Cited by 215Luminescence and Fluorescent MaterialsOptical Imaging and Spectroscopy TechniquesMolecular Sensors and Ion Detection

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Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow

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Ding, Bingbing, Xiao, Yuling, Zhou, Hui, Zhang, Xiao, Qu, Chunrong, Xu, Fuchun, Deng, Zixin, Cheng, Zhen, Hong, Xuechuan·2019·Journal of Medicinal Chemistry

DOI 10.1021/acs.jmedchem.8b01682

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Abstract

Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by the indocyanine green structure, a series of polymethine dyes with both absorption and emission in the NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in the NIR-IIa (1300-1400 nm) subwindow under 1064 nm excitation with that in the NIR-II window under 808 nm excitation. The signal-background ratio and the tumor-normal tissue ratio achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.

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Authors: Ding, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X.
Affiliations: Wuhan University (CN)
Stanford University (US)
Tibet University (CN)
Corresponding author: Hong, Xuechuan
ORCID: Ding, Bingbing
Xiao, Yuling
Zhou, Hui
Zhang, Xiao
Qu, Chunrong
Deng, Zixin
Cheng, Zhen
Hong, Xuechuan
Venue: Journal of Medicinal Chemistry
Publisher: American Chemical Society (ACS)
Published: 2018-12-02
Volume: 62
Issue: 4
Pages: 2049-2059
ISSN: 0022-2623 (ISSN-L)
1520-4804
DOI: 10.1021/acs.jmedchem.8b01682
OpenAlex: W2902088541
Cited by: 215
References: 36
Citations by year: 2026: 15 · 2025: 21 · 2024: 28 · 2023: 22 · 2022: 34 · 2021: 33 · 2020: 43 · 2019: 19
FWCI: 8.87
Type: journal article
Language: en
Open access: green
www.osti.gov
Locations: Journal of Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders: National Cancer Institute (P50 CA114747)
Ministry of Education of the People's Republic of China
Natural Science Foundation of Jiangsu Province (BK20160387)
Office of Science
U.S. Department of Energy (DE-SC0008397)
China Scholarship Council
National Natural Science Foundation of China (81573383, 81773674, 21390402)
Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals
Shenzhen Municipality (JCYJ20170303170809222)
Scientifc and Technologic Council of Suzhou (SYG201521)
Hubei Province (2017CFA024, 2017CFB711, 2016ACA126)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Keywords: polymethine dyes, NIR-II imaging, small-molecule fluorophores, 1064 nm excitation, 808 nm excitation, blood pool imaging, U87 glioma, tumor imaging, signal-to-background ratio
MeSH terms: Density Functional Theory, Animals, Female, Fluorescence, Fluorescent Dyes, Heterocyclic Compounds, 2-Ring, Humans, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Models, Chemical, Neoplasms, Neovascularization, Pathologic, Integrin alphaVbeta3, Cell Line, Tumor, Small Molecule Libraries, Optical Imaging

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