üstün, T. B., & Kessler, R. C. (2009) · Die Psychiatrie · doi:10.1055/s-0038-1671923 · Cited by 132 · cited 2× · see citing works
“The World Mental Health (WMH) Surveys (Kessler et al. 2009), a series of cross-sectional population surveys of common mental disorders, provide an unprecedented opportunity to investigate the SES gradient in treatment of mental disorders at the level of the individual survey respondent as a joint function of disorder…”
BackgroundSelf-citationSelf‐reported use of mental health services versus administrative records: care to recall?
Rhodes, A. E., & Fung, K. (2004) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.172 · Cited by 120 · cited 1× · see citing works
“Third, the treatment measures were limited to self-reports, which have been found to over-estimate treatment compared with administrative records (Rhodes & Fung, 2004).”
(2008) · Cited by 110 · see citing works
Self-citationWhat is the impact of socio-economic inequalities on the use of mental health services?
Amaddeo, F., & Jones, J. (2007) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00004565 · Cited by 86 · cited 1× · see citing works
“The small amount of research that exists on mental disorder treatment quality finds that low-SES patients are significantly more likely than other patients to receive lower-quality treatment (Amaddeo & Jones, 2007; Young & Rabiner, 2015).”
BackgroundRacial/ethnic differences in parent-reported barriers to accessing children’s health services.
Young, A. S., & Rabiner, D. (2015) · Psychological Services · doi:10.1037/a0038701 · Cited by 81 · cited 1× · see citing works
“The small amount of research that exists on mental disorder treatment quality finds that low-SES patients are significantly more likely than other patients to receive lower-quality treatment (Amaddeo & Jones, 2007; Young & Rabiner, 2015).”
BackgroundMental Disorders Around the World
Scott, K. M., de Jonge, P., Stein, D. J., & Kessler, R. C. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316336168 · Cited by 75 · cited 1× · see citing works
“More details about between-survey differences and prevalence estimates of individual disorders are reported elsewhere (Scott et al. 2017).”
BackgroundSelf-citationten Have, M., Nuyen, J., Beekman, A., & de Graaf, R. (2013) · Psychological Medicine · doi:10.1017/s0033291713000135 · Cited by 63 · see citing works
Tello, J. E., Mazzi, M. A., Tansella, M., Bonizzato, P., Jones, J., & Amaddeo, F. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00558.x · Cited by 42 · cited 2× · see citing works
“Why did we find weaker and less consistent associations of income and education with treatment than previous studies (Rossi et al. 2005; Tello et al. 2005; Steele et al. 2007)?”
ResultStein, D. J., Karam, E. G., Shahly, V., Hill, E. D., King, A., Petukhova, M., Atwoli, L., Bromet, E. J., Florescu, S., Haro, J. M., et al. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0957-8 · Cited by 40 · cited 1× · see citing works
“Models of this form have been shown to be useful in a number of prior WMH analyses (e.g. McGrath et al. 2016; Stein et al. 2016).”
MethodSelf-citationDeterminants of once-only contact in a community-based psychiatric service
Rossi, A., Amaddeo, F., Sandri, M. F., & Tansella, M. (2004) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-005-0845-x · Cited by 18 · cited 2× · see citing works
“Why did we find weaker and less consistent associations of income and education with treatment than previous studies (Rossi et al. 2005; Tello et al. 2005; Steele et al. 2007)?”
ResultWolter, K. M. (n.d.) · Statistics for Social and Behavioral Sciences · doi:10.1007/978-0-387-35099-8_1
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Cited by
Sorted by citations
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Factors associated with health service utilisation for common mental disorders: a systematic review
Roberts, T., Esponda, G. M., Krupchanka, D., Shidhaye, R. R., Patel, V., & Rathod, S. D. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1837-1 · Cited by 355 · see citing works
“However, a recent analysis of WMHS data by Evans-Lacko et al. (2017) found that differences in treatment rates in the WMHS by socio-economic status were predominantly accounted for by education rather than income [112].”
BackgroundResultLoneliness and suicide mitigation for students using GPT3-enabled chatbots
Maples, B., Cerit, M., Vishwanath, A., & Pea, R. (2024) · npj Mental Health Research · doi:10.1038/s44184-023-00047-6 · Cited by 250 · see citing works
MentaLLaMA: Interpretable Mental Health Analysis on Social Media with Large Language Models
Yang, K., Zhang, T., Kuang, Z., Xie, Q., Huang, J., & Ananiadou, S. (2024) · International World Wide Web Conference (WWW) · doi:10.1145/3589334.3648137 · Cited by 214 · see citing works
“Mental health-related issues are posing increasing threats to public health worldwide [9], but remain underestimated due to the lack of social awareness and stigma [30].”
