Oligosaccharide Analysis by Mass Spectrometry: A Review of Recent Developments

Electrospray Ionization for Mass Spectrometry of Large Biomolecules

Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634

Protein and polymer analyses up to m/z 100 000 by laser ionization time‐of‐flight mass spectrometry

Tanaka, K., Waki, H., Ido, Y., Akita, S., Yoshida, Y., Yoshida, T., & Matsuo, T. (1988) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1290020802 · Cited by 3,175

Glycosylation in Cellular Mechanisms of Health and Disease

Ohtsubo, K., & Marth, J. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.019 · Cited by 2,788

A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates

Domon, B., & Costello, C. E. (1988) · Glycoconjugate Journal · doi:10.1007/bf01049915 · Cited by 2,729

Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry

Syka, J. E. P., Coon, J. J., Schroeder, M. J., Shabanowitz, J., & Hunt, D. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402700101 · Cited by 2,370

Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers.

Hillenkamp, F., Karas, M., Beavis, R. C., & Chait, B. T. (1991) · Analytical Chemistry · doi:10.1021/ac00024a716 · Cited by 1,930

Electron Capture Dissociation of Multiply Charged Protein Cations. A Nonergodic Process

Zubarev, R. A., Kelleher, N. L., & McLafferty, F. W. (1998) · Journal of the American Chemical Society · doi:10.1021/ja973478k · Cited by 1,881

Phases of Biomarker Development for Early Detection of Cancer

Pepe, M. S., Etzioni, R., Feng, Z., Potter, J. D., Thompson, M. L., Thornquist, M., Winget, M., & Yasui, Y. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.14.1054 · Cited by 1,686

Glycans in cancer and inflammation — potential for therapeutics and diagnostics

Dube, D. H., & Bertozzi, C. R. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1751 · Cited by 1,598

Mass spectrometry of oligosaccharides

Zaia, J. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.10073 · Cited by 804

Infrared Multiphoton Dissociation of Large Multiply Charged Ions for Biomolecule Sequencing

Little, D. P., Speir, J. P., Senko, M. W., O'Connor, P. B., & McLafferty, F. W. (1994) · Analytical Chemistry · doi:10.1021/ac00090a004 · Cited by 753

Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates

Harvey, D. J. (1999) · Mass Spectrometry Reviews · doi:10.1002/(sici)1098-2787(1999)18:6<349::aid-mas1>3.0.co;2-h · Cited by 725

Pivotal Evaluation of the Accuracy of a Biomarker Used for Classification or Prediction: Standards for Study Design

Pepe, M. S., Feng, Z., Janes, H., Bossuyt, P. M., & Potter, J. D. (2008) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djn326 · Cited by 717

Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks

Wolf-Yadlin, A., Hautaniemi, S., Lauffenburger, D. A., & White, F. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608638104 · Cited by 493

Glycan labeling strategies and their use in identification and quantification

Ruhaak, L. R., Zauner, G., Huhn, C., Bruggink, C., Deelder, A. M., & Wuhrer, M. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3532-z · Cited by 479

Glycoproteomics based on tandem mass spectrometry of glycopeptides

Wuhrer, M., Catalina, M. I., Deelder, A. M., & Hokke, C. H. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.09.041 · Cited by 415

Structural analysis of N- and O-glycans released from glycoproteins

Jensen, P. H., Karlsson, N. G., Kolarich, D., & Packer, N. H. (2012) · Nature Protocols · doi:10.1038/nprot.2012.063 · Cited by 407

Cotton HILIC SPE Microtips for Microscale Purification and Enrichment of Glycans and Glycopeptides

Selman, M. H. J., Hemayatkar, M., Deelder, A. M., & Wuhrer, M. (2011) · Analytical Chemistry · doi:10.1021/ac1027116 · Cited by 343

Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics☆

Kitteringham, N. R., Jenkins, R. E., Lane, C. S., Elliott, V. L., & Park, B. K. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.11.013 · Cited by 343

Development of an Annotated Library of Neutral Human Milk Oligosaccharides

Wu, S., Tao, N., German, J. B., Grimm, R., & Lebrilla, C. B. (2010) · Journal of Proteome Research · doi:10.1021/pr100362f · Cited by 311

GlycoBase and autoGU: tools for HPLC-based glycan analysis

Campbell, M. P., Royle, L., Radcliffe, C. M., Dwek, R. A., & Rudd, P. M. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn090 · Cited by 290

Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine

Karas, M., Bahr, U., & Dülcks, T. (2000) · Fresenius' Journal of Analytical Chemistry · doi:10.1007/s002160051561 · Cited by 275

Annotation and Structural Analysis of Sialylated Human Milk Oligosaccharides

Wu, S., Grimm, R., German, J. B., & Lebrilla, C. B. (2011) · Journal of Proteome Research · doi:10.1021/pr101006u · Cited by 268

Mass spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer

Purves, R. W., Guevremont, R., Day, S., Pipich, C. W., & Matyjaszczyk, M. S. (1998) · Review of Scientific Instruments · doi:10.1063/1.1149255 · Cited by 265

Derivatization of carbohydrates for analysis by chromatography; electrophoresis and mass spectrometry

