Cited by 21DNA and Nucleic Acid ChemistryDNA Repair MechanismsCarcinogens and Genotoxicity Assessment

UV-Induced TA Photoproducts: Formation and Hydrolysis in Double-Stranded DNA

Asgatay, Saâdia, Martinez, Agathe, Coantic-Castex, Stéphanie, Harakat, Dominique, Philippe, Coralie, Douki, Thierry, Clivio, Pascale·2010·Journal of the American Chemical Society

Abstract

Hydrolysis of TA photoproduct leads to two derivatives presenting different formation kinetic profiles depending on the oligomer content. The formation efficiency of TA photoproducts in UV-C-irradiated DNA slightly exceeds the formation of the trans,syn cyclobutane pyrimidine dimer at TT sites.

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Crossref · 10.1021/ja1023173

Cites

21 of 21 references verified0 citation errors · 0 not checkable

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  • Cytosine hydrates and adenine-containing dimers have been isolated in model systems, but their yields are about two orders of magnitude lower than bipyrimidine photoproducts in double-stranded DNA.

    “Other photoproducts such as cytosine hydrates (41,42) or adenine-containing dimers (43,44) have been isolated in model systems but their yields are 2 orders of magnitude lower than that of bipyrimidine photoproducts in double-stranded (ds) DNA.”

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Authors
Asgatay, S., Martinez, A., Coantic-Castex, S., Harakat, D., Philippe, C., Douki, T., & Clivio, P.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, UFR de Pharmacie, Université de Reims Champagne Ardenne, 51 rue Cognacq-Jay, F-51096 Reims Cedex, France, UFR des Sciences Exactes et Naturelles, Bâtiment 18, Europol’Agro, BP 1039, F-51687 Reims Cedex 2, France, and CEA, INAC, SCIB, UJF & CNRS, LCIB (UMR_E 3 CEA-UJF et FRE 3200), Laboratoire “Lésions des Acides Nucléiques”, 17 Rue des Martyrs, F-38054 Grenoble Cedex 9, France
Corresponding author
  • Douki, Thierry
  • Clivio, Pascale
Venue
Journal of the American Chemical Society
Published
2010-07-13
Volume
132
Issue
30
Pages
10260-10261
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W1998317045
Cited by
21
References
21
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2014: 2 · 2013: 5 · 2012: 2
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the American Chemical Society (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-07-PCVI-0004)
  • Centre National de la Recherche Scientifique
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords
UV-induced DNA damage, double-stranded DNA, UV-C irradiation, cyclobutane pyrimidine dimers
MeSH terms
DNA, Hydrolysis, Pyrimidine Dimers, Ultraviolet Rays, Photochemical Processes

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