UV-Induced TA Photoproducts: Formation and Hydrolysis in Double-Stranded DNA
Abstract
Hydrolysis of TA photoproduct leads to two derivatives presenting different formation kinetic profiles depending on the oligomer content. The formation efficiency of TA photoproducts in UV-C-irradiated DNA slightly exceeds the formation of the trans,syn cyclobutane pyrimidine dimer at TT sites.
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Cytosine hydrates and adenine-containing dimers have been isolated in model systems, but their yields are about two orders of magnitude lower than bipyrimidine photoproducts in double-stranded DNA.
“Other photoproducts such as cytosine hydrates (41,42) or adenine-containing dimers (43,44) have been isolated in model systems but their yields are 2 orders of magnitude lower than that of bipyrimidine photoproducts in double-stranded (ds) DNA.”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [44]
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- Authors
- Asgatay, S., Martinez, A., Coantic-Castex, S., Harakat, D., Philippe, C., Douki, T., & Clivio, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, UFR de Pharmacie, Université de Reims Champagne Ardenne, 51 rue Cognacq-Jay, F-51096 Reims Cedex, France, UFR des Sciences Exactes et Naturelles, Bâtiment 18, Europol’Agro, BP 1039, F-51687 Reims Cedex 2, France, and CEA, INAC, SCIB, UJF & CNRS, LCIB (UMR_E 3 CEA-UJF et FRE 3200), Laboratoire “Lésions des Acides Nucléiques”, 17 Rue des Martyrs, F-38054 Grenoble Cedex 9, France
- Corresponding author
- Douki, Thierry
- Clivio, Pascale
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-07-13
- Volume
- 132
- Issue
- 30
- Pages
- 10260-10261
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1998317045
- Cited by
- 21
- References
- 21
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-07-PCVI-0004)
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- UV-induced DNA damage, double-stranded DNA, UV-C irradiation, cyclobutane pyrimidine dimers
- MeSH terms
- DNA, Hydrolysis, Pyrimidine Dimers, Ultraviolet Rays, Photochemical Processes
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