Antimicrobial Nano-Agents: The Copper Age

Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis

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Antimicrobial activity of metals: mechanisms, molecular targets and applications

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The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms

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Chronic Wound Healing: A Review of Current Management and Treatments

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Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets

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Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes

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Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

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Persistent bacterial infections and persister cells

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A Review on Antibiotic Resistance: Alarm Bells are Ringing

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Host-directed therapies for bacterial and viral infections

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Transport and interactions of nanoparticles in the kidneys

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Toxicity of Nanoparticles and an Overview of Current Experimental Models.

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Copper Sulfide Nanoparticles for Photothermal Ablation of Tumor Cells

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Bacterial cellulose: a versatile biopolymer for wound dressing applications

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Understanding the Antibacterial Mechanism of CuO Nanoparticles: Revealing the Route of Induced Oxidative Stress

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Glomerular barrier behaves as an atomically precise bandpass filter in a sub-nanometre regime

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Combinatorial Photothermal and Immuno Cancer Therapy Using Chitosan-Coated Hollow Copper Sulfide Nanoparticles

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Copper-induced vascular endothelial growth factor expression and wound healing

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Metal Oxide Nanoparticles as Biomedical Materials

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Nanoparticle cytotoxicity depends on intracellular solubility: Comparison of stabilized copper metal and degradable copper oxide nanoparticles

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Copper Metal–Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes

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A review on nanoparticle based treatment for wound healing

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Quantifying drivers of antibiotic resistance in humans: a systematic review

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A Novel Anti-Influenza Copper Oxide Containing Respiratory Face Mask

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Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing

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CuO Nanoparticle Interaction with Human Epithelial Cells: Cellular Uptake, Location, Export, and Genotoxicity

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Copper-nanoparticle-embedded hydrogel for killing bacteria and promoting wound healing with photothermal therapy

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Cell membrane damage and protein interaction induced by copper containing nanoparticles—Importance of the metal release process

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Chitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings

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Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

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Cu and CuO nanoparticles immobilized by silica thin films as antibacterial materials and photocatalysts

Akhavan, O., & Ghaderi, E. (2010) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2010.06.036 · Cited by 261

Therapeutic gold, silver, and platinum nanoparticles

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Copper-Alloy Surfaces and Cleaning Regimens against the Spread of SARS-CoV-2 in Dentistry and Orthopedics. From Fomites to Anti-Infective Nanocoatings

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Polypropylene with embedded copper metal or copper oxide nanoparticles as a novel plastic antimicrobial agent: Novel antimicrobial plastic materials

Delgado, K., Quijada, R., Palma, R., & Palza, H. (2011) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2011.03069.x · Cited by 226

Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing

Wang, X., Lv, F., Li, T., Han, Y., Yi, Z., Liu, M., Chang, J., & Wu, C. (2017) · ACS Nano · doi:10.1021/acsnano.7b05858 · Cited by 226

Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds

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The neglected role of copper ions in wound healing

Kornblatt, A. P., Nicoletti, V. G., & Travaglia, A. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.02.012 · Cited by 221

Chitosan-based copper nanocomposite accelerates healing in excision wound model in rats

Gopal, A., Kant, V., Gopalakrishnan, A., Tandan, S. K., & Kumar, D. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.02.033 · Cited by 217

How Mammalian Cells Acquire Copper: An Essential but Potentially Toxic Metal

Kaplan, J. H., & Maryon, E. B. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2015.11.025 · Cited by 216

Copper signalling: causes and consequences

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Nanomaterials for Wound Healing: Scope and Advancement

Kalashnikova, I., Das, S., & Seal, S. (2015) · Nanomedicine · doi:10.2217/nnm.15.82 · Cited by 209

Biogenic nanoparticles: copper, copper oxides, copper sulphides, complex copper nanostructures and their applications

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Bacterial cellulose nanocomposites: An all-nano type of material

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Can Regenerative Medicine and Nanotechnology Combine to Heal wounds? the Search for the Ideal Wound Dressing

Zarrintaj, P., Moghaddam, A. S., Manouchehri, S., Atoufi, Z., Amiri, A., Amirkhani, M. A., Nilforoushzadeh, M. A., Saeb, M. R., Hamblin, M. R., & Mozafari, M. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0173 · Cited by 199

