In Vitro Bioassays for Assessing Estrogenic Substances

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519

Developmental effects of endocrine-disrupting chemicals in wildlife and humans.

Colborn, T., vom Saal, F. S., & Soto, A. M. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101378 · Cited by 3,445

Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?

Sharpe, R. M., & Skakkebaek, N. E. (1993) · The Lancet · doi:10.1016/0140-6736(93)90953-e · Cited by 1,849

Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving

Krishnan, A. V., Stathis, P., Permuth, S. F., Tokes, L., & Feldman, D. I. (1993) · Endocrinology · doi:10.1210/en.132.6.2279 · Cited by 1,613

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B

Kastner, P., Krust, A., Turcotte, B., Stropp, U., Tora, L., Gronemeyer, H., & Chambon, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08280.x · Cited by 1,534

Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen

Routledge, E. J., & Sumpter, J. P. (1996) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620150303 · Cited by 1,504

Environmentally persistent alkylphenolic compounds are estrogenic

White, R., Jobling, S., Hoare, S., Sumpter, J. P., & Parker, M. G. (1994) · Endocrinology · doi:10.1210/en.135.1.175 · Cited by 1,451

Functional domains of the human estrogen receptor

Kumar, V., Green, S., Stack, G., Berry, M., Jin, J.-R., & Chambon, P. (1987) · Cell · doi:10.1016/0092-8674(87)90581-2 · Cited by 1,316

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

Berthois, Y., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2496 · Cited by 1,307

A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic.

Jobling, S., Reynolds, T., White, R., Parker, M. G., & Sumpter, J. P. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103582 · Cited by 1,259

The human estrogen receptor has two independent nonacidic transcriptional activation functions

Tora, L., White, J., Brou, C., Tasset, D., Webster, N., Scheer, E., & Chambon, P. (1989) · Cell · doi:10.1016/0092-8674(89)90031-7 · Cited by 1,048

Estrogenicity of resin-based composites and sealants used in dentistry.

Olea, N., Pulgar, R., Pérez, P., Olea-Serrano, F., Rivas, A., Novillo-Fertrell, A., Pedraza, V, Soto, A. M., & Sonnenschein, C. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104298 · Cited by 1,041

Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes

Jobling, S., & Sumpter, J. P. (1993) · Aquatic Toxicology · doi:10.1016/0166-445x(93)90064-8 · Cited by 987

Xenoestrogens released from lacquer coatings in food cans.

Brotons, J. A., Olea-Serrano, M. F., Villalobos, M., Pedraza, V, & Olea, N. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103608 · Cited by 942

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

Göttlicher, M., Widmark, E., Li, Q., & Gustafsson, J. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4653 · Cited by 857

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

Berry, M., Metzger, D., & Chambon, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07469.x · Cited by 767

Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations

Adlercreutz, H. (1990) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365519009085798 · Cited by 761

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

Allenby, G., Bocquel, M. T., Saunders, M., Kazmer, S., Speck, J., Rosenberger, M., Lovey, A., Kastner, P., Grippo, J. F., & Chambon, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.30 · Cited by 754

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

Cavaillès, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P. J., & Parker, M. G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00044.x · Cited by 751

Selection of Intrinsic Horizontal Connections in the Visual Cortex by Correlated Neuronal Activity

Löwel, S., & Singer, W. (1992) · Science · doi:10.1126/science.1372754 · Cited by 707

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

Hollenberg, S. M., & Evans, R. M. (1988) · Cell · doi:10.1016/0092-8674(88)90145-6 · Cited by 684

Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells

Berger, J., Hauber, J., Hauber, R., Geiger, R., & Cullen, B. R. (1988) · Gene · doi:10.1016/0378-1119(88)90219-3 · Cited by 667

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C., & Brown, M. (1994) · Science · doi:10.1126/science.8197458 · Cited by 637

Transcriptional activation and nuclear targeting signals of the human androgen receptor.

