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Single-Step Rapid Assembly of DNA Origami Nanostructures for Addressable Nanoscale Bioreactors
Abstract
Self-assembled DNA origami nanostructures have shown great promise for bottom-up construction of complex objects with nanoscale addressability. Here we show that DNA origami-based 1D nanoribbons and nanotubes are one-pot assembled with controllable sizes and nanoscale addressability with high speed (within only 10-20 min), exhibiting extraordinarily high cooperativity that is often observed in assembly of natural molecular machines in cells (e.g. ribosome). By exploiting the high specificity of DNA-based self-assembly, we can precisely anchor proteins on these DNA origami nanostructures with sub-10 nm resolution and at the single-molecule level. We attach a pair of enzymes (horseradish peroxidase and glucose oxidase) at the inner side of DNA nanotubes and observe high coupling efficiency of enzyme cascade within this confined nanospace. Hence, DNA nanostructures with such unprecedented properties shed new light on the design of nanoscale bioreactors and nanomedicine and provide an artificial system for studying enzyme activities and cascade in highly organized and crowded cell-mimicking environments.
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Cites
Carbon Nanotubes--the Route Toward Applications
Baughman, R. H., Zakhidov, A. A., & de Heer, W. A. (2002) · Science · doi:10.1126/science.1060928 · Cited by 10,267
Folding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,354
Chemically Derived, Ultrasmooth Graphene Nanoribbon Semiconductors
Li, X., Wang, X., Zhang, L., Lee, S., & Dai, H. (2008) · Science · doi:10.1126/science.1150878 · Cited by 4,790
Gold Nanoparticles in Chemical and Biological Sensing
Saha, K., Agasti, S. S., Kim, C., Li, X., & Rotello, V. M. (2012) · Chemical Reviews · doi:10.1021/cr2001178 · Cited by 4,620
Design and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857
Seeman, N. C. (2003) · Nature · doi:10.1038/nature01406 · Cited by 2,782
Self-assembly of DNA into nanoscale three-dimensional shapes
Douglas, S. M., Dietz, H., Liedl, T., Högberg, B., Graf, F., & Shih, W. M. (2009) · Nature · doi:10.1038/nature08016 · Cited by 2,571
Toward Self‐Organization and Complex Matter
Lehn, J. (2002) · ChemInform · doi:10.1002/chin.200240281 · Cited by 2,277
DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
Kuzyk, A., Schreiber, R., Fan, Z., Pardatscher, G., Roller, E.-M., Högele, A., Simmel, F. C., Govorov, A. O., & Liedl, T. (2012) · Nature · doi:10.1038/nature10889 · Cited by 2,216
Graphene-Based Antibacterial Paper
Hu, W., Peng, C., Luo, W., Lv, M., Li, X., Li, D., Huang, Q., & Fan, C. (2010) · ACS Nano · doi:10.1021/nn101097v · Cited by 2,003
Self-citationDNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires
Yan, H., Park, S. H., Finkelstein, G., Reif, J. H., & LaBean, T. H. (2003) · Science · doi:10.1126/science.1089389 · Cited by 1,762
Self-assembly of a nanoscale DNA box with a controllable lid
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B., Stark, H., Oliveira, C. L. P., et al. (2009) · Nature · doi:10.1038/nature07971 · Cited by 1,627
Self-citationDNA-guided crystallization of colloidal nanoparticles
Nykypanchuk, D., Maye, M. M., van der Lelie, D., & Gang, O. (2008) · Nature · doi:10.1038/nature06560 · Cited by 1,530
DNA-programmable nanoparticle crystallization
Park, S. Y., Lytton-Jean, A. K. R., Lee, B., Weigand, S., Schatz, G. C., & Mirkin, C. A. (2008) · Nature · doi:10.1038/nature06508 · Cited by 1,515
A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis
He, S., Song, B., Li, D., Zhu, C., Qi, W., Wen, Y., Wang, L., Song, S., Fang, H., & Fan, C. (2010) · Advanced Functional Materials · doi:10.1002/adfm.200901639 · Cited by 1,376
Self-citationFolding DNA into Twisted and Curved Nanoscale Shapes
