Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum
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Mu-opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic "liking" reactions to sweetness and appetitive "wanting" for food reward. How do these two NAc-VP hotspots interact? To probe their interaction and limbic circuit properties, we assessed whether opioid activation of one hotspot recruited the other hotspot (neurobiologically) and whether opioid hedonic and incentive motivational amplification by either opioid hotspot required permissive opioid coactivation in the other (behaviorally). We found that NAc and VP hotspots reciprocally modulated Fos expression in each other and that the two hotspots were needed together to enhance sucrose "liking" reactions, essentially cooperating within a single hedonic NAc-VP circuit. In contrast, the NAc hotspot dominated for opioid stimulation of eating and food intake ("wanting"), independent of VP activation. This pattern reveals differences between limbic opioid circuits that control reward "liking" and "wanting" functions.
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Pleasurable or rewarding experiences comprise an anticipatory 'wanting' component and an 'in-the-moment enjoyment' (liking) component.
“Current evidence suggests that, cognitively, pleasurable or rewarding experiences, in general, comprise a “looking forward to” anticipatory component, which is cognitively driven (i.e., “wanting”) (23, 24), and an “in-the-moment enjoyment” (i.e., “liking”) component (25, 26).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [25]
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- Authors
- Smith, K. S., & Berridge, K. C.
- Affiliations
- University of Michigan (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-02-14
- Volume
- 27
- Issue
- 7
- Pages
- 1594-1605
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673729
- OpenAlex
- W2038105537
- Cited by
- 450
- References
- 64
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 9 · 2023: 11 · 2022: 19 · 2021: 20 · 2020: 63 · 2019: 34 · 2018: 26 · 2017: 18 · 2016: 23 · 2015: 25 · 2014: 25 · 2013: 27 · 2012: 23
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DC00011)
- National Institute of Mental Health (MH-63649, R01MH063649)
- National Institute on Drug Abuse (DA015188, R01DA015188)
- National Institute on Deafness and Other Communication Disorders (DC010011, T32DC000011)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- nucleus accumbens shell, ventral pallidum, mu-opioid receptor, hedonic liking, food reward, dietary intake, Fos expression, limbic circuits, incentive motivation
- MeSH terms
- Analgesics, Opioid, Analysis of Variance, Animals, Behavior, Animal, Drug Interactions, Enkephalin, Leucine, Feeding Behavior, Gene Expression Regulation, Globus Pallidus, Immunohistochemistry, Male, Naloxone, Narcotic Antagonists, Neural Pathways, Nucleus Accumbens, Reward, Taste, Oncogene Proteins v-fos, Rats, Sprague-Dawley, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Rats
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