Simental, J. A., Sar, M., Lane, M. V., French, F. S., & Wilson, E. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52466-2 · Cited by 631

Phytoestrogen Interaction with Estrogen Receptors in Human Breast Cancer Cells

MARTIN, P. M., HORWITZ, K. B., RYAN, D. S., & McGUIRE, W. L. (1978) · Endocrinology · doi:10.1210/endo-103-5-1860 · Cited by 601

Steroid hormone receptors compete for factors that mediate their enhancer function

Meyer, M.-E., Gronemeyer, H., Turcotte, B., Bocquel, M.-T., Tasset, D., & Chambon, P. (1989) · Cell · doi:10.1016/0092-8674(89)90918-5 · Cited by 566

Medical hypothesis: xenoestrogens as preventable causes of breast cancer.

Davis, D. L., Bradlow, H. L., Wolff, M., Woodruff, T., Hoel, D. G., & Anton-Culver, H. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101372 · Cited by 533

Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG)

Adlercreutz, H., Höckerstedt, K., Bannwart, C., Bloigu, S., Hämäläinen, E., Fotsis, T., & Ollus, A. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90200-7 · Cited by 503

Environmental Estrogenic Effects of Alkylphenol Ethoxylates

Nimrod, A. C., & Benson, W. H. (1996) · Critical Reviews in Toxicology · doi:10.3109/10408449609012527 · Cited by 500

Reporter genes: Application to the study of mammalian gene transcription

Alam, J., & Cook, J. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90601-5 · Cited by 470

MCF-7: A human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors

Horwitz, K. B., Costlow, M. E., & McGuire, W. L. (1975) · Steroids · doi:10.1016/0039-128x(75)90110-5 · Cited by 453

Dietary phytoestrogens and cancer: in vitro and in vivo studies

Adlercreutz, H., Mousavi, Y., Clark, J., Höckerstedt, K., Hämäläinen, E., Wähälä, K., Mäkelä, T., & Hase, T. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90359-q · Cited by 432

Species-Specific Recombinant Cell Lines as Bioassay Systems for the Detection of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-like Chemicals

Garrison, P. (1996) · Fundamental and Applied Toxicology · doi:10.1006/faat.1996.0056 · Cited by 405

Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor

Miksicek, R. J. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90005-1 · Cited by 380

Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets

Adlercreutz, H., Fotsis, T., Bannwart, C., Wähälä, K., Mäkelä, T., Brunow, G., & Hase, T. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90310-9 · Cited by 378

Firefly luciferase as a tool in molecular and cell biology

Gould, S. J., & Subramani, S. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90353-3 · Cited by 375

Distinct classes of transcriptional activating domains function by different mechanisms

Tasset, D., Tora, L., Fromental, C., Scheer, E., & Chambon, P. (1990) · Cell · doi:10.1016/0092-8674(90)90394-t · Cited by 357

In vitro bioassays of non-steroidal phytoestrogens

Markiewicz, L., Garey, J., Adlercreutz, H., & Gurpide, E. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90009-l · Cited by 335

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

Nagpal, S., Saunders, M., Kastner, P., Durand, B., Nakshatri, H., & Chambon, P. (1992) · Cell · doi:10.1016/0092-8674(92)90250-g · Cited by 334

Estrogenic action of DDT and its analogs

Welch, R. M., Levin, W., & Conney, A. H. (1969) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(69)90117-3 · Cited by 314

Quantitation of parameters that determine the rate of ovalbumin synthesis

Palmiter, R. D. (1975) · Cell · doi:10.1016/0092-8674(75)90167-1 · Cited by 291

Vitellogenin synthesis in cultured hepatocytes; an in vitro test for the estrogenic potency of chemicals

Pelissero, C., Flouriot, G., Foucher, J. L., Bennetau, B., Dunoguès, J., Le Gac, F., & Sumpter, J. P. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90086-c · Cited by 284

The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

Nunez, A. M., Berry, M., Imler, J. L., & Chambon, P. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03443.x · Cited by 264

The E-screen assay: a comparison of different MCF7 cell stocks.

