The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interaction of Fine Particles and Nanoparticles with Red Blood Cells Visualized with Advanced Microscopic Techniques
Abstract
So far, little is known about the interaction of nanoparticles with lung cells, the entering of nanoparticles, and their transport through the blood stream to other organs. The entering and localization of different nanoparticles consisting of differing materials and of different charges were studied in human red blood cells. As these cells do not have any phagocytic receptors on their surface, and no actinmyosin system, we chose them as a model for nonphagocytic cells to study how nanoparticles penetrate cell membranes. We combined different microscopic techniques to visualize fine and nanoparticles in red blood cells: (I) fluorescent particles were analyzed by laser scanning microscopy combined with digital image restoration, (II) gold particles were analyzed by conventional transmission electron microscopy and energy filtering transmission electron microscopy, and (III) titanium dioxide particles were analyzed by energy filtering transmission electron microscopy. By using these differing microscopic techniques we were able to visualize and detect particles < or = 0.2 microm and nanoparticles in red blood cells. We found that the surface charge and the material of the particles did not influence their entering. These results suggest that particles may penetrate the red blood cell membrane by a still unknown mechanism different from phagocytosis and endocytosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Passage of inhaled particles into the blood circulation in humans
Nemmar, A., Hoet, P. H. M., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., & Nemery, B. (2002) · Circulation · doi:10.1161/hc0402.104118 · Cited by 1,719
Limbach, L. K., Li, Y., Grass, R. N., Brunner, T. J., Hintermann, M. A., Muller, M., Gunther, D., & Stark, W. J. (2005) · Environmental Science & Technology · doi:10.1021/es051043o · Cited by 779
Cited by
Nanomaterials and nanoparticles: Sources and toxicity
Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789
Occurrence, behavior and effects of nanoparticles in the environment
Nowack, B., & Bucheli, T. D. (2007) · Environmental Pollution · doi:10.1016/j.envpol.2007.06.006 · Cited by 2,286
The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
De Jong, W. H., Hagens, W. I., Krystek, P., Burger, M. C., Sips, A. J. A. M., & Geertsma, R. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.12.037 · Cited by 1,615
Titanium dioxide nanoparticles: a review of current toxicological data
Shi, H., Magaye, R., Castranova, V., & Zhao, J. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-15 · Cited by 1,498
Engineered nanoparticles interacting with cells: size matters
Shang, L., Nienhaus, K., & Nienhaus, G. U. (2014) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-12-5 · Cited by 1,316
Emergence of Nanoplastic in the Environment and Possible Impact on Human Health
Lehner, R., Weder, C., Petri-Fink, A., & Rothen-Rutishauser, B. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b05512 · Cited by 1,242
Self-citationUnderstanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Sousa de Almeida, M., Susnik, E., Drasler, B., Taladriz-Blanco, P., Petri-Fink, A., & Rothen-Rutishauser, B. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01127d · Cited by 1,079
Self-citationAssessment of microplastics in freshwater systems: A review
Li, C., Busquets, R., & Campos, L. C. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135578 · Cited by 954
Calderón-Garcidueñas, L., Solt, A. C., Henríquez-Roldán, C., Torres-Jardón, R., Nuse, B., Herritt, L., Villarreal-Calderón, R., Osnaya, N., Stone, I., García, R., et al. (2008) · Toxicologic Pathology · doi:10.1177/0192623307313011 · Cited by 937
Limbach, L. K., Wick, P., Manser, P., Grass, R. N., Bruinink, A., & Stark, W. J. (2007) · Environmental Science & Technology · doi:10.1021/es062629t · Cited by 889
