The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Acoustic Purification of Extracellular Microvesicles
Open accessAbstract
Microvesicles (MVs) are an increasingly important source for biomarker discovery and clinical diagnostics. The small size of MVs and their presence in complex biological environment, however, pose technical challenges in sample preparation, particularly when sample volumes are small. We herein present an acoustic nanofilter system that size-specifically separates MVs in a continuous and contact-free manner. The separation uses ultrasound standing waves to exert differential acoustic force on MVs according to their size and density. By optimizing the design of the ultrasound transducers and underlying electronics, we were able to achieve a high separation yield and resolution. The "filter size-cutoff" can be controlled electronically in situ, which enables versatile MV-size selection. We applied the acoustic nanofilter to isolate nanoscale (<200 nm) vesicles from cell culture media as well as MVs in stored red blood cell products. With the capacity for rapid and contact-free MV isolation, the developed system could become a versatile preparatory tool for MV analyses.
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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Cited by
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099
Exosomes: key players in cancer and potential therapeutic strategy
Dai, J., Su, Y., Zhong, S., Cong, L., Liu, B., Yang, J., Tao, Y., He, Z., Chen, C., & Jiang, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00261-0 · Cited by 1,186
Exosomes as a new frontier of cancer liquid biopsy
Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 855
Tian, Y., Gong, M., Hu, Y., Liu, H., Zhang, W., Zhang, M., Hu, X., Aubert, D., Zhu, S., Wu, L., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1697028 · Cited by 643
Exosome Biochemistry and Advanced Nanotechnology for Next‐Generation Theranostic Platforms
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Extracellular vesicles: A bright star of nanomedicine
Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120467 · Cited by 368
Role of Exosomes as a Treatment and Potential Biomarker for Stroke
Otero-Ortega, L., Laso-García, F., Gómez-de Frutos, M., Fuentes, B., Diekhorst, L., Díez-Tejedor, E., & Gutiérrez-Fernández, M. (2019) · Translational Stroke Research · doi:10.1007/s12975-018-0654-7 · Cited by 105
Microfluidic Technology for the Isolation and Analysis of Exosomes
Wu, Y., Wang, Y., Lu, Y., Luo, X., Huang, Y., Xie, T., Pilarsky, C., Dang, Y., & Zhang, J. (2022) · Micromachines · doi:10.3390/mi13101571 · Cited by 91
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Self-citationAnalysis of extracellular vesicles as emerging theranostic nanoplatforms
Xing, Y., Cheng, Z., Wang, R., Lv, C., James, T. D., & Yu, F. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213506 · Cited by 67
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Wang, W., Wu, C., & Jin, H. (2019) · Experimental Dermatology · doi:10.1111/exd.13857 · Cited by 59
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Avgoulas, D. I., Tasioulis, K. S., Papi, R. M., & Pantazaki, A. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051439 · Cited by 57
Recent advances in microfluidic methods in cancer liquid biopsy
Iliescu, F. S., Poenar, D. P., Yu, F., Ni, M., Chan, K. H., Cima, I., Taylor, H. K., Cima, I., & Iliescu, C. (2019) · Biomicrofluidics · doi:10.1063/1.5087690 · Cited by 51
Techniques for increasing the yield of stem cell-derived exosomes: What factors may be involved?
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Tian, T., Qiao, S., & Tannous, B. A. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c07981 · Cited by 27
Recent advances in isolation and detection of exosomal microRNAs related to Alzheimer's disease
Pishbin, E., Sadri, F., Dehghan, A., Kiani, M. J., Hashemi, N., Zare, I., Mousavi, P., & Rahi, A. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115705 · Cited by 25
The Role of Exosomes in Pancreatic Cancer From Bench to Clinical Application: An Updated Review
Chen, K., Wang, Q., Kornmann, M., Tian, X., & Yang, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.644358 · Cited by 24
Li, X., Chen, J., Yang, Y., Cai, H., Ao, Z., Xing, Y., Li, K., Yang, K., Guan, W., Friend, J., et al. (2025) · Microsystems & Nanoengineering · doi:10.1038/s41378-025-00916-4 · Cited by 17
Metadata
- Authors
- Lee, K., Shao, H., Weissleder, R., & Lee, H.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-02-16
- Volume
- 9
- Issue
- 3
- Pages
- 2321-2327
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1965152917
- Cited by
- 534
- References
- 2
- FWCI
- 16.83
- Type
- journal article
- Language
- en
- Open access
- green
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