BackgroundJohnson, S., Dalton‐Locke, C., Baker, J. A., Hanlon, C., Salisbury, T. T., Fossey, M. J., Newbigging, K., Carr, S., Hensel, J. M., Carrà, G., et al. (2022) · World Psychiatry · doi:10.1002/wps.20962 · Cited by 156 · see citing works
Ramos, G., Ponting, C., Labao, J. P., & Sobowale, K. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103990 · Cited by 122 · see citing works
Global impact of the COVID-19 pandemic on mental health services: A systematic review
Duden, G. S., Gersdorf, S., & Stengler, K. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.08.013 · Cited by 124 · see citing works
The Therapeutic Role of Ketogenic Diet in Neurological Disorders
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska‐Chmiel, I. (2022) · Nutrients · doi:10.3390/nu14091952 · Cited by 125 · see citing works
Minding the treatment gap: results of the Singapore Mental Health Study
Subramaniam, M., Abdin, E., Vaingankar, J. A., Shafie, S., Chua, H. C., Tan, W. M., Tan, K. B., Verma, S. K., Heng, D., & Chong, S. A. (2019) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-019-01748-0 · Cited by 105 · see citing works
Schleider, J. L., Zapata, J. P., Rapoport, A., Wescott, A., Ghosh, A., Kaveladze, B., Szkody, E. M., & Ahuvia, I. L. (2025) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081423-025033 · Cited by 108 · see citing works
Environmental Toxicant Exposure and Depressive Symptoms
Guo, J., Garshick, E., Si, F., Tang, Z., Lian, X., Wang, Y. Q., Li, J., & Koutrakis, P. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.20259 · Cited by 111 · see citing works
Yan, G., Zhang, Y., Wang, S., Yan, Y., Liu, M., Tian, M., & Tian, W. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115958 · Cited by 104 · see citing works
Long term economic impact associated with childhood bullying victimisation
Brimblecombe, N., Evans-Lacko, S. E., Knapp, M. R. J., King, D., Takizawa, R., Maughan, B., & Arseneault, L. (2018) · Social Science & Medicine · doi:10.1016/j.socscimed.2018.05.014 · Cited by 95 · see citing works
Self-citationYang, K., Zhang, T., & Ananiadou, S. (2022) · Information Processing & Management · doi:10.1016/j.ipm.2022.102961 · Cited by 95 · see citing works
A systematic review on automated clinical depression diagnosis
Mao, K., Wu, Y., & Chen, J. (2023) · npj Mental Health Research · doi:10.1038/s44184-023-00040-z · Cited by 91 · see citing works
“As the World Health Organization (WHO) has reported, over 75% of individuals with depression in low and mid-income countries do not receive quali fi ed psychotherapy 2 .”
Depression underdiagnosis: Prevalence and associated factors. A population-based study
Faisal‐Cury, A., Ziebold, C., Rodrigues, D. M. D. O., & Matijasevich, A. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.04.025 · Cited by 86 · see citing works
Sadeghi, M., Richer, R., Egger, B., Schindler‐Gmelch, L., Rupp, L. H., Rahimi, F., Berking, M., & Eskofier, B. M. (2024) · npj Mental Health Research · doi:10.1038/s44184-024-00112-8 · Cited by 95 · see citing works
Lee, Y. Y., Chisholm, D., Eddleston, M., Gunnell, D., Fleischmann, A., Konradsen, F., Bertram, M., Mihalopoulos, C., Brown, R. J., Santomauro, D. F., et al. (2020) · The Lancet Global Health · doi:10.1016/s2214-109x(20)30493-9 · Cited by 79 · see citing works
Liwinski, T., Lang, U. E., Brühl, A. B., & Schneider, E. (2023) · Biomedicines · doi:10.3390/biomedicines11123128 · Cited by 76 · see citing works
“However, many depressed individuals receive no mental health care, especially in low-and middle-income countries, where 75% of patients receive no treatment [10].”
BackgroundHu, X., Chen, Y., Wang, X., Jia, K., Zhang, H., Wang, Y., Chu, H., Zhong, X., Lin, M., Chen, P., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202312897 · Cited by 78 · see citing works
Gaiha, S. M., Salisbury, T. T., Usmani, S., Koschorke, M., Raman, U., & Petticrew, M. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03350-8 · Cited by 66 · see citing works
“Thus, although an estimated 10–20% of youth aged 10–24 years suffer from mental health problems, [4] 63– 86% of all mental health problems that require a diagnosis generally go undetected [5].”
BackgroundLiwinski, T., & Lang, U. E. (2023) · Nutrients · doi:10.3390/nu15173859 · Cited by 74 · see citing works
“Despite the availability of effective treatments for depression, the majority of individuals in low- and middle-income countries do not receive adequate care due to various barriers, including insufficient investment in mental health care, a scarcity of trained healthcare providers, and the presence of societal stigma…”
BackgroundFernández, D., Vigo, D., Sampson, N. A., Hwang, I., Aguilar-Gaxiola, S., Al-Hamzawi, A. O., Alonso, J., Andrade, L. H., Bromet, E. J., de Girolamo, G., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291720000884 · Cited by 65 · see citing works
Li, X.-L., Wei, J., Zhang, X., Meng, Z., & Zhu, W. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1085091 · Cited by 69 · see citing works
McCullock, S. P., & Scrivano, R. M. (2022) · Clinical Psychology Review · doi:10.1016/j.cpr.2022.102242 · Cited by 69 · see citing works
Bear, H. A., Ayala‐Nunes, L., Ramos, G., Manchanda, T., Fernandes, B., Chabursky, S., Walper, S., Watkins, E. R., & Fazel, M. S. (2024) · Journal of Medical Internet Research · doi:10.2196/48964 · Cited by 61 · see citing works
“These groups are exposed to risk factors for poor mental health and experience disparities in mental health care, including lower access to care, poorer treatment quality, and limited engagement in treatment [5,10,12].”
