Orexins and fear: Implications for the treatment of anxiety disorders

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Entry‐into‐humans study with ACT‐462206, a novel dual orexin receptor antagonist, comparing its pharmacodynamics with almorexant

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Plasma Orexin-A Levels in COPD Patients with Hypercapnic Respiratory Failure

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Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour

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Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

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The Brainstem in Emotion: A Review

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The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders

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SB‐334867, an orexin receptor 1 antagonist, decreased seizure and anxiety in pentylenetetrazol‐kindled rats

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Facilitation of Contextual Fear Extinction by Orexin-1 Receptor Antagonism Is Associated with the Activation of Specific Amygdala Cell Subpopulations

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Activation of orexin/hypocretin neurons is associated with individual differences in cued fear extinction

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Orexin signaling during social defeat stress influences subsequent social interaction behaviour and recognition memory

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When and How Does the Auditory Cortex Influence Subcortical Auditory Structures? New Insights About the Roles of Descending Cortical Projections

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Subcortical encoding of agent-relevant associative signals for adaptive social behavior in the macaque

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International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology

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The orexin (hypocretin) neuropeptide system is a target for novel therapeutics to treat cocaine use disorder with alcohol coabuse

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Dysregulation of the orexin/hypocretin system is not limited to narcolepsy but has far‐reaching implications for neurological disorders

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Fasting enhances extinction retention and prevents the return of fear in humans

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Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons

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Manipulation of rapid eye movement sleep via orexin and GABAA receptor modulators differentially affects fear extinction in mice: effect of stable versus disrupted circadian rhythm

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Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol

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Hypocretinergic system in the medial preoptic area promotes maternal behavior in lactating rats

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Orexinergic pathway as a potential therapeutic candidate for the modulation of glucose homeostasis

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Chronic orexin-1 receptor blockage attenuates depressive behaviors and provokes PSD-95 expression in a rat model of depression

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Drug treatment strategies for insomnia in patients with post-traumatic stress disorder

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An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour

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The research domain criteria framework in drug discovery for neuropsychiatric diseases: focus on negative valence

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CO2 reactivity as a biomarker of exposure-based therapy non-response: study protocol

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Orexin A Differentially Influences the Extinction Retention of Recent and Remote Fear Memory

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Neural pathways from hypothalamic orexin neurons to the ventrolateral preoptic area mediate sleep impairments induced by conditioned fear

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Preclinical behavioral and pharmacological treatments for enhancing fear extinction in adolescence

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Hypothalamic orexins as possible therapeutic agents in threat and spatial memory disorders

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The Orexin System in Addiction: Neuromodulatory Interactions and Therapeutic Potential

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Overexpression of ORX or MCH Protects Neurological Function Against Ischemic Stroke

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Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear

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Empathy and prosocial behavior powered by orexin-driven theta oscillations

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Early life stress and hormonal status influence orexin‐1 receptor expression in structures regulating cardiorespiratory responses to CO2

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Functional Anatomy of the Structures of the Limbic System Involved in the Development of Neuropsychiatric Disorders: A Review

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Neurobiología del trastorno de estrés postraumático

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Sleep disturbances in traumatic exposure and post-traumatic stress disorder

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Sex and Orexins: Uncovering a Mechanism Underlying Sex Differences in Stress Susceptibility

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Hypocretin role in posttraumatic stress disorder-like behaviors induced by a novel stress protocol in mice

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Analysis of Anxiety Disorders and Post-Traumatic Stress Disorders for Screening Anxiolytic Drugs and Linking Preclinical and Clinical Research

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Insulin-Like Growth Factor I Modulates Vulnerability to Stress Through Orexin NeuronsPreprint

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The Hypocretin/Orexin System and Fear Learning

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Facilitation of contextual fear extinction by orexin-1 receptor antagonism is associated with the activation of specific amygdala cell subpopulations

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The orexinergic crossroads: Bidirectional links between sleep-wake disturbances and the pathogenesis of Alzheimer's disease in the aging brain

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The Hypocretin/Orexin System and Fear Learning

Flores, Á., & Berrendero, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813751-2.00008-5

The role of the orexin system in the neurobiology of anxiety disorders: Potential for a novel treatment target

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Orexin and fear; potential role of OX1R antagonist for treating anxiety disorders and PTSD

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Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit

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The underlying mechanisms of the orexin (hypocretin) system in anxiety and fear

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