Harvey, D. J. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.11.010 · Cited by 260

Mass Spectrometry and the Emerging Field of Glycomics

Zaia, J. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.07.016 · Cited by 252

Native ion mobility-mass spectrometry and related methods in structural biology

Konijnenberg, A., Butterer, A., & Sobott, F. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.11.013 · Cited by 245

Mass Spectrometry and Glycomics

Zaia, J. (2010) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2009.0146 · Cited by 242

Negative-Ion Electrospray Mass Spectrometry of Neutral Underivatized Oligosaccharides

Chai, W., Piskarev, V., & Lawson, A. M. (2001) · Analytical Chemistry · doi:10.1021/ac0010126 · Cited by 221

Chemical Technologies for Probing Glycans

Prescher, J. A., & Bertozzi, C. R. (2006) · Cell · doi:10.1016/j.cell.2006.08.017 · Cited by 215

Hydrophilic Interaction Chromatography-Based High-Throughput Sample Preparation Method for N-Glycan Analysis from Total Human Plasma Glycoproteins

Ruhaak, L. R., Huhn, C., Waterreus, W.-J., de Boer, A. R., Neusüss, C., Hokke, C. H., Deelder, A. M., & Wuhrer, M. (2008) · Analytical Chemistry · doi:10.1021/ac800630x · Cited by 208

Regulation of Glycan Structures in Animal Tissues

Nairn, A. V., York, W. S., Harris, K., Hall, E. M., Pierce, J. M., & Moremen, K. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801964200 · Cited by 206

Oligosaccharide analysis by graphitized carbon liquid chromatography–mass spectrometry

Ruhaak, L. R., Deelder, A. M., & Wuhrer, M. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2664-5 · Cited by 201

Collision-induced dissociation with Fourier transform mass spectrometry

Cody, R. B., Burnier, R. C., & Freiser, B. S. (1982) · Analytical Chemistry · doi:10.1021/ac00238a029 · Cited by 201

Characterizing ion mobility-mass spectrometry conformation space for the analysis of complex biological samples

Fenn, L. S., Kliman, M., Mahsut, A., Zhao, S. R., & McLean, J. A. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2666-3 · Cited by 198

Comparison of the Human and Bovine Milk N-Glycome via High-Performance Microfluidic Chip Liquid Chromatography and Tandem Mass Spectrometry

Nwosu, C. C., Aldredge, D. L., Lee, H., Lerno, L. A., Zivkovic, A. M., German, J. B., & Lebrilla, C. B. (2012) · Journal of Proteome Research · doi:10.1021/pr300008u · Cited by 193

Recent advances in hydrophilic interaction liquid chromatography (HILIC) for structural glycomics

Zauner, G., Deelder, A. M., & Wuhrer, M. (2011) · ELECTROPHORESIS · doi:10.1002/elps.201100247 · Cited by 192

Complementary Structural Information from a Tryptic N-Linked Glycopeptide via Electron Transfer Ion/Ion Reactions and Collision-Induced Dissociation

Hogan, J. M., Pitteri, S. J., Chrisman, P. A., & McLuckey, S. A. (2005) · Journal of Proteome Research · doi:10.1021/pr049770q · Cited by 190

Determination of site-specific glycan heterogeneity on glycoproteins

Kolarich, D., Jensen, P. H., Altmann, F., & Packer, N. H. (2012) · Nature Protocols · doi:10.1038/nprot.2012.062 · Cited by 188

The proteoglycan bikunin has a defined sequence

Ly, M., Leach, F. E., Laremore, T. N., Toida, T., Amster, I. J., & Linhardt, R. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.673 · Cited by 184

Annotation and structural elucidation of bovine milk oligosaccharides and determination of novel fucosylated structures

Aldredge, D. L., Geronimo, M. R., Hua, S., Nwosu, C. C., Lebrilla, C. B., & Barile, D. (2013) · Glycobiology · doi:10.1093/glycob/cwt007 · Cited by 180

Electron detachment dissociation of glycosaminoglycan tetrasaccharides

Wolff, J. J., Amster, I. J., Chi, L., & Linhardt, R. J. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.09.020 · Cited by 179

Identification of protein-bound carbohydrates by mass spectrometry

Harvey, D. J. (2001) · PROTEOMICS · Cited by 169

GlycReSoft: A Software Package for Automated Recognition of Glycans from LC/MS Data

Maxwell, E., Tan, Y., Tan, Y., Hu, H., Benson, G., Aizikov, K., Conley, S., Staples, G. O., Slysz, G. W., Smith, R. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045474 · Cited by 168

Structural resolution of carbohydrate positional and structural isomers based on gas-phase ion mobility-mass spectrometry

Fenn, L. S., & McLean, J. A. (2011) · Phys. Chem. Chem. Phys. · doi:10.1039/c0cp01414a · Cited by 167

Comparison of hydrophilic-interaction, reversed-phase and porous graphitic carbon chromatography for glycan analysis

Melmer, M., Stangler, T., Premstaller, A., & Lindner, W. F. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.10.122 · Cited by 164