Pokhrel, P., Karmacharya, R., Taylor Salisbury, T., Carswell, K., Kohrt, B. A., Jordans, M. J. D., Lempp, H., Thornicroft, G., & Luitel, N. P. (2021) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-021-01386-0 · Cited by 55 · see citing works
“3% of people with anxiety, mood or substance disorders in low or middle-income countries (LMICs) received no treatment in the past 12 months [1].”
BackgroundSelf-citationJing, R., Jin, G., Guo, Y., Zhang, Y., & Li, L. (2022) · Computers in Human Behavior · doi:10.1016/j.chb.2022.107480 · Cited by 66 · see citing works
Wang, Q., Shen, Z., Zhang, S., Sun, Y., Zheng, F., & Li, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1022053 · Cited by 61 · see citing works
“Neurological disorders have become the second leading cause of death in the world (Evans-Lacko et al., 2018), and it is also an important cause of disability and premature death.”
BackgroundRong, J., Cheng, P., Li, D., Wang, X., & Zhao, D. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102443 · Cited by 61 · see citing works
Human state anxiety classification framework using EEG signals in response to exposure therapy
Muhammad, F., & Al-Ahmadi, S. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265679 · Cited by 52 · see citing works
“Researchers have reported that children with anxiety disorder have poor performance at school, miss out on important social experiences and become drug addicts [20, 21].”
BackgroundVerbascoside: A neuroprotective phenylethanoid glycosides with anti-depressive properties
Zhao, Y. P., Wang, S., Pan, J., & Ma, K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155027 · Cited by 59 · see citing works
Liu, H., Zhi, J., Zhang, C., Huang, S., Ma, Y., Luo, D., & Shi, L. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.104 · Cited by 54 · see citing works
Zhang, X., Zhang, X., Chen, W., Li, C., & Yu, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-60278-1 · Cited by 65 · see citing works
Lee, H. S., Wright, C., Ferranto, J., Buttimer, J., Palmer, C. E., Welchman, A., Mazor, K. M., Fisher, K. A., Smelson, D., O’Connor, L., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1505024 · Cited by 55 · see citing works
Systematic review of probiotics as an adjuvant treatment for psychiatric disorders
Forth, E., Buehner, B. J., Storer, A., Sgarbossa, C., Milev, R. V., & Meyyappan, A. C. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1111349 · Cited by 54 · see citing works
Heyat, M. B. B., Akhtar, F., Munir, F., Sultana, A., Muaad, A. Y. M., Gul, I., Sawan, M., Asghar, W., Iqbal, S. M. A., Baig, A. A., et al. (2024) · Complex & Intelligent Systems · doi:10.1007/s40747-024-01346-x · Cited by 56 · see citing works
Borges, G. L. G., Aguilar‐Gaxiola, S., Andrade, L. H., Benjet, C. L., Cía, A. H., Kessler, R. C., Orozco, R., Sampson, N. A., Stagnaro, J. C., Torres, Y., et al. (2019) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796019000477 · Cited by 52 · see citing works
Self-citationWang, L., Wang, Z., Lan, Y., Tuo, Y., Ma, S., & Liu, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03568 · Cited by 53 · see citing works
The treatment gap for mental disorders and associated factors in the Czech Republic
Kågström, A., Alexová, A., Tušková, E., Csajbók, Z., Schomerus, G., Formánek, T., Mladá, K., Winkler, P., & Čermáková, P. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2019.04.003 · Cited by 51 · see citing works
“As opposed to previous studies conducted in other countries [31,32], the present analysis shows that education was unrelated to utilization of MHS in the Czech Republic, but did influence which professional individuals were willing to seek help from.”
ResultCannabinoid CB1 Receptor Involvement in the Actions of CBD on Anxiety and Coping Behaviors in Mice
Austrich-Olivares, A., García‐Gutiérrez, M. S., Illescas, L., Gasparyan, A., & Manzanares, J. (2022) · Pharmaceuticals · doi:10.3390/ph15040473 · Cited by 49 · see citing works
App-Based Interventions for Moderate to Severe Depression
Bae, H., Shin, H., Ji, H.-G., Kwon, J. S., Kim, H., & Hur, J. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.44120 · Cited by 47 · see citing works
Marconcin, P., Barak, S., Ferrari, G., Gouveia, É. R., Nascimento, M. D. M., Willig, R., Varela, M., & Marques, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114055 · Cited by 48 · see citing works
“More specifically, many older adults are at risk of developing frailty and depression—both geriatric syndromes that cause disability and contribute to the global burden of disease [1,2].”
