Increased In Vivo Glucose Recovery via Nitric Oxide Release
Open accessAbstract
The in vivo glucose recovery of subcutaneously implanted nitric oxide (NO)-releasing microdialysis probes was evaluated in a rat model using saturated NO solutions to steadily release NO. Such methodology resulted in a constant NO flux of 162 pmol cm(-2) s(-1) from the probe membrane over 8 h of perfusion daily. The in vivo effects of enhanced localized NO were evaluated by monitoring glucose recovery over a 14 day period, with histological analysis thereafter. A difference in glucose recovery was observed starting at 7 days for probes releasing NO relative to controls. Histological analysis at 14 days revealed lessened inflammatory cell density at the probe surface and decreased capsule thickness. Collectively, the results suggest that intermittent sustained NO release from implant surfaces may improve glucose diffusion for subcutaneously implanted sensors by mitigating the foreign body reaction.
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Nitric oxide-releasing microdialysis probes after 7 days recovered larger glucose concentrations compared to controls, indicating lower resistance to mass transfer in the surrounding tissue.
“The NO-releasing probes after 7 d were reported to recover larger glucose concentrations compared to controls (Figure 4), indicating lower resistance to mass transfer in the surrounding tissue.”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [239]
The authors concluded that the mitigated foreign body response by nitric oxide release was at least partially responsible for the superior glucose recovery.
“The authors concluded that the mitigated FBR by NO release was thus at least partially responsible for the superior glucose recovery.”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [239]
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- Authors
- Nichols, S. P., Le, N. N., Klitzman, B., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- Corresponding author
- Schoenfisch, Mark H.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-01-14
- Volume
- 83
- Issue
- 4
- Pages
- 1180-1184
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- PMC
- PMC3039076
- OpenAlex
- W2065992574
- Cited by
- 26
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 2
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (EB 000708, R01EB000708)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- nitric oxide release, glucose recovery, subcutaneous glucose sensor, microdialysis probe, foreign body reaction, glucose diffusion, capsule thickness, inflammation, implant surface modification
- MeSH terms
- Animals, Cell Count, Glucose, Inflammation, Male, Nitric Oxide, Microdialysis, Rats
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