Comparative Glycomic Mapping through Quantitative Permethylation and Stable-Isotope Labeling

Kang, P., Mechref, Y., Kyselova, Z., Goetz, J. A., & Novotny, M. V. (2007) · Analytical Chemistry · doi:10.1021/ac062098r · Cited by 163

Combining High-Energy C-Trap Dissociation and Electron Transfer Dissociation for Protein O-GlcNAc Modification Site Assignment

Zhao, P., Viner, R., Teo, C. F., Boons, G.-J., Horn, D., & Wells, L. (2011) · Journal of Proteome Research · doi:10.1021/pr2002726 · Cited by 161

Site-Specific Glycan-Peptide Analysis for Determination of N-Glycoproteome Heterogeneity

Parker, B. L., Thaysen‐Andersen, M., Solis, N., Scott, N. E., Larsen, M. R., Graham, M. E., Packer, N. H., & Cordwell, S. J. (2013) · Journal of Proteome Research · doi:10.1021/pr400783j · Cited by 159

Tools for glycomics: relative quantitation of glycans by isotopic permethylation using 13CH3I

Álvarez-Manilla, G., Warren, N. L., Abney, T., Atwood, J., Azadi, P., York, W. S., Pierce, M., & Orlando, R. (2007) · Glycobiology · doi:10.1093/glycob/cwm033 · Cited by 157

Comprehensive native glycan profiling with isomer separation and quantitation for the discovery of cancer biomarkers

Hua, S. S., An, H. J., Özcan, S., Ro, G. S., Soares, S., White, R. D., & Lebrilla, C. B. (2011) · The Analyst · doi:10.1039/c1an15093f · Cited by 154

Application of Fourier transform ion cyclotron resonance mass spectrometry to oligosaccharides

Park, Y., & Lebrilla, C. B. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20010 · Cited by 151

Quantitation by Isobaric Labeling: Applications to Glycomics

Atwood, J., Cheng, L., Álvarez-Manilla, G., Warren, N. L., York, W. S., & Orlando, R. (2007) · Journal of Proteome Research · doi:10.1021/pr070476i · Cited by 149

Negative Electron Transfer Dissociation of Glycosaminoglycans

Wolff, J. J., Leach, F. E., Laremore, T. N., Kaplan, D. A., Easterling, M. L., Linhardt, R. J., & Amster, I. J. (2010) · Analytical Chemistry · doi:10.1021/ac100554a · Cited by 147

Mass spectrometric glycan rearrangements

Wuhrer, M., Deelder, A. M., & van der Burgt, Y. E. M. (2011) · Mass Spectrometry Reviews · doi:10.1002/mas.20337 · Cited by 146

Quantification of Bovine Milk Oligosaccharides Using Liquid Chromatography–Selected Reaction Monitoring–Mass Spectrometry

Fong, B., Ma, L., & McJarrow, P. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202035m · Cited by 146

Glycomics using mass spectrometry

Wuhrer, M. (2012) · Glycoconjugate Journal · doi:10.1007/s10719-012-9376-3 · Cited by 145

Ion Mobility–Mass Spectrometry of Complex Carbohydrates: Collision Cross Sections of Sodiated N-linked Glycans

Pagel, K., & Harvey, D. J. (2013) · Analytical Chemistry · doi:10.1021/ac400403d · Cited by 144

Method for milk oligosaccharide profiling by 2-aminobenzamide labeling and hydrophilic interaction chromatography

Mariño, K. V., Lane, J. A., Abrahams, J. L., Struwe, W. B., Harvey, D. J., Marotta, M., Hickey, R. M., & Rudd, P. M. (2011) · Glycobiology · doi:10.1093/glycob/cwr067 · Cited by 143

UniCarb-DB: a database resource for glycomic discovery

Hayes, C. A., Karlsson, N. G., Struwe, W. B., Lisacek, F., Rudd, P. M., Packer, N. H., & Campbell, M. P. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr137 · Cited by 142

Profile of native N‐linked glycan structures from human serum using high performance liquid chromatography on a microfluidic chip and time‐of‐flight mass spectrometry

Chu, C. S., Niñonuevo, M. R., Clowers, B. H., et al. (2009) · PROTEOMICS · doi:10.1002/pmic.200800249 · Cited by 140

Oligosaccharide sequencing technology

Rudd, P. M., Gulle, G. R., Küster, B., Harvey, D. J., Opdenakker, G., & Dwek, R. A. (1997) · Nature · doi:10.1038/40677 · Cited by 139

Negative ion graphitised carbon nano‐liquid chromatography/mass spectrometry increases sensitivity for glycoprotein oligosaccharide analysis

Karlsson, N. G., Wilson, N. L., Wirth, H., Dawes, P. A., Joshi, H. J., & Packer, N. H. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1626 · Cited by 134

Nanoliquid chromatography‐mass spectrometry of oligosaccharides employing graphitized carbon chromatography on microchip with a high‐accuracy mass analyzer

Niñonuevo, M. R., An, H. J., Yin, H., Killeen, K., Grimm, R., Ward, R. E., German, B. J., & Lebrilla, C. B. (2005) · Electrophoresis · doi:10.1002/elps.200500246 · Cited by 132

