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Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer
Open accessAbstract
A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.
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Citations
Cites
Daniel, M.-C., & Astruc, D. (2004) · Chemical Reviews · doi:10.1021/cr030698+ · Cited by 12,446
Photodynamic therapy for cancer
Dolmans, D. E. J. G. J., Fukumura, D., & Jain, R. K. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1071 · Cited by 6,758
Synthesis of thiol-derivatised gold nanoparticles in a two-phase Liquid–Liquid system
Brust, M., Walker, M., Bethell, D., Schiffrin, D. J., & Whyman, R. (1994) · J. Chem. Soc., Chem. Commun. · doi:10.1039/c39940000801 · Cited by 6,707
Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells
Chithrani, B. D., Ghazani, A. A., & Chan, W. C. W. (2006) · Nano Letters · doi:10.1021/nl052396o · Cited by 4,879
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
Homola, J. (2008) · Chemical Reviews · doi:10.1021/cr068107d · Cited by 4,525
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Photodynamic therapy and anti-tumour immunity
Castano, A. P., Mroz, P., & Hamblin, M. R. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1894 · Cited by 2,676
Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
Connor, E. E., Mwamuka, J., Gole, A., Murphy, C. J., & Wyatt, M. D. (2005) · Small · doi:10.1002/smll.200400093 · Cited by 2,406
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
The role of apoptosis in response to photodynamic therapy: what, where, why, and how
Oleinick, N. L., Morris, R. L., & Belichenko, I. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b108586g · Cited by 1,503
Cited by
Nanomaterials for Theranostics: Recent Advances and Future Challenges
Lim, E.-K., Kim, T., Paik, S., Haam, S., Huh, Y.-M., & Lee, K. (2015) · Chemical Reviews · doi:10.1021/cr300213b · Cited by 1,233
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
A bioorthogonal system reveals antitumour immune function of pyroptosis
Wang, Q., Wang, Y., Ding, J., Wang, C., Zhou, X., Gao, W., Huang, H., Shao, F., & Liu, Z. (2020) · Nature · doi:10.1038/s41586-020-2079-1 · Cited by 1,083
Gold Nanoparticles in Diagnostics and Therapeutics for Human Cancer
Singh, P., Pandit, S., Mokkapati, V. R. S. S., Garg, A., Ravikumar, V., & Mijakovic, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071979 · Cited by 1,038
Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin
Brown, S. D., Nativo, P., Smith, J.-A., Stirling, D., Edwards, P. R., Venugopal, B., Flint, D. J., Plumb, J. A., Graham, D., & Wheate, N. J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja908117a · Cited by 865
Rare earth fluoride nano-/microcrystals: synthesis, surface modification and application
Li, C., & Lin, J. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00031k · Cited by 675
Quantum dots in biomedical applications
Wagner, A. M., Knipe, J. M., Orive, G., & Peppas, N. A. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.022 · Cited by 632
Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications
Kong, F.-Y., Zhang, J.-W., Li, R.-F., Wang, Z.-X., Wang, W.-J., & Wang, W. (2017) · Molecules · doi:10.3390/molecules22091445 · Cited by 615
Gold Nanoparticles in Cancer Treatment
Sztandera, K., Gorzkiewicz, M., & Klajnert-Maculewicz, B. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00810 · Cited by 607
Nanotechnology in Therapeutics: A Focus on Nanoparticles as A Drug Delivery System
Bamrungsap, S., Zhao, Z., Chen, T., Wang, L., Li, C., Fu, T., & Tan, W. (2012) · Nanomedicine · doi:10.2217/nnm.12.87 · Cited by 606
PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation
Prencipe, G., Tabakman, S. M., Welsher, K., Liu, Z., Goodwin, A. P., Zhang, L., Henry, J., & Dai, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809086q · Cited by 600
Fan, H., Yan, G., Zhao, Z., Hu, X., Zhang, W., Liu, H., Fu, X., Fu, T., Zhang, X., & Tan, W. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201510748 · Cited by 567
Shen, Y., Jin, E., Zhang, B., Murphy, C. J., Sui, M., Zhao, J., Wang, J., Tang, J., Fan, M., Van Kirk, E., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909475m · Cited by 565
pH-Induced Aggregation of Gold Nanoparticles for Photothermal Cancer Therapy
