Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

Studies and Perspectives of Protein Kinase C

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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Protein kinase C and lipid signaling for sustained cellular responses

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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Protein Kinase C: Structure, Function, and Regulation

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The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

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The extended protein kinase C superfamily

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Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

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Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

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Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

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Regulation of protein kinase C

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Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

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Protein kinase C as a possible receptor protein of tumor‐promoting phorbol esters

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The C2 domain calcium‐binding motif: Structural and functional diversity

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Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

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Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

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Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals

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A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

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AKAPs: from structure to function

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Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

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Activation of protein kinase C by tyrosine phosphorylation in response to H 2 O 2

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Multiple pathways control protein kinase C phosphorylation

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Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes

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Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

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Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

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An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

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Identification of intracellular receptor proteins for activated protein kinase C.

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12–rapamycinassociated protein

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

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Immunodeficiency in Protein Kinase Cβ-Deficient Mice

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Protein kinase C isozymes and substrates

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

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Cellular Signaling

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Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

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Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans

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Taxonomy and function of C1 protein kinase C homology domains

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The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

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Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation

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Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

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Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

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Ca2+ bridges the C2 membrane-binding domain of protein kinase Cα directly to phosphatidylserine

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Supersensitivity to allosteric GABAA receptor modulators and alcohol in mice lacking PKCε

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Signaling through protein kinase C

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C2 Region-derived Peptides Inhibit Translocation and Function of β Protein Kinase C in Vivo

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Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

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Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules

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Signaling and Subcellular Targeting by Membrane-Binding Domains

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Protein kinase C binding partners

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Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

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The Coatomer Protein β′-COP, a Selective Binding Protein (RACK) for Protein Kinase Cε

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Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function.

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Protein kinase Cδ

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Direct Visualization of the Translocation of the γ-Subspecies of Protein Kinase C in Living Cells Using Fusion Proteins with Green Fluorescent Protein

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The molecular basis for protein kinase A anchoring revealed by solution NMR.

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Two types of complementary DNAs of rat brain protein kinase C: Heterogeneity determined by alternative splicing

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Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

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Phosphorylation of Protein Kinase C-α on Serine 657 Controls the Accumulation of Active Enzyme and Contributes to Its Phosphatase-resistant State

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Interaction of Proteins With Lipid Headgroups: Lessons from Protein Kinase C

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Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.

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Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Cα

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Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

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Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.

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Eyes wide shut: Protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters

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Structure of the protein kinase Cβ phospholipid-binding C2 domain complexed with Ca2+

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Biosynthesis and Posttranslational Modifications of Protein Kinase C in Human Breast Cancer Cells

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The C1 and C2 Domains of Protein Kinase C Are Independent Membrane Targeting Modules, with Specificity for Phosphatidylserine Conferred by the C1 Domain

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Requirement for negative charge on “activation loop” of protein kinase C.

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Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C

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The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation

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Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes

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PHARMACOLOGIC MODULATION OF PROTEIN KINASE C ISOZYMES: THE ROLE OF RACKS AND SUBCELLULAR LOCALISATION

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Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes

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Non-equivalent Roles for the First and Second Zinc Fingers of Protein Kinase Cδ

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Solution structure of a cysteine rich domain of rat protein kinase C

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Threonine-497 is a critical site for permissive activation of protein kinase Cα

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Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine.

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Carboxyl-terminal Phosphorylation Regulates the Function and Subcellular Localization of Protein Kinase C βII

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Protein Kinase Cα Contains Two Activator Binding Sites That Bind Phorbol Esters and Diacylglycerols with Opposite Affinities

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Crystal structure of the C2 domain from protein kinase C-δ

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Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex.

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Control by phosphorylation

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The Carboxyl Terminus of Protein Kinase C Provides a Switch to Regulate Its Interaction with the Phosphoinositide-dependent Kinase, PDK-1

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Phosphorylation of Protein Kinase Cδ (PKCδ) at Threonine 505 Is Not a Prerequisite for Enzymatic Activity

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Interactions between Protein Kinase C and Pleckstrin Homology Domains

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Dual Role of Pseudosubstrate in the Coordinated Regulation of Protein Kinase C by Phosphorylation and Diacylglycerol

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Association of Immature Hypophosphorylated Protein Kinase Cε with an Anchoring Protein CG-NAP

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Complete Activation of Protein Kinase C by an Antipeptide Antibody Directed against the Pseudosubstrate Prototope

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The regulatory region of protein kinase C gamma. Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters, and divalent cations.

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Requirements of Protein Kinase Cδ for Catalytic Function

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Oxidative Stress and Vanadate Induce Tyrosine Phosphorylation of Phosphoinositide-Dependent Kinase 1 (PDK1)

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