Structural determination of N‐linked glycans by matrix‐assisted laser desorption/ionization and electrospray ionization mass spectrometry

Harvey, D. J. (2005) · PROTEOMICS · doi:10.1002/pmic.200401248 · Cited by 126

Carbonyl-Reactive Tandem Mass Tags for the Proteome-Wide Quantification of N-Linked Glycans

Hahne, H., Neubert, P., Kuhn, K., Etienne, C. L., Bomgarden, R. D., Rogers, J. C., & Küster, B. (2012) · Analytical Chemistry · doi:10.1021/ac300197c · Cited by 125

IDAWG: Metabolic Incorporation of Stable Isotope Labels for Quantitative Glycomics of Cultured Cells

Orlando, R., Lim, J., Atwood, J., Angel, P. M., Fang, M., Aoki, K., Álvarez-Manilla, G., Moremen, K. W., York, W. S., Tiemeyer, M., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr8010028 · Cited by 122

Annotation of a Serum N-Glycan Library for Rapid Identification of Structures

Aldredge, D. L., An, H. J., Tang, N., Waddell, K., & Lebrilla, C. B. (2012) · Journal of Proteome Research · doi:10.1021/pr2011439 · Cited by 121

Quantification of neutral human milk oligosaccharides by graphitic carbon high-performance liquid chromatography with tandem mass spectrometry

Bao, Y., Chen, C., & Newburg, D. S. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.10.003 · Cited by 121

Separation and Identification of Isomeric Glycopeptides by High Field Asymmetric Waveform Ion Mobility Spectrometry

Creese, A. J., & Cooper, H. J. (2012) · Analytical Chemistry · doi:10.1021/ac203321y · Cited by 114

Electron Transfer Dissociation of Milk Oligosaccharides

Han, L., & Costello, C. E. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0117-9 · Cited by 113

Disaccharide analysis of glycosaminoglycan mixtures by ultra-high-performance liquid chromatography–mass spectrometry

Yang, B., Chang, Y., Weyers, A. M., Sterner, E., & Linhardt, R. J. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.12.063 · Cited by 111

Structure elucidation of native N‐ and O‐linked glycans by tandem mass spectrometry (tutorial)

An, H. J., & Lebrilla, C. B. (2010) · Mass Spectrometry Reviews · doi:10.1002/mas.20283 · Cited by 109

Efficient analysis of urinary glycosaminoglycans by LC-MS/MS in mucopolysaccharidoses type I, II and VI

Auray‐Blais, C., Bhérer, P., Gagnon, R., Young, S. P., Zhang, H. H., An, Y., Clarke, J. T. R., & Millington, D. S. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2010.09.003 · Cited by 109

Mass spectrometry of glycans

Han, L., & Costello, C. E. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913070031 · Cited by 108

The GH18 family of chitinases: Their domain architectures, functions and evolutions

Huang, Q., Xie, X., Liang, G., Gong, F., Wang, Y., Wei, X., Wang, Q., Ji, Z., & Chen, Q. (2011) · Glycobiology · doi:10.1093/glycob/cwr092 · Cited by 106

A chip‐based amide‐HILIC LC/MS platform for glycosaminoglycan glycomics profiling

Staples, G. O., Bowman, M. J., Costello, C. E., Hitchcock, A. M., Lau, J. M., Leymarie, N., Miller, C., Naimy, H., Shi, X., & Zaia, J. (2009) · PROTEOMICS · doi:10.1002/pmic.200701008 · Cited by 102

A quantitative and comprehensive method to analyze human milk oligosaccharide structures in the urine and feces of infants

Leoz, M. L. A. D., Wu, S., Strum, J. S., Niñonuevo, M. R., Gaerlan, S. C., Mirmiran, M., German, J. B., Mills, D. A., Lebrilla, C. B., & Underwood, M. A. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-6817-1 · Cited by 100

Semi-Automated Identification of N-Glycopeptides by Hydrophilic Interaction Chromatography, nano-Reverse-Phase LC–MS/MS, and Glycan Database Search

Pompach, P., Chandler, K. B., Lan, R. S.-L., Edwards, N. J., & Goldman, R. (2012) · Journal of Proteome Research · doi:10.1021/pr201183w · Cited by 99

Glycopeptide Analysis, Recent Developments and Applications

Desaire, H. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r112.026567 · Cited by 99

Heparin Characterization: Challenges and Solutions

Jones, C. J., Béni, S., Limtiaco, J. F. K., Langeslay, D. J., & Larive, C. K. (2011) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061010-113911 · Cited by 99

Characterizing plant cell wall derived oligosaccharides using hydrophilic interaction chromatography with mass spectrometry detection

Leijdekkers, A. G. M., Sanders, M. G., Schols, H. A., & Gruppen, H. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.10.068 · Cited by 90

Gas-Phase Electron Transfer Reactions from Multiply-Charged Anions to Rare Gas Cations

Herron, W. J., Goeringer, D. E., & McLuckey, S. A. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00151a021 · Cited by 89

