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Nanoscale Energy Deposition by X-ray Absorbing Nanostructures
Abstract
Here we wish to demonstrate a unique property of nanomaterials: energy deposition with nanometer precision from low-energy electrons released from these nanostructures interacting with hard X-ray radiation in aqueous solution. Three effects combine to cause this phenomenon: (1) localized absorption of X-rays by nanostructures, (2) effective release of low-energy electrons from small nanostructures, and (3) efficient deposition of energy in water in the form of radicals and electrons. This combination creates localized X-ray absorption and localized energy deposition of nanometer precision. We confirmed the theoretically predicted nanoscale energy deposition distribution by measuring hydroxyl radical-induced DNA strand breaks, and observed enhanced damage to a 5600-bp DNA molecule from approximately 10 chemically conjugated small gold nanoparticles under X-ray radiation. These results provide a general guidance to applications of this new concept in many fields including radiation chemistry, radiology, radiation oncology, biochemistry, biology, and nanotechnology.
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Metadata
- Authors
- Carter, J. D., Cheng, N. N., Qu, Y., Suarez, G. D., & Guo, T.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-09-14
- Volume
- 111
- Issue
- 40
- Pages
- 11622-11625
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W2083361390
- Cited by
- 261
- References
- 24
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- closed
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