Villalobos, M., Olea, N., Brotons, J. A., Olea-Serrano, M. F., Ruiz de Almodovar, J. M., & Pedraza, V (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103844 · Cited by 263

Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

Godowski, P. J., Picard, D., & Yamamoto, K. R. (1988) · Science · doi:10.1126/science.3043662 · Cited by 253

Mitogenic stimulation of human breast cancer cells in a growth factor‐defined medium: Synergistic action of insulin and estrogen

van der Burg, B., Rutteman, G. R., Blankenstein, M. A., de Laat, S. W., & van Zoelen, E. J. J. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041340112 · Cited by 247

17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: A comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA

Spink, D. C., Eugster, H.-P., Lincoln, D. W., Schuetz, J. D., Schuetz, E. G., Johnson, J. A., Kaminsky, L. S., & Gierthy, J. F. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90404-k · Cited by 244

Functional toxicology: a new approach to detect biologically active xenobiotics.

McLachlan, J. A. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101386 · Cited by 236

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

Metzger, D., Ali, S., Bornert, J.-M., & Chambon, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.16.9535 · Cited by 231

Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture

Mousavi, Y., & Adlercreutz, H. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90393-w · Cited by 223

v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA

Zenke, M., Muñoz, A., Sap, J., Vennström, B., & Beug, H. (1990) · Cell · doi:10.1016/0092-8674(90)90068-p · Cited by 221

Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells

Pagliacci, M. C., Smacchia, M., Migliorati, G., Grignani, F., Riccardi, C., & Nicoletti, I. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)00262-4 · Cited by 211

Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation

Jayaraman, T., Ondrias, K., Ondria, E., & Marks, A. R. (1996) · Science · doi:10.1126/science.272.5267.1492 · Cited by 209

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

Mader, S., Leroy, P., Chen, J. Y., & Chambon, P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54192-2 · Cited by 203

Bioflavonoid interaction with rat uterine type ii binding sites and cell growth inhibition

Markaverich, B. M., Roberts, R. R., Alejandro, M. A., Johnson, G. A., Middleditch, B. S., & Clark, J. H. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90078-7 · Cited by 203

The effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17β-estradiol 4-hydroxylase

Spink, D. C., Hayes, C. L., Young, N. R., Christou, M., Sutter, T. R., Jefcoate, C. R., & Gierthy, J. F. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90037-x · Cited by 195

Estrogen control of prolactin synthesis in vitro.

Lieberman, M. E., Maurer, R. A., & Gorski, J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.12.5946 · Cited by 189

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

Wrenn, C. K., & Katzenellenbogen, B. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80497-9 · Cited by 186

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells.

Spink, D. C., Lincoln, D. W., Dickerman, H. W., & Gierthy, J. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6917 · Cited by 186

Inhibitory Cross-Talk between Steroid Hormone Receptors: Differential Targeting of Estrogen Receptor in the Repression of Its Transcriptional Activity by Agonist- and Antagonist-Occupied Progestin Receptors

Kraus, W. L., Weis, K. E., & Katzenellenbogen, B. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1847 · Cited by 185

A Simple and Sensitive Microtiter Plate Estrogen Bioassay Based on Stimulation of Alkaline Phosphatase in Ishikawa Cells: Estrogenic Action of Δ5Adrenal Steroids*

LITTLEFIELD, B. A., GURPIDE, E., MARKIEWICZ, L., McKINLEY, B., & HOCHBERG, R. B. (1990) · Endocrinology · doi:10.1210/endo-127-6-2757 · Cited by 181

Regulation of Cathepsin-D and pS2 Gene Expression by Growth Factors in MCF7 Human Breast Cancer Cells

Cavailles, V., Garcia, M., & Rochefort, H. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-3-552 · Cited by 178

Estrogens Stimulate Cell Proliferation and Induce Secretory Proteins in a Human Breast Cancer Cell Line (T47D)*

CHALBOS, D., VIGNON, F., KEYDAR, I., & ROCHEFORT, H. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-2-276 · Cited by 177

Antiestrogenic Effect of R5020, a Synthetic Progestin in Human Breast Cancer Cells in Culture*

Vignon, F., Bardon, S., Chalbos, D., & Rochefort, H. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1124 · Cited by 173

Androgens inhibit basal and estrogen-induced cell proliferation in the ZR-75-1 human breast cancer cell line.

Poulin, R., Baker, D., & Labrie, F. (1988) · Breast Cancer Research and Treatment · doi:10.1007/bf01805942 · Cited by 172

Stimulation of breast cancer cellsin vitro by the environmental estrogen enterolactone and the phytoestrogen equol

Welshons, W. V., Murphy, C. S., Koch, R., Calaf, G., & Jordan, V. C. (1987) · Breast Cancer Research and Treatment · doi:10.1007/bf01810580 · Cited by 158

Uterine peroxidase as a marker for estrogen action.