Structural Analysis of Bikunin Glycosaminoglycan

Chi, L., Wolff, J. J., Laremore, T. N., Restaino, O. F., Xie, J., Schiraldi, C., Toida, T., Amster, I. J., & Linhardt, R. J. (2008) · Journal of the American Chemical Society · doi:10.1021/ja0778500 · Cited by 86

Complete Mass Spectral Characterization of a Synthetic Ultralow-Molecular-Weight Heparin Using Collision-Induced Dissociation

Kailemia, M. J., Li, L., Ly, M., Linhardt, R. J., & Amster, I. J. (2012) · Analytical Chemistry · doi:10.1021/ac3015824 · Cited by 86

Isomer-specific chromatographic profiling yields highly sensitive and specific potential N-glycan biomarkers for epithelial ovarian cancer

Hua, S. S., Williams, C. C., Dimapasoc, L. M., Ro, G. S., Özcan, S., Miyamoto, S., Lebrilla, C. B., An, H. J., & Leiserowitz, G. S. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.12.079 · Cited by 83

Negative-Ion Electron Capture Dissociation: Radical-Driven Fragmentation of Charge-Increased Gaseous Peptide Anions

Yoo, H. J., Wang, N., Zhuang, S., Song, H., & Håkansson, K. (2011) · Journal of the American Chemical Society · doi:10.1021/ja207736y · Cited by 82

Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry

Walker, S. H., Lilley, L. M., Enamorado, M. F., Comins, D. L., & Muddiman, D. C. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0140-x · Cited by 79

Quantification of glycopeptides by multiple reaction monitoring liquid chromatography/tandem mass spectrometry

Song, E., Pyreddy, S., & Mechref, Y. S. (2012) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.6290 · Cited by 78

Highly Sensitive MALDI Analyses of Glycans by a New Aminoquinoline-Labeling Method Using 3-Aminoquinoline/α-Cyano-4-hydroxycinnamic Acid Liquid Matrix

Kaneshiro, K., Fukuyama, Y., Iwamoto, S., Sekiya, S., & Tanaka, K. (2011) · Analytical Chemistry · doi:10.1021/ac103203v · Cited by 76

Ion mobility mass spectrometry for peptide analysis

Harvey, S. R., MacPhee, C. E., & Barran, P. E. (2011) · Methods · doi:10.1016/j.ymeth.2011.05.004 · Cited by 76

Mannose7 Glycan Isomer Characterization by IMS-MS/MS Analysis

Zhu, F., Lee, S., Valentine, S. J., Reilly, J. P., & Clemmer, D. E. (2012) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-012-0491-y · Cited by 75

Automated glycopeptide analysis--review of current state and future directions

Dallas, D. C., Martin, W. F., Hua, S. S., & German, J. B. (2012) · Briefings in Bioinformatics · doi:10.1093/bib/bbs045 · Cited by 75

193 nm Ultraviolet Photodissociation of Deprotonated Sialylated Oligosaccharides

Ko, B. J., & Brodbelt, J. S. (2011) · Analytical Chemistry · doi:10.1021/ac201751u · Cited by 73

Methods for the quantitation of human milk oligosaccharides in bacterial fermentation by mass spectrometry

Niñonuevo, M. R., Ward, R. E., LoCascio, R. G., German, J. B., Freeman, S. L., Barboza, M., Mills, D. A., & Lebrilla, C. B. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.11.010 · Cited by 71

Characterization of glycoprotein digests with hydrophilic interaction chromatography and mass spectrometry

Gilár, M., Yu, Y., Ahn, J., Xie, H., Han, H., Ying, W., & Qian, X. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.05.028 · Cited by 71

Ion Mobility Mass Spectrometry for Extracting Spectra of N-Glycans Directly from Incubation Mixtures Following Glycan Release: Application to Glycans from Engineered Glycoforms of Intact, Folded HIV gp120

Harvey, D. J., Sobott, F., Crispin, M., et al. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-010-0053-0 · Cited by 68

Ultra-performance ion-pairing liquid chromatography with on-line electrospray ion trap mass spectrometry for heparin disaccharide analysis

Yang, B., Weyers, A. M., Baik, J. Y., Sterner, E., Sharfstein, S. T., Mousa, S. A., Zhang, F., Dordick, J. S., & Linhardt, R. J. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.04.003 · Cited by 68

Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas

Fasciotti, M., Sanvido, G. B., Santos, V. G., et al. (2012) · Journal of Mass Spectrometry · doi:10.1002/jms.3089 · Cited by 66

Use of graphitised carbon negative ion LC–MS to analyse enzymatically digested glycosaminoglycans

Karlsson, N. G., Schulz, B. L., Packer, N. H., & Whitelock, J. M. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.07.014 · Cited by 66

Hyphenated techniques for the analysis of heparin and heparan sulfate

Yang, B., Solakyildirim, K., Chang, Y., & Linhardt, R. J. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4117-6 · Cited by 65

Reversed-phase liquid-chromatographic mass spectrometric N-glycan analysis of biopharmaceuticals

Higel, F., Demelbauer, U. M., Seidl, A., Frieß, W., & Sörgel, F. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6690-3 · Cited by 64

