Bioaccumulation of Perfluoroalkyl Substances by Daphnia magna in Water with Different Types and Concentrations of Protein
Abstract
Perfluoroalkyl substances (PFASs) are sometimes regarded as proteinophilic compounds, however, there is no research report about the effect of environmental protein on the bioaccumulation of PFASs in waters. In the present study we investigated influences of protein on the bioaccumulation of six kinds of PFASs by Daphnia magna in water; it included perfluorooctane sulfonate, perfluorooctanoic acid, perfluorononanoic acid, perfluorodecanoic acid, perfluoroundecanoic acid, and perfluorododecanoic acid. Two types of protein including bovine albumin from animal and soy peptone from plant were compared and the effects of protein concentration were investigated. Both types of protein at high concentrations (10 and 20 mg L(-1)) suppressed the bioaccumulation of PFASs. When protein concentration increased from 0 to 20 mg L(-1), the decreasing ratios of the PFAS body burden (35.3-52.9%) in Daphnia magna induced by bovine albumin were significantly higher than those (22.0-36.6%) by soy peptone. The dialysis bag experiment results showed that the binding of PFASs to protein followed the Freundlich isotherm, suggesting it is not a linear partitioning process but an adsorption-like process. The partition coefficients of PFASs between bovine albumin and water were higher compared to soy peptone; this resulted in higher reducing rates of freely dissolved concentrations of PFASs with increasing bovine albumin concentration, leading to a stronger suppression of PFAS bioaccumulation. However, the presence of both types of protein with a low concentration (1 mg L(-1)) enhanced the bioaccumulation of PFASs. Furthermore, the water-based bioaccumulation factor based on the freely dissolved concentrations of PFASs even increased with and the depuration rate constants of PFASs from Daphnia magna decreased with protein concentration, suggesting that protein would not only reduce the bioavailable concentrations and uptake rates of PFASs but also lower the elimination rates of PFASs in Daphnia magna. Because these two opposite effects would change with different protein concentrations in water, the net effect of protein on PFAS bioaccumulation would also vary with protein concentration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PFASs can be accumulated by aquatic organisms.
“Many investigators have found that PFASs could be accumulated by aquatic organisms”
From Short- and long-chain perfluoroalkyl substances in the water, suspended particulate matter, and surface sediment of a turbid river (2016) · cites this paper as Xia et al., 2013
Cites
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641 · see citing works
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750 · see citing works
Biological Monitoring of Polyfluoroalkyl Substances: A Review
Houde, M., Martin, J. W., Letcher, R. J., Solomon, K. R., & Muir, D. C. G. (2006) · Environmental Science & Technology · doi:10.1021/es052580b · Cited by 1,259 · see citing works
Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices
Hansen, K. J., Clemen, L. A., Ellefson, M. E., & Johnson, H. O. (2001) · Environmental Science & Technology · doi:10.1021/es001489z · Cited by 923 · see citing works
Monitoring of Perfluorinated Compounds in Aquatic Biota: An Updated Review: PFCs in Aquatic Biota
Houde, M., De Silva, A. O., Muir, D. C. G., & Letcher, R. J. (2011) · Environmental Science & Technology · doi:10.1021/es104326w · Cited by 847 · see citing works
The toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742 · see citing works
Binding of perfluorinated fatty acids to serum proteins
Jones, P. D., Hu, W., Coen, W. D., Newsted, J. L., & Giesy, J. P. (2003) · Environmental Toxicology and Chemistry · doi:10.1897/02-553 · Cited by 628 · see citing works
Subchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys
Seacat, A. M. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.249 · Cited by 564 · see citing works
Trophic magnification factors: Considerations of ecology, ecosystems, and study design
Borgå, K., Kidd, K. A., Muir, D. C., Berglund, O., Conder, J. M., Gobas, F. A., Kucklick, J., Malm, O., & Powell, D. E. (2012) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.244 · Cited by 531 · see citing works
Taniyasu, S., Kannan, K., Horii, Y., Hanari, N., & Yamashita, N. (2003) · Environmental Science & Technology · doi:10.1021/es0303440 · Cited by 509 · see citing works
DIETARY ACCUMULATION OF PERFLUORINATED ACIDS IN JUVENILE RAINBOW TROUT (ONCORHYNCHUS MYKISS)
Martin, J. W., Mabury, S. A., Solomon, K. R., & Muir, D. C. G. (2003) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620220125 · Cited by 475 · see citing works
Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe
Barber, J. L., Berger, U., Chaemfa, C., Huber, S., Jahnke, A., Temme, C., & Jones, K. C. (2007) · Journal of Environmental Monitoring · doi:10.1039/b701417a · Cited by 353 · see citing works
Schultz, M. M., Barofsky, D. F., & Field, J. A. (2003) · Environmental Engineering Science · doi:10.1089/109287503768335959 · Cited by 351 · see citing works
Aquatic humic substances—Influence on fate and treatment of pollutants
Ikan, R. (1990) · Organic Geochemistry · doi:10.1016/0146-6380(90)90087-g · Cited by 319 · see citing works
Protein degradation during anaerobic wastewater treatment: derivation of stoichiometry
Ramsay, I. R., & Pullammanappallil, P. C. (2001) · Biodegradation · doi:10.1023/a:1013116728817 · Cited by 281 · see citing works
Chen, X., Xia, X., Wang, X., Qiao, J., & Chen, H. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.04.018 · Cited by 247 · see citing works
Self-citationCampbell, P. G. C., Twiss, M. R., & Wilkinson, K. J. (1997) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f97-161 · Cited by 236 · see citing works
Yang, L., Zhu, L. Y., & Liu, Z. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.02.075 · Cited by 230 · see citing works
Bruggeman, W. A., Martron, L. B. J. M., Kooiman, D., et al. (1981) · Chemosphere · doi:10.1016/0045-6535(81)90082-5 · Cited by 222 · see citing works
Novel perspectives on the bioaccumulation of PFCs–the concentration dependency
Liu, C., Gin, K. Y. H., Chang, V. W. C., Goh, B. P. L., & Reinhard, M. (2011) · Environmental Science & Technology · doi:10.1021/es202078n · Cited by 168 · see citing works
Xia, X., Yang, Z., & Zhang, X. (2009) · Environmental Science & Technology · doi:10.1021/es8036675 · Cited by 134 · see citing works
Self-citationBerger, U. (2008) · Environmental Science & Technology · doi:10.1021/es800529h · Cited by 124 · see citing works
Humic Acids Reduce Bioaccumulation of Some Polycyclic Aromatic Hydrocarbons
Leversee, G. J., Landrum, P. F., Giesy, J. P., et al. (1983) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f83-311 · Cited by 111 · see citing works
Bioaccumulation and uptake routes of perfluoroalkyl acids in Daphnia magna
Dai, Z., Xia, X., Guo, J., & Jiang, X. (2012) · Chemosphere · doi:10.1016/j.chemosphere.2012.08.026 · Cited by 102 · see citing works
Self-citationTraina, S. J., McAvoy, D. C., & Versteeg, D. J. (1996) · Environmental Science & Technology · doi:10.1021/es950512r · Cited by 88 · see citing works
Covalent binding of perfluorinated fatty acids to proteins in the plasma, liver and testes of rats
Vanden Heuvel, J. P., Kuslikis, B. I., & Peterson, R. E. (1992) · Chemico-Biological Interactions · doi:10.1016/0009-2797(92)90003-4 · Cited by 84 · see citing works
Lasier, P. J., Washington, J. W., Hassan, S. M., & Jenkins, T. M. (2011) · Environmental Toxicology and Chemistry · doi:10.1002/etc.622 · Cited by 82 · see citing works
Xia, X., Yu, H. W., Yang, Z. F., et al. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.01.075 · Cited by 78 · see citing works