Novel synthesis of Falcaria vulgaris leaf extract conjugated copper nanoparticles with potent cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing activities under in vitro and in vivo condition

Zangeneh, M. M., Ghaneialvar, H., Akbaribazm, M., Ghanimatdan, M., Abbasi, N., Goorani, S., Pirabbasi, E., & Zangeneh, A. (2019) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2019.111556 · Cited by 181

Antimicrobial Activity of Starch Hydrogel Incorporated with Copper Nanoparticles

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Copper nanoparticles promote rapid wound healing in acute full thickness defect via acceleration of skin cell migration, proliferation, and neovascularization

Alizadeh, S., Seyedalipour, B., Shafieyan, S., Kheime, A., Mohammadi, P., & Aghdami, N. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.07.110 · Cited by 162

3D Printing of Antimicrobial Alginate/Bacterial-Cellulose Composite Hydrogels by Incorporating Copper Nanostructures

Gutierrez, E., Burdiles, P. A., Quero, F., Fluxá, P. P., Olate‐Moya, F., & Palza, H. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01048 · Cited by 157

CuS nanoagents for photodynamic and photothermal therapies: Phenomena and possible mechanisms

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GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015) · BioMed Research International · doi:10.1155/2015/648108 · Cited by 144

Light‐Induced Chiral Iron Copper Selenide Nanoparticles Prevent β‐Amyloidopathy In Vivo

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Ultrasmall-in-Nano Approach: Enabling the Translation of Metal Nanomaterials to Clinics

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A Review on Synthesis, Characterization and Applications of Copper Nanoparticles Using Green Method

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Cost Effective, Green Synthesis of Copper Oxide Nanoparticles Using Fruit Extract of Syzygium alternifolium (Wt.) Walp., Characterization and Evaluation of Antiviral Activity

Yugandhar, P., Thirumalanadhuni, V., Rao, Y. J., Devi, P. U. M., Golla, N., & Savithramma, N. (2018) · Journal of Cluster Science · doi:10.1007/s10876-018-1395-1 · Cited by 132

Assessment of the Lung Toxicity of Copper Oxide Nanoparticles: Current Status

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In vitro and in vivo toxicity studies of copper sulfide nanoplates for potential photothermal applications

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Biogenic synthesis of copper nanoparticles by natural polysaccharides and Pleurotus ostreatus fermented fenugreek using gamma rays with antioxidant and antimicrobial potential towards some wound pathogens

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Green synthesis and chemical characterization of copper nanoparticles using Allium saralicum leaves and assessment of their cytotoxicity, antioxidant, antimicrobial, and cutaneous wound healing properties

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Synthesis of copper-containing bioactive glass nanoparticles using a modified Stöber method for biomedical applications

Zheng, K., Dai, X., Lu, M., Hüser, N., Taccardi, N., & Boccaccini, A. R. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.11.016 · Cited by 118

Global health concerns stirred by emerging viral infections

Luo, G. G., & Gao, S. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25683 · Cited by 115

Shape-dependent bactericidal activity of copper oxide nanoparticle mediated by DNA and membrane damage

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Rational Design of a Transferrin-Binding Peptide Sequence Tailored to Targeted Nanoparticle Internalization

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Unexpected Role of the Copper Transporter ATP7A in PDGF-Induced Vascular Smooth Muscle Cell Migration

Ashino, T., Varadarajan, S., Urao, N., Oshikawa, J., Chen, G., Wang, H., Huo, Y., Finney, L. A., Vogt, S., McKinney, R. D., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.225334 · Cited by 103

Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets

Wang, W., Li, B., Yang, H., Lin, Z., Chen, L., Li, Z., Ge, J., Zhang, T., Xia, H., Li, L., et al. (2020) · Nano Research · doi:10.1007/s12274-020-2824-7 · Cited by 102

Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice

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Biosynthesis of copper nanoparticles using Allium eriophyllum Boiss leaf aqueous extract; characterization and analysis of their antimicrobial and cutaneous wound‐healing potentials

Zhao, H., Su, H., Ahmeda, A. F., Sun, Y., Li, Z., Zangeneh, M. M., Nowrozi, M., Zangeneh, A., & Moradi, R. (2020) · Applied Organometallic Chemistry · doi:10.1002/aoc.5587 · Cited by 93