BackgroundBifftu, B. B., Takele, W. W., Guracho, Y. D., & Yehualashet, F. A. (2018) · Depression Research and Treatment · doi:10.1155/2018/1592596 · Cited by 44 · see citing works
“Factors such as fear of stigma and embarrassment, lack of time, comorbid substance use, demographic and geographical variation [50], co-morbid chronic illness [49, 55], psychosocial factors [5, 43, 56–58], perceived cause, accessibility, and effectiveness of the treatment [59, 60] were associated with the treatment ga…”
BackgroundMethodClosing the treatment gap for alcohol use disorders in low- and middle-income countries
Nadkarni, A., Gandhi, Y., Bhatia, U., & Velleman, R. (2023) · Cambridge Prisms: Global Mental Health · doi:10.1017/gmh.2022.57 · Cited by 46 · see citing works
“%) was in the general medical sector followed by the specialist mental health sector (14%); while the treatment rates were much lower in the human services sector (e.g., religious or spiritual advisor, social worker) and complementary alternative medicine sector (4% each) (Evans-Lacko et al., 2018).”
BackgroundRameez, S., & Nasir, A. (2023) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_391_22 · Cited by 46 · see citing works
“[39] Using our complimentary analysis framework, the obstacles and promoters that influence the primary care practitioner’s activities offer a practical strategy to overcome hurdles linked to mental healthcare services in primary care to improve the health outcomes of LMICs.”
BackgroundMethodInfluentialShawon, M. S. R., Hossain, F. B., Hasan, M., & Rahman, M. R. (2024) · Cambridge Prisms Global Mental Health · doi:10.1017/gmh.2024.37 · Cited by 47 · see citing works
“A recent study conducted in India with a representative population revealed that mental health problems were more prevalent among middle-aged individuals, residents of urban-metro areas, less educated individuals and households with lower income (Evans-Lacko et al., 2018).”
BackgroundMental Health and Substance Use Disorders
Mundt, A. P., Rozas-Serri, E., Beigel, L., Irarrázaval, M., Cabieses, B., V, & Baranyi, G. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99967-0.00193-9 · Cited by 45 · see citing works
Exploring depression in adults over a decade: a review of longitudinal studies
de Sousa, R. D., Zagalo, D. M., Costa, T., de Almeida, J. M. C., Canhão, H., & Rodrigues, A. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06828-x · Cited by 44 · see citing works
“Findings from the WHO World Mental Health (WMH) Surveys indicate that, despite the existence of established and effective therapies for mental disorders, over 75% of individuals in low-and middle-income countries do not receive treatment [4].”
van den Broek, M., Gandhi, Y., Sureshkumar, D. S., Prina, M. A., Bhatia, U., Patel, V., Singla, D. R., Velleman, R. D. B., Weiss, H. A., Garg, A., et al. (2023) · PLOS Global Public Health · doi:10.1371/journal.pgph.0002302 · Cited by 46 · see citing works
“The results are further organised based on their effects: (1) positive, significant; (2) positive, not significant; (3) positive trend favouring the intervention but lacking data to evaluate effect sizes; and [4] no effect.”
InfluentialBerlowitz, I., Torres, E., Walt, H., Wolf, U., Maake, C., & Martin-Soelch, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.594591 · Cited by 42 · see citing works
“…2015), where treatments are known to be markedly underprovided on a global scale (see worldwide treatment gap in mental health; Kohn et al., 2004; WHO, 2008; Evans-Lacko et al., 2017) and where chronicity is common (Costello et al., 2002; Brandon et al., 2007; Koob and Le Moal, 2008; WHO, 2008).”
BackgroundApplication of Intranasal Administration in the Delivery of Antidepressant Active Ingredients
Jin, Z., Han, Y., Zhang, D., Li, Z., Jing, Y., Hu, B., & Sun, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102070 · Cited by 44 · see citing works
“More than 75% of patients in countries with a shortage of medical resources and healthcare personnel go untreated [1].”
BackgroundZhang, L., Sun, H., Liu, Z., Yang, J., & Liu, Y. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05531-7 · Cited by 52 · see citing works
“Data from the World Health Organization (WHO) revealed that it affects approximately 4.4% of the global population [2] and projected that depression would be a leading contributor to the global burden of disease by 2030 [3].”
BackgroundInfluentialNLRP3-Dependent Pyroptosis: A Candidate Therapeutic Target for Depression
Wan, T., Li, X., Fu, M., Gao, X., Li, P., & Guo, W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.863426 · Cited by 44 · see citing works
“Affluent environments will reduce depressive manifestations, while the majority of depressed patients in low- and middle-income countries do not receive effective treatment (Evans-Lacko et al., 2018; Gu et al., 2021).”
BackgroundProcess evaluation of a district mental healthcare plan in Nepal: a mixed-methods case study
Luitel, N. P., Breuer, E., Adhikari, A., Kohrt, B. A., Lund, C., Komproe, I. H., & Jordans, M. J. D. (2020) · BJPsych Open · doi:10.1192/bjo.2020.60 · Cited by 41 · see citing works
Self-citationOrozco, R., Vigo, D., Benjet, C. L., Borges, G. L. G., Aguilar‐Gaxiola, S., Andrade, L. H., Cía, A. H., Hwang, I. H., Kessler, R. C., Piazza, M., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.02.031 · Cited by 42 · see citing works
Self-citationHogg, B., Moreno‐Alcázar, A., Tóth, M. D., Serbanescu, I., Aust, B., Leduc, C., Paterson, C., Tsantila, F., Abdulla, K., Pashoja, A. C., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01443-3 · Cited by 48 · see citing works
“This is related to a range of factors, such as lower country-income level and socio-economic status [7, 8] and male gender [9].”