Nam, J., Won, N., Jin, H., Chung, H., & Kim, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902062j · Cited by 542
Gold nanoparticles: opportunities and challenges in nanomedicine
Arvizo, R., Bhattacharya, R., & Mukherjee, P. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425241003777010 · Cited by 538
A Chlorin-Based Nanoscale Metal–Organic Framework for Photodynamic Therapy of Colon Cancers
Lu, K., He, C., & Lin, W. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b04069 · Cited by 469
Gold nanoparticle platforms as drug and biomacromolecule delivery systems
Duncan, B., Kim, C., & Rotello, V. M. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.06.004 · Cited by 469
Nanoparticles in Drug Delivery: From History to Therapeutic Applications
Afzal, O., Altamimi, A. S. A., Nadeem, M. S., Alzarea, S. I., Almalki, W. H., Tariq, A., Mubeen, B., Murtaza, B. N., Iftikhar, S., Riaz, N., et al. (2022) · Nanomaterials · doi:10.3390/nano12244494 · Cited by 468
Nanoscale metal–organic frameworks for phototherapy of cancer
Lan, G., Ni, K., & Lin, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.007 · Cited by 420
Skin cancer and new treatment perspectives: A review
Simões, M. C. F., Sousa, J. J. S., & Pais, A. A. C. C. (2015) · Cancer Letters · doi:10.1016/j.canlet.2014.11.001 · Cited by 414
Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery
Guo, S., Li, D., Zhang, L., Li, J., & Wang, E. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.042 · Cited by 398
Park, Y. I., Kim, H. M., Kim, J. H., Moon, K. C., Yoo, B., Lee, K. T., Lee, N., Choi, Y., Park, W., Ling, D., et al. (2012) · Advanced Materials · doi:10.1002/adma.201202433 · Cited by 395
Nanoparticle Technologies for Cancer Therapy
Alexis, F., Pridgen, E. M., Langer, R., & Farokhzad, O. C. (2010) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-00477-3_2 · Cited by 364
Nanomaterials formulations for photothermal and photodynamic therapy of cancer
Shibu, E. S., Hamada, M., Murase, N., & Biju, V. (2013) · Journal of Photochemistry and Photobiology C: Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2012.09.004 · Cited by 356
Ma, Y., Li, X., Li, A., Yang, P., Zhang, C., & Tang, B. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201708005 · Cited by 355
Doane, T. L., Chuang, C.-H., Hill, R. J., & Burda, C. (2012) · Accounts of Chemical Research · doi:10.1021/ar200113c · Cited by 346
Self-citationEntrapment of Hydrophobic Drugs in Nanoparticle Monolayers with Efficient Release into Cancer Cells
Kim, C. K., Ghosh, P., Pagliuca, C., Zhu, Z.-J., Menichetti, S., & Rotello, V. M. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808137c · Cited by 340
Prabaharan, M., Grailer, J. J., Pilla, S., Steeber, D. A., & Gong, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.048 · Cited by 337
Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules
Vigderman, L., & Zubarev, E. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.05.004 · Cited by 305
The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis
Jain, A., & Cheng, K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.016 · Cited by 304
Gong, H., Dong, Z., Liu, Y., Yin, S., Cheng, L., Xi, W., Xiang, J., Liu, K., Li, Y., & Liu, Z. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201401451 · Cited by 274
Multimodal drug delivery using gold nanoparticles
Kim, C.-K., Ghosh, P., & Rotello, V. M. (2009) · Nanoscale · doi:10.1039/b9nr00112c · Cited by 267
Hypericin-assisted photodynamic therapy against anaplastic thyroid cancer
Kim, H., Kim, S. W., Seok, K. H., Hwang, C. W., Ahn, J.-C., Jin, J.-O., & Kang, H. W. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.08.008 · Cited by 61
Tumor delivery of Photofrin® by PLL-g-PEG for photodynamic therapy
Kano, A., Taniwaki, Y., Nakamura, I., Shimada, N., Moriyama, K., & Maruyama, A. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.02.016 · Cited by 34
Metadata
- Authors
- Cheng, Y., Samia, A. C., Meyers, J. D., Panagopoulos, I., Fei, B., & Burda, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-22
- Volume
- 130
- Issue
- 32
- Pages
- 10643-10647
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2067389663
- Cited by
- 733
- References
- 33
- FWCI
- 32.00
- Type
- journal article
- Language
- en
- Open access
- green
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