Marine endophytic actinomycetes assisted synthesis of copper nanoparticles (CuNPs): Characterization and antibacterial efficacy against human pathogens

Rasool, U., & Hemalatha, S. (2017) · Materials Letters · doi:10.1016/j.matlet.2017.02.055 · Cited by 92

Renal Clearance and Degradation of Glutathione-Coated Copper Nanoparticles

Yang, S., Sun, S., Zhou, C., Hao, G., Liu, J., Ramezani, S., Yu, M., Sun, X., & Zheng, J. (2015) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5b00003 · Cited by 90

Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the copper biodistribution and gastrointestinal and hepatic morphology and function in a rat model

Cholewińska, E., Ognik, K., Fotschki, B., Zduńczyk, Z., & Juśkiewicz, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197083 · Cited by 89

Copper Sulfide Nanoparticles-Incorporated Hyaluronic Acid Injectable Hydrogel With Enhanced Angiogenesis to Promote Wound Healing

Zhou, W., Zi, L., Cen, Y., You, C., & Tian, M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00417 · Cited by 89

Chitosan-pluronic based Cu nanocomposite hydrogels for prototype antimicrobial applications

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Biochemical, Histological, and Memory Impairment Effects of Chronic Copper Toxicity: A Model for Non-Wilsonian Brain Copper Toxicosis in Wistar Rat

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Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System

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Chitosan coating of copper nanoparticles reducesin vitrotoxicity and increases inflammation in the lung

Worthington, K. S., Adamcakova‐Dodd, A., Wongrakpanich, A., Mudunkotuwa, I. A., Mapuskar, K. A., Joshi, V. B., Guymon, C. A., Spitz, D. R., Grassian, V. H., Thorne, P. S., et al. (2013) · Nanotechnology · doi:10.1088/0957-4484/24/39/395101 · Cited by 81

Catheters coated with Zn-doped CuO nanoparticles delay the onset of catheter-associated urinary tract infections

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In-Situ Growth of Metal Oxide Nanoparticles on Cellulose Nanofibrils for Dye Removal and Antimicrobial Applications

Valencia, L., Kumar, S., Nomena, E. M., Salazar‐Alvarez, G., & Mathew, A. P. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c01511 · Cited by 81

Commonalities between Copper Neurotoxicity and Alzheimer’s Disease

Patel, R., & Aschner, M. (2021) · Toxics · doi:10.3390/toxics9010004 · Cited by 78

Novel Biosynthesis of Copper Nanoparticles Using Zingiber and Allium sp. with Synergic Effect of Doxycycline for Anticancer and Bactericidal Activity

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Bringing Again Noble Metal Nanoparticles to the Forefront of Cancer Therapy

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Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response

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Inhibition of pathogenic bacterial growth on excision wound by green synthesized copper oxide nanoparticles leads to accelerated wound healing activity in Wistar Albino rats

Renu, S., Athmanathan, B., Shivashangari, K. S., & Ravikumar, V. (2015) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-015-5543-y · Cited by 73

Antimicrobial and Biocompatible Polycaprolactone and Copper Oxide Nanoparticle Wound Dressings against Methicillin-Resistant Staphylococcus aureus

Balcucho, J., Narváez, D. M., & Castro-Mayorga, J. L. (2020) · Nanomaterials · doi:10.3390/nano10091692 · Cited by 73

Pulmonary inflammation caused by chitosan microparticles

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Probing the Interaction of Bovine Serum Albumin with Copper Nanoclusters: Realization of Binding Pathway Different from Protein Corona

Akhuli, A., Chakraborty, D., Agrawal, A. K., & Sarkar, M. (2021) · Langmuir · doi:10.1021/acs.langmuir.0c03176 · Cited by 66

The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles

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Hydrogel-based artificial enzyme for combating bacteria and accelerating wound healing

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Effect of sonication and serum proteins on copper release from copper nanoparticles and the toxicity towards lung epithelial cells

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Photothermal effect by NIR-responsive excretable ultrasmall-in-nano architectures

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Combined chemo-photothermal treatment of three-dimensional head and neck squamous cell carcinomas by gold nano-architectures

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Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

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Anti–Methicillin-Resistant Staphylococcus aureus Nanoantibiotics

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Mild Synthesis of Copper Nanoparticles with Enhanced Oxidative Stability and Their Application in Antibacterial Films

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