Dietz, H., Douglas, S. M., & Shih, W. M. (2009) · Science · doi:10.1126/science.1174251 · Cited by 1,335
Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra
He, Y., Ye, T., Su, M., Zhang, C., Ribbe, A. E., Jiang, W., & Mao, C. (2008) · Nature · doi:10.1038/nature06597 · Cited by 1,304
Challenges and opportunities for structural DNA nanotechnology
Pinheiro, A. V., Han, D., Shih, W. M., & Yan, H. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.187 · Cited by 1,292
DNA Origami with Complex Curvatures in Three-Dimensional Space
Han, D., Pal, S., Nangreave, J., Deng, Z., Liu, Y., & Yan, H. (2011) · Science · doi:10.1126/science.1202998 · Cited by 1,214
DNA-Programmable Nanoparticle Crystallization*
Park, S. Y., Lytton-Jean, A. K. R., Lee, B., Weigand, S., Schatz, G. C., & Mirkin, C. A. (2020) · Spherical Nucleic Acids · doi:10.1201/9781003056690-3 · Cited by 1,179
Interface-Confined Ferrous Centers for Catalytic Oxidation
Fu, Q., Li, W.-X., Yao, Y., Liu, H., Su, H.-Y., Ma, D., Gu, X.-K., Chen, L., Wang, Z., Zhang, H., et al. (2010) · Science · doi:10.1126/science.1188267 · Cited by 1,017
Self-citationEnhanced ethanol production inside carbon-nanotube reactors containing catalytic particles
Pan, X., Fan, Z., Chen, W., Ding, Y., Luo, H., & Bao, X. (2007) · Nature Materials · doi:10.1038/nmat1916 · Cited by 969
Jungmann, R., Steinhauer, C., Scheible, M., Kuzyk, A., Tinnefeld, P., & Simmel, F. C. (2010) · Nano Letters · doi:10.1021/nl103427w · Cited by 903
Li, J., Pei, H., Zhu, B., Liang, L., Wei, M., He, Y., Chen, N., Li, D., Huang, Q., & Fan, C. (2011) · ACS Nano · doi:10.1021/nn202774x · Cited by 748
Self-citationTarget-Responsive Structural Switching for Nucleic Acid-Based Sensors
Li, D., Song, S., & Fan, C. (2010) · Accounts of Chemical Research · doi:10.1021/ar900245u · Cited by 737
Self-citationEnzyme cascades activated on topologically programmed DNA scaffolds
Wilner, O. I., Weizmann, Y., Gill, R., Lioubashevski, O., Freeman, R., & Willner, I. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.50 · Cited by 701
Fu, J., Liu, M., Liu, Y., Woodbury, N. W., & Yan, H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300897h · Cited by 699
An immobile nucleic acid junction constructed from oligonucleotides
Kallenbach, N. R., Ma, R.-I., & Seeman, N. C. (1983) · Nature · doi:10.1038/305829a0 · Cited by 646
A DNA Nanostructure‐based Biomolecular Probe Carrier Platform for Electrochemical Biosensing
Pei, H., Lu, N., Wen, Y., Song, S., Liu, Y., Yan, H., & Fan, C. (2010) · Advanced Materials · doi:10.1002/adma.201002767 · Cited by 563
Self-citationSelf-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays
Ke, Y., Lindsay, S., Chang, Y., Liu, Y., & Yan, H. (2008) · Science · doi:10.1126/science.1150082 · Cited by 460
A structural understanding of the dynamic ribosome machine
Steitz, T. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2352 · Cited by 448
Pei, H., Liang, L., Yao, G., Li, J., Huang, Q., & Fan, C. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201202356 · Cited by 408
Self-citationFree-standing nanoparticle superlattice sheets controlled by DNA
Cheng, W., Campolongo, M. J., Cha, J. J., Tan, S. J., Umbach, C. C., Muller, D. A., & Luo, D. (2009) · Nature Materials · doi:10.1038/nmat2440 · Cited by 398
Programmable molecular recognition based on the geometry of DNA nanostructures
Woo, S., & Rothemund, P. W. K. (2011) · Nature Chemistry · doi:10.1038/nchem.1070 · Cited by 380
Folding and cutting DNA into reconfigurable topological nanostructures
Han, D., Pal, S., Liu, Y., & Yan, H. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.193 · Cited by 329
Loading and selective release of cargo in DNA nanotubes with longitudinal variation
Lo, P. K., Karam, P., Aldaye, F. A., McLaughlin, C. K., Hamblin, G. D., Cosa, G., & Sleiman, H. F. (2010) · Nature Chemistry · doi:10.1038/nchem.575 · Cited by 320