BackgroundThe Typing Cure: Experiences with Large Language Model Chatbots for Mental Health Support
Song, I., Pendse, S. R., Kumar, N., & Choudhury, M. D. (2025) · Proceedings of the ACM on Human-Computer Interaction · doi:10.1145/3757430 · Cited by 103 · see citing works
“This need to accommodate the LLM’s linguistic capabilities sometimes hindered the ability of participants to fully express themselves, revealing a significant limitation in the LLM chatbots’ design.”
Packness, A., Halling, A., Simonsen, E. H., Waldorff, F. B., & Hastrup, L. H. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-023844 · Cited by 40 · see citing works
“%) had concerns related to Knowledge, or how to find help for MHC. Transport was not a problem for 78.6%, with only 11.7% reporting that it negatively affected access.”
InfluentialJiang, N., Wei, S., Zhang, Y., He, W., Pei, H., Huang, H. M., Wang, Q., & Liu, X. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.688703 · Cited by 43 · see citing works
“4%, respectively, and major depression was listed as the third-highest cause of the global disease burden in 2008 and was predicted to take the lead by 2030 (3, 4).”
BackgroundDual-Stream Multiple Instance Learning for Depression Detection With Facial Expression Videos
Shangguan, Z., Liu, Z., Li, G., Chen, Q., Ding, Z., & Hu, B. (2022) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2022.3204757 · Cited by 43 · see citing works
“More specifically, across all countries at different income levels, people with depression are often underdiag-nosed, and even non-depressed people are often misdiagnosed and prescribed antidepressants [2].”
BackgroundŠtuhec, M., Hahn, M., Tašková, I., Bayraktar, İ., Fitzgerald, I., Molitschnig, L.-T., Tatarević, A., Lindner, N., Agnoletto, L., & da Costa, F. A. (2023) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-023-01643-4 · Cited by 40 · see citing works
“Although effective pharmacological and non-pharmacological treatments are available, more than 75% of people in low-and middle-income countries receive no treatment [5].”
BackgroundTian, F., Zhang, H., Tan, Y., Zhu, L., Shen, L., Qian, K., Hu, B., Schuller, B. W., & Yamamoto, Y. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3487012 · Cited by 44 · see citing works
Adolescent mental health in sub-Saharan Africa: crisis? What crisis? Solution? What solution?
Hart, C., & Norris, S. A. (2024) · Global Health Action · doi:10.1080/16549716.2024.2437883 · Cited by 44 · see citing works
Sapbamrer, R., Chittrakul, J., Sirikul, W., Kitro, A., Chaiut, W., Panya, P., Amput, P., Chaipin, E., Sutalangka, C., Sidthilaw, S., et al. (2022) · Sustainability · doi:10.3390/su14031189 · Cited by 38 · see citing works
“Psychological stress is an important factor affecting depression [28,29], and it can increase the risk of depression.”
BackgroundAurizki, G. E., & Wilson, I. (2022) · International Journal of Nursing Practice · doi:10.1111/ijn.13046 · Cited by 39 · see citing works
“(Alonso et al., 2018; Evans-Lacko et al., 2018).”
Ibrahim, M. M., Basalious, E. B., El-Nabarawi, M. A., Makhlouf, A. I. A., Sayyed, M. E., & Ibrahim, I. T. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01528-7 · Cited by 39 · see citing works
“There are nearly 300 million patients living with depression all over the world which indicates its global prevalence [1, 4].”
BackgroundThe Multi-Sites Trial on the Effects of Therapeutic Gardening on Mental Health and Well-Being
Yang, Y., Ro, E., Lee, T.-J., An, B.-C., Hong, K., Yun, H.-J., Park, E.-Y., Cho, H.-R., Yun, S., Park, M., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19138046 · Cited by 37 · see citing works
Marlow, M., Skeen, S., Hunt, X., Sundin, P., Weiss, R. E., Mofokeng, S., Makhetha, M., Cluver, L. D., Sherr, L., & Tomlinson, M. (2022) · SSM - Mental Health · doi:10.1016/j.ssmmh.2022.100167 · Cited by 36 · see citing works
General Anxiety Disorder-7 Questionnaire as a marker of low socioeconomic status and inequity
Nunes, J. C., Carroll, M. K., Mahaffey, K. W., Califf, R. M., Doraiswamy, P. M., Short, S., Shah, S. H., Swope, S., Williams, D., Hernandez, A. F., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.085 · Cited by 40 · see citing works
Self-citationSpatial–Temporal EEG Fusion Based on Neural Network for Major Depressive Disorder Detection
Zhang, B., Wei, D., Yan, G., Li, X., Su, Y., & Cai, H. (2023) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-023-00567-x · Cited by 35 · see citing works
“Although the existing treatment methods combined with related drugs can alleviate MDD to some extent, due to the differences in global medical resources and economic development level, the proportion of doctors and patients is unbalanced, especially for mental diseases, and more than 75% of MDD patients in economicall…”
Key Considerations in Planning for Substance Use Treatment: Estimating Treatment Need and Demand
Ritter, A. J., Mellor, R., Chalmers, J., Sunderland, M., & Lancaster, K. (2019) · Journal of Studies on Alcohol and Drugs Supplement · doi:10.15288/jsads.2019.s18.22 · Cited by 35 · see citing works
“Unsurprisingly, the extent of the treatment gap also varies between high-, middle-, and low-income countries (Evans-Lacko et al., 2018).”