Self-citationBioavailability of atrazine, pyrene and benzo[a]pyrene in European river waters
Akkanen, J., Penttinen, S., Haitzer, M., et al. (2001) · Chemosphere · doi:10.1016/s0045-6535(01)00038-8 · Cited by 77 · see citing works
Perfluorinated Compounds in Water, Sediment and Soil from Guanting Reservoir, China
Wang, T., Chen, C., Naile, J. E., Khim, J. S., Giesy, J. P., & Lü, Y. (2011) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-011-0307-y · Cited by 75 · see citing works
Jahnke, A., Ahrens, L., Ebinghaus, R., Berger, U., Barber, J. L., & Temme, C. (2007) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-006-1008-y · Cited by 74 · see citing works
Shi, Y., Pan, Y., Wang, J., & Cai, Y. (2011) · Journal of Environmental Monitoring · doi:10.1039/c1em10772k · Cited by 72 · see citing works
Xia, X., Chen, X., Zhao, X., Chen, H., & Shen, M. (2012) · Environmental Science & Technology · doi:10.1021/es303024x · Cited by 61 · see citing works
Self-citationLegierse, K. C. H. M., Sijm, D. T. H. M., van Leeuwen, K., et al. (1998) · Aquatic Toxicology · doi:10.1016/s0166-445x(97)00092-1 · Cited by 31 · see citing works
Study on the Langmuir aggregation of fluorinated surfactants on protein
Li, L., Xu, Z. S., & Song, G. W. (2008) · Journal of Fluorine Chemistry · doi:10.1016/j.jfluchem.2008.10.007 · Cited by 28 · see citing works
Rayne, S., & Forest, K. (2009) · Environmental Science & Technology · doi:10.1021/es9013079 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zhao, P., Xia, X., Dong, J., Xia, N., Jiang, X., Li, Y., & Zhu, Y. (2016) · Science of The Total Environment · doi:10.1016/j.scitotenv.2016.05.221 · Cited by 322 · see citing works
Self-citationSima, M. W., & Jaffé, P. R. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143793 · Cited by 242 · see citing works
Lewis, A. J., Yun, X., Spooner, D. E., Kurz, M. J., McKenzie, E. R., & Sales, C. M. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153561 · Cited by 184 · see citing works
Wen, W., Xia, X., Hu, D., Zhou, D., Wang, H., Zhai, Y., & Lin, H. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b03647 · Cited by 101 · see citing works
Self-citationSimpson, S. L., Liu, Y., Spadaro, D. A., Wang, X., Kookana, R. S., & Batley, G. E. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146008 · Cited by 51 · see citing works
Research priorities for the environmental risk assessment of per- and polyfluorinated substances
Gkika, I. S., Xie, G., van Gestel, C. A. M., Ter Laak, T. L., Vonk, J. A., van Wezel, A. P., & Kraak, M. H. S. (2023) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5729 · Cited by 28 · see citing works
- Authors
- Xia, X., Rabearisoa, A. H., Jiang, X., & Dai, Z.
- Affiliations
- Beijing Normal University (CN)
- Corresponding author
- Xia, Xinghui
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-08-22
- Volume
- 47
- Issue
- 19
- Pages
- 10955-10963
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2315376186
- Cited by
- 102
- References
- 36
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 14 · 2023: 9 · 2022: 13 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 5 · 2015: 4 · 2014: 3
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Environmental Science & Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- perfluorinated compounds, PFAS bioaccumulation, Daphnia magna, bovine serum albumin, soy peptone, protein binding, protein concentration effects, PFOS, perfluorooctanoic acid, perfluorodecanoic acid, perfluoroundecanoic acid, perfluorononanoic acid, perfluorododecanoic acid, partition coefficient, Freundlich isotherm, bioaccumulation factor
- MeSH terms
- Animals, Daphnia, Fatty Acids, Fluorocarbons, Fresh Water, Peptones, Serum Albumin, Bovine, Water Pollutants, Chemical, Alkanesulfonic Acids, Soybean Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
