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Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow
Open accessAbstract
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by the indocyanine green structure, a series of polymethine dyes with both absorption and emission in the NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in the NIR-IIa (1300-1400 nm) subwindow under 1064 nm excitation with that in the NIR-II window under 808 nm excitation. The signal-background ratio and the tumor-normal tissue ratio achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.
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“The introduction of tripyrylium heterocycles leads to the development 5H5 (absorption λmax = 1069 nm, emission λmax = 1125 nm).44”
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Cites
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Self-citationAlecu, I. M., Zheng, J., Zhao, Y., & Truhlar, D. G. (2010) · Journal of Chemical Theory and Computation · doi:10.1021/ct100326h · Cited by 1,667
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy
Hong, G., Diao, S., Antaris, A. L., & Dai, H. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00008 · Cited by 1,403
Through-skull fluorescence imaging of the brain in a new near-infrared window
Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052
He, S., Song, J., Qu, J., & Cheng, Z. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00234g · Cited by 1,021
Self-citationMultifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995
Welsher, K., Sherlock, S. P., & Dai, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014501108 · Cited by 958
Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658
A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging
Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15269 · Cited by 623
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Zhou, H., Yang, H. N., Tang, L., Wang, Y., Li, Y., Liu, N., Zeng, X., Yan, Y. Q., Wu, J., Chen, S., et al. (2019) · Journal of Materials Chemistry C · doi:10.1039/c9tc01929d · Cited by 35
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Self-citationSwamy, M. M. M., Murai, Y., Monde, K., Tsuboi, S., Swamy, A. K., & Jin, T. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c01000 · Cited by 34
Wong, K. C. Y., & Sletten, E. M. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102131 · Cited by 31
McNamara, L. E., Boyn, J.-N., Melnychuk, C., Anferov, S. W., Mazziotti, D. A., Schaller, R. D., & Anderson, J. S. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c04976 · Cited by 33
Liu, Y., Zhang, Z., Hou, X., Ding, Q., Zeng, S., Shen, H., Gong, W., Ding, T., Mahmood, Z., Zeng, X., et al. (2025) · Advanced Materials · doi:10.1002/adma.202420006 · Cited by 30
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Self-citationGe, R.-T., Xiong, F., Chen, Z.-B., Wang, Y., Zheng, L., Zhou, J., Wu, D., & Zhang, S.-Y. (2025) · Chem · doi:10.1016/j.chempr.2025.102489 · Cited by 28
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Zhang, L., Wang, X., Zhao, J., Sun, B., & Wang, W. (2023) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.3c00104 · Cited by 28
Cui, C., Li, J., Fang, J. Y., Zhao, Y., Zhang, Y., Ye, S., Wang, A., Feng, Y., Mao, Q., Qin, H., et al. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.03.023 · Cited by 28
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Lu, S. L., Xue, L., Yang, M., Wang, J., Li, Y., Jiang, Y., Hong, X., Wu, M., & Xiao, Y. (2022) · Nano Research · doi:10.1007/s12274-022-4592-z · Cited by 29
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He, X., Yu, J., Hu, J., Wei, W., Sun, K., Chen, J., Cai, Z., Liu, M., Xu, Y., & Sun, B. (2023) · ACS Materials Letters · doi:10.1021/acsmaterialslett.3c00978 · Cited by 20
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Li, Q., Liu, Y., Zhao, B., Lei, J., Lu, S. L., Gong, W., Liang, K., Wu, J., Hong, X., & Xiao, Y. (2022) · Chemical Communications · doi:10.1039/d2cc00082b · Cited by 20
Self-citationXie, Y., Qin, Z., Qian, M., Ren, T., & Yuan, L. (2024) · Chemical Research in Chinese Universities · doi:10.1007/s40242-024-3264-9 · Cited by 19
Zhao, X., Cheng, J., Zhang, L., Yun, B., Yan, K., Wu, B., Liu, X., Zhang, F., & Lei, Z. (2023) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2023.101691 · Cited by 17
Wu, F., Liu, S., Zheng, B., Cao, W., Zhu, Y., Yang, J., & Xiong, H. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102218 · Cited by 17
Wang, B., Zhou, H., Chen, L., Ding, Y., Zhang, X., Chen, H., Liu, H., Li, P., Chen, Y., Yin, C., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202408874 · Cited by 16
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Liu, M.-H., Zhang, Z., Yang, Y., & Chan, Y. (2020) · Angewandte Chemie · doi:10.1002/ange.202011914 · Cited by 10
Wang, M., Wang, X., Wei, R., Zhang, Y., Chen, J., Luo, X. L., Qian, X. H., & Yang, Y. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.134382 · Cited by 10
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Qin, Y., Guo, J., Qin, Y., Xu, Z., Fang, M., Fu, H., Cui, M., & Zhou, K. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c04745 · Cited by 10
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Yang, G., Wang, Y., Zhou, S. D., Chen, L., Chen, Y., Liu, Y., Liang, X., Yin, C., Zhou, H., & Fan, Q. (2022) · Dyes and Pigments · doi:10.1016/j.dyepig.2022.110960 · Cited by 6
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Xi, X., & Feng, W. (2024) · Materials Research Bulletin · doi:10.1016/j.materresbull.2024.112889 · Cited by 4
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Wang, Y., Ren, B., Chang, X., Kim, J. S., Pan, W., Zeng, X., Xiao, Y., & Hong, X. (2026) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2026.118780 · Cited by 2
Self-citationKong, Y., Wang, J., Gan, W., Jiang, Q., Yang, Y., & Zhang, F. (2026) · Advanced Functional Materials · doi:10.1002/adfm.74922 · Cited by 2
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Metadata
- Authors
- Ding, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X.
- Affiliations
- Wuhan University (CN)
- Stanford University (US)
- Tibet University (CN)
- Corresponding author
- Hong, Xuechuan
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-12-02
- Volume
- 62
- Issue
- 4
- Pages
- 2049-2059
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2902088541
- Cited by
- 215
- References
- 36
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 28 · 2023: 22 · 2022: 34 · 2021: 33 · 2020: 43 · 2019: 19
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.osti.gov
- Locations
- Journal of Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Cancer Institute (P50 CA114747)
- Ministry of Education of the People's Republic of China
- Natural Science Foundation of Jiangsu Province (BK20160387)
- Office of Science
- U.S. Department of Energy (DE-SC0008397)
- China Scholarship Council
- National Natural Science Foundation of China (81573383, 81773674, 21390402)
- Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals
- Shenzhen Municipality (JCYJ20170303170809222)
- Scientifc and Technologic Council of Suzhou (SYG201521)
- Hubei Province (2017CFA024, 2017CFB711, 2016ACA126)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- polymethine dyes, NIR-II imaging, small-molecule fluorophores, 1064 nm excitation, 808 nm excitation, blood pool imaging, U87 glioma, tumor imaging, signal-to-background ratio
- MeSH terms
- Density Functional Theory, Animals, Female, Fluorescence, Fluorescent Dyes, Heterocyclic Compounds, 2-Ring, Humans, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Models, Chemical, Neoplasms, Neovascularization, Pathologic, Integrin alphaVbeta3, Cell Line, Tumor, Small Molecule Libraries, Optical Imaging
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