BackgroundChang, H., Zong, Y., Zheng, W., Xiao, Y., Wang, X., Zhu, J., Shi, M., Cheng, L., & Yang, H. J. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/acbe20 · Cited by 35 · see citing works
“Given different definitions, diagnostic criteria, epidemiological survey methods and tools for depression, more than 75% of people in low- and middle-income countries are untreated [11], so current evaluationmetrics highlight the lack of prospective evidence for biomarkers as predictors of MDD [12].”
BackgroundQiao, F., Wang, X., Han, Y., et al. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341404 · Cited by 35 · see citing works
Khalil, S. S., Tawfik, N. S., & Spruit, M. R. (2024) · Patterns · doi:10.1016/j.patter.2024.100990 · Cited by 35 · see citing works
El-Hachem, S. S., Lakkis, N. A., Osman, M. H., Issa, H. G., & Beshara, R. Y. (2023) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-023-02470-8 · Cited by 53 · see citing works
Shumet, S., Kassew, T., Azale, T., Ayano, G., Abebaw, D., Tesfaw, G., Wonde, M., Getinet, W., & Amare, T. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s311601 · Cited by 33 · see citing works
Evans-Lacko, S., Hahn, J. S., Peter, L.-J., & Schomerus, G. (2022) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000788 · Cited by 32 · see citing works
“These barriers are more highly represented among low socioeconomic groups [7] further perpetuating a cycle of disadvantage.”
BackgroundSelf-citationTrends of mental health care utilization among US adults from 1999 to 2018
Wang, J., Qiu, Y., & Zhu, X. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05156-2 · Cited by 35 · see citing works
“The reasons may be that individuals with higher PIR and age are likely to have higher SES, quality of life and self-satisfaction, which may reduce the requirements for mental health care [27, 32, 33].”
BackgroundCao, H., Wu, Y., Yin, H., Sun, Y., Yuan, H., & Tao, M. (2024) · JMIR Public Health and Surveillance · doi:10.2196/49609 · Cited by 32 · see citing works
“At the same time, the COVID-19 pandemic has heightened anxiety, increasing the incidence of ADs and their disease burden [50].”
BackgroundKabra, A., Garg, R., Brimson, J. M., Živković, J., Almawash, S., Ayaz, M., Nawaz, A., Hassan, S. S. U., & BUNGAU, S. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1046599 · Cited by 31 · see citing works
“Despite several clinically effective drugs for treating depression, people in more than 75% of middle and low-income counties do not receive treatment (Evans-Lacko et al., 2018; Ahsan et al., 2022).”
BackgroundAntidepressant mechanisms of ketamine’s action: NF-κB in the spotlight
Sokołowska, P., Karbownik, M. S., Jóźwiak-Bębenista, M., Dobielska, M., Kowalczyk, E., & Wiktorowska‐Owczarek, A. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115918 · Cited by 33 · see citing works
Intelligent Internet of Medical Things for Depression: Current Advancements, Challenges, and Trends
Heyat, M. B. B., Adhikari, D., Akhtar, F., Parveen, S., Zeeshan, H. M., Ullah, H., Chen, Y.-H., Wang, L., & Sawan, M. (2025) · International Journal of Intelligent Systems · doi:10.1155/int/6801530 · Cited by 32 · see citing works
“According to WHO, mental illness is a signifcant global public health problem [10, 11].”
Smith, L., Shin, J. I., Butler, L., Barnett, Y., Oh, H. Y., Jacob, L., Kostev, K., Veronese, N., Soysal, P., Tully, M. A., et al. (2022) · Depression and Anxiety · doi:10.1002/da.23250 · Cited by 32 · see citing works
“Although there are effective treatments for mental disorders, more than 75% of people in LMICs receive no treatment (Evans‐Lacko et al., 2018).”
BackgroundNeurobiological mechanisms of mood disorders: Stress vulnerability and resilience
Pereira, C. M., Castro, F. C. D. A. Q., Barcelos, R. M., Chiepe, K. C. M. B., Rossoni, J. V., Ambrósio, R. P., Chiarelli-Neto, O., & Pesarico, A. P. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1006836 · Cited by 32 · see citing works
Use of mental health services by children with mental disorders in two major cities in Brazil
Fatori, D., Salum, G. A., Rohde, L. A., Pan, P. M., Bressan, R., Evans-Lacko, S., Polanczyk, G., Miguel, E. C., & Graeff-Martins, A. S. (2019) · Psychiatric Services · doi:10.1176/appi.ps.201800389 · Cited by 30 · see citing works
Self-citationPhysical exercise and major depressive disorder in adults: systematic review and meta-analysis
Bedoya, É. A. P., López, L. F. P., Galvis, D. A. L., Jaimes, D. A. R., & Moreira, O. C. (2023) · Scientific Reports · doi:10.1038/s41598-023-39783-2 · Cited by 38 · see citing works
“Considering patient preferences is important, as medications may have adverse events and may be difficult to access in low-and middle-income countries 14,53 .”
