A longitudinal study of language decline in Alzheimer’s disease and frontotemporal dementia
Abstract
Language decline is usually the fastest and predominant change in primary progressive aphasia (PPA). In Alzheimer's disease (AD), it is usually associated with global cognitive deficits. Decreased speech output, reduced conversational initiation, echolalia, and changes in the pragmatics of conversation are seen in the behavioral variant of frontotemporal dementia (FTD-bv), however, the evolution of language disturbance in FTD-bv patients is rarely examined systematically with a standardized language battery. We aimed to longitudinally track the nature of language change in FTD-bv, PPA, and AD using a standardized measure of language functioning. We also explored the nature of language deficits between semantic dementia (SD) patients and the fluent subgroup of PPA patients. The Western Aphasia Battery was administered to 105 AD, 20 FTD-bv, 54 PPA, and 10 SD patients on 2 occasions with approximately 1 year between assessments. Ninety-nine of these patients were examined an additional year. FTD-bv and PPA patients showed a faster language decline than AD patients. The eventual overlap in language functioning in FTD-bv and PPA suggests that these syndromes belong to the same spectrum of disorders. In conclusion, longitudinal language assessment provides us with a unique understanding of the evolution and progression of language deterioration in various dementias. (JINS, 2007, 13, 237–245.)
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Despite cognitive heterogeneity, disease progression in bvFTD has been marked by decline in executive functioning, memory, language and attention (1 to 8 years).
“Despite cognitive heterogeneity, disease progression in bvFTD has been marked by decline in executive functioning, memory, language and attention (1 to 8 years) (Blair et al., 2007; Wicklund et al., 2007; Smits et al., 2015; Ramanan et al., 2017).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Blair et al., 2007
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
(1967) · Medical Entomology and Zoology · Cited by 7,532 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Self-citationWeıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,012 · see citing works
SEMANTIC DEMENTIA: PROGRESSIVE FLUENT APHASIA WITH TEMPORAL LOBE ATROPHY
HODGES, J. R., PATTERSON, K., OXBURY, S., & FUNNELL, E. (1992) · Brain · doi:10.1093/brain/115.6.1783 · Cited by 1,710 · see citing works
The Selective Impairment of Semantic Memory
Warrington, E. (1975) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747508400525 · Cited by 1,509 · see citing works
Clinical and Pathological Diagnosis of Frontotemporal Dementia
McKhann, G. M. (2001) · Archives of Neurology · doi:10.1001/archneur.58.11.1803 · Cited by 1,475 · see citing works
Slowly progressive aphasia without generalized dementia
Mesulam, M. (1982) · Annals of Neurology · doi:10.1002/ana.410110607 · Cited by 1,241 · see citing works
Mesulam, M. ‐. (2001) · Annals of Neurology · doi:10.1002/ana.91 · Cited by 1,001 · see citing works
Semantic dementia: A form of circumscribed cerebral atrophy
Snowden, J. S., Goulding, P., & Neary, D. (1989) · Behavioural Neurology · doi:10.1155/1989/124043 · Cited by 944 · see citing works
The evolution and pathology of frontotemporal dementia
Kertesz, A., McMonagle, P., Blair, M., Davidson, W., & Munoz, D. G. (2005) · Brain · doi:10.1093/brain/awh598 · Cited by 609 · see citing works
Self-citationClinicopathological correlates in frontotemporal dementia
Hodges, J. R., Davies, R. R., Xuereb, J. H., Casey, B., Broe, M., Bak, T. H., Kril, J. J., & Halliday, G. M. (2004) · Annals of Neurology · doi:10.1002/ana.20203 · Cited by 580 · see citing works
Frontal behavioral inventory: diagnostic criteria for frontal lobe dementi
Kertesz, A., Davidson, W., & Fox, H. (1997) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100021053 · Cited by 571 · see citing works
Self-citationA study of language functioning in Alzheimer patients
Appell, J., KERTESZ, A. E., & Fisman, M. (1982) · Brain and Language · doi:10.1016/0093-934x(82)90006-2 · Cited by 524 · see citing works
Self-citationPrimary Progressive Aphasia — A Language-Based Dementia
Mesulam, M. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022435 · Cited by 471 · see citing works
Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP
Josephs, K. A., Petersen, R. C., Knopman, D. S., Boeve, B. F., Whitwell, J. L., Duffy, J. R., Parisi, J. E., & Dickson, D. W. (2006) · Neurology · doi:10.1212/01.wnl.0000191307.69661.c3 · Cited by 455 · see citing works
Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis
Gustafson, L. (1987) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(87)90022-7 · Cited by 389 · see citing works
Aphasia in dementia of the Alzheimer type
Cummings, J. L., Benson, D. F., Hill, M. A., & Read, S. (1985) · Neurology · doi:10.1212/wnl.35.3.394 · Cited by 337 · see citing works
Hodges, J. R., Patterson, K., Ward, R., Garrard, P., Bak, T., Perry, R., & Gregory, C. (1999) · Neuropsychology · doi:10.1037/0894-4105.13.1.31 · Cited by 335 · see citing works
Hodges, J. R., Patterson, K. E., Ward, R., Garrard, P., Bak, T., Perry, R. J., & Gregory, C. A. (1999) · Neuropsychology · doi:10.1037//0894-4105.13.1.31 · Cited by 332 · see citing works
Uber die Beziehungen der senilen Hirnatrophie zur Aphasie
Pick, A. (1892) · Medical Entomology and Zoology · Cited by 310 · see citing works
The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia
KERTESZ, A. E., Martínez‐Lage, P., Davidson, W., & Muñoz, D. G. (2000) · Neurology · doi:10.1212/wnl.55.9.1368 · Cited by 304 · see citing works
Self-citationNonfluent progressive aphasia and semantic dementia: A comparative neuropsychological study
Hodges, J. R., & Patterson, K. E. (1996) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700001685 · Cited by 301 · see citing works
The Rise and Fall of Frequency and Imageability: Noun and Verb Production in Semantic Dementia
Bird, H., Ralph, M. A. L., Patterson, K. E., & Hodges, J. R. (2000) · Brain and Language · doi:10.1006/brln.2000.2293 · Cited by 277 · see citing works
Primary progressive aphasia—differentiation from Alzheimer's disease
Mesulam, M. (1987) · Annals of Neurology · doi:10.1002/ana.410220414 · Cited by 274 · see citing works
Frontotemporal dementia (Pick’s disease): Clinical features and assessment
Hodges, J. R. (2001) · Neurology · doi:10.1212/wnl.56.suppl_4.s6 · Cited by 254 · see citing works
The pathology and nosology of primary progressive aphasia
KERTESZ, A. E., Hudson, L., Mackenzie, I. R., & Muñoz, D. G. (1994) · Neurology · doi:10.1212/wnl.44.11.2065 · Cited by 243 · see citing works
Self-citationGrossman, M., Mickanin, J., Onishi, K., Hughes, E., D’Esposito, M., Xin-sheng, D., Alavi, A. A., & Reivich, M. (1996) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1996.8.2.135 · Cited by 216 · see citing works
Language disorders in dementia of the Alzheimer type
Murdoch, B. E., Chenery, H. J., Wilks, V., & Boyle, R. S. (1987) · Brain and Language · doi:10.1016/0093-934x(87)90064-2 · Cited by 205 · see citing works
Ash, S., Moore, P., Antani, S., McCawley, G., Work, M., & Grossman, M. (2006) · Neurology · doi:10.1212/01.wnl.0000210435.72614.38 · Cited by 204 · see citing works
Cognitive and Behavioral Neurology
Finger, E. C., & Daffner, K. R. (2011) · Springer eBooks · doi:10.1007/978-0-387-88555-1_8 · Cited by 200 · see citing works
Clinical Picture of Frontal Lobe Degeneration of Non-Alzheimer Type
Gustafson, L. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107313 · Cited by 172 · see citing works
The Aphasia Quotient: The Taxonomic Approach to Measurement of Aphasic Disability
KERTESZ, A. E., & Poole, E. (2004) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100120736 · Cited by 157 · see citing works
Self-citationPrimary progressive aphasia: Diagnosis, varieties, evolution
KERTESZ, A. E., Davidson, W., MCCABE, P., TAKAGI, K., & Muñoz, D. G. (2003) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617703950041 · Cited by 156 · see citing works
Self-citationFallacies in the pathological confirmation of the diagnosis of Alzheimer’s disease
Bowler, J., Muñoz, D., Merskey, H., & Hachinski, V. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.1.18 · Cited by 148 · see citing works
The Aphasia Quotient: The Taxonomic Approach to Measurement of Aphasic Disability
KERTESZ, A. E., & Poole, E. (1974) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s031716710001951x · Cited by 128 · see citing works
Self-citationMarczinski, C. A., & KERTESZ, A. E. (2005) · Brain and Language · doi:10.1016/j.bandl.2005.11.001 · Cited by 112 · see citing works
Self-citationProfiles of language impairment in primary progressive aphasia.
Karbe, H., Kertesz, A., & Polk, M. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540020069020 · Cited by 99 · see citing works
Self-citationKertesz, A. (2003) · The Neurologist · doi:10.1097/01.nrl.0000094943.84390.cf · Cited by 92 · see citing works
Self-citationA longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia.
