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Balancing Bacteria–Osteoblast Competition through Selective Physical Puncture and Biofunctionalization of ZnO/Polydopamine/Arginine-Glycine-Aspartic Acid-Cysteine Nanorods
Abstract
Bacterial infection and lack of bone tissue integration are two major concerns of orthopedic implants. In addition, osteoinductivity often decreases and toxicity may arise when antibacterial agents are introduced to increase the antibacterial ability. Here hybrid ZnO/polydopamine (PDA)/arginine-glycine-aspartic acid-cysteine (RGDC) nanorod (NR) arrays are designed and prepared on titanium (Ti) implants to not only enhance the osteoinductivity but also effectively kill bacteria simultaneously, which are ascribed to the selective physical puncture and the biofunctionalization of ZnO/PDA/RGDC nanorods during the competition between bacteria and osteoblasts. That is, owing to the much larger size of osteoblasts than bacteria, the hybrid NRs can puncture bacteria but not damage osteoblasts. Meanwhile, the cytocompatibility can be enhanced through the suppression of both reactive oxygen species and higher Zn 2+ concentration by the covering of PDA and RGDC. The in vitro results confirm the selective puncture of the bacterial membrane and the better osteoinductivity. In vivo tests also show much higher antibacterial efficacy of the hybrid NRs with far less amounts of lobulated neutrophils and adherent bacteria in the surrounding tissues. In addition, the hybrid NRs also accelerate formation of new bone tissues (20.1% higher than pure Ti) and osteointegration between implants and newly formed tissues (32.0% higher than pure Ti) even in the presence of injected bacteria. This work provides a surface strategy for designing implants with desirable ability of osseointegration and infection prevention simultaneously, which will exhibit tremendous clinical potential in orthopedic and dental applications.
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Citations
Cites
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965
Ti based biomaterials, the ultimate choice for orthopaedic implants – A review
Geetha, M., Singh, A. K., Asokamani, R., & Gogia, A. K. (2009) · Progress in Materials Science · doi:10.1016/j.pmatsci.2008.06.004 · Cited by 5,416
Liu, Y., Ai, K., & Lu, L. (2014) · Chemical Reviews · doi:10.1021/cr400407a · Cited by 4,794
Growth of Arrayed Nanorods and Nanowires of ZnO from Aqueous Solutions
Vayssieres, L. (2003) · Advanced Materials · doi:10.1002/adma.200390108 · Cited by 2,706
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
Hersel, U., Dahmen, C., & Kessler, H. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00343-0 · Cited by 2,582
Liu, Y., Ai, K., Liu, J., Deng, M., He, Y., & Lu, L. (2013) · Advanced Materials · doi:10.1002/adma.201204683 · Cited by 2,019
Li, Y., Zhang, W., Niu, J., & Chen, Y. (2012) · ACS Nano · doi:10.1021/nn300934k · Cited by 1,660
Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings
Lee, H., Rho, J., & Messersmith, P. B. (2009) · Advanced Materials · doi:10.1002/adma.200801222 · Cited by 1,495
Mechanisms of nanotoxicity: Generation of reactive oxygen species
Fu, P. P., Xia, Q., Hwang, H.-M., Ray, P. C., & Yu, H. (2014) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2014.01.005 · Cited by 1,398
Reversible Super-hydrophobicity to Super-hydrophilicity Transition of Aligned ZnO Nanorod Films
Feng, X., Feng, L., Jin, M., Zhai, J., Jiang, L., & Zhu, D. (2004) · Journal of the American Chemical Society · doi:10.1021/ja038636o · Cited by 1,183
ZnO nanowire and nanobelt platform for nanotechnology
Wang, Z. L. (2009) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2009.02.001 · Cited by 1,157