Ringe, D., & Petsko, G. A. (2008) · Science · doi:10.1126/science.1159747 · Cited by 262
DNA-programmed assembly of nanostructures
Gothelf, K. V., & LaBean, T. H. (2005) · Organic & Biomolecular Chemistry · doi:10.1039/b510551j · Cited by 253
Self-citationProgrammed Two-Dimensional Self-Assembly of Multiple DNA Origami Jigsaw Pieces
Rajendran, A., Endo, M., Katsuda, Y., Hidaka, K., & Sugiyama, H. (2011) · ACS Nano · doi:10.1021/nn1031627 · Cited by 202
Metallization of Branched DNA Origami for Nanoelectronic Circuit Fabrication
Liu, J., Geng, Y., Pound, E., Gyawali, S., Ashton, J. R., Hickey, J., Woolley, A. T., & Harb, J. N. (2011) · ACS Nano · doi:10.1021/nn1035075 · Cited by 198
A Route to Scale Up DNA Origami Using DNA Tiles as Folding Staples
Zhao, Z., Yan, H., & Liu, Y. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906225 · Cited by 137
Analogic China map constructed by DNA
Qian, L., Wang, Y., Zhang, Z., Zhao, J., Pan, D., Zhang, Y., Liu, Q., Fan, C., Hu, J., & He, L. (2006) · Chinese Science Bulletin · doi:10.1007/s11434-006-2223-9 · Cited by 132
Self-citationGold nanoparticles for high-throughput genotyping of long-range haplotypes
Chen, P., Pan, D., Fan, C., Chen, J., Huang, K., Wang, D., Zhang, H., Li, Y., Feng, G., Liang, P., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.141 · Cited by 114
Self-citationSelf-assembly of DNA nanotubes with controllable diameters
Wilner, O. I., Orbach, R., Henning, A., Teller, C., Yehezkeli, O., Mertig, M., Harries, D., & Willner, I. (2011) · Nature Communications · doi:10.1038/ncomms1535 · Cited by 82
Two-dimensional DNA origami assemblies using a four-way connector
Endo, M., Sugita, T., Rajendran, A., Katsuda, Y., Emura, T., Hidaka, K., & Sugiyama, H. (2011) · Chemical Communications · doi:10.1039/c0cc05306f · Cited by 79
Asymmetric DNA Origami for Spatially Addressable and Index‐Free Solution‐Phase DNA Chips
Zhang, Z., Wang, Y., Fan, C., Li, C., Li, Y., Qian, L., Fu, Y., Shi, Y., Hu, J., & He, L. (2010) · Advanced Materials · doi:10.1002/adma.201000151 · Cited by 71
Self-citationDNA origami-based nanoribbons: assembly, length distribution, and twist
Jungmann, R., Scheible, M. B., Kuzyk, A., Pardatscher, G., Castro, C. E., & Simmel, F. C. (2011) · Nanotechnology · doi:10.1088/0957-4484/22/27/275301 · Cited by 65
By what means should nanoscaled materials be constructed: molecule, medium, or human?
Ariga, K., Hu, X., Mandal, S., & Hill, J. P. (2009) · Nanoscale · doi:10.1039/b9nr00105k · Cited by 47
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Li, J., Green, A. A., Yan, H., & Fan, C. (2017) · Nature Chemistry · doi:10.1038/nchem.2852 · Cited by 353
Self-citationFramework nucleic acids as programmable carrier for transdermal drug delivery
Wiraja, C., Zhu, Y., Lio, D. C. S., Yeo, D. C., Xie, M., Fang, W., Li, Q., Zheng, M., Van Steensel, M., Wang, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09029-9 · Cited by 294
Self-citationBiocatalytic cascades operating on macromolecular scaffolds and in confined environments
Vázquez-González, M., Wang, C., & Willner, I. (2020) · Nature Catalysis · doi:10.1038/s41929-020-0433-1 · Cited by 293
Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications
Jahanban-Esfahlan, R., Seidi, K., Jahanban-Esfahlan, A., Jaymand, M., Alizadeh, E., Majdi, H., Najjar, R., Javaheri, T., & Zare, P. (2019) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s227193 · Cited by 50
Metadata
- Authors
- Fu, Y., Zeng, D., Chao, J., Jin, Y., Zhang, Z., Liu, H., Li, D., Ma, H., Huang, Q., Gothelf, K. V., & Fan, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-12-28
- Volume
- 135
- Issue
- 2
- Pages
- 696-702
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2054731715
- Cited by
- 272
- References
- 48
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
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