Drug-loaded and superparamagnetic iron oxide nanoparticle surface-embedded amphiphilic block copolymer micelles for integrated chemotherapeutic drug delivery and MR imaging

Hu, Jinming; Qian, Yinfeng; Wang, Xiaofeng; Liu, Tao; Liu, Shiyong

doi:10.1021/la203992q

Cited by 124Nanoparticle-Based Drug DeliveryAdvanced Polymer Synthesis and CharacterizationAdvanced Drug Delivery Systems

Drug-loaded and superparamagnetic iron oxide nanoparticle surface-embedded amphiphilic block copolymer micelles for integrated chemotherapeutic drug delivery and MR imaging

Hu, Jinming, Qian, Yinfeng, Wang, Xiaofeng, Liu, Tao, Liu, Shiyong·2012·Langmuir

DOI 10.1021/la203992q

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Abstract

We report on the fabrication of organic/inorganic hybrid micelles of amphiphilic block copolymers physically encapsulated with hydrophobic drugs within micellar cores and stably embedded with superparamagnetic iron oxide (SPIO) nanoparticles within hydrophilic coronas, which possess integrated functions of chemotherapeutic drug delivery and magnetic resonance (MR) imaging contrast enhancement. Poly(ε-caprolactone)-b-poly(glycerol monomethacrylate), PCL-b-PGMA, and PCL-b-P(OEGMA-co-FA) amphiphilic block copolymers were synthesized at first by combining ring-opening polymerization (ROP), atom transfer radical polymerization (ATRP), and post- modification techniques, where OEGMA and FA are oligo(ethylene glycol) monomethyl ether methacrylate and folic acid-bearing moieties, respectively. A model hydrophobic anticancer drug, paclitaxel (PTX), and 4 nm SPIO nanoparticles were then loaded into micellar cores and hydrophilic coronas, respectively, of mixed micelles fabricated from PCL-b-PGMA and PCL-b-P(OEGMA-co-FA) diblock copolymers by taking advantage of the hydrophobicity of micellar cores and strong affinity between 1,2-diol moieties in PGMA and Fe atoms at the surface of SPIO nanoparticles. The controlled and sustained release of PTX from hybrid micelles was achieved, exhibiting a cumulative release of ~61% encapsulated drugs (loading content, 8.5 w/w%) over ~130 h. Compared to that of surfactant-stabilized single SPIO nanoparticles (r(2) = 28.3 s(-1) mM(-1) Fe), the clustering of SPIO nanoparticles within micellar coronas led to considerably enhanced T(2) relaxivity (r(2) = 121.1 s(-1) mM(-1) Fe), suggesting that hybrid micelles can serve as a T(2)-weighted MR imaging contrast enhancer with improved performance. Moreover, preliminary experiments of in vivo MR imaging were also conducted. These results indicate that amphiphilic block copolymer micelles surface embedded with SPIO nanoparticles at the hydrophilic corona can act as a new generation of nanoplatform integrating targeted drug delivery, controlled release, and disease diagnostic functions.

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Iron oxide nanoparticles can be entrapped inside vesicles like liposomes or polymeric micelles.
“Iron oxide nanoparticles can be entrapped inside of vesicles like liposomes [94–97] or polymeric micelles [98–101].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [98]

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Authors: Hu, J., Qian, Y., Wang, X., Liu, T., & Liu, S.
Affiliations: University of Science and Technology of China (CN)
First Affiliated Hospital of Anhui Medical University (CN)
Corresponding author: Qian, Yinfeng
Liu, Shiyong
ORCID: Hu, Jinming
Qian, Yinfeng
Wang, Xiaofeng
Liu, Shiyong
Venue: Langmuir
Publisher: American Chemical Society (ACS)
Published: 2011-11-11
Volume: 28
Issue: 4
Pages: 2073-2082
ISSN: 0743-7463 (ISSN-L)
1520-5827
DOI: 10.1021/la203992q
OpenAlex: W2016194530
Cited by: 124
References: 53
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 23 · 2012: 11
FWCI: 6.02
Type: journal article
Language: en
Open access: closed
Locations: Langmuir (publishedVersion)
PubMed (publishedVersion)
Funders: Fundamental Research Funds for the Central Universities
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: superparamagnetic iron oxide nanoparticles, drug delivery, MRI contrast enhancement, paclitaxel, folic acid, sustained drug release, T2 relaxivity, nanoparticle corona, targeted drug delivery, in vivo MRI
MeSH terms: Antineoplastic Agents, Contrast Media, Drug Carriers, Ferric Compounds, Magnetic Resonance Imaging, Micelles, Models, Molecular, Molecular Conformation, Polymers, Surface Properties, Paclitaxel, Hydrophobic and Hydrophilic Interactions, Polymerization, Magnets

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Drug-loaded and superparamagnetic iron oxide nanoparticle surface-embedded amphiphilic block copolymer micelles for integrated chemotherapeutic drug delivery and MR imaging

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