The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Nanoscale Energy Deposition by X-ray Absorbing Nanostructures
Abstract
Here we wish to demonstrate a unique property of nanomaterials: energy deposition with nanometer precision from low-energy electrons released from these nanostructures interacting with hard X-ray radiation in aqueous solution. Three effects combine to cause this phenomenon: (1) localized absorption of X-rays by nanostructures, (2) effective release of low-energy electrons from small nanostructures, and (3) efficient deposition of energy in water in the form of radicals and electrons. This combination creates localized X-ray absorption and localized energy deposition of nanometer precision. We confirmed the theoretically predicted nanoscale energy deposition distribution by measuring hydroxyl radical-induced DNA strand breaks, and observed enhanced damage to a 5600-bp DNA molecule from approximately 10 chemically conjugated small gold nanoparticles under X-ray radiation. These results provide a general guidance to applications of this new concept in many fields including radiation chemistry, radiology, radiation oncology, biochemistry, biology, and nanotechnology.
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Cites
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Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865
Wang, H., Mu, X., He, H., & Zhang, X.-D. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.11.003 · Cited by 572
Physical basis and biological mechanisms of gold nanoparticle radiosensitization
Butterworth, K. T., McMahon, S. J., Currell, F. J., & Prise, K. M. (2012) · Nanoscale · doi:10.1039/c2nr31227a · Cited by 478
Gold nanoparticles for cancer radiotherapy: a review
Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., Solov’yov, A. V., Prise, K. M., Golding, J., & Mason, N. J. (2016) · Cancer Nanotechnology · doi:10.1186/s12645-016-0021-x · Cited by 445
Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles
McMahon, S. J., Hyland, W. B., Muir, M. F., Coulter, J. A., Jain, S., Butterworth, K. T., Schettino, G., Dickson, G. R., Hounsell, A. R., O'Sullivan, J. M., et al. (2011) · Scientific Reports · doi:10.1038/srep00018 · Cited by 429
The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment
Bai, X., Wang, Y., Song, Z., Feng, Y., Chen, Y., Zhang, D., & Feng, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072480 · Cited by 377
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Roadmap to Clinical Use of Gold Nanoparticles for Radiation Sensitization
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Metadata
- Authors
- Carter, J. D., Cheng, N. N., Qu, Y., Suarez, G. D., & Guo, T.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-09-14
- Volume
- 111
- Issue
- 40
- Pages
- 11622-11625
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W2083361390
- Cited by
- 261
- References
- 24
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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