BackgroundDivergent suicidal symptomatic activations converge on somato-cognitive action network in depression
Li, J., Wang, D., Xia, J., Zhang, C., Meng, Y., Xu, S., Chen, H., & Liao, W. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02450-7 · Cited by 32 · see citing works
“Depression is a common mental illness, with approximately 280 million people affected around the world [1].”
BackgroundGiebel, C. M., Corcoran, R., Goodall, M., Campbell, N., Gabbay, M., Daras, K., Barr, B., Wilson, T. J., & Kullu, C. (2020) · BMC Public Health · doi:10.1186/s12889-020-08820-4 · Cited by 31 · see citing works
“Taking a more international view, the WHO has shown that higher levels of education for example are linked to better treatment in low-, middle-, and highincome countries [2], whilst disparities in access to mental health treatments are also widely reported in the US for example [25].”
BackgroundResultSarkar, S., Tom, A., & Mandal, P. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2021.1908359 · Cited by 29 · see citing works
“The treatment gap seems to lower in high income countries as compared to LMICs, probably reflecting the differences in barriers and facilitators experienced by the patients (Evans-Lacko et al, 2018).”
BackgroundExamining the mental health services among people with mental disorders: a literature review
Gao, Y., Burns, R. A., Leach, L., Chilver, M. R., & Butterworth, P. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05965-z · Cited by 34 · see citing works
Guerra, V., López-Núñez, C., Vaca, S., & Torres-Carrión, P. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.813894 · Cited by 33 · see citing works
Collegian help seeking: the role of self-compassion and self-coldness
Dschaak, Z. A., Spiker, D. A., Berney, E. C., Miller, M. E., & Hammer, J. H. (2019) · Journal of Mental Health · doi:10.1080/09638237.2019.1677873 · Cited by 28 · see citing works
Kagee, A., Bantjes, J. R., Saal, W., & Sterley, A. (2020) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2020.09.005 · Cited by 28 · see citing works
Habimana, S., Biracyaza, E., Mpunga, T., Nsabimana, E., Kayitesi, F., Nzamwita, P., & Jansen, S. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.972360 · Cited by 28 · see citing works
Tsai, W.-H., Yeh, W.-L., Chou, C.-H., Wu, C., Lai, C., Yeh, Y., Liao, C., & Wu, C.-C. (2023) · Biomedicines · doi:10.3390/biomedicines11041068 · Cited by 27 · see citing works
Rosas-Sánchez, G. U., Germán-Ponciano, L. J., Guillén-Ruiz, G., Cueto‐Escobedo, J., Limón-Vázquez, A. K., Rodríguez‐Landa, J. F., & Soria-Fregozo, C. (2024) · Biomedicines · doi:10.3390/biomedicines12122744 · Cited by 30 · see citing works
“Despite this complexity and the numerous biological factors involved, antidepressants can have adverse effects that reduce adherence to treatment [39,40].”
Automatic Identification of Depression Using Facial Images with Deep Convolutional Neural Network
Kong, X., Yao, Y., Wang, C., Wang, Y., Teng, J., & Qi, X. (2022) · Medical Science Monitor · doi:10.12659/msm.936409 · Cited by 27 · see citing works
“It has obvious advantages over shallow models in feature extraction and model fitting, and it is good at mining abstract distributed feature representations with good generalization ability from the original input data [10,11].”
BackgroundDysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder
Pasquini, L., Fryer, S. L., Eisendrath, S. J., Segal, Z. V., Lee, A. J., Brown, J. A., Saggar, M., & Mathalon, D. H. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.10.009 · Cited by 26 · see citing works
“Major depressive disorder (MDD) is a common, debilitating disorder and is among the leading causes of disability worldwide (1).”
BackgroundRoberts, T., Shidhaye, R. R., Patel, V., & Rathod, S. D. (2020) · BMC Health Services Research · doi:10.1186/s12913-020-05162-0 · Cited by 25 · see citing works
“In support of this hypothesis, evidence from the World Mental Health Surveys [72] and from a large dataset from the USA [73] both showed that lack of perceived need for treatment and preferring to handle the problem themselves are the most common barriers to treatment-seeking, indicating that demand for mental health…”
ResultInfluential
- Authors
- Evans-Lacko, S., Aguilar-Gaxiola, S., Al-Hamzawi, A., Alonso, J., Benjet, C., Bruffaerts, R., Chiu, W. T., Florescu, S., de Girolamo, G., Gureje, O., Haro, J. M., He, Y., Hu, C., Karam, E. G., Kawakami, N., Lee, S., Lund, C., Kovess-Masfety, V., Levinson, D., Navarro-Mateu, F., Pennell, B. E., Sampson, N. A., Scott, K. M., Tachimori, H., ten Have, M., Viana, M. C., Williams, D. R., Wojtyniak, B. J., Zarkov, Z., Kessler, R. C., Chatterji, S., & Thornicroft, G.