Comparative Glycomics Using a Tetraplex Stable-Isotope Coded Tag

Bowman, M. J., & Zaia, J. (2010) · Analytical Chemistry · doi:10.1021/ac100108w · Cited by 64

Software for automated interpretation of mass spectrometry data from glycans and glycopeptides

Woodin, C. L., Maxon, M., & Desaire, H. (2012) · The Analyst · doi:10.1039/c2an36042j · Cited by 64

Hydrophilic interaction liquid chromatography coupled to mass spectrometry for the characterization of prebiotic galactooligosaccharides

Hernández‐Hernández, O., Calvillo, I., Lebrón‐Aguilar, R., et al. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.11.047 · Cited by 64

N -Glycan Profiling of Dried Blood Spots

Ruhaak, L. R., Miyamoto, S., Kelly, K. L., & Lebrilla, C. B. (2011) · Analytical Chemistry · doi:10.1021/ac202775t · Cited by 64

Preparation, Separation, and Conformational Analysis of Differentially Sulfated Heparin Octasaccharide Isomers Using Ion Mobility Mass Spectrometry

Seo, Y., Andaya, A., & Leary, J. A. (2012) · Analytical Chemistry · doi:10.1021/ac203190k · Cited by 58

Rapid profiling of bovine and human milk gangliosides by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry

Lee, H., An, H. J., Lerno, L., German, J. B., & Lebrilla, C. B. (2010) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2010.10.020 · Cited by 56

Online Reverse Phase-High-Performance Liquid Chromatography-Fluorescence Detection-Electrospray Ionization-Mass Spectrometry Separation and Characterization of Heparan Sulfate, Heparin, and Low-Molecular Weight-Heparin Disaccharides Derivatized with 2-Aminoacridone

Galeotti, F., & Volpi, N. (2011) · Analytical Chemistry · doi:10.1021/ac201426e · Cited by 56

Confident identification of isomeric N ‐glycan structures by combined ion mobility mass spectrometry and hydrophilic interaction liquid chromatography

Yamaguchi, Y., Nishima, W., Re, S., et al. (2012) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.6412 · Cited by 56

Monolithic Capillary Column Based Glycoproteomic Reactor for High-Sensitive Analysis of N-Glycoproteome

Liu, J., Wang, F., Lin, H., Zhu, J., Bian, Y., Cheng, K., & Zou, H. (2013) · Analytical Chemistry · doi:10.1021/ac400315n · Cited by 55

Characterization of O-Sulfopeptides by Negative Ion Mode Tandem Mass Spectrometry: Superior Performance of Negative Ion Electron Capture Dissociation

Hersberger, K. E., & Håkansson, K. (2012) · Analytical Chemistry · doi:10.1021/ac301536r · Cited by 54

Travelling wave ion mobility and negative ion fragmentation for the structural determination of N‐linked glycans

Harvey, D. J., Scarff, C. A., Edgeworth, M. J., Crispin, M., Scanlan, C. N., Sobott, F., Allman, S. A., Baruah, K., Pritchard, L. K., & Scrivens, J. H. (2013) · Electrophoresis · doi:10.1002/elps.201200669 · Cited by 53

Rapid glycopeptide enrichment and N-glycosylation site mapping strategies based on amine-functionalized magnetic nanoparticles

Kuo, C., Wu, I., Hsiao, H., & Khoo, K. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-5724-1 · Cited by 53

Toward a Platform for Comprehensive Glycan Sequencing

Reinhold, V. N., Zhang, H., Hanneman, A. J. S., & Ashline, D. J. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r112.026823 · Cited by 52

LC-MSn Analysis of Isomeric Chondroitin Sulfate Oligosaccharides Using a Chemical Derivatization Strategy

Huang, R., Pomin, V. H., & Sharp, J. S. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0174-0 · Cited by 51

Hexuronic Acid Stereochemistry Determination in Chondroitin Sulfate Glycosaminoglycan Oligosaccharides by Electron Detachment Dissociation

Leach, F. E., Ly, M., Laremore, T. N., Wolff, J. J., Perlow, J., Linhardt, R. J., & Amster, I. J. (2012) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-012-0428-5 · Cited by 50

Delineating Diseases by IMS-MS Profiling of Serum N-linked Glycans

Isailović, D., Plasencia, M. D., Gaye, M. M., Stokes, S. T., Kurulugama, R. T., Pungpapong, V., Zhang, M., Kyseľová, Z., Goldman, R., Mechref, Y. S., et al. (2011) · Journal of Proteome Research · doi:10.1021/pr200777u · Cited by 50

Ion Mobility-Mass Spectrometry Analysis of Serum N-linked Glycans from Esophageal Adenocarcinoma Phenotypes

Gaye, M. M., Valentine, S. J., Hu, Y., Mirjankar, N., Hammoud, Z. T., Mechref, Y. S., Lavine, B. K., & Clemmer, D. E. (2012) · Journal of Proteome Research · doi:10.1021/pr300756e · Cited by 49

Quantitative Structural Characterization of Local N-Glycan Microheterogeneity in Therapeutic Antibodies by Energy-Resolved Oxonium Ion Monitoring