Lyttle, C. R., & DeSombre, E. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3162 · Cited by 158

Effects of dichlorodiphenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17β-[3H]estradiol binding to rat uterine receptor

Nelson, J. A. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90436-5 · Cited by 156

Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.

Cavaillès, V., Augereau, P., & Rochefort, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.203 · Cited by 150

Decline in sperm counts: an artefact of changed reference range of “normal”?

Bromwich, P., Cohen, J., Steward, I., & Walker, A. (1994) · BMJ · doi:10.1136/bmj.309.6946.19 · Cited by 147

Response of Human CYP1-Luciferase Plasmids to 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Polycyclic Aromatic Hydrocarbons

Postlind, H., Vu, T., Tukey, R. H., & Quattrochi, L. C. (1993) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1993.1031 · Cited by 145

Naturally-Occurring Estrogens in Plant Foodstuffs - A Review

Verdeal, K., & Ryan, D. S. (1979) · Journal of Food Protection · doi:10.4315/0362-028x-42.7.577 · Cited by 142

A Single Amino Acid That Determines the Sensitivity of Progesterone Receptors to RU486

Benhamou, B., Garcia, T., Lerouge, T., Vergezac, A., Gofflo, D., Bigogne, C., Chambon, P., & Gronemeyer, H. (1992) · Science · doi:10.1126/science.1372753 · Cited by 135

Synergistic activation of transcription by the human estrogen receptor bound to tandem responsive elements.

Ponglikitmongkol, M., White, J. H., & Chambon, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07392.x · Cited by 129

Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced pS2 expression.

Zacharewski, T. R., Bondy, K. L., McDonell, P. J., & Wu, Z.-F. (1994) · PubMed · Cited by 125

Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumour flare

Reddel, R. R., & Sutherland, R. L. (1984) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(84)90062-2 · Cited by 123

Estrogens and growth factors induce the mRNA of the 52K-pro-cathepsin-D secreted by breast cancer cells

Cavaillès, V., Augerau, P., Mj, M. C., & Rochefort, H. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.5.1903 · Cited by 121

Lipophilic impurities, not phenolsulfonphthalein, account for the estrogenic activity in commercial preparations of phenol red

Bindal, R. D., Carlson, K. E., Katzenellenbogen, B. S., & Katzenellenbogen, J. A. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90352-4 · Cited by 115

An androgen-inducible expression system for Saccharomyces cerevisiae

Purvis, I. J., Chotai, D., Dykes, C. W., et al. (1991) · Gene · doi:10.1016/0378-1119(91)90563-q · Cited by 112

Estrogenic activity in vivo and in vitro of some diethylstilbestrol metabolites and analogs

Korach, K. S., Metzler, M., & McLachlan, J. A. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.1.468 · Cited by 112

Stimulatory effects of 4-hydroxytamoxifen on proliferation of human endometrial adenocarcinoma cells (Ishikawa line).

Anzai, Y., Holinka, C. F., Kuramoto, H., & Gurpide, E. (1989) · PubMed · Cited by 109

Detection of Estrogen- and Dioxin-like Activity in Pulp and Paper Mill Black Liquor and Effluent Using in vitro Recombinant Receptor/Reporter Gene Assays

Zacharewski, T. R., Berhane, K., Gillesby, B. E., et al. (1995) · Environmental Science & Technology · doi:10.1021/es00008a037 · Cited by 105

Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast.

Garabedian, M. J., & Yamamoto, K. R. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.11.1245 · Cited by 103

Identification of a negative regulatory function for steroid receptors.

