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Cited by 296

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Label-Free Plasmonic Detection of Biomolecular Binding by a Single Gold Nanorod

Open access
Nusz, Greg J., Marinakos, Stella M., Curry, Adam C., Dahlin, Andreas, Höök, Fredrik, Wax, Adam, Chilkoti, Ashutosh·2008·Analytical Chemistry

Abstract

We report the use of individual gold nanorods as plasmonic transducers to detect the binding of streptavidin to individual biotin-conjugated nanorods in real time on a surface. Label-free detection at the single-nanorod level was performed by tracking the wavelength shift of the nanorod-localized surface plasmon resonant scattering spectrum using a dark-field microspectroscopy system. The lowest streptavidin concentration that was experimentally measured was 1 nM, which is a factor of 1000-fold lower than the previously reported detection limit for streptavidin binding by biotinylated single plasmonic nanostructures. We believe that the current optical setup is able to reliably measure wavelength shifts as small as 0.3 nm. Binding of streptavidin at 1 nM concentration induces a mean resonant wavelength shift of 0.59 nm suggesting that we are currently operating at close to the limit of detection of the system.

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Metadata

Authors
Nusz, G. J., Marinakos, S. M., Curry, A. C., Dahlin, A., Höök, F., Wax, A., & Chilkoti, A.
Venue
Analytical Chemistry
Published
2008-01-16
Volume
80
Issue
4
Pages
984-989
ISSN
  • 0003-2700 (ISSN-L)
  • 1520-6882
OpenAlex
W1966226618
Cited by
296
References
36
FWCI
11.02
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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