Toyama, A., Nakagawa, H., Matsuda, K., Sato, T., Nakamura, Y., & Ueda, K. (2012) · Analytical Chemistry · doi:10.1021/ac3023372 · Cited by 49

Characterization of galactooligosaccharides derived from lactulose

Hernández‐Hernández, O., Montañés, F., Clemente, A., Moreno, F. J., & Sanz, M. L. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.05.029 · Cited by 49

The glycolyzer: Automated glycan annotation software for high performance mass spectrometry and its application to ovarian cancer glycan biomarker discovery

Kronewitter, S. R., Leoz, M. L. A. D., Strum, J. S., An, H. J., Dimapasoc, L. M., Guerrero, A., Miyamoto, S., Lebrilla, C. B., & Leiserowitz, G. S. (2012) · PROTEOMICS · doi:10.1002/pmic.201100273 · Cited by 48

Glycan profiling of monoclonal antibodies using zwitterionic-type hydrophilic interaction chromatography coupled with electrospray ionization mass spectrometry detection

Mauko, L., Nordborg, A., Hutchinson, J. P., Lacher, N. A., Hilder, E. F., & Haddad, P. R. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.09.035 · Cited by 47

Mass Spectrometric Analysis of Sulfated N- and O-Glycans

Khoo, K., & Yu, S. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)78001-0 · Cited by 46

In-Gel Nonspecific Proteolysis for Elucidating Glycoproteins: A Method for Targeted Protein-Specific Glycosylation Analysis in Complex Protein Mixtures

Nwosu, C. C., Huang, J., Aldredge, D. L., Strum, J. S., Hua, S. S., Seipert, R. R., & Lebrilla, C. B. (2012) · Analytical Chemistry · doi:10.1021/ac302574f · Cited by 45

Relative quantitation of glycosylation variants by stable isotope labeling of enzymatically released N-glycans using [12C]/[13C] aniline and ZIC-HILIC-ESI-TOF-MS

Giménez, E., Sanz‐Nebot, V., & Rizzi, A. M. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7178-5 · Cited by 42

Discovery and Structural Characterization of Fucosylated Oligomannosidic N-Glycans in Mushrooms

Grass, J., Pabst, M., Kolarich, D., Pöltl, G., Léonard, R., Brecker, L., & Altmann, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.191304 · Cited by 41

Functional roles of glycogene and N‐glycan in multidrug resistance of human breast cancer cells

Ma, H., Miao, X., Ma, Q., Zheng, W., Zhou, H., & Li, J. (2013) · IUBMB Life · doi:10.1002/iub.1133 · Cited by 40

Comparison of ZIC-HILIC and graphitized carbon-based analytical approaches combined with exoglycosidase digestions for analysis of glycans from monoclonal antibodies

Mauko, L., Lacher, N. A., Pelzing, M., Nordborg, A., Haddad, P. R., & Hilder, E. F. (2012) · Journal of Chromatography B · doi:10.1016/j.jchromb.2012.10.043 · Cited by 39

Structural Analysis of N-Glycans by the Glycan-Labeling Method Using 3-Aminoquinoline-Based Liquid Matrix in Negative-Ion MALDI-MS

Nishikaze, T., Kaneshiro, K., Kawabata, S.-I., & Tanaka, K. (2012) · Analytical Chemistry · doi:10.1021/ac302286e · Cited by 39

Glycopeptide Enrichment for MALDI-TOF Mass Spectrometry Analysis by Hydrophilic Interaction Liquid Chromatography Solid Phase Extraction (HILIC SPE)

Jensen, P. H., Mysling, S., Højrup, P., & Jensen, O. N. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-146-2_10 · Cited by 39

Chip-based nLC-TOF-MS is a highly stable technology for large-scale high-throughput analyses

Ruhaak, L. R., Taylor, S. L., Miyamoto, S., Kelly, K. L., Leiserowitz, G. S., Gandara, D. R., Lebrilla, C. B., & Kim, K. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-6908-z · Cited by 38

Enrichment strategies in glycomics based lung cancer biomarker development

Ruhaak, L., Nguyen, U., Stroble, C., Taylor, S. L., Taguchi, A., Hanash, S., Lebrilla, C., Kim, K., & Miyamoto, S. (2013) · PROTEOMICS - Clinical Applications · doi:10.1002/prca.201200131 · Cited by 38

Mass Spectrometric Method for Determining the Uronic Acid Epimerization in Heparan Sulfate Disaccharides Generated Using Nitrous Acid

Gill, V. L., Wang, Q., Shi, X., & Zaia, J. (2012) · Analytical Chemistry · doi:10.1021/ac3016054 · Cited by 37

Cytology by infrared micro-spectroscopy: Automatic distinction of cell types in urinary cytology

Bird, B., Romeo, M., Diem, M., Bedrossian, K., Laver, N., & Naber, S. P. (2008) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2008.03.006 · Cited by 36

In-Depth Characterization of N-Linked Oligosaccharides Using Fluoride-Mediated Negative Ion Microfluidic Chip LC–MS

Ni, W., Bones, J., & Karger, B. L. (2013) · Analytical Chemistry · doi:10.1021/ac3031898 · Cited by 36

