The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow
Open accessAbstract
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by the indocyanine green structure, a series of polymethine dyes with both absorption and emission in the NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in the NIR-IIa (1300-1400 nm) subwindow under 1064 nm excitation with that in the NIR-II window under 808 nm excitation. The signal-background ratio and the tumor-normal tissue ratio achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The introduction of tripyrylium heterocycles leads to the development 5H5 (absorption λmax = 1069 nm, emission λmax = 1125 nm).44”
Citations
Cites
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Self-citationAlecu, I. M., Zheng, J., Zhao, Y., & Truhlar, D. G. (2010) · Journal of Chemical Theory and Computation · doi:10.1021/ct100326h · Cited by 1,667
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy
Hong, G., Diao, S., Antaris, A. L., & Dai, H. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00008 · Cited by 1,403
Through-skull fluorescence imaging of the brain in a new near-infrared window
Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052
He, S., Song, J., Qu, J., & Cheng, Z. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00234g · Cited by 1,021
Self-citationMultifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995
Welsher, K., Sherlock, S. P., & Dai, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014501108 · Cited by 958
Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658
A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging
Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15269 · Cited by 623
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–215 of 215
Near-IR Polymethine Fluorophores Absorbing Beyond 1000 nm
Trauner, D. H., & Fischer, C. (2019) · Synfacts · doi:10.1055/s-0037-1612119
Kamimura, M. (2020) · Springer eBooks · doi:10.1007/978-981-15-9627-8_3
14.6.5 Thiopyrylium Salts (Update 2021)
Wang, M., & Jiang, X. (2021) · Haug Verlag in Georg Thieme Verlag KG eBooks · doi:10.1055/sos-sd-114-00706
A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Li, Y., Qiao, X., & Hong, X. (2023) · Journal of Visualized Experiments · doi:10.3791/64875
Self-citationZhao, X., Cheng, J., Zhang, L., Yun, B., Yan, K., Wu, B., Liu, X., Zhang, F., & Lei, Z. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4520136
Shelkovnikov, V. V., Doroshenko, D. D., Kargapolova, I. Y., Kozlakov, P. A., Shestakov, N. A., & Sotnikova, Y. S. (2025) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162025010200
Real‐Time Detection of Burn Wound Infection via a Turn‐On NIR‐II Fluorescent Probe
Lu, K., Yang, S., Wang, M., Zhang, M., Zhou, B., Yang, K., Kirienko, N. V., & Xiao, H. (2026) · Chemistry - A European Journal · doi:10.1002/chem.70982
Understanding violations of Kasha’s rule in the heptamethine indolizine-cyanine dye SO3C7
Kruse, N. A., Saucier, M. A., Delcamp, J. H., & Hammer, N. I. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.146507
Qin, Y., You, Y., Yu, Y., Xie, Y., Sha, Y., Feng, J., Zeng, Y., Zhang, J., Lei, Z., Lu, C., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103342 · Cited by 1
Zhan, L., Chen, Y., Hu, J., Wang, C., Liu, H., Yao, D., & Wang, D. (2026) · Advanced Materials · doi:10.1002/adma.74089 · Cited by 1
Wang, B., Wen, J., Ma, Y., Wang, F., Yue, T., Tian, J., Rong, L., & Du, Y. (2026) · PhotoniX Life · doi:10.3724/pxlife.2026-0010
Huang, R., Li, H., Zhu, H., Hu, L., He, L., Hao, Y.-Q., Yang, F.-Y., Ren, T., & Yuan, L. (2026) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2026.119081 · Cited by 2
Coordination chemistry of NIR-II chromophore–metal hybrids for deep-tissue cancer theranostics
Bhowmik, R., Raza, M. K., Musib, D., & Roy, M. (2026) · Dalton Transactions · doi:10.1039/d6dt01459c · Cited by 2
Combinatorial Construction of a NIR-II Polymethine Dye Library
Li, T., Chen, Q., Yang, X., Wang, X., Xu, L., Yao, T., Chen, G., Li, C., Jiang, J., & Wang, Q. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c13760
Zhang, Z., Yang, G., Liu, Y., Yu, Y., Zeng, X., Yin, C., Hong, X., & Zhou, H. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.113475
Self-citation
Metadata
- Authors
- Ding, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X.
- Affiliations
- Wuhan University (CN)
- Stanford University (US)
- Tibet University (CN)
- Corresponding author
- Hong, Xuechuan
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-12-02
- Volume
- 62
- Issue
- 4
- Pages
- 2049-2059
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2902088541
- Cited by
- 215
- References
- 36
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 28 · 2023: 22 · 2022: 34 · 2021: 33 · 2020: 43 · 2019: 19
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.osti.gov
- Locations
- Journal of Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Cancer Institute (P50 CA114747)
- Ministry of Education of the People's Republic of China
- Natural Science Foundation of Jiangsu Province (BK20160387)
- Office of Science
- U.S. Department of Energy (DE-SC0008397)
- China Scholarship Council
- National Natural Science Foundation of China (81573383, 81773674, 21390402)
- Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals
- Shenzhen Municipality (JCYJ20170303170809222)
- Scientifc and Technologic Council of Suzhou (SYG201521)
- Hubei Province (2017CFA024, 2017CFB711, 2016ACA126)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- polymethine dyes, NIR-II imaging, small-molecule fluorophores, 1064 nm excitation, 808 nm excitation, blood pool imaging, U87 glioma, tumor imaging, signal-to-background ratio
- MeSH terms
- Density Functional Theory, Animals, Female, Fluorescence, Fluorescent Dyes, Heterocyclic Compounds, 2-Ring, Humans, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Models, Chemical, Neoplasms, Neovascularization, Pathologic, Integrin alphaVbeta3, Cell Line, Tumor, Small Molecule Libraries, Optical Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