McDonnell, D. P., Vegeto, E., & O'Malley, B. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10563 · Cited by 102

Progestin effects on growth in the human breast cancer cell line T-47D—Possible therapeutic implications

Hissom, J. R., & Moore, M. R. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91022-9 · Cited by 98

Failure of Chloro-S-triazine-Derived Compounds to Induce Estrogen Receptor-Mediated Responsesin Vivoandin Vitro

Connor, K. T. (1996) · Fundamental and Applied Toxicology · doi:10.1006/faat.1996.0046 · Cited by 93

Human estrogen receptor regulation in a yeast model system and studies on receptor agonists and antagonists

Lyttle, C. R., Damián‐Matsumura, P., Juul, H., & Butt, T. R. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90108-u · Cited by 93

Estrogen sulfates: Biological and ultrastructural responses and metabolism in MCF-7 human breast cancer cells

Pasqualini, J. R., Gelly, C., & Lecerf, F. (1986) · Breast Cancer Research and Treatment · doi:10.1007/bf01807336 · Cited by 91

An Estrogen-Binding Protein and Endogenous Ligand in Saccharomyces cerevisiae : Possible Hormone Receptor System

Feldman, D., Do, Y., Burshell, A., Stathis, P., & Loose, D. S. (1982) · Science · doi:10.1126/science.6289434 · Cited by 88

Differential Functional Activities of Rainbow Trout and Human Estrogen Receptors Expressed in the Yeast Saccharomyces cerevisiae

Petit, F. G., Valotaire, Y., & Pakdel, F. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.584_2.x · Cited by 83

Effects of human breast fibroblasts on growth and 17β-estradiol dehydrogenase activity of MCF-7 cells in culture

Adams, E. F., NEWTON, C. J., Braunsberg, H., Shaikh, N. A., Ghilchik, M., & James, V. H. T. (1988) · Breast Cancer Research and Treatment · doi:10.1007/bf01805840 · Cited by 82

Subpopulations of MCF7 cells separated by Percoll gradient centrifugation: a model to analyze the heterogeneity of human breast cancer.

Resnicoff, M., Medrano, E. E., Podhajcer, O. L., Bravo, A., Bover, L. C., & Mordoh, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7295 · Cited by 81

Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors.

Heery, D. M., Zacharewski, T. R., Pierrat, B., Gronemeyer, H., Chambon, P., & Losson, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4281 · Cited by 80

Catecholestrogens are MCF-7 cell estrogen receptor agonists

Schütze, N., Vollmer, G., Tiemann, I., Geiger, M., & Knüppen, R. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90319-r · Cited by 76

Enhancement of 2- and 16α-estradiol hydroxylation in MCF-7 human breast cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Gierthy, J. F., Lincoln, D. W., Kampcik, S. J., Dickerman, H. W., Bradlow, H. L., Niwa, T., & Swaneck, G. E. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80279-1 · Cited by 76

The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast

Privalsky, M. L., Sharif, M., & Yamamoto, K. R. (1990) · Cell · doi:10.1016/0092-8674(90)90423-c · Cited by 75

Multiple actions of synthetic ‘progestins’ on the growth of ZR-75-1 human breast cancer cells: Anin vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids

Poulin, R., Baker, D., Poirier, D., & Labrie, F. (1991) · Breast Cancer Research and Treatment · doi:10.1007/bf01806369 · Cited by 73

Differential Sensitivity of Rat Uterine Growth and Epithelium Hypertrophy to Estrogens and Antiestrogens

Branham, W. S., Zehr, D. R., & Sheehan, D. M. (1993) · Experimental Biology and Medicine · doi:10.3181/00379727-203-43602 · Cited by 72

A Sensitive Bioassay for Detection of Dietary Estrogens in Animal Feeds

Welshons, W. V., Rottinghaus, G. E., Nonneman, D., Dolan-Timpe, M., & Ross, P. F. (1990) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/104063879000200403 · Cited by 70

Oestrogenic activity of tamoxifen and its metabolites on gene regulation and cell proliferation in MCF-7 breast cancer cells

Johnson, M., Westley, B., & May, F. (1989) · British Journal of Cancer · doi:10.1038/bjc.1989.153 · Cited by 65

Functional analysis of the human estrogen receptor using a phenotypic transactivation assay in yeast

Pierrat, B., Heery, D. M., Lemoine, Y., & Losson, R. (1992) · Gene · doi:10.1016/0378-1119(92)90277-v · Cited by 61

Inhibition of postconfluent focus production in cultures of MCF-7 human breast cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Gierthy, J. F., & Lincoln, D. W. (1988) · Breast Cancer Research and Treatment · doi:10.1007/bf01805943 · Cited by 61

