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Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease

Goyal, Deepti, Shuaib, Suniba, Mann, Sukhmani, Goyal, Bhupesh·2017·ACS Combinatorial Science
DOI 10.1021/acscombsci.6b00116
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Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically accepted treatment to cure or halt its progression. The worldwide effort to develop peptide-based inhibitors of amyloid-β (Aβ) aggregation can be considered an unplanned combinatorial experiment. An understanding of what has been done and achieved may advance our understanding of AD pathology and the discovery of effective therapeutic agents. We review here the history of such peptide-based inhibitors, including those based on the Aβ sequence and those not derived from that sequence, containing both natural and unnatural amino acid building blocks. Peptide-based aggregation inhibitors hold significant promise for future AD therapy owing to their high selectivity, effectiveness, low toxicity, good tolerance, low accumulation in tissues, high chemical and biological diversity, possibility of rational design, and highly developed methods for analyzing their mode of action, proteolytic stability (modified peptides), and blood-brain barrier (BBB) permeability.

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Metadata

Authors
Goyal, D., Shuaib, S., Mann, S., & Goyal, B.
Venue
ACS Combinatorial Science
Publisher
American Chemical Society (ACS)
Published
2017-01-18
Volume
19
Issue
2
Pages
55-80
ISSN
  • 2156-8944 (ISSN-L)
  • 2156-8952
DOI
10.1021/acscombsci.6b00116
OpenAlex
W2564069686
Cited by
227
References
22
FWCI
15.62
Type
journal article
Language
en
Open access
closed
Funders
Science and Engineering Research Board (SB/FT/CS-013/2014, SERB/F/4167/2015-16)

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CoChat. (2026). Citation check: Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease. https://app.cochat.ai/papers/10.1021/acscombsci.6b00116
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Goyal, D., Shuaib, S., Mann, S., & Goyal, B. (2017). Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease. ACS Combinatorial Science. https://doi.org/10.1021/acscombsci.6b00116

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