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Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow
Open accessAbstract
Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by the indocyanine green structure, a series of polymethine dyes with both absorption and emission in the NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in the NIR-IIa (1300-1400 nm) subwindow under 1064 nm excitation with that in the NIR-II window under 808 nm excitation. The signal-background ratio and the tumor-normal tissue ratio achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.
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“The introduction of tripyrylium heterocycles leads to the development 5H5 (absorption λmax = 1069 nm, emission λmax = 1125 nm).44”
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Cites
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,048
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Self-citationAlecu, I. M., Zheng, J., Zhao, Y., & Truhlar, D. G. (2010) · Journal of Chemical Theory and Computation · doi:10.1021/ct100326h · Cited by 1,667
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy
Hong, G., Diao, S., Antaris, A. L., & Dai, H. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00008 · Cited by 1,403
Through-skull fluorescence imaging of the brain in a new near-infrared window
Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052
He, S., Song, J., Qu, J., & Cheng, Z. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00234g · Cited by 1,021
Self-citationMultifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995
Welsher, K., Sherlock, S. P., & Dai, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014501108 · Cited by 958
Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658
A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging
Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15269 · Cited by 623
Self-citationDonor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance
Yang, Q., Hu, Z., Zhu, S., Ma, R., Ma, H., Ma, Z., Wan, H., Zhu, T., Jiang, Z., Liu, W., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b10334 · Cited by 554
Rational Design of Molecular Fluorophores for Biological Imaging in the NIR‐II Window
Yang, Q., Ma, Z., Wang, H., Zhou, B., Zhu, S., Zhong, Y., Wang, J., Wan, H., Antaris, A., Ma, R., et al. (2017) · Advanced Materials · doi:10.1002/adma.201605497 · Cited by 467
Self-citationA bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues
Wan, H., Yue, J., Zhu, S., Uno, T., Zhang, X., Yang, Q., Yu, K., Hong, G., Wang, J., Li, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03505-4 · Cited by 450
Self-citationFluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
Diao, S., Blackburn, J. L., Hong, G., Antaris, A. L., Chang, J., Wu, J. Z., Zhang, B., Cheng, K., Kuo, C. J., & Dai, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201507473 · Cited by 417
Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging
Cosco, E. D., Caram, J. R., Bruns, O. T., Franke, D., Day, R. A., Farr, E. P., Bawendi, M. G., & Sletten, E. M. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706974 · Cited by 415
Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore
Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., et al. (2016) · Advanced Materials · doi:10.1002/adma.201600706 · Cited by 386
Self-citationLiu, L., Wang, S., Zhao, B., Pei, P., Fan, Y., Li, X., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201802889 · Cited by 349
Biological imaging without autofluorescence in the second near-infrared region
Diao, S., Hong, G., Antaris, A. L., Blackburn, J. L., Cheng, K., Cheng, Z., & Dai, H. (2015) · Nano Research · doi:10.1007/s12274-015-0808-9 · Cited by 346
Self-citationNovel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer
Sun, Y., Qu, C., Chen, H., He, M., Tang, C. C., Shou, K., Hong, S., Yang, M., Jiang, Y., Ding, B., et al. (2016) · Chemical Science · doi:10.1039/c6sc01561a · Cited by 293
Self-citationZhu, S., Yang, Q., Antaris, A. L., Yue, J., Ma, Z., Wang, H., Huang, W., Wan, H., Wang, J., Diao, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617990114 · Cited by 281
Sun, Y., Ding, M., Zeng, X., Xiao, Y., Wu, H., Zhou, H., Ding, B., Qu, C., Hou, W., Aga, E.-B., et al. (2017) · Chemical Science · doi:10.1039/c7sc00251c · Cited by 265
Self-citationNovel near-infrared II aggregation-induced emission dots for in vivo bioimaging
Lin, J., Zeng, X., Xiao, Y., Tang, L., Nong, J., Liu, Y., Zhou, H., Ding, B., Xu, F., Tong, H., et al. (2018) · Chemical Science · doi:10.1039/c8sc04363a · Cited by 242
Self-citationUltrastable and Biocompatible NIR‐II Quantum Dots for Functional Bioimaging