Enhanced Antibacterial Activity of Nanocrystalline ZnO Due to Increased ROS‐Mediated Cell Injury
Applerot, G., Lipovsky, A., Dror, R., Perkas, N., Nitzan, Y., Lubart, R., & Gedanken, A. (2009) · Advanced Functional Materials · doi:10.1002/adfm.200801081 · Cited by 1,031
Bactericidal activity of black silicon
Ivanova, E. P., Hasan, J., Webb, H. K., Gervinskas, G., Juodkazis, S., Truong, V. K., Wu, A. H. F., Lamb, R. N., Baulin, V. A., Watson, G. S., et al. (2013) · Nature Communications · doi:10.1038/ncomms3838 · Cited by 973
He, W., Kim, H.-K., Wamer, W. G., Melka, D., Callahan, J. H., & Yin, J.-J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja410800y · Cited by 850
CT artifacts: causes and reduction techniques
Boas, F. E., & Fleischmann, D. (2012) · Imaging in Medicine · doi:10.2217/iim.12.13 · Cited by 848
A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability
Li, P., Poon, Y. F., Li, W., Zhu, H.-Y., Yeap, S. H., Cao, Y., Qi, X., Zhou, C., Lamrani, M., Beuerman, R. W., et al. (2011) · Nature Materials · doi:10.1038/nmat2915 · Cited by 822
Dopamine-Induced Reduction and Functionalization of Graphene Oxide Nanosheets
Xu, L. Q., Yang, W. J., Neoh, K.-G., Kang, E.-T., & Fu, G. D. (2010) · Macromolecules · doi:10.1021/ma101526k · Cited by 785
Advantages of RGD peptides for directing cell association with biomaterials
Bellis, S. L. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.02.029 · Cited by 745
Zhou, J., Xu, N. S., & Wang, Z. L. (2006) · Advanced Materials · doi:10.1002/adma.200600200 · Cited by 739
Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface
Busscher, H. J., van der Mei, H. C., Subbiahdoss, G., Jutte, P. C., van den Dungen, J. J. A. M., Zaat, S. A. J., Schultz, M. J., & Grainger, D. W. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004528 · Cited by 707
Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles
Song, W., Zhang, J., Guo, J., Zhang, J., Ding, F., Li, L., & Sun, Z. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.10.003 · Cited by 636
Jin, G., Qin, H., Cao, H., Qian, S., Zhao, Y., Peng, X., Zhang, X., Liu, X., & Chu, P. K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.074 · Cited by 406
Self-citationBalancing osteoblast functions and bacterial adhesion on functionalized titanium surfaces
Neoh, K. G., Hu, X., Zheng, D., & Kang, E. T. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.018 · Cited by 330
Stimulation of bone growth following zinc incorporation into biomaterials
Qiao, Y., Zhang, W., Tian, P., Meng, F., Zhu, H., Jiang, X., Liu, X., & Chu, P. K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.101 · Cited by 318
Self-citationHuo, K., Zhang, X., Wang, H., Zhao, L., Liu, X., & Chu, P. K. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.071 · Cited by 306
Self-citationvan Oosten, M., Schäfer, T., Gazendam, J. A. C., Ohlsen, K., Tsompanidou, E., de Goffau, M. C., Harmsen, H. J. M., Crane, L. M. A., Lim, E., Francis, K. P., et al. (2013) · Nature Communications · doi:10.1038/ncomms3584 · Cited by 289
Nanostructured titanium-based materials for medical implants: Modeling and development
Mishnaevsky, L., Levashov, E., Valiev, R. Z., Segurado, J., Sabirov, I., Enikeev, N., Prokoshkin, S., Solov’yov, A. V., Korotitskiy, A., Gutmanas, E., et al. (2014) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2014.04.002 · Cited by 268
Shape-Dependent Biomimetic Inhibition of Enzyme by Nanoparticles and Their Antibacterial Activity
Cha, S.-H., Hong, J., McGuffie, M., Yeom, B., VanEpps, J. S., & Kotov, N. A. (2015) · ACS Nano · doi:10.1021/acsnano.5b03247 · Cited by 262
Osteogenic activity and antibacterial effect of zinc ion implanted titanium
Jin, G., Cao, H., Qiao, Y., Meng, F., Zhu, H., & Liu, X. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2014.02.025 · Cited by 258