Bile acids influence the growth, oestrogen receptor and oestrogen-regulated proteins of MCF-7 human breast cancer cells

Pr, B., Wilton, J., Jones, C., et al. (1992) · British Journal of Cancer · doi:10.1038/bjc.1992.115 · Cited by 60

Optimization of estrogen growth response in MCF-7 cells

Wiese, T. E., Kral, L. G., Dennis, K. E., Butler, W. B., & Brooks, S. C. (1992) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02631033 · Cited by 59

Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions

van der Burg, B., Kalkhoven, E., Isbrücker, L., & de Laat, S. W. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90257-j · Cited by 58

An Antiestrogenic Action of Androgens in Human Breast Cancer Cells*

MacIndoe, J. H., & Etre, L. A. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-4-836 · Cited by 54

GROWTH STIMULATION OF T47D HUMAN BREAST CANCER CELLS BY THE ANTI- PROGESTIN RU486

BOWDEN, R. T., Hissom, J. R., & MOORE, M. R. (1989) · Endocrinology · doi:10.1210/endo-124-5-2642 · Cited by 54

Phytoestrogens: new ligands for rat and human α-fetoprotein

Garreau, B., Vallette, G., Adlercreutz, H., Wähälä, K., Mäkelä, T., Benassayag, C., & Nunez, E. A. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(91)90095-f · Cited by 53

The Phytoestrogen Congeners of Alcoholic Beverages: Current Status

Gavaler, J. S., Rosenblum, E. R., Deal, S. R., & Bowie, B. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-208-43839 · Cited by 51

Topographic recognition of cyclic hydrocarbons and related compounds by receptors for androgens, estrogens, and glucocorticoids

Chang, C., & Liao, S. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90303-7 · Cited by 47

Stimulation of 17β‐estradiol metabolism in MCF‐7 cells by bromochloro‐ and chloromethyl‐substituted dibenzo‐p‐dioxins and dibenzofurans: Correlations with antiestrogenic activity

Spink, D. C., Johnson, J. A., Connor, S., Aldous, K. M., & Gierthy, J. F. (1994) · Journal of Toxicology and Environmental Health · doi:10.1080/15287399409531856 · Cited by 47

v-myb blocks granulocyte colony-stimulating factor-induced myeloid cell differentiation but not proliferation.

Patel, G., Kreider, B. L., Rovera, G., & Reddy, E. P. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2269 · Cited by 45

The Stimulation of Uterine Complement Component C3 Gene Expression by Antiestrogens

Sundstrom, S. A., Komm, B. S., Xu, Q. S., Boundy, V. A., & Lyttle, C. R. (1990) · Endocrinology · doi:10.1210/endo-126-3-1449 · Cited by 44

Regulation of pS2 Gene Expression by Affinity Labeling and Reversibly Binding Estrogens and Antiestrogens: Comparison of Effects on the Native Gene and on pS2-Chloramphenicol Acetyltransferase Fusion Genes Transfected into MCF-7 Human Breast Cancer Cells

Weaver, C. A., Springer, P. A., & Karzenellenbogen, B. S. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-10-936 · Cited by 43

Estrogen action in the uterus: The requisite for sustained estrogen binding in the nucleus

Gorski, J., & Raker, B. (1974) · Gynecologic Oncology · doi:10.1016/0090-8258(74)90014-6 · Cited by 42

Alkaline phosphatase as a reporter enzyme

Yoon, K., Thiede, M. A., & Rodan, G. A. (1988) · Gene · doi:10.1016/0378-1119(88)90220-x · Cited by 42

Specific Region in Hormone Binding Domain Is Essential for Hormone Binding and Trans-Activation by Human Androgen Receptor

Govindan, M. V. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-3-417 · Cited by 41

Influence of culture conditions on the estrogenic cell growth stimulation of human breast cancer cells

Ruedl, C., Cappelletti, V., Coradini, D., Granata, G., & di Fronzo, G. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90327-h · Cited by 33

Lack of estrogenic potential of progesterone- or 19-nor-progesterone-derived progestins as opposed to testosterone or 19-nor-testosterone derivatives on endometrial Ishikawa cells

Botella, J., Duranti, E., Viader, V., et al. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00156-t · Cited by 33