- Affiliations
- King's College London (GB)
- University of Al-Qadisiyah (IQ)
- Universitat Pompeu Fabra (ES)
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- KU Leuven (BE)
- Harvard University (US)
- National School of Public Health, Management and Professional Development (RO)
- University College Hospital, Ibadan (NG)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Shanghai Jiao Tong University (CN)
- Shenzhen KangNing Hospital (CN)
- University of Balamand (LB)
- The University of Tokyo (JP)
- Chinese University of Hong Kong (HK)
- University of Cape Town (ZA)
- Israel Ministry of Health (IL)
- University of Michigan (US)
- University of Otago (NZ)
- National Center of Neurology and Psychiatry (JP)
- Universidade Federal do Espírito Santo (BR)
- Narodowy Instytut Zdrowia Publicznego PZH – Państwowy Instytut Badawczy (PL)
- National Center of Public Health and Analyses (BG)
- World Health Organization (CH)
- Corresponding author
- Kessler, R. C.
- ORCID
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-11-27
- Volume
- 48
- Issue
- 9
- Pages
- 1560-1571
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC6878971
- OpenAlex
- W2766194567
- Semantic Scholar
- d18855ad1dcd6dbf240bfdef5f70607523fa0ee3
- Cited by
- 781
- References
- 35
- Citations by year
- 2026: 110 · 2025: 164 · 2024: 179 · 2023: 145 · 2022: 123 · 2021: 26 · 2020: 18 · 2019: 10 · 2018: 4
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
- London School of Economics and Political Science Research Online (London School of Economics and Political Science) (submittedVersion)
- London School of Economics and Political Science Theses Online (London School of Economics and Political Science) (submittedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Research Portal (King's College London) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
- Funders
- Robert Wood Johnson Foundation (044708, Grant 044708)
- John D. and Catherine T. MacArthur Foundation (R01 DA016558, R13-MH066849)
- John W. Alden Trust
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- World Health Organization
- University of Michigan
- South London and Maudsley NHS Foundation Trust
- King's College Hospital NHS Foundation Trust
- Universidad CES
- National Institute for Health and Care Research (FP7/2007–2013)
- King's College London
- European Commission (EAHC 20081308, 20081308, 2007–2013, FP7 2007-2013, QLG5–1999-01042, SANCO2004123, 2004123, FP7/2007)
- Public Health Agency
- Fundação de Amparo à Pesquisa do Estado de São Paulo (03/00204-3, 03/00204?)
- Generalitat de Catalunya (01042)
- Bundesministerium für Gesundheit
- National Insurance Institute of Israel
- Ministry of Health, Labour and Welfare (H25-SEISHIN-IPPAN-006, H13-SHOGAI-023)
- Universidade de Lisboa
- Ministerio de Ciencia y Tecnología (SAF 2000 158-CE)
- Fundación para la Formación e Investigación Sanitarias de la Región de Murcia
- Servicio Murciano de Salud
- Regione Piemonte (00/0028)
- Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu
- Servier
- H. Lundbeck A/S
- Fundação Champalimaud (R01 MH070884)
- Ministerio de Salud
- Ministerstwo Zdrowia
- National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
- Substance Abuse and Mental Health Services Administration
- U.S. Public Health Service (R01-DA016558, R13‐MH066849, R01- MH069864)
- Pfizer Foundation (R01‐MH069864, R01-DA016558, R13-MH066849, R03-TW006481)
- Pan American Health Organization
- Executive Agency for Health and Consumers
- Fundação para a Ciência e a Tecnologia
- Instituto de Salud Carlos III (CB06/02/0046, RETICS RD06/0011, RD06/0011, FIS 00/0028, CIBER CB06/02/0046)
- Norway Grants
- Consejería de Sanidad y Política Social, Comunidad Autónoma de la Región de Murcia
- Departament de Salut, Generalitat de Catalunya
- National Institute of Mental Health (R13-MH-066849, R01‐MH070884, R01MH061905, R01MH059575, MH60220, MH070884, U01MH060220, R01‐MH069864)
- National Institute on Drug Abuse (R01DA016558)
- Fogarty International Center (FIRCA R03TW006481, R03TW006481)
- FP7 Ideas: European Research Council (337673)
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Health › Health disparities and outcomes
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Keywords
- mental health treatment gap, socioeconomic status, anxiety disorders, mood disorders, substance use disorders, income, mental health services, financial barriers, low- and middle-income countries
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Mental Disorders, Developing Countries, Female, Health Surveys, Humans, Male, Mental Health, Middle Aged, Patient Acceptance of Health Care, Psychotherapy, Socioeconomic Factors, Multivariate Analysis, Logistic Models, Developed Countries, Internationality, Healthcare Disparities, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-09-28.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-09-28.
Cited sources are checked by gpt-6-sol.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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