Self-citationInfluence of sulfur content on bone formation and antibacterial ability of sulfonated PEEK
Ouyang, L., Zhao, Y., Jin, G., Lu, T., Li, J., Qiao, Y., Ning, C., Zhang, X., Chu, P. K., & Liu, X. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.017 · Cited by 254
Self-citationXie, X., Mao, C., Liu, X., Zhang, Y., Cui, Z., Yang, X., Yeung, K. W. K., Pan, H., Chu, P. K., & Wu, S. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06702 · Cited by 254
Self-citationXia, D., Shen, Z., Huang, G., Wang, W., Yu, J. C., & Wong, P. K. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b00531 · Cited by 250
Schwartz, V. B., Thétiot, F., Ritz, S., Pütz, S., Choritz, L., Lappas, A., Förch, R., Landfester, K., & Jonas, U. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201102980 · Cited by 243
Min, J., Choi, K. Y., Dreaden, E. C., Padera, R. F., Braatz, R. D., Spector, M., & Hammond, P. T. (2016) · ACS Nano · doi:10.1021/acsnano.6b00087 · Cited by 232
H. Müller, K., Kulkarni, J., Motskin, M., Goode, A., Winship, P., Skepper, J. N., Ryan, M. P., & Porter, A. E. (2010) · ACS Nano · doi:10.1021/nn101192z · Cited by 224
The control of cell adhesion and viability by zinc oxide nanorods
Lee, J., Kang, B. S., Hicks, B., Chancellor, T. F., Chu, B. H., Wang, H.-T., Keselowsky, B. G., Ren, F., & Lele, T. P. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.05.029 · Cited by 215
Luo, R., Tang, L., Zhong, S., Yang, Z., Wang, J., Weng, Y., Tu, Q., Jiang, C., & Huang, N. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am3027635 · Cited by 212
Biomedical Applications of Functionalized ZnO Nanomaterials: from Biosensors to Bioimaging
Zhu, P., Weng, Z., Li, X., Liu, X., Wu, S., Yeung, K. W. K., Wang, X., Cui, Z., Yang, X., & Chu, P. K. (2016) · Advanced Materials Interfaces · doi:10.1002/admi.201500494 · Cited by 193
Self-citationOxidative Self-Polymerization of Dopamine in an Acidic Environment
Zheng, W., Fan, H., Wang, L., & Jin, Z. (2015) · Langmuir · doi:10.1021/acs.langmuir.5b02757 · Cited by 185
High‐Mobility ZnO Thin Film Transistors Based on Solution‐processed Hafnium Oxide Gate Dielectrics
Esro, M., Vourlias, G., Somerton, C., Milne, W. I., & Adamopoulos, G. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201402684 · Cited by 182
Zhao, Z., Yan, R., Yi, X., Li, J., Rao, J., Guo, Z., Yang, Y., Li, W., Li, Y.-Q., & Chen, C. (2017) · ACS Nano · doi:10.1021/acsnano.7b00041 · Cited by 182
Self-citationShen, X., Hu, Y., Xu, G., Chen, W., Xu, K., Ran, Q., Ma, P., Zhang, Y., Li, J., & Cai, K. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5049338 · Cited by 179
Self-citationPan, G., Sun, S., Zhang, W., Zhao, R., Cui, W., He, F., Huang, L., Lee, S.-H., Shea, K. J., Shi, Q., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b09770 · Cited by 166
Zaveri, T. D., Dolgova, N. V., Chu, B. H., Lee, J., Wong, J., Lele, T. P., Ren, F., & Keselowsky, B. G. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.055 · Cited by 158
Response of rat osteoblast-like cells to microstructured model surfaces in vitro
Liao, H. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00379-4 · Cited by 154
Surface functionalization of biomaterials by radical polymerization
Zhou, T., Zhu, Y., Li, X., Liu, X., Yeung, K. W. K., Wu, S., Wang, X., Cui, Z., Yang, X., & Chu, P. K. (2016) · Progress in Materials Science · doi:10.1016/j.pmatsci.2016.04.005 · Cited by 145
Self-citationWu, S., Liu, X., Hu, T., Chu, P. K.-H., Ho, J., Chan, Y., Yeung, K., Chu, C. L., Hung, T., Huo, K., et al. (2008) · Nano Letters · doi:10.1021/nl802145n · Cited by 144
Self-citationFunctionalizing Calcium Phosphate Biomaterials with Antibacterial Silver Particles
Lee, J. S., & Murphy, W. L. (2012) · Advanced Materials · doi:10.1002/adma.201203370 · Cited by 136