Zebibula, A., Alifu, N., Xia, L., Sun, C., Yu, X., Xue, D., Liu, L., Li, G., & Qian, J. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703451 · Cited by 216
Shou, K., Tang, Y., Chen, H., Chen, S., Zhang, L., Zhang, A., Fan, Q., Yu, A., & Cheng, Z. (2018) · Chemical Science · doi:10.1039/c8sc00206a · Cited by 199
Self-citationLi, C., Li, F., Zhang, Y., Zhang, W., Zhang, X., & Wang, Q. (2015) · ACS Nano · doi:10.1021/acsnano.5b05503 · Cited by 174
Self-citationSun, Y., Zeng, X., Xiao, Y., Liu, C., Zhu, H., Zhou, H., Chen, Z., Xu, F., Wang, J., Zhu, M., et al. (2018) · Chemical Science · doi:10.1039/c7sc04774f · Cited by 161
Self-citationCheng, K., Chen, H., Jenkins, C. H., Zhang, G., Zhao, W., Zhang, Z., Han, F., Fung, J., Yang, M., Jiang, Y., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b05966 · Cited by 156
Self-citationWang, W., Ma, Z., Zhu, S., Wan, H., Yue, J., Ma, H., Ma, R., Yang, Q., Wang, Z., Li, Q., et al. (2018) · Advanced Materials · doi:10.1002/adma.201800106 · Cited by 148
Near‐Infrared II Dye‐Protein Complex for Biomedical Imaging and Imaging‐Guided Photothermal Therapy
Zeng, X., Xiao, Y., Lin, J., Li, S., Zhou, H., Nong, J., Xu, G., Wang, H., Xu, F., Wu, J., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800589 · Cited by 147
Self-citationXue, Z., Zeng, S., & Hao, J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.037 · Cited by 133
Feng, Y., Zhu, S., Antaris, A. L., Chen, H., Xiao, Y., Lu, X., Jiang, L., Diao, S., Yu, K., Wang, Y., et al. (2017) · Chemical Science · doi:10.1039/c6sc04897h · Cited by 111
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Ding, M., Wang, H., Qu, C., Xu, F., Zhu, Y., Lv, G., Lu, Y., Zhou, Q., Zhou, H., Zeng, X., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.041 · Cited by 64
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Qu, C., Ding, M., Zhu, Y., Lu, Y., Du, J., Miller, M., Tian, J., Zhu, J., Xu, J., Wen, M., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00304 · Cited by 60
Self-citationNew NIR-II dyes without a benzobisthiadiazole core
Zhou, H., Xiao, Y., & Hong, X. (2018) · Chinese Chemical Letters · doi:10.1016/j.cclet.2018.08.009 · Cited by 40
Self-citationProteomic Analysis and NIR-II Imaging of MCM2 Protein in Hepatocellular Carcinoma
Yang, J. H., Xie, Q., Zhou, H., Chang, L., Wei, W., Wang, Y., Li, H., Deng, Z., Xiao, Y., Wu, J., et al. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00181 · Cited by 39
Self-citationNew glowing dyes in vivo imaging with wavelengths beyond 1500 nm
Yang, J., & Hong, X. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9341-7 · Cited by 13
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Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 547
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Li, B., Zhao, M., Feng, L., Dou, C., Ding, S., Zhou, G., Lu, L., Zhang, H., Chen, F., Li, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16924-z · Cited by 374
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Metadata
- Authors
- Ding, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X.
- Affiliations
- Wuhan University (CN)
- Stanford University (US)
- Tibet University (CN)
- Corresponding author
- Hong, Xuechuan
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-12-02
- Volume
- 62
- Issue
- 4
- Pages
- 2049-2059
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2902088541
- Cited by
- 215
- References
- 36
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 28 · 2023: 22 · 2022: 34 · 2021: 33 · 2020: 43 · 2019: 19
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.osti.gov
- Locations
- Journal of Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Cancer Institute (P50 CA114747)
- Ministry of Education of the People's Republic of China
- Natural Science Foundation of Jiangsu Province (BK20160387)
- Office of Science
- U.S. Department of Energy (DE-SC0008397)
- China Scholarship Council
- National Natural Science Foundation of China (81573383, 81773674, 21390402)
- Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals
- Shenzhen Municipality (JCYJ20170303170809222)
- Scientifc and Technologic Council of Suzhou (SYG201521)
- Hubei Province (2017CFA024, 2017CFB711, 2016ACA126)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- polymethine dyes, NIR-II imaging, small-molecule fluorophores, 1064 nm excitation, 808 nm excitation, blood pool imaging, U87 glioma, tumor imaging, signal-to-background ratio
- MeSH terms
- Density Functional Theory, Animals, Female, Fluorescence, Fluorescent Dyes, Heterocyclic Compounds, 2-Ring, Humans, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Models, Chemical, Neoplasms, Neovascularization, Pathologic, Integrin alphaVbeta3, Cell Line, Tumor, Small Molecule Libraries, Optical Imaging
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