The role of the opioid system in binge eating disorder
Open accessAbstract
Binge eating disorder is characterized by excessive, uncontrollable consumption of palatable food within brief periods of time. Excessive intake of palatable food is thought to be driven by hedonic, rather than energy homeostatic, mechanisms. However, reward processing does not only comprise consummatory actions; a key component is represented by the anticipatory phase directed at procuring the reward. This phase is highly influenced by environmental food-associated stimuli, which can robustly enhance the desire to eat even in the absence of physiological needs. The opioid system (endogenous peptides and their receptors) has been strongly linked to the rewarding aspects of palatable food intake, and perhaps represents the key system involved in hedonic overeating. Here we review evidence suggesting that the opioid system can also be regarded as one of the systems that regulates the anticipatory incentive processes preceding binge eating hedonic episodes.
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Methylation at the mu-opioid receptor (MOR) gene is most strongly associated with drug addiction as well as incentive motivation for processed food.
“While methylation at the mu-opioid receptor (MOR) gene is most strongly associated with drug addiction [144] as well as incentive motivation for processed food [145,146], decreased methylation at the kappa-opioid receptor (KOR) in the anterior insula has been shown in child abuse [147] (discussed further in Section 4.1).”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [145]
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- [46]Petrovich GD Ross CA Gallagher M Holland PC Learned contextual cue potentiates eating in rats Physiol Behav 2007 90 2-3 362 367 10.1016/j.physbeh.2006.09.031 17078980 PMC1892280 · DOI
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- Authors
- Giuliano, C., & Cottone, P.
- Affiliations
- University of Cambridge (GB)
- Boston University (US)
- Corresponding author
- Giuliano, Chiara
- ORCID
- Cottone, Pietro
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-10-26
- Volume
- 20
- Issue
- 6
- Pages
- 537-545
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- PMC
- PMC4831059
- OpenAlex
- W2270587601
- Cited by
- 45
- References
- 90
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 7
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Apollo (University of Cambridge) (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH091945)
- National Institute on Drug Abuse (R01DA030425)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- binge eating disorder, opioid system, opioid receptors, food reward, palatable food intake, incentive salience
- MeSH terms
- Animals, Brain, Humans, Receptors, Opioid, Reward, Binge-Eating Disorder, Anticipation, Psychological
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