Antimicrobial effect of polydopamine coating on Escherichia coli
Iqbal, Z., Lai, E. P. C., & Avis, T. J. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm34825j · Cited by 135
James, S., Feltis, B., de Jonge, M. D., Sridhar, M., Kimpton, J. A., Altissimo, M., Mayo, S. C., Zheng, C., Hastings, A. S., Howard, D. L., et al. (2013) · ACS Nano · doi:10.1021/nn403118u · Cited by 130
The Topographic Effect of Zinc Oxide Nanoflowers on Osteoblast Growth and Osseointegration
Park, J. K., Kim, Y.-J., Yeom, J., Jeon, J. H., Yi, G., Je, J. H., & Hahn, S. K. (2010) · Advanced Materials · doi:10.1002/adma.201002255 · Cited by 129
Rouabhia, M., Asselin, J., Tazi, N., Messaddeq, Y., Levinson, D. J., & Zhang, Z. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am4027983 · Cited by 123
Pezzella, A., d’Ischia, M., Napolitano, A., Palumbo, A., & Prota, G. (1997) · Tetrahedron · doi:10.1016/s0040-4020(97)00494-8 · Cited by 117
Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants
Xu, Z., Li, M., Li, X., Liu, X., Ma, F., Wu, S., Yeung, K., Han, Y. N., & Chu, P. K.-H. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b04161 · Cited by 116
Self-citationWong, D. S. H., Li, J., Yan, X., Wang, B., Li, R., Zhang, L., & Bian, L. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b04958 · Cited by 116
Self-citationJin, G., Qin, H., Cao, H., Qiao, Y., Zhao, Y., Peng, X., Zhang, X., Liu, X., & Chu, P. K.-H. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.06.040 · Cited by 114
Self-citationWang, T., Liu, X., Zhu, Y., Cui, Z., Yang, X. J., Pan, H., Yeung, K., & Wu, S. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00103 · Cited by 83
Self-citationZinc-Binding Sites on Selected Flavonoids
Wei, Y., & Guo, M. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-0099-0 · Cited by 66
Ultrasensitive Vertical Piezotronic Transistor Based on ZnO Twin Nanoplatelet
Wang, L., Liu, S., Feng, X., Xu, Q., Bai, S., Zhu, L., Chen, L., Qin, Y., & Wang, Z. L. (2017) · ACS Nano · doi:10.1021/acsnano.7b01374 · Cited by 65
Desseaux, S., & Klok, H. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.12.011 · Cited by 53
Biomaterials control of pluripotent stem cell fate for regenerative therapy
Pérez, R. A., Choi, S., Han, C., Kim, J., Shim, H., Leong, K. W., & Kim, H. (2016) · Progress in Materials Science · doi:10.1016/j.pmatsci.2016.05.003 · Cited by 46
Impact of RGD Nanopatterns Grafted onto Titanium on Osteoblastic Cell Adhesion
Nguyen, M. N., Lebarbé, T., Zouani, O. F., Pichavant, L., Durrieu, M., & Héroguez, V. (2012) · Biomacromolecules · doi:10.1021/bm201812u · Cited by 36
Cytotoxic evaluation of nanostructured zinc oxide (ZnO) thin films and leachates
Petrochenko, P. E., Zhang, Q., Bayati, M. R., Skoog, S. A., Phillips, K. S., Kumar, G., Narayan, R. J., & Goering, P. L. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.05.004 · Cited by 34
Liao, H., Miao, X., Ye, J., Wu, T., Deng, Z., Li, C., Jia, J., Cheng, X., & Wang, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b00666 · Cited by 34
The Effects of Feeding Pinus Pinea Seeds on Some Blood Values in Male New Zealand White Rabbits
Yildiz-Gul, O., Gülay, M. Ş., Ata, A., Balic, A., & Demirtaş, A. (2010) · Journal of Animal and Veterinary Advances · doi:10.3923/javaa.2010.2655.2658 · Cited by 4
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Metadata
- Authors
- Li, J., Tan, L., Liu, X., Cui, Z., Yang, X., Yeung, K. W. K., Chu, P. K., & Wu, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-10-23
- Volume
- 11
- Issue
- 11
- Pages
- 11250-11263
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2765850901
- Cited by
- 300
- References
- 66
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- closed
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