Antioxidant/lipoxygenase inhibitory activities and chemical compositions of selected essential oils
Abstract
Twenty-five essential oils were tested for antioxidant activities using a conjugated diene assay, the aldehyde/carboxylic acid assay, the DPPH free radical scavenging assay, and the malonaldehyde/gas chromatography (MA/GC) assay. They were also tested for lipoxygenase inhibitory activities using the lipoxygenase inhibitor-screening assay. Thyme oil exhibited the greatest antioxidant effect in all assays (80-100%) except in the DPPH assay (60%). Clove leaf oil showed activities comparable to those of thyme oil (53-100%). Cinnamon leaf oil showed strong activities in the aldehyde/carboxylic acid assay (100%) and DPPH assay (84%), but only moderate activities in the conjugated diene assay (24%) and MA/GC assay (48%). Basil oil exhibited a strong effect in the DPPH assay (86%) and moderate activities in the MA/GC assay (35%). Bergamot oil exhibited 100% antioxidant activity in the aldehyde/carboxylic acid assay. Eucalyptus and chamomile oils showed appreciable activities only in the conjugated diene assay. Bitter orange oil exhibited moderate antioxidant activity (53%) only in the MA/GC assay. Aloe vera oil exhibited the greatest lipoxygenase inhibitory activity (96%), followed by thyme oil (86%) and bergamot oil (85%) at a concentration of 0.5 microg/mL. Chamomile oil showed slight lipoxygenase inhibitory activity at 0.5 microg/mL but strong lipoxygenase inducing activity at 5 microg/mL (-123%). Thyme and clove leaf oils contained high levels of thymol (23%) and eugenol (77%), respectively, as a principal of the antioxidant activity. The results obtained in the present study suggest that some essential oils possess strong medicinal activities, which can be utilized for treatment of certain diseases.
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Oils of Thymus vulgaris, Eugenia caryophyllus, Cinnamomum zeylanicum Blume., Ocimum basilicum L. and Illicium verum Hook. f. prevented the oxidation of hexanal to hexanoic acid promoted by heat and pure air in a sealed system after 40 days of storage.
“The authors [43] using this method showed that the oils of Thymus vulgaris, Eugenia caryophyllus, Cinnamomum zeylanicum Blume., Ocimum basilicum L. and Illicium verum Hook. f. were able to prevent the oxidation of hexanal to hexanoic acid promoted by heat and pure air introduced in a sealed system, after 40 days of storage.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [43]
Thymus vulgaris, Eugenia caryophyllus, and Ocimum basilicum essential oils had appreciable antioxidant activities comparable to α-tocopherol in the conjugated diene assay.
“The oils of Thymus vulgaris L. (thyme), [Eugenia caryophyllus (C. Spreng) Bull et Hare] (clove), and Ocimum basilicum L. (basil) had appreciable antioxidant activities, comparable to that of α-tocopherol, the reference chosen by the authors [43].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [43]
Basil oil, a good antioxidant in the conjugated diene assay, had only moderate activity in the malonaldehyde GC test.
“Basil oil, that was considered a good antioxidant when the activity was measured through the conjugated diene assay, did not stand out in this test, in which was only considered as possessing moderate activity.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [43]
In the GC method for malonaldehyde, Thymus vulgaris and Eugenia caryophyllus oils possessed the strongest antioxidant activity, comparable to α-tocopherol.
“This method was followed by [43] that demonstrated the oils of Thymus vulgaris and Eugenia caryophyllus possessed the strongest activity, even comparable to that of α-tocopherol.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [43]
The low importance of phenolic compounds for preventing hexanal oxidation is suggested because Illicium verum oil, mainly constituted by anethole, prevented hexanal oxidation.
“Such results may demonstrate the low importance of phenolic compounds to prevent hexanal oxidation, since Illicium verum oil was mainly cosnstituted by anethole [43].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [43]
At higher concentrations of thyme oil, its antioxidant capacity decreased.
“However, in the same work the authors also reported that at higher concentrations of thyme oil, such capacity decreased.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [43]
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- Authors
- Wei, A., & Shibamoto, T.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Shibamoto, Takayuki
- ORCID
- Shibamoto, Takayuki
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-25
- Volume
- 58
- Issue
- 12
- Pages
- 7218-7225
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2024880021
- Cited by
- 241
- References
- 22
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 18 · 2023: 17 · 2022: 21 · 2021: 20 · 2020: 18 · 2019: 14 · 2018: 17 · 2017: 14 · 2016: 16 · 2015: 16 · 2014: 14 · 2013: 6 · 2012: 21
- FWCI
- 17.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- essential oils, antioxidant activity, lipoxygenase inhibition, thyme essential oil, clove leaf oil, cinnamon leaf oil, basil essential oil, bergamot essential oil, eucalyptus oil, chamomile essential oil, thymol, eugenol, chemical composition, DPPH radical scavenging, lipid peroxidation
- MeSH terms
- Antioxidants, Oils, Volatile, Plant Oils, Plants, Lipoxygenase Inhibitors
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