Oestrogen directly stimulates growth factor signal transduction pathways in human breast cancer cells

van der Burg, B., de Groot, R. P., Isbrücker, L., Kruijer, W., & de Laat, S. W. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90185-8 · Cited by 32

Progesterone metabolism in T47Dco human breast cancer cells—II. Intracellular metabolic path of progesterone and synthetic progestins

Horwitz, K. B., Pike, A. W., Gonzalez-Aller, C., & Fennessey, P. V. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90323-7 · Cited by 29

Control of transcription of the chicken progesterone receptor gene. In vitro and in vivo studies

Turcotte, B., Meyer, M.-É., Gross-Bellard, M., Dretzen, G., Gronemeyer, H., & Chambon, P. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52285-7 · Cited by 28

Direct stimulation by estrogen of growth factor signal transduction pathways in human breast cancer cells

van der Burg, B., de Groot, R. P., Isbrücker, L., Kruijer, W., & de Laat, S. W. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90194-n · Cited by 22

ESTROGEN STRUCTURE-RECEPTOR FUNCTION RELATIONSHIPS

Brooks, S. C., Wappler, N. L., Corombos, J. D., Doherty, L. M., & Horwitz, J. E. (1987) · De Gruyter eBooks · doi:10.1515/9783110850260-017 · Cited by 22

Induction and inhibition of estradiol hydroxylase activities in MCF-7 human breast cancer cells in culture

Niwa, T., Bradlow, H. L., Fishman, J., & Swaneck, G. E. (1990) · Steroids · doi:10.1016/0039-128x(90)90032-7 · Cited by 21

Rat liver c-erbA β1 thyroid hormone receptor is a constitutive activator in yeast (Saccharomyces cerevisiae): Essential role of domains D,E and F in hormone-independent transcription

Ohashi, H., Yang, Y.-F., & Walfish, P. G. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91015-5 · Cited by 21

Tissue culture conditions determine the effects of estrogen and growth factors on the anchorage independent growth of human breast cancer cell lines

Zugmaier, G., Knabbe, C., Fritsch, C., Simpson, S., Ennis, B. W., Lippman, M. E., & Dickson, R. B. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90367-e · Cited by 17

The relationship between growth and androstenedione metabolism in four cell lines of human breast carcinoma cells in culture.

Perel, E., Daniilescu, D., Kharlip, L., Blackstein, M. E., & Killinger, D. W. (1985) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(85)90023-1 · Cited by 17

Determination of estradiol2- and 16-alpha-hydroxylase activities in MCF-7 human breast cancer cells in culture using radiometric analysis

Niwa, T., Bradlow, H. L., Fishman, J., & Swaneck, G. E. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90309-9 · Cited by 14

Pharmaceuticals, Personal Care Products, and Endocrine Disruptors in Water: Implications for the Water Industry

Snyder, S. A., Westerhoff, P., Yoon, Y., & Sedlak, D. L. (2003) · Environmental Engineering Science · doi:10.1089/109287503768335931 · Cited by 930

Determination of Endocrine-Disrupting Phenolic Compounds and Estrogens in Surface and Drinking Water by HRGC−(NCI)−MS in the Picogram per Liter Range

Kuch, H. M., & Ballschmiter, K. (2001) · Environmental Science & Technology · doi:10.1021/es010034m · Cited by 734

Review of evidence: Are endocrine-disrupting chemicals in the aquatic environment impacting fish populations?

Mills, L. J., & Chichester, C. (2005) · Science of The Total Environment · doi:10.1016/j.scitotenv.2004.12.070 · Cited by 532

Dioxin-Like and Non-Dioxin-Like Toxic Effects of Polychlorinated Biphenyls (PCBs): Implications For Risk Assessment

Giesy, J. P., & Kannan, K. (1998) · Critical Reviews in Toxicology · doi:10.1080/10408449891344263 · Cited by 494

Identification of Estrogen Receptor β2, A Functional Variant of Estrogen Receptor β Expressed in Normal Rat Tissues

Petersen, D. N., Tkalcevic, G. T., Koza-Taylor, P. H., Turi, T. G., & Brown, T. A. (1998) · Endocrinology · doi:10.1210/endo.139.3.5840 · Cited by 310