Marczinski, C. A., Davidson, W., & KERTESZ, A. E. (2004) · PubMed · Cited by 85 · see citing works
Self-citationKERTESZ, A. E., & Muñoz, D. G. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077155 · Cited by 76 · see citing works
Self-citationThe Dissolution of Language in Alzheimer's Disease
KERTESZ, A. E., Appell, J., & Fisman, M. (1986) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s031716710003701x · Cited by 73 · see citing works
Self-citationLanguage disturbances in corticobasal degeneration
Frattali, C., Grafman, J. H., Patronas, N. J., et al. (2000) · Neurology · doi:10.1212/wnl.54.4.990 · Cited by 73 · see citing works
Primary progressive aphasia and Pick complex
KERTESZ, A. E., & Muñoz, D. G. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00345-3 · Cited by 60 · see citing works
Self-citationA longitudinal study of sentence comprehension difficulty in primary progressive aphasia
Grossman, M. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.039966 · Cited by 58 · see citing works
Neary, D. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb01601.x · Cited by 50 · see citing works
The Neuropsychological Signature of Primary Progressive Aphasia
Zakzanis, K. K. (1999) · Brain and Language · doi:10.1006/brln.1999.2140 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Language performance in Alzheimer's disease and mild cognitive impairment: A comparative review
Taler, V., & Phillips, N. A. (2008) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390701550128 · Cited by 529 · see citing works
Mueller, K. D., Hermann, B., Mecollari, J., & Turkstra, L. S. (2018) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1446513 · Cited by 336 · see citing works
Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia
Rogalski, E., Cobia, D., Harrison, T. M., Wieneke, C., Weintraub, S., & Mesulam, M.-M. (2011) · Neurology · doi:10.1212/wnl.0b013e31821ccd3c · Cited by 252 · see citing works
Abnormalities of connected speech in semantic dementia vs Alzheimer's disease
Sajjadi, S. A., Patterson, K., Tomek, M., & Nestor, P. J. (2012) · Aphasiology · doi:10.1080/02687038.2012.654933 · Cited by 142 · see citing works
O’Connell, M. E., Crossley, M., Cammer, A., Morgan, D., Allingham, W., Cheavins, B., Dalziel, D., Lemire, M., Mitchell, S., & Morgan, E. (2014) · Dementia · doi:10.1177/1471301212474143 · Cited by 97 · see citing works
Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review
Geraudie, A., Battista, P., García, A. M., Allen, I. E., Miller, Z. A., Gorno-Tempini, M. L., & Montembeault, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.015 · Cited by 80 · see citing works
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Grossman, M., Xie, S. X., Libon, D. J., Wang, X., Massimo, L., Moore, P., Vesely, L., Berkowitz, R., Chatterjee, A., Coslett, H. B., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000303816.25065.bc · Cited by 77 · see citing works
Harciarek, M., & Cosentino, S. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.763340 · Cited by 77 · see citing works
Wicklund, A. H., Rademaker, A., Johnson, N., Weitner, B. B., & Weintraub, S. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815bf8a5 · Cited by 26 · see citing works
XIE, S. X., LIBON, D. J., WANG, X., MASSIMO, L., MOORE, P., VESELY, L., KHAN, A., CHATTERJEE, A., COSLETT, H. B., HURTIG, H. I., et al. (2010) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617709991317 · Cited by 27 · see citing works
Cognitive decline in the behavioral variant of frontotemporal dementia
Diehl-Schmid, J., Bornschein, S., Pohl, C., Förstl, H., Kurz, A., & Jahn, T. (2011) · International Psychogeriatrics · doi:10.1017/s104161021000164x · Cited by 13 · see citing works
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García, A. M., DeLeon, J., & Tee, B. L. (2022) · Encyclopedia of Behavioral Neuroscience, 2nd edition · doi:10.1016/b978-0-12-819641-0.00042-6 · Cited by 10 · see citing works
Fieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
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- Authors
- BLAIR, M., MARCZINSKI, C. A., DAVIS-FAROQUE, N., & KERTESZ, A.
- Affiliations
- St Joseph's Health Care (CA)
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-02-02
- Volume
- 13
- Issue
- 2
- Pages
- 237-245
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W2091134191
- Cited by
- 154
- References
- 47
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 10 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 13 · 2015: 6 · 2014: 5 · 2013: 12 · 2012: 7
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- language loss, Alzheimer's disease, frontotemporal dementia, behavioral variant frontotemporal dementia, primary progressive aphasia, semantic dementia, Western Aphasia Battery, language deterioration
- MeSH terms
- Aged, Alzheimer Disease, Analysis of Variance, Dementia, Female, Humans, Language Tests, Longitudinal Studies, Male, Middle Aged, Disease Progression, Aphasia, Primary Progressive, In Vitro Techniques
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