The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of Cancer
Open accessAbstract
A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.
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Metadata
- Authors
- Cheng, Y., Samia, A. C., Meyers, J. D., Panagopoulos, I., Fei, B., & Burda, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-22
- Volume
- 130
- Issue
- 32
- Pages
- 10643-10647
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2067389663
- Cited by
- 733
- References
- 33
- FWCI
- 32.00
- Type
- journal article
- Language
- en
- Open access
- green
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