French, R. A., Jacobson, A. R., Kim, B., Isley, S. L., Penn, R. L., & Baveye, P. C. (2009) · Environmental Science & Technology · doi:10.1021/es802628n · Cited by 788
Nanoparticles for direct nose-to-brain delivery of drugs
Mistry, A., Stolnik, S., & Illum, L. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.019 · Cited by 734
The Adverse Effects of Air Pollution on the Nervous System
Genc, S., Zadeoglulari, Z., Fuss, S. H., & Genc, K. (2012) · Journal of Toxicology · doi:10.1155/2012/782462 · Cited by 717
Nanotechnology and Water Treatment: Applications and Emerging Opportunities
Theron, J., Walker, J. A., & Cloete, T. E. (2008) · Critical Reviews in Microbiology · doi:10.1080/10408410701710442 · Cited by 716
Engineered nanoparticles in wastewater and wastewater sludge – Evidence and impacts
Brar, S. K., Verma, M., Tyagi, R. D., & Surampalli, R. Y. (2010) · Waste Management · doi:10.1016/j.wasman.2009.10.012 · Cited by 716
Assessment of the In Vivo Toxicity of Gold Nanoparticles
Chen, Y.-S., Hung, Y.-C., Liau, I., & Huang, G. S. (2009) · Nanoscale Research Letters · doi:10.1007/s11671-009-9334-6 · Cited by 695
Hamouda, R. A., Hussein, M. H., Abo-elmagd, R. A., & Bawazir, S. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-49444-y · Cited by 658
Barrier Capacity of Human Placenta for Nanosized Materials
Wick, P., Malek, A., Manser, P., Meili, D., Maeder-Althaus, X., Diener, L., Diener, P.-A., Zisch, A., Krug, H. F., & von Mandach, U. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901200 · Cited by 584
Nanotoxicology: An Interdisciplinary Challenge
Krug, H. F., & Wick, P. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201001037 · Cited by 556
In vitro assessments of nanomaterial toxicity
Jones, C. F., & Grainger, D. W. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.005 · Cited by 554
Titanium dioxide in our everyday life; is it safe?
Skocaj, M., Filipic, M., Petkovic, J., & Novak, S. (2011) · Radiology and Oncology · doi:10.2478/v10019-011-0037-0 · Cited by 549
Micro- and nanoplastic induced cellular toxicity in mammals: A review
Banerjee, A., & Shelver, W. L. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142518 · Cited by 492
Handy, R. D., & Shaw, B. J. (2007) · Health, Risk & Society · doi:10.1080/13698570701306807 · Cited by 391
Nanomaterials in food and agriculture: An overview on their safety concerns and regulatory issues
Jain, A., Ranjan, S., Dasgupta, N., & Ramalingam, C. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1160363 · Cited by 367
Wang, T., Bai, J., Jiang, X., & Nienhaus, G. U. (2012) · ACS Nano · doi:10.1021/nn203892h · Cited by 362
Physiologically Based Pharmacokinetic Modeling of Nanoparticles
Li, M., Al-Jamal, K. T., Kostarelos, K., & Reineke, J. (2010) · ACS Nano · doi:10.1021/nn1018818 · Cited by 351
Hussain, S., Boland, S., Baeza-Squiban, A., Hamel, R., Thomassen, L. C. J., Martens, J. A., Billon-Galland, M. A., Fleury-Feith, J., Moisan, F., Pairon, J.-C., et al. (2009) · Toxicology · doi:10.1016/j.tox.2009.04.001 · Cited by 347
Delfino, R. J., Staimer, N., Tjoa, T., Gillen, D. L., Polidori, A., Arhami, M., Kleinman, M. T., Vaziri, N. D., Longhurst, J., & Sioutas, C. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0800194 · Cited by 332
Anagnosti, L., Varvaresou, A., Pavlou, P., Protopapa, E., & Carayanni, V. (2021) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2020.111883 · Cited by 281
Toxicology of Nanomaterials Used in Nanomedicine
Zhao, J., & Castranova, V. (2011) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2011.615113 · Cited by 280
Modeling the Thermodynamics of the Interaction of Nanoparticles with Cell Membranes
Ginzburg, V. V., & Balijepalli, S. (2007) · Nano Letters · doi:10.1021/nl072053l · Cited by 253
Metadata
- Authors
- Rothen-Rutishauser, B. M., Schürch, S., Haenni, B., Kapp, N., & Gehr, P.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-04-05
- Volume
- 40
- Issue
- 14
- Pages
- 4353-4359
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2040330716
- Cited by
- 534
- References
- 2
- FWCI
- 19.32
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