Selective Enhancement of Carbohydrate Ion Abundances by Diamond Nanoparticles for Mass Spectrometric Analysis

Wu, C., Wang, C.-C., Lai, Y., Lee, H., Lin, J.-D., Lee, Y. T., & Wang, Y. (2013) · Analytical Chemistry · doi:10.1021/ac3036469 · Cited by 35

Structural Separations by Ion Mobility-MS for Glycomics and Glycoproteomics

Fenn, L. S., & MCLEAN, J. A. J. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-146-2_12 · Cited by 35

High performance IT-MSn sequencing of glycans

Jiao, J., Zhang, H., & Reinhold, V. N. (2011) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2011.01.016 · Cited by 34

Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry

Zhou, W., & Håkansson, K. (2011) · Current Proteomics · doi:10.2174/157016411798220826 · Cited by 31

Mass Spectrometry of Carbohydrates: Newer Aspects

Rodrigues, J. A., Taylor, A. M., Sumpton, D. P., Reynolds, J. C., Pickford, R., & THOMAS‐OATES, J. E. (2007) · Advances in carbohydrate chemistry and biochemistry · doi:10.1016/s0065-2318(07)61003-8 · Cited by 26

Glycosaminoglycan Characterization by Electrospray Ionization Mass Spectrometry Including Fourier Transform Mass Spectrometry

Laremore, T. N., Leach, F. E., Solakyildirim, K., Amster, I. J., & Linhardt, R. J. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)78003-4 · Cited by 25

Electron capture dissociation of divalent metal-adducted sulfated oligosaccharides

Liu, H., & Håkansson, K. (2010) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2010.10.030 · Cited by 25

Databases and Tools in Glycobiology

Artemenko, N. V., McDonald, A. G., Davey, G. P., & Rudd, P. M. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-921-1_21 · Cited by 24

Identification and Accurate Quantitation of Biological Oligosaccharide Mixtures

Strum, J. S., Kim, J., Wu, S., Leoz, M. L. A. D., Peacock, K. S., Grimm, R., German, J. B., Mills, D. A., & Lebrilla, C. B. (2012) · Analytical Chemistry · doi:10.1021/ac301128s · Cited by 23

Understanding the Effect of the Counterion on the Reverse-Phase Ion-Pair High-Performance Liquid Chromatography (RPIP-HPLC) Resolution of Heparin-Related Saccharide Anomers

Jones, C. J., Béni, S., & Larive, C. K. (2011) · Analytical Chemistry · doi:10.1021/ac2013724 · Cited by 22

Profiling glycol-split heparins by high-performance liquid chromatography/mass spectrometry analysis of their heparinase-generated oligosaccharides

Alekseeva, A., Casu, B., Torri, G., Pierro, S., & Naggi, A. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.11.011 · Cited by 21

Typing of Blood-Group Antigens on Neutral Oligosaccharides by Negative-Ion Electrospray Ionization Tandem Mass Spectrometry

Zhang, H., Zhang, S., Tao, G., Zhang, Y., Mulloy, B., Zhan, X., & Chai, W. (2013) · Analytical Chemistry · doi:10.1021/ac400700e · Cited by 21

Targeted analysis of glycomics liquid chromatography/mass spectrometry data

Dreyfuss, J. M., Jacobs, C. L., Gindin, Y., Benson, G., Staples, G. O., & Zaia, J. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4235-1 · Cited by 20

Fragmentation of neutral oligosaccharides using the MALDI LTQ Orbitrap

Rohmer, M., Baeumlisberger, D., Stahl, B., et al. (2010) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2010.11.008 · Cited by 17

Quantitative Analysis of Glycoprotein Glycans

Orlando, R. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-146-2_13 · Cited by 15

Novel data analysis tool for semiquantitative LC-MS-MS2 profiling of N-glycans

Peltoniemi, H., Natunen, S., Ritamo, I., Valmu, L., & Räbinä, J. (2012) · Glycoconjugate Journal · doi:10.1007/s10719-012-9412-3 · Cited by 14

Click aspartic acid as H ILIC SPE material for selective enrichment of N-linked glycopeptides

Li, X., Shen, G., Zhang, F., Yang, B., & Liang, X. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.10.003 · Cited by 11

Mass spectrometry approaches to glycomic and glycoproteomic analyses

Ruhaak, L. R., Xu, G., Li, Q., Goonatilleke, E., & Lebrilla, C. B. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00732 · Cited by 395

Functional and nutraceutical properties of fructo-oligosaccharides derivatives: A review

Rahim, M. A., Saeed, F., Khalid, W., Hussain, M., & Anjum, F. M. (2021) · International Journal of Food Properties · doi:10.1080/10942912.2021.1986520 · Cited by 108

Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry for Quantitative Analysis of Glycans Labeled with Multiplex Carbonyl-Reactive Tandem Mass Tags

Zhong, X., Chen, Z., Snovida, S., Liu, Y., Rogers, J. C., & Li, L. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01835 · Cited by 92

Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2013–2014

Harvey, D. J. (2018) · Mass Spectrometry Reviews · doi:10.